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SOP 17: NCU

Apnoea of Prematurity
Definition

Cessation of breathing for > 10 s with


Cessation of breathing for OR - Bradycardia < 100 bpm
> 20 s Or
- Cyanosis or low SpO2

Investigations
Evaluate for Sepsis: Rule out Anaemia: Rule out Hypothermia
✓ Full Blood Picture ✓ Haemoglobin ✓ Measure Temperature
✓ CRP
✓ Lumbar Puncture
Rule out Hypoglycaemia:
✓ Blood Culture
✓ Random Blood Glucose

Management
Tactile Stimulation
Supportive therapy
When Sepsis is Suspected
Maintain
Antibiotics KMC if possible
normal body
temperature

No spontaneous breathing Maintain


Start ventilation normal blood
glucose
Caffeine Citrate Available Caffeine Citrate Not Available
Maintain
Caffeine Citrate Aminophylline SpO2
✓ Loading dose: 20 mg/kg (IV) ✓ Loading dose: 5 mg/kg over 10 min (IV)
✓ Maintenance dose: 2.5 mg/kg ✓ Maintenance dose: 1 – 3 mg/kg every 12 hours
between
every 12 hours (IV) (IV or orally only if feeding is tolerated well) 88% and
✓ Duration: Until no more apnoea for 5 – 7 days, or 95%
until baby reaches 34 weeks GA

If Hb is
If low SpO2 or difficulty breathing below
transfusion
CPAP or Oxygen threshold,
give blood
Apnoea Monitor transfusion
or Pulse Oximeter

MoHCDGEC (2019) National Guideline for Neonatal Care and Establishment of Neonatal Care Unit, p 67-68

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