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SOP 19: NCU

Meconium Aspiration Syndrome


A condition in which a newborn aspirated meconium-stained amniotic fluid
after passing meconium in-utero and develops respiratory distress

Risk Factors Clinical Features


- Post-term delivery - Onset: Immediately or a few hours after birth
- Fetal distress - Respiratory distress
- Perinatal asphyxia - Cyanosis/hypoxia
- Maternal infection or - Meconium-stained skin/umbilical cord/nails
morbidity e.g. - Pulmonary hypertension
diabetes, hypertension - Signs of post-term delivery

Management Investigations
Evidence of meconium-stained amniotic fluid ✓ Continuous pulse
AND floppy neonate, bradycardia, and/or oximetry
apnoea? ✓ Chest x-ray
Yes No
✓ ECG
✓ Blood gas analysis
(metabolic acidosis?)
Suction of meconium ✓ Septic work-up
immediately after
delivery
Supportive Care
Temperature
regulation and
Dry and stimulate the baby minimal handling

Maintain Systolic
Is the baby breathing? Blood Pressure >
Pulmonary BP
Yes No

Adequate
Resuscitate and stabilize sedation if on
ventilator

Options depending on severity of disease: ✓ Antibiotic therapy


✓ Oxygen therapy ✓ Surfactant therapy
✓ Consider CPAP or mechanical ventilation ✓ ECMO in severe cases

WHO (2016) Surfactant for meconium aspiration syndrome in term and late preterm infants

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