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    Shyam Sathyamoorthi
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    The document describes an optimization study of an allylic rearrangement reaction by varying reaction conditions such as reagent, solvent, temperature and time. It shows that using sodium borohydride as the reagent in DMF at room temperature for 30 minutes gave the best yield of 64% for product P1 and 20% for product P2, outperforming other test conditions listed in the table including variations in solvent, temperature and reagent.

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    The document describes an optimization study of an allylic rearrangement reaction by varying reaction conditions such as reagent, solvent, temperature and time. It shows that using sodium borohydride as the reagent in DMF at room temperature for 30 minutes gave the best yield of 64% for product P1 and 20% for product P2, outperforming other test conditions listed in the table including variations in solvent, temperature and reagent.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    5 views1 page

    Optimization Table

    Uploaded by

    Shyam Sathyamoorthi
    The document describes an optimization study of an allylic rearrangement reaction by varying reaction conditions such as reagent, solvent, temperature and time. It shows that using sodium borohydride as the reagent in DMF at room temperature for 30 minutes gave the best yield of 64% for product P1 and 20% for product P2, outperforming other test conditions listed in the table including variations in solvent, temperature and reagent.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Table 1. Optimization of an allylic rearrangement.

    Entr Temp.,Tim
    Reagent Solvent P1/P2a
    y e
    1 1M HCl (aqueous) THF RT, 30 min 60/20
    2 1M HCl (aqueous) THF 35 °C, 30 62/20
    min
    3 1M HCl (aqueous) THF 0 °C, 30 50/22
    min
    4 NaBH4 (2 equiv) DMF RT, 30 min 64/20
    5 NaBH4 (2 equiv) DMSO RT, 30 min 62/20
    6 NaBH4 (2 equiv) MeOH RT, 30 min 56/11
    7 NaBH4 (2 equiv) DMA RT, 30 min 6/4
    8 NaBH4 (2 equiv) THF RT, 30 min 43/7
    9 LiBH4 (2 equiv) THF RT, 30 min 10/0

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