Name: Satomi Samson

Section: 3NU09

Name of Drug Mechanism of Action Dosage Indications Contraindications Adverse Reactions Nursing Alert
Brand Name: Principal intracellular 1 tab TID Hypokalemia. Hypersensitivity. GI:Nausea, vomiting, ● Monitor I&O
Caliumdurone action; essential for Prophylaxis during Renal insufficiency, diarrhea, abdominal ratio and
maintenance of treatment with hyperkalemia, distension. pattern in
Generic Name: intracellular saluretic diuretics, untreated Addison’s BodyWhole:Pain, patients
Potassium Chloride isotonicity, especially in disease, stricture of mental confusion, receiving the
transmission of combination with the esophagus irritability, parenteral
nerve impulses, digitalis. and/or obstructive listlessness, drug. If
contraction of changes in the paresthesias of oliguria
cardiac, skeletal, alimentary tract. extremities, muscle occurs, stop
and smooth weakness and infusion
muscles, heaviness of limbs, promptly and
maintenance of difficulty in notify
normal kidney swallowing, flaccid physician.
function, and for paralysis.
enzyme activity. Urogenital:Oliguria,
Plays a prominent anuria.
role in both Hematologic:Hyperk
formation and alemia.
correction of Respiratory:Respirat
imbalances in acid- ory distress.
base metabolism. CV:Hypotension,
bradycardia; cardiac
depression,
arrhythmias, or
arrest; altered
sensitivity to digitalis
glycosides. ECG
changes in
hyperkalemia:
Name: Satomi Samson
Section: 3NU09
Tenting (peaking) of
T wave (especially in
right precordial
leads), lowering of R
with deepening of S
waves and
depression of RST;
prolonged P-R
interval, widened
QRS complex,
decreased amplitude
and disappearance
of P waves,
prolonged Q-T
interval, signs of
right and left bundle
block, deterioration
of QRS contour and
finally ventricular
fibrillation and death.
Name: Satomi Samson
Section: 3NU09

Name of Drug Mechanism of Action Dosage Indications Contraindications Adverse Reactions Nursing Alert
Brand Name: Duloxetine is a ● Depression – ● Adults: Hypersensitivity to Discontinuation of ● Watch for
Duloxetine combined serotonin Duloxetine the active substance duloxetine
the starting signs of
(5-HT) and or to any of the (particularly when
dose is 60mg, (Cymbalta) is
Generic Name: noradrenaline (NA) excipients. abrupt) commonly neuroleptic
Cymbalta reuptake inhibitor. It taken once a indicated for
Concomitant use of leads to withdrawal malignant
weakly inhibits day and this the treatment Duloxetine symptoms.
dopamine reuptake syndrome,
can be of: Major (Cymbalta) with Dizziness, sensory
with no significant
affinity for increased to Depressive non-selective disturbances including
histaminergic, 120mg, taken Disorder. irreversible (including
hyperthermia,
dopaminergic, monoamine oxidase paresthesia or
once a day ● Diabetic
cholinergic and inhibitors (MAOIs) is electric shock-like diaphoresis,
adrenergic receptors. ● Anxiety – the Neuropathic
contraindicated (see sensations,
Duloxetine
generalized
starting dose Pain. Interactions). particularly in the
dose-dependently ● Generalized Liver disease head), sleep muscle
is 30mg, taken
increases extracellular
once a day Anxiety resulting in hepatic disturbances rigidity,
levels of serotonin and
Disorder.
impairment (see (including insomnia
noradrenaline in and this can altered
various brain areas of Pharmacology: and intense
be increased ● Fibromyalgia
animals. Pharmacokinetics dreams), fatigue, mental
to 60mg, taken with or without under Actions). somnolence,
status,
once a day depression. Duloxetine agitation and
● Nerve pain – ● Chronic pain (Cymbalta) should anxiety, nausea tachycardia,
(CP) states not be used in and/or vomiting, changes in
the starting
combination with headache, myalgia,
dose is 60mg associated blood
fluvoxamine, irritability, diarrhea,
taken once a with: Diabetic
ciprofloxacin, or hyperhidrosis and pressure
day, and this Peripheral enoxacine (i.e., vertigo
(BP), and
can be Neuropathic potent CYP1A2
Name: Satomi Samson
Section: 3NU09
increased to Pain (DPNP); inhibitors) since the incontinence.
60mg taken Fibromyalgia combination results
Symptoms
twice a day (FM); Chronic in elevated plasma
concentrations of typically
● Stress urinary Lower Back
duloxetine (see occur within
incontinence – Pain (CLBP); Interactions).
the starting Osteoarthritis Severe renal 4–14 days
dose is 20mg, (OA) impairment after initiation
taken twice a (creatinine clearance
of drug
less than 30 mL/min)
day and this
(see Precautions). therapy, but
can be
can occur at
increased to
40mg, taken any time
twice a day, during drug
after 2 weeks use. Report
these signs to
the physician
immediately.
● Be alert for
new seizures
or increased
seizure
activity,
especially at
the onset of
Name: Satomi Samson
Section: 3NU09
drug
treatment.
Document
the number,
duration, and
severity of
seizures, and
report these
findings
immediately
to the
physician.
● Inform
physician if
patient
demonstrates
other mood
changes such
as anxiety,
nervousness,
restlessness,
or other signs
Name: Satomi Samson
Section: 3NU09
of increased
mania.

Name of Drug Mechanism of Action Dosage Indications Contraindications Adverse Reactions Nursing Alert
Brand Name: Tamsulosin is an Oral Management of History of orthostatic Significant: Orthostatic ● Avoid physical
Tamsulosin antagonist of Benign prostatic outflow obstruction in hypotension. Severe hypotension, floppy iris therapy
α1-adrenoceptors, hyperplasia male patients with renal impairment (CrCl syndrome in cataract interventions
Generic Name:
Flomax which mediate smooth Adult: 400 mcg once prostatic hyperplasia. <10 mL/min) and and glaucoma surgery, that cause
muscle tone in the daily. Alternatively, hepatic impairment hypersensitivity systemic
prostate. This leads to may increase dose to (Child-Pugh scores reactions, MI vasodilation
the relaxation of 800 mcg once daily >9). Concomitant use exacerbations. (large
smooth muscle in the after 2-4 weeks if with strong CYP3A4 Cardiac disorders: whirlpool,
bladder neck and response is inhibitors in patients Palpitations. Hubbard tank).
prostate thereby inadequate. who are CYP2D6 poor Eye disorders: Blurred Additive effects
improving urine flow metabolisers. vision, visual of this drug
and reducing the impairment. and the
symptoms of benign Gastrointestinal intervention
prostatic hyperplasia disorders: may cause a
(BPH). Constipation, dangerous fall
diarrhoea, nausea, in BP.
vomiting, dry mouth. ● To minimize
orthostatic
Name: Satomi Samson
Section: 3NU09
General disorders and hypotension,
administration site advise patient
conditions: Asthenia. to move slowly
Nervous system when
disorders: Headache, assuming a
dizziness. more upright
Reproductive system position.
and breast
disorders:Ejaculation
disorders including
retrograde ejaculation,
ejaculation failure,
priapism.
Respiratory, thoracic
and mediastinal
disorders: Cough,
pharyngitis, sinusitis,
rhinitis, epistaxis.
Skin and
subcutaneous tissue
disorders: Rash,
pruritus, urticaria, skin
desquamation,
erythema multiforme,
dermatitis exfoliative.
Name: Satomi Samson
Section: 3NU09
Vascular disorders:
Hypotension.