[2] D–979

Roll No. ................................... 2. The given compound is :

CH 3
H NHCH 3

H OH
D–979 C6 H5
(a) D(–) Ephedrin
M. Sc. (Fourth Semester) (Main/ATKT)
(b) D(+) Ephedrin
EXAMINATION, May-June, 2020 (c) Nicotine
CHEMISTRY (d) Coline

Paper No. CH–20 3. The given structure is :

(Natural Product and Medicinal Chemistry)

Time : Three Hours ] [ Maximum Marks : 80

Note : Attempt all Sections as directed. (a) Santonin

Section—A 1 each (b) Phytol

(Objective/Multiple Choice Questions) (c) Morphine

(d) Zingiberene
Note : Attempt all questions.
4. Which one of the following is a alkaloid ?
Choose the correct answer :
(a) Bile acid
1. Which one of the following is not a terpenoids ? (b) Quinine
(a) Abiotic acid (c) Citral

(b) Farnesol (d) Luteolin

5. Which combination is true for terpenoids and alkaloids
(c) Atropine
respectively ?
(d) Zingiberene (a) Citral and Phytol

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(b) Morphine and Zingiberene 9. Which one of the following is not a steroid ?
(c) Atropine and Coline (a) Bile acid
(d) Geraniol and Morphine
(b) Cholesterol
6. The given structure is :
(c) Progesterone

(d) Diadzine

10. The given structure is :

(a) Aldosterone
(b) Testosterone
(c) Progesterone
(d) Androsterone (a) Cholesterol
(b) Progesterone
7. The given structure is :
(c) Estrone
(d) Testosterone
11. What does the symbol P present in a QSAR equation ?
(a) pH
(a) Cholesterol (b) Plasma concentration
(b) Bile acid (c) Partition coefficient
(c) Esterone (d) Prodrug
(d) Testosterone 12. Which one of the following statement is true ?
8. Which one of the following is plant pigment ? (a) Drug and drug targets have similar molecules weights.
(a) Butein (b) Drugs are generally smaller than drug targets.
(b) Bile acid (c) Drugs are generally larger than drug targets.
(c) Vitexin (d) There is no general rule regarding the relative size of
(d) Azacrin drugs and their targets.

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13. What is meant by the led compound in medicinal chemistry ? 17. 8-amino quinolone derivatives is :
(a) A drug containing the element lead. (a) Santonin
(b) A leading drug in a particular area of medicine.
(b) Paludrine
(c) A compound that act as the starting point for drug
design and development. (c) Pyremethamine

(d) A drug which is normally the first to be prescribed for (d) Isopentaquine
a particular element.
18. 4-amino quinolone derivatives is :
14. Which of the following needs to be established before the,
(a) Pyrementhamine
search for a lead compound takes place ?
(b) Camaquine
(a) The pharmacophore
(c) Mepacrine
(b) Structural-activity relationship
(d) Azacrine
(c) A bioassay
19. The given structure is :
(d) Patents

15. The reasons for determining bioavailability are :

(a) A rheological parameter of blood
(b) Amount of substance obtain orally and quantity of
(a) Azacrine
intake
(b) Mepacrine
(c) The extent of absorption and hepatic first-pass effect
(c) Camaquine
(d) Glomerular filtration effect
(d) Pyremethamine
16. Pyrimidine and Biguanid derivatives is :
20. Which one of the following is not a antibiotic ?
(a) Paludrine
(a) Streptomocine
(b) Pamaquine
(b) Tetramycine
(c) Primaquine (c) Chloramphenicol
(d) Pentaquine (d) Pamaquine

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Section—B 2 each Section—D 3 each

(Very Short Answer Type Questions) (Long Answer Type Questions)
Note : Attempt all questions. Note : Attempt all questions.

1. Draw the structure of beta carotene. 1. What are terpenoids ? Discuss the synthesis and application

2. What is morphine ? of menthol.

3. Draw the structure of testosterone. Or

4. What is hirsutidin ? What are alkaloids ? Discuss the synthesis and application of
5. What are soft drugs ? nicotine.

6. Define pharmacophore. 2. What are Steroids ? Discuss the biosynthesis of cholesterol.

7. Draw the structure of streptomycin. Or
8. Draw the structure of pyrimethamine.
Discuss the synthesis steps in Quercetin-3-glucoside and
Section—C 3 each cyaniding.
(Short Answer Type Questions)
3. What do you mean by pharmakokinetic and
Note : Attempt all questions.
phamakodynamic ? Explain.
1. Write the synthesis and mechanism of citral. Or
2. Write the synthesis and mechanism of quinine. Write a short note on induced fit theory and QSAR.
3. Discuss the structural feature of bile acid.
4. What are Antibiotics ? Discuss the synthesis of penicillin.
4. What are plant pigment. Draw the structure of Apigenin,
Mycretin and Butein. Or

5. Discuss the factor affecting the development of a new drug. What are the antimalaria agents ? Discuss the synthesis and
6. Explain the significance of drug metabolism in medicinal applications of isopentaquine.
chemistry.
7. What are alkaylating agents ?
8. Discuss the synthesis and process of chloramphenicol. D–979

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