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Fertility and Sterility

Volume 56, Issue 3, September 1991, Pages 408-413

Gynecology-endocrinology

The stimulus responsible for the peritoneal

fluid inflammation observed in infertile
women with endometriosis*
Author links open overlay
panelA.F. Haney M.D. † ‡, Susan Jenkins M.D. † §, J. Brice
Weinberg M.D. ∥
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Objective
We tested the hypothesis that menstrual debris from ectopic
endometrium is the stimulus responsible for eliciting the peritoneal
fluid (PF) inflammation observed in infertile women with
endometriosis.

Design, Setting, Patients

The extent of endometriosis was correlated with the PF volume and
total PF cell count retrospectively in 135 infertile women with
endometriosis.

Results
The volume and total cell count were positively correlated, whereas
the total cell count was negatively correlated with the extent of
endometriosis. Despite a similar negative trend, no statistically
significant correlation was noted between the volume and the extent of
endometriosis. These relationships did not change when the data were
reanalyzed deleting those pathological features contributing to the
endometriosis score but not capable of producing intraperitoneal
menstrual debris, i.e., adhesions and encapsulated ovarian
endometriomas.

Conclusions
These findings indicate that menstrual debris from ectopic
endometrium is probably not a major factor in the elicitation of the
observed PF inflammation in infertile women with endometriosis and
suggest an inverse relationship may exist between PF inflammation
and the extent of endometriosis.

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REFERENCES
1. 1.
T.S. Drake, S.A. Metz, G.M. Grunert, W.F. O’Brien
Peritoneal fluid volume in endometriosis

Fertil Steril, 34 (1980), p. 280

Google Scholar
2. 2.
A.F. Haney, J.J. Muscato, J.B. Weinberg
Peritoneal fluid cell populations in infertility patients

Fertil Steril, 35 (1981), p. 696

Google Scholar
3. 3.
J. Halme, S. Becker, M.G. Hammond, M.H.G. Raj, S. Raj
Increased activation of pelvic macrophages in infertile women with
mild endometriosis

Am J Obstet Gynecol, 145 (1983), p. 333

Google Scholar
4. 4.
D.L. Olive, A.F. Haney, J.B. Weinberg
 The nature of the intraperitoneal exudate associated with
infertility: peritoneal fluid and serum lysozyme activity

Fertil Steril, 48 (1987), p. 802

Google Scholar
5. 5.
H. Fakih, B. Baggett, G. Holtz, Y.K. Tsang, J.C. Lee, H.O. 
Williamson
Interleukin-1: a possible role in the infertility associated with
endometriosis

Fertil Steril, 47 (1987), p. 213

Google Scholar
6. 6.
J. Eisermann, M.J. Gast, J. Pineda, R.R. Odem, J.L. Collins
Tumor necrosis factor in peritoneal fluid of women undergoing
laparoscopic surgery

Fertil Steril, 50 (1988), p. 573

Google Scholar
7. 7.
N. Gleicher, W.P. Dmowski, I. Seigel, T.L. Liv, J. Friberg, E. 
Radwanska, V. Toder
Lymphocyte subsets in endometriosis

Obstet Gynecol, 63 (1984), p. 463

Google Scholar
8. 8.
G. Soldati, A. Piffaretti-Yanez, A. Campana, M. Marchini, M
. Luerti, M. Balerna
 Effect of peritoneal fluid on sperm motility and velocity distribution
using objective measurements

Fertil Steril, 52 (1989), p. 113

Google Scholar
9. 9.
R.N. Morcos, W.E. Gibbons, W.E. Findley
Effect of peritoneal fluid on in vitro cleavage of 2-cell mouse
embryos: a possible role in infertility associated with
endometriosis

Fertil Steril, 44 (1985), p. 678

Google Scholar
10. 10.

K.J. Chacho, M. Stronkowski-Chacho, P.J. Andressen, A. S
commegna
Peritoneal fluid in patients with and without endometriosis:
prostanoids and macrophages and their effect on the
spermatozoa penetration assay

Am J Obstet Gynecol, 154 (1986), p. 1290

Google Scholar
11. 11.

C.E. Sueldo, H. Lambert, A. Steinleitner, G. Rathwick, J. S
wanson
The effect of peritoneal fluid from patients with endometriosis on
murine sperm-oocyte interaction

Fertil Steril, 48 (1987), p. 697

Google Scholar
12. 12.

H. Suginami, K. Yano, K. Watanabe, S. Matsuura
 A factor inhibiting ovum capture by the oviductal fimbriae present
in endometriosis peritoneal fluid

Fertil Steril, 46 (1986), p. 1140

Google Scholar
13. 13.

D.L. Olive, A.F. Haney
Endometriosis-associated infertility: a critical review of therapeutic
approaches

Obstet Gynecol Surv, 41 (1986), p. 538

Google Scholar
14. 14.

J. Halme, M.G. Hammond, J.F. Hulka
Retrograde menstruation in healthy women and in patients with
endometriosis

Obstet Gynecol, 64 (1984), p. 151

Google Scholar
15. 15.

A.F. Haney, M.A. Misukonis, J.B. Weinberg
Macrophages and infertility: oviductal macrophages as potential
mediators of infertility

Fertil Steril, 39 (1983), p. 310

Google Scholar
16. 16.

R. Van Furth, J.A. Raeburn, T.L. Van Zwet

Characteristics of human mononuclear phagocytes

Blood, 54 (1979), p. 485
 Google Scholar
17. 17.

A.F. Haney, J.B. Weinberg
Reduction of the intraperitoneal inflammation associated with
endometriosis by treatment with medroxyprogesterone acetate

Am J Obstet Gynecol, 159 (1988), p. 450

Google Scholar
18. 18.

American Fertility Society

Revised American Fertility Society classification of endometriosis,
1985

Fertil Steri, 43 (1985), p. 351

Google Scholar
19. 19.

C.H. Syrop, J. Halme
Cyclic changes of peritoneal fluid parameters in normal and
infertile patients

Obstet Gynecol, 69 (1987), p. 3

Google Scholar
20. 20.

J. Halme, S. Becker, S. Haskill
Altered maturation and function of peritoneal macrophages:
possible role in the pathogenesis of endometriosis

Am J Obstet Gynecol, 156 (1987), p. 783

Google Scholar
21. 21.
 R.W. Steele, W.P. Dmowski, D.J. Marmar
Immunologic aspects of human endometriosis

Am J Reprod Immunol, 6 (1984), p. 33

Google Scholar
22. 22.

S. Mathur, M.R. Peress, H.O. Williamson, C.D. Youmans, S
.A. Maney, A.J. Garvin, P.F. Rust, H.H. Fudenberg
Autoimmunity to endometrium and ovary in endometriosis

Clin Exp Immunol, 50 (1982), p. 259

Google Scholar
23. 23.

R.A. Wild, P.G. Satyaswarop, A.C. Shivers
Epithelial localization of antoendometrial antibodies associated
with endometriosis

Am J Reprod Immunol Microbiol, 13 (1987), p. 62

Google Scholar
24. 24.

D. Kreiner, F.B. Fromowitz, D.A. Richardson, D. Kenigsber
g
Endometrial immunofluorescence associated with endometriosis
and pelvic inflammatory disease

Fertil Steril, 46 (1986), p. 243

Google Scholar
25. 25.

N. Gleicher, A. El-Roeiy, E. Cofino, J. Friberg
Is endometriosis an autoimmune disease?
 Obstet Gynecol, 70 (1987), p. 115
Google Scholar

Cited by (0)
*

Supported by the Veteran’s Administration Research Service,

and by grant P50 AR 39162 from the National Institutes of
Health, Bethesda, Maryland.
†

Division of Reproductive Endocrinology and Infertility,

Department of Obstetrics and Gynecology, Duke University
Medical Center.
‡

Reprint requests: A. F. Haney, M.D., Box 2971, Duke University

Medical Center, Durham, North Carolina 27710.
§

Present address: Group Health Association, 1920 L Street, N.

W., Washington, D.C.
∥

Department of Medicine, Duke University and Veteran’s

Administration Medical Center.
Copyright © 1991 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights
reserved.
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