Confidential

Japan Bio Products Co., Ltd

Overseas Department
June 2018
Yoko OCHIAI
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 Skin trauma caused by machine and device

 Safety of combining with other treatment and solutions
 Duration and application session limits
 Safety and addictives: paraben, fragrant
 Long down time, QOL
Skin
trauma

Down Combina
time tion

Duration
Safety
limit
Effectiveness

1. Whitening Suppresses the generation of the melanin pigment that causes age
spots and dullness

2. Moisturizing Maintain moisture

3. Cell proliferation & reproduction Enhances metabolism, normalizes turnovers and produce healthy
skin

4. Collagen generation Support collagen generation determine skin elasticity

5. Blood circulation promotion Promotes blood circulation, produce healthy skin

6. Anti-oxidation effect Suppress the occurrence of the active enzymes

7. Anti-inflammatory affect Adjust and recovers the immune system, suppresses allergic
responses

8. Anti-allergic effect Adjust, recovers immune system, suppresses allergic responses

9. Immunostimulant effect Enhances immune system, help to produce healthy skin

10. Amino acid supplementation Increase energy metabolism of skin cell, supplies material for cell
reproduction
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Cleopatra Hippocrates 1st Qin Emperor Yang Guifei

(-B.C.30) (B.C.460-370) (B.C.259-210) (A.C.719-756)

To maintain her beauty, Father of medicine. It First emperor who Queen of a Chinese
Cleopatra is said to is said that he used made Great wall. Said emperor. Appearance
use placenta for anti- placenta in clinical to use placenta as an was attractive
aging purpose. application. immortal medicine. enough to evoke a
nationwide war. Used
placenta as sexual
medicine.
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Curacen Essence

Key features 2mL/Vial for iontophoresis, derma rollers, meso therapy, derma shine

Recovery of damaged skin & dermis,

Anti-wrinkle effect, Anti-inflammatory.
Benefits
Accelerate whitening of skin, improve hydration
and sagging.
Relative advantage Direct delivery to site.

Application Whitening, pigment maintenance, anti-wrinkle.

Classification
pH 7.1 Cosmetics

11 Amino Acids

✔Bio Stimulator
✔Bio Activator
✔Bio Regenerator
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Sterilization
Employing Products
Donor Acceptance 3 Different Specification
Screening Inspection Methods Test
Individual inspection by
HBV/HCV/HIV 1. Organic solvent HBV/HCV/HIV/HTLV/Parvovir
weight, color, smell, etc.
2. Digestive enzyme + acid us-B19
processing
3. 121℃x20 minutes
autoclave

Over 65 years experiences

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Korean study

Safety profile of test drug during clinical study in Korea

HBV Negative
HCV Negative
HIV Negative
Parvovirus B19 Negative
VDRL Negative
10mL/kg subcutaneous injection to 5 mice All alive
Anti-histamine No serious findings
Antigen sensitivity No serious findings

“Efficacy and safety of human placenta extract in alleviating climacteric symptoms: Prospective,
randomized, double-blind, placebo-controlled trial”, Yoo-Kyung Lee, Hyun Hoon Chung and Soon-
Beom Kang, J. Obstet. Gynaecol. Res. 2009
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 Accumulated processing know-how of Laennec allows isolation of various

active amino acids which otherwise would be lost.

Laennec contains much larger active ingredients than counter part

100

90 Water Amino acid Peptide

80
Organic material(％)

70

60

50

40
Competitor A
30
Laennec
20

10 Curacen
Temperature(C)
0
0 100 200 300 400 500 600

Internal data.
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Components of Curacen
Amino acids Spec
Function
(NLTmg)

De-toxicate systemic ammonia, and promote urination. Utilized as rapid energy source,
Glutamine 0.43
and accelerate recovery from fatigue after exercise.
Degrades lactic acid to ease fatigue in TCA cycle. Promotes urine synthesis to excrete
Asparagine 0.32 toxic ammonia. Stimulate skin turn-over. Support hold water in keratinous layer and
maintain skin moisture.
Leucine 0.25 Strengthen muscles. Support liver function. Supply energy for exercise.
Stimulate growth hormone excretion that leads to vasodilation and improve blood flow.
Arginine 0.24 Ameliorate male infertility, sexual disorders, fatigue, impaired immunity, skin glycation,
obesity and aging.
Mediate tissue repair and glucose metabolism. Accelerate recovery from fatigue, and
Lysine 0.23
enhance liver function. Recently utilized as a ingredient of hair grow products.
Major amino acids as the source of collagen and elastin, which consist skin. Also
Proline 0.23
important as Natural Moisturizing Factor. Helps lipid burning.
Mediate lipid burning. Utilized as primary source of energy. Reported as Alanine improves
Alanine 0.21
alcohol metabolism.
Exist primarily in skin keratinous layer and keep skin moisture. The source of neurotic cells
Serine 0.19
consisting brain. Keeps healthy brain function.
Prevent lipid accumulation in the liver. Stimulate body metabolism, growth and
Threonine 0.14
development.
Valine 0.13 Strengthen muscles, support liver function. Supply energy during exercise.
Amino acids 0.31 Other amino acids than above.
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Allocation Dosage Duration Method

Upper 1 vial 1 session per week. Dermapen, Derma

R
cheeks 2ml Minimum 5 session, roller, Derma shine,
/session total 8 sessions JBP Nanoneedle
recommended for 34G4mm nappage
maximum result meso

Cheeks 2 vials 1 session per week. Dermapen, Derma

+chin 4ml Minimum 5 session, roller, Derma shine,
/session total 8 sessions JBP Nanoneedle
recommended for 34G4mm nappage
maximum result meso

Data provided by courtesy of Dr. Shinichi Soyano at Kanda Aesthetic Surgery Clinic
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Simple 5 Steps
1. Mark area with a white pen
2. Lidocaine cream for 20 minutes
3. Remove 2. above and sterilize the marked area
4. Apply Curacen Essence with Nanoneedle 34G4mm,
1 vial per cheek, 50 to 100 injection sites.
5. Gently press with gauze cotton

Curacen Essence JBP Nanoneedle 34G4mm

1 vial 2ml per cheek
Right after the treatment

Data provided by courtesy of Dr. Shinichi Soyano at Kanda Aesthetic Surgery Clinic
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Data provided by courtesy of Dr. Shinichi Soyano at Kanda Aesthetic Surgery Clinic
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Simple 5 Steps
1. Mark area with a white pen
2. Lidocaine cream for 20
minutes
3. Remove 2. above and
sterilize the marked area
4. Apply Curacen R
Essence with
Dermashine .
5. Gently press with gauze
cotton
Note: During the sessions some
leakage were found

Data provided by courtesy of Dr. Shinichi Soyano at Kanda Aesthetic Surgery Clinic
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(g/dL) 2.5

2
Level of hemoglobin

1.5

0.5

-0.5

-1

-1.5
Base Line 1W 2W 3W 4W

Synopsis
Tested cosmetics Curacen Essence
# of patients n=3 ( Age 40’s -60’s women )
Objective Evaluate Curacen Essence on improvement of skin tone
Test method Skin Color Sensor (SCS-1).
Measure average of 3 locations on cheek one week after the application.
Dosing regimen Subcutaneously introduce 1 vial 2mL on one cheek weekly
Test Period January to March, 2018

Data provided by courtesy of Dr. Shinichi Soyano at Kanda Aesthetic Surgery Clinic
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Before
After 5 sessions After 8 sessions
2017 Oct 25

Data provided by courtesy of Dr. Shinichi Soyano at Kanda Aesthetic Surgery Clinic
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Before After 5 sessions After 8 sessions

2017 Oct 25
Data provided by courtesy of Dr. Shinichi Soyano at Kanda Aesthetic Surgery Clinic
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End point was skin hydration and elasticity (Soft plus standard), derma thickness (Digital
Ultrasound Image system), Pore, wrinkle and pigment quantity and size (Visia system)

Synopsis

Tested cosmetics Curacen Essence

# of patients n=20 divided to 2 groups

Age 40’s -50’s females with age related changes in skin (wrinkles, pigment spots,
hydration, enlarged pores etc)

Objective Evaluate Curacen Essence on improvement of skin tone

Test method Injection in face using micropapular and linear methods

Dosing regimen Injection conducted once a week, 2ml at a time

1st group 10 patients received total 10 x 2ml Curacen injection
2nd group 10 patients received total 5 x 2ml Curacen injection

“Placental medication Curacen in mesotherapy of aging skin”, Karimova I et al, Injection Methods in Cosmetology, (3), 2011
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 Skin hydration, elasticity, melanin content and pH improvement observed irrespective of

number of total injection and continued post 2 weeks of treatment.

 Among the criteria, humidity improved significantly.

 Same treatment effect regardless of number of total injection.

10 injections

5 injections

* P<0.05

“Placental medication Curacen in mesotherapy of aging skin”, Karimova I et al, Injection Methods in Cosmetology, (3), 2011
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 More uniform distribution of dermal framework fibers was

observed.
 Same treatment effect regardless of number of total injection.
10 injections 5 injections

Ultrasound scan before (left) and after ( right ) Ultrasound scan before ( left ) and after ( right )
treatment with Curacen treatment with Curacen

“Placental medication Curacen in mesotherapy of aging skin”, Karimova I et al, Injection Methods in Cosmetology, (3), 2011
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 Anti-inflammatory and immunostimulant.

Help to heal fast skin trauma caused by
treatment, less down time improves
customers QOL

 Easily combine with other treatment

 Highly safe, no limit of sessions

 Improves skin tone, humidity and elasticity

 Promote collagen and elasticity

Natural Remedy
for Total Anti-Aging
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