Gastrointestinal reactions and rotavirus vaccination based upon analys... https://pubmed.ncbi.nlm.nih.

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Hepatogastroenterology. 2004 Mar-Apr;51(56):465-9.

Gastrointestinal reactions and rotavirus vaccination

based upon analysis of the Vaccine Adverse Events
Reporting System (VAERS) database for 1999. A
model for the calculation of the incidence rates and
statistical significance of adverse events following
immunization
David A Geier 1 , Mark R Geier

Affiliations
PMID: 15086184

Abstract
!" #$% &'()* +",-. /The purpose of this study was to extend previous publications and examine
the Vaccine Adverse Events Reporting System (VAERS) database for the incidence of
gastrointestinal reactions reported following tetra-valent rhesus-human reassortant rotavirus
vaccine (RRV-TV).

01 23' * '4
'%5 /The VAERS database was analyzed for adverse reactions reported for the entire
year of 1999 following RRV-TV using Microsoft Access. In this study, the incidence rates of
adverse reactions reported to VAERS following acellular diphtheria, pertussis and tetanus (DTaP)
vaccine, whole-cell DTP vaccine, live polio (OPV) vaccine and pediatric hepatitis B vaccine were
used as control vaccine groups.

61 .( 42./The results of a chi-square analysis showed that rotavirus vaccine was statistically
significantly over represented by serious gastrointestinal reactions in comparison to vaccine
control groups.

7' ) #4(.,'). /This analysis demonstrated that the VAERS database provides a way to detect
whether RRV-TV elevates the risk of adverse reactions compared to control vaccines given to
similar age groups when appropriate denominators (number of annual doses given) are employed.
Because of its massive size and the availability of numerous vaccine control groups, the VAERS
database provides data on adverse reactions following vaccination that is available nowhere else.

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