PMID- 27053630

OWN - NLM
STAT- MEDLINE
DCOM- 20170803
LR - 20220410
IS - 1468-3288 (Electronic)
IS - 0017-5749 (Linking)
VI - 66
IP - 6
DP - 2017 Jun
TI - The effect of heritability and host genetics on the gut microbiota and
metabolic
syndrome.
PG - 1031-1038
LID - 10.1136/gutjnl-2015-311326 [doi]
AB - OBJECTIVE: Metabolic syndrome (MetS) arises from complex interactions between

host genetic and environmental factors. Although it is now widely accepted

that
the gut microbiota plays a crucial role in host metabolism, current knowledge
on
the effect of host genetics on specific gut microbes related to MetS status
remains limited. Here, we investigated the links among host genetic factors,
gut
microbiota and MetS in humans. DESIGN: We characterised the gut microbial
community composition of 655 monozygotic (n=306) and dizygotic (n=74) twins
and
their families (n=275), of which approximately 18% (121 individuals) had
MetS. We
evaluated the association of MetS status with the gut microbiota and
estimated
the heritability of each taxon. For the MetS-related and heritable taxa, we
further investigated their associations with the apolipoprotein A-V gene
(APOA5)
single nucleotide polymorphism (SNP) rs651821, which is known to be
associated
with triglyceride levels and MetS. RESULTS: Individuals with MetS had a lower
gut
microbiota diversity than healthy individuals. The abundances of several taxa

were associated with MetS status; Sutterella, Methanobrevibacter and

Lactobacillus were enriched in the MetS group, whereas Akkermansia,
Odoribacter
and Bifidobacterium were enriched in the healthy group. Among the taxa
associated
with MetS status, the phylum Actinobacteria, to which Bifidobacterium
belongs,
had the highest heritability (45.7%). Even after adjustment for MetS status,
reduced abundances of Actinobacteria and Bifidobacterium were significantly
linked to the minor allele at the APOA5 SNP rs651821. CONCLUSIONS: Our
results
suggest that an altered microbiota composition mediated by a specific host
genotype can contribute to the development of MetS.
CI - Published by the BMJ Publishing Group Limited. For permission to use (where
not
already granted under a licence) please go to
http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Lim, Mi Young
AU - Lim MY
AD - Department of Environmental Health Sciences, Graduate School of Public
Health,
Seoul National University, Seoul, Republic of Korea.
AD - Institute of Health and Environment, Seoul National University, Seoul,
Republic
of Korea.
FAU - You, Hyun Ju
AU - You HJ
AD - Department of Environmental Health Sciences, Graduate School of Public
Health,
Seoul National University, Seoul, Republic of Korea.
AD - Institute of Health and Environment, Seoul National University, Seoul,
Republic
of Korea.
AD - Center for Human and Environmental Microbiome, Seoul National University,
Seoul,
Republic of Korea.
FAU - Yoon, Hyo Shin
AU - Yoon HS
AD - Department of Environmental Health Sciences, Graduate School of Public
Health,
Seoul National University, Seoul, Republic of Korea.
FAU - Kwon, Bomi
AU - Kwon B
AD - Department of Environmental Health Sciences, Graduate School of Public
Health,
Seoul National University, Seoul, Republic of Korea.
FAU - Lee, Jae Yoon
AU - Lee JY
AD - Department of Environmental Health Sciences, Graduate School of Public
Health,
Seoul National University, Seoul, Republic of Korea.
FAU - Lee, Sunghee
AU - Lee S
AD - Department of Environmental Health Sciences, Graduate School of Public
Health,
Seoul National University, Seoul, Republic of Korea.
FAU - Song, Yun-Mi
AU - Song YM
AD - Department of Family Medicine, Samsung Medical Center, Sungkyunkwan
University
School of Medicine, Seoul, Republic of Korea.
FAU - Lee, Kayoung
AU - Lee K
AD - Department of Family Medicine, Busan Paik Hospital, Inje University College
of
Medicine, Busan, Republic of Korea.
FAU - Sung, Joohon
AU - Sung J
AD - Department of Epidemiology, Graduate School of Public Health, Seoul National
University, Seoul, Republic of Korea.
FAU - Ko, GwangPyo
AU - Ko G
AD - Department of Environmental Health Sciences, Graduate School of Public
Health,
Seoul National University, Seoul, Republic of Korea.
AD - Center for Human and Environmental Microbiome, Seoul National University,
Seoul,
Republic of Korea.
AD - N-Bio, Seoul National University, Seoul, Republic of Korea.
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
PT - Twin Study
DEP - 20160406
PL - England
TA - Gut
JT - Gut
JID - 2985108R
RN - 0 (APOA5 protein, human)
RN - 0 (Apolipoprotein A-V)
RN - 0 (RNA, Ribosomal, 16S)
SB - IM
MH - Adult
MH - Aged
MH - Aged, 80 and over
MH - Alleles
MH - Apolipoprotein A-V/*genetics
MH - Bacteroidetes/isolation & purification
MH - Betaproteobacteria/isolation & purification
MH - Bifidobacterium/isolation & purification
MH - Dysbiosis/microbiology
MH - Feces/microbiology
MH - Female
MH - *Gastrointestinal Microbiome
MH - Gene-Environment Interaction
MH - Genotype
MH - Humans
MH - Lactobacillus/isolation & purification
MH - Male
MH - Metabolic Syndrome/*genetics/*microbiology
MH - Methanobrevibacter/isolation & purification
MH - Middle Aged
MH - Polymorphism, Single Nucleotide
MH - RNA, Ribosomal, 16S/*analysis
MH - Verrucomicrobia/isolation & purification
MH - Young Adult
OTO - NOTNLM
OT - *ENERGY METABOLISM
OT - *ENTERIC BACTERIAL MICROFLORA
OT - *GENETIC POLYMORPHISMS
EDAT- 2016/04/08 06:00
MHDA- 2017/08/05 06:00
CRDT- 2016/04/08 06:00
PHST- 2015/12/21 00:00 [received]
PHST- 2016/03/10 00:00 [revised]
PHST- 2016/03/12 00:00 [accepted]
PHST- 2016/04/08 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2016/04/08 06:00 [entrez]
AID - gutjnl-2015-311326 [pii]
AID - 10.1136/gutjnl-2015-311326 [doi]
PST - ppublish
SO - Gut. 2017 Jun;66(6):1031-1038. doi: 10.1136/gutjnl-2015-311326. Epub 2016 Apr
6.