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Page 1 of 26
lP
lP
lP
CAREWELL PHARMA - A Family Of Learning
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SUBSCRIBE us on YOUTUBE ( Watch Videos Free)
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UNIT-1 STEREO|SoMER1SM
re
re
Ca
Ca
somasThe a -those dhorial supstanus which has
Sama mole ularormula bu diffe swcural
prmulo andni phunomuia iskouwn as
a
a
Tso meism". (thuy hae olso diffent pogesties
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-Ch-oH Ch-0-h
lP
lP
lP
Cehyl olohol) (Dinthyl ethur).
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w
w
re
re
Tsomejsm
Ca
Ca
Suua StercoisoMenjm
IcoySm (SaMA Molesdan and
same Moleula formula sduchura formula,
a
a
bur diftt in shucuM). bu differt arangemn
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rm
fafdm in spaa dut to
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Chaun TsomerisM rotatim).
lP
lP
lP
Posihion Isomensm
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Meamovism
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funcional
re
re
Taulameism 1 Optical Geomerical

Ca
Ca
Tomerism ToMeal om
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Website :- www.carewellpharma.in
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Visit website For Download Notes(FREE)

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Page 2 of 26
lP
lP
lP
el
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el
w
re
re
StereokonmeriM t is form of iomotsm in whin
a
Ca
Ca
Moletvies hae-hi sam molewln formula
aud san sbvctural ormul bu different in amngumv
of atomsl4oups in spau
e 2 dichlorochnt
a
a
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rm
OR
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Cis- 12-didhloroetnnuA
lP
lP
lP
Trans-1,2-djbrotHun
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Optical isomerism > It is a typ o steeoisomerjum, in
w
w
a
re
re
which Molewles nave Same Molecwlar, stncrual
Ca
formula and also

melhug poju boiliug polut, dunsihy
hae Same Ca
physicol propenhes,
ek- Bur H
difer in theur bthavour pwards gu
Ty also ha Sama Specific rotahion of gu
bu wih opposie sign
a
a
rm
rm
rm
Lachic fAcid (CgMo)
ha
ha
ha
lP
lP
lP
CooH C0oH
el
el
el
HO (-H HC-DH
w
w
re
re
Ca
Ca
Ophrical acive (ormpount whidh has pOwento voal th

ophal atiuitzy) plane polani tud Lugn.
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rm
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P
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Page 3 of 26
lP
lP
lP
el
el
el
w
calfttiul
Oph
re
re
Ca
Ca
Th of any Substanu o
power rotau plan
polaised ligm (PpL) fpom axs to doRwiL or s
aticdocRwiL divechim is Calldophcal achu And
Substant i known as optical acfive subshnu
or
a
a
Delerminahion,
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rm
rm
Polaricer (Nítol prism)- (alo3, wMch gahoned ondinany
odinany
ha
ha
ha
ig OnL panL and make PPL Cpla
lP
lP
lP
polanised lht).
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A
w
w
re
re
Cordinay ugJ (Nicol prismJ CPlana polarikad Lgh
Ca
Ca
Polavimeler,ohidh checR and Maakns ophical acHt
Soluhion (ueckina)
0 ekwise
Fotahon
E/
a
a
rm
rm
rm
Ordinany Nicol PPL Polarimuler
Ligt prism anhclockuL

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Rotah'on
lP
lP
lP
Lugh passus Hhrovgh

firsHy ordina Ntol prismMa iF
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pass tii Ligh fom polamimuler

PPL (plan polaviud Lu), thun
w
filled a sdlution whith w have to

re
re
in which we
tubt
atiuty
Ca
Ca
CheR optical
PPL qots unaffecked o staigk th soluhn
o Conmpou nd is opticolly inactive but f th pPL
(ompound (solutin) ic opticall achive"

rofat Hun
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rm
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P
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Page 4 of 26
lP
lP
lP
el
el
el
w
re
re
Ca
Ca
a
a
rm
rm
rm
ha
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lP
lP
lP
el
el
el
w
w
Rotaiom is of two typus
re
re
PPL clocRwic direcion,A soluhonis
Ca
Dextro otatoy" as "D"

Ca
denot or
F PPL rotales auticlotkwisL diretion. thu soluhm is
"Levo rotalon denoe a L Or

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a
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rm
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lP
lP
lP
el
el
el
w
w
re
re
Ca
Ca
a
a
rm
rm
rm
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ha

P
P
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Page 5 of 26
lP
lP
lP
el
el
el
w
re
re
.Enauhiomers
Ca
Ca
Tha qptical isours whch a non-super
mpoable Mirror imag Of each ae Callad

othor
"enautiomer" and pocess of omatton of

a
a
Yotation of 180 is Lallod Enantomuninm
rm
rm
rm
enauiomer Dy
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Lachc aud
lP
lP
lP
COoH
el
el
el
COOH
Mior imaaA oF
w
w
H-C-oH
re
re
H each thur aud
Ca
Ca
alo nm-Supen
imposabl
Enautioms dife rom On OMothy in thhee dimnsi

a
a
rm
rm
rm
Spatial OrranguMwit.
ha
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ha
Muling poin, densit olubilil,
, cölbUY
Thy hove SAmA
lP
lP
lP
reathiui acids+baun.
el
el
el
and tonands
w
Speufic of plan polaajsd

re
re
ditfernt roalon
Th hove
Ca
Ca
towads ophicol achiut. A) Levo (-

Dexo (+3
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a
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rm
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Page 6 of 26
lP
lP
lP
el
el
el
w
DiasteeoisoMAU AM
re
re
Tha shereoisoms
Ca
Ca
thar ak nom-miror image ofF
and also on-super imposolblu oF eah othur
OL Called"Diasteeoiomars".
atlesF two Stereotenhs

a
a
Diasereoisoms have differen propertle, suh as mlig
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rm
poi boiling poul e
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lP
lP
lP
COOH COOH
AO
el
el
el
-OH H--DH
w
w
H
DiasveoiBMrs
re
re
H- C- OH Ho- -H
Ca
ChoH
Ca
0 A
a
a
H-C -0H H-CoH Ota serebisomrd
rm
rm
Br- -H H-C-Rr rm
ha
ha
ha
1
lP
lP
lP
el
el
el
DiasfenoisoMOS
w
C
re
re
HO-C-H Ho- C-H

Ca
Ca
H- C
-B -C- H
Enouiomrt
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a
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rm
rm
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Page 7 of 26
lP
lP
lP
el
el
el
w
Elemnt of Hmmay
re
re
Ca
Ca
Those COmpounds whidh Can be dividud nto an
enval paats fom any plan Called Summuhi(o Compoumd
) Plan oFF Summihy

A plan whdh diuidus an objed
a
a
uo
rm
rm
rm
fwb ummumal alves Is allad
pla Cummu
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ha
f of
PlanSummuhy.
lP
lP
lP
el
el
el
w
w
H - Br
re
re
pla of symma
Ca
Ca
in)
ii) Cenb of Summuy
AHSo koM a» "poiw of suymmetv".
a
a
rm
rm
ougn
rm
Tfa spaight inus thar Can be draun -
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ha
ha
Cenre F
OF MoleculR MeeF idethical atoms a
lP
lP
lP
equal disanu t tonb

el
el
el
w
H
re
re
Ca
Ca
CI
H
poiut of Summuby
a
a
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rm
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Page 8 of 26
lP
lP
lP
el
el
el
-A
w
w
Meso CompOunds
re
re
Compound with two or moe asummuic
Ca
Ca
Carbon afoms bu also having a plan o
Sy Mhuy is CallLd tu Meto CDMPOds"
plau oft summuY, O half of- t mole cule is mirror
imag of othon half
a
a
rm
rm
rm
laauc aud CODH
ha
ha
ha
H C -DH
--plaus oF
lP
lP
lP
H-C-0H
el
el
el
w
w
C60H
re
re
thesa typs oF coMpound an optical Inative du to
Ca
iemal Copansotin
Ca
uval Molewle
hosa mole wles whdh Cannot Superimposabl
On its mrvor imag.(nn-supn.imposabu).
a
a
thesA MOLQwie OA ophcal alive whidh Yotai
rm
rm
plam poloiud lugk

rm
ha
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ha
chial eans andids-
lP
lP
lP
(
el
el
el
U
w
w
re
re
onna
Ca
Ca
b
Supu
imporeb
a
a
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rm
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Page 9 of 26
lP
lP
lP
el
el
el
-Lachc aud CooH
w
CooH
re
re
Ca
Ca
CH H
OH
Chia Mole CUlAs also have "du'ral coxte" or

"symmemic tonbM atom"
a
a
rm
rm
rm
Chiva Coxtte (Chial (bm atom)
ha
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7 A caxbn atbm which
atacud wih our diffeei
lP
lP
lP
otomsqioups
Lochc aud
el
el
el
an.
w
w
Ca Cabon atomn also RouM asymhMC Conbon
re
re
Ca
Achival MOlwlei Ca
Thos molewlea wch L supeimposada
On is irror îMagus.
Bu tu a ophicol inacive moleculus whjch an

uga.
a
a
Wo Yotalu plan polai ud
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rm
AA A
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Com b
lP
lP
lP
Sup
inmposd
el
el
el
w
DichloroAvovomuhan
re
re
H H
H
Ca
Ca
w 180 Ratai
Cc
Cam be 9**l
Supn impoud CA
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rm
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P
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Page 10 of 26
lP
lP
lP
el
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el
Representahion of of Molecule
strudtl
w
re
re
Wedga
Ca Dash [ uyjing
Ca
wedga pojecrionJ
Thes A 3D epecenahion of MaleColes.
These Onr VSLd or bolh thial f adjval Molecule

Thuy photr chon s ULd ehahuonaswcu, in widh
a
a
rm
rm
rm
Hwd cdbma/g rou ML M phu Ond ot a in
ha
ha
ha
above vd blow plau
lP
lP
lP
el
el
el
CHO
Dan below the plan
w
w
re
re
plane wWedar4 Aooe plaus
Ca
CyOH OH Ca
-fiscuew Proyrctiom
s tL D lepr suntahion of moleculo

a
a
epeseta
rm
rm
rm
Tn th mod Mok wl o by uoss
ha
ha
ha
liu Cevthe of ius is assuMd as
lP
lP
lP
Canbon atom.
H
el
el
el
w
H H
re
re
HO H
Ca
Ca
H
C4,oH
(-0)
a
a
rm
rm
rm
ha
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ha

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P
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a
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Page 11 of 26
lP
lP
lP
el
el
el
Wedas- Dacbh
w
low to ConveuF poorcctim to ficchn paojeciom
re
re
Ca
Ca
This Conveagim is ipoau fo tu (D 4L) and (R4S)
Coufiqnahm of ole cules
Tn his, 20 choctu o motecul is (onveat fujo

2D strucuL
a
a
rm
rm
rm
L
ha
ha
ha
( wih tu plans
(1tm) tt
lP
lP
lP
Balow plant
el
el
el
CI ( foove tni plau
w
w
re
re
Thoca atomlqroub
Ca
on
which aNL On Ca
plau Kpecen
veutal li in fisthen Phorccim.
Then Watch wedo-dash Stuctu fm tha cida on
whchaboue de below plan" plan" alms/qoup atachad.
Thun tha s
a
a
aom/group ohich M your luft sidl pu
rm
rm
rm
left du thaabn/qoup widh isn
ha
ha
ha
Maur slda, pu in aur de u fison
lP
lP
lP
PTtcfion"
el
el
el
w
w
re
re
H
Br-C-H
Ca
Ca
C C
Wedgs-Dash" "fischn fvojechon
a
a
rm
rm
rm
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ha

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P
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rm
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Page 12 of 26
lP
lP
lP
el
el
el
NOMENCLATURE OF OPTICAL TOMERS
w
re
re
O DL Sustem -(Kelative Cowfiquolion)
Ca
Ca
fischer and
Th D/Lysem os developed by
Rosanoff arovnd 1900.
This Mehod is USed or phital adtve Ompound.
whihwhidh coRwisA rotuhon

O
a
a
has
rm
rm
rm
Rigwt hand sida ()
Repesenkd a D+) Dexo rdjajbry
ha
ha
ha
whichwhih hs anhidocRwlsa rotahom ok
lP
lP
lP
ft hand sids (9) rotahion-
el
el
el
Cepesoncd as Lt) worotator
w
w
re
re
This D configurahion is Uud fo amlno atid 2 Coaboydioles.
Ca
In tis onfiqurattom, "Glyuraldmyde

i Ca
vud as a
kfeuna lompond.
CHO
HO
-oH H
a
a
H HO
rm
rm
rm
ha
ha
ha
D- Glycoaldshyda L-Glyuraldihyd.
lP
lP
lP
el
el
el
Rulus
w
proptr fischur projehion formula of mouul.

re
re
1) Draw
) tigmat oxidiuo goup must bon top.(f not Hhun

Ca
Ca
FRasrang tuis).
11) Oburve boibm Most chiral (asymmubic) (avbon, if t coutain
-OHANH a nank tun "D,fat left +than "L
a
a
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rm
rm
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ha

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P
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a
a
rm
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rm
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Page 13 of 26
lP
lP
lP
el
el
el
lin
w
ventical lin
Lonqestt chain is always on
PRsw tnan 0/L aL
re
re
-OH nd-NH boM a
Ca
Ca
dtided by -NH q1oup
examplt
HO
,
H CoH HoC4
a
a
CHoH
rm
rm
rm
DG), -oH qroup is L-), -oH qmp is
ha
ha
ha
sida On left ide
on 1gt
lP
lP
lP
CHO th lmgUst chain should bi on vedial
el
el
el
lin 7
w
w
HO
So rotali locRwia(xcept top).
re
re
Ca
Ca
o
CHO
CHO D(+) -oH
Ho
HhOH H
H ngkt sidL
a
a
Ch0H Hignust Oxidiznd group MUSF b on top.
rm
rm
fix
rm
HO H So, Rotta 186
to
ha
ha
ha
CHO
40H CHO Dt), -bH
lP
lP
lP
group is on
HO -H
el
el
el
tha igh
CHO
w
w
re
re
CHO CHO
CoH
Ca
Ca
H -H
4N H
HO
FH H
H
Chy CM,oH
SYTTT '
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
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Page 14 of 26
lP
lP
lP
el
el
el
w
CHO
CHO
OHO o
re
re
-H -OH
Ca
Ca
H H
oH HO-
-OH Ho- H
4OH h0H Cho

a
a
rm
rm
rm
CHO
CHO
ha
ha
ha
H- OH HD -H
lP
lP
lP
HD H H
el
el
el
H OH HD H
w
w
H oH HO- - H
re
re
Ca
Ca
4. CODH C60H
N H
a
a
CrhoH
Cho
rm
rm
rm
ha
ha
ha
.
lP
lP
lP
A DEryho EryHhros
el
el
el
2. tveocA threos
w
C D
re
re
. f
GlUCOLA CAucoSA
3.E
Ca
Ca
Amuinocid
G1 fiminb aud H
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
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Page 15 of 26
lP
lP
lP
el
el
el
System of isoMar
w
cfomanclatu ophical
re
re
This "absolue Coufiqvration, whith
is
Ca
Is Ustd
for "optical
Ca
adive (onpounds
R Rectus Ceight, whidh yotal PPL dodkws

S Sinistr eH), hih otal PPL otidodkuis
This tonfiquratm wa qiven by th stiørdtst (turcpeon)
a
a
rm
rm
rm
R Cohn, tk. Tngold and V.dog So, it is also known 0
ha
ha
ha
"CIP sustem" ( Cahn Tngold pulog].
lP
lP
lP
SEQVEN(E RULE (for RS onfigurahin, IF isnnussayto Rnou
el
el
el
w
w
fisty ideudify all dhival CLnbe,thin deuda priouhy of
re
re
numaur
al attachud atoms/aroups actondivg tothein aleml
Ca
1.. hig afomic nUmbtL wih vM

Ca
prioi
sFo NC H , thei at.umb l6) a) s)=96) 1.
wo or MOK otoms/gnoup oftahud to tu chiral
Centre R SAm tun qive priouhy accoding to then

a
a
rm
rm
rm
"xt oton/aroup aud So
SO On-
-CHO, -CoDH,-
ha
ha
ha
G0R -(SOR - CooH ) CHo
-
lP
lP
lP
T owes piou om/aoup musF b on bottom 4

el
el
el
top of vetille ins.

w
w
re
re
SoMLtmdionol goup wih th poioium ondu

Ca
Ca
-T) -r)-u) sH)- F oR) -on) - No) NH-cch

- -
- - -
(ou -cooR) LoDH- CHo -4oH -ce9-C=l7

CHg 7 -
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 16 of 26
lP
lP
lP
el
el
el
Rules for Rs Coufiqunahin
w
re
re
O Th aom/qroup attachud wih a dhiral con. ae acsiqnud
Ca
Ca
wi a numbi acLording to cquenu ul
No, NOD, 4 t lowesF prionty goup is on veciid lía,
+hon
Rotahion of
0- 0 is clockwia, Confiqundhion
MusF bL
R- ectus
a
a
rm
rm
rm
lotafion of
O is audtclo cMpisa, conftauratin
ha
ha
ha
MUst b Stnis te
lP
lP
lP
O Bur, Sf th lowect prioily goup ion evizontzl lina,
el
el
el
thun, (oPpOSLTE)
w
w
Rotalton af ) is clockwta, coufiquaton îs
re
re
Kotohion of O is antdodkul st, onftaurahon is "e"
Ca
Ca
-
a
a
rm
rm
rm
ha
lowest
ha
ha
pioulu qroup IS on veahial If
lP
lP
lP
O
el
el
el
-
w
w
re
re
Ca
Ca
lowe pioity goup fs on hoizontal 1iw

a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 17 of 26
lP
lP
lP
el
el
el
w
F
re
re
Ca
Ca
CODH
TO
S-Couiqunahion
-Cowfqwahon
R- Configunaho)
a
a
rm
rm
rm
CooH
ha
ha
ha
HO
lP
lP
lP
COOH
HO-
H C (
el
el
el
w
w
4oH S-Caf
re
re
S-Cnefigwaltm
-f
Ca
UHd Ca
oH
H -oM
HD -H
H
a
a
HO
rm
rm
rm
CcoH
ha
ha
ha
lP
lP
lP
oH GH R-Cat
el
el
el
w
H
re
re
Ca
Ca
CooH
CooH
(D
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 18 of 26
lP
lP
lP
el
el
el
w
re
re
Ca
Ca
a
a
clockwL\
rm
rm
rm
12
Ophcal adh (ompomd
RotanA
ha
ha
ha
lP
lP
lP
NomndatuuL (igh
el
el
el
S1)
w
w
RO
re
re
- iuhi tockwsse
R
Ca
Ca
Rataho
Suft
a
a
rm
rm
rm
Rectx uist
OO0)
ha
ha
ha
T\ali labu -0-
lP
lP
lP
el
el
el
w
w
re
re
Ca
Ca
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 19 of 26
lP
lP
lP
el
el
el
w
re
re
Ca
Ca
a
a
RoTATIO
rm
rm
rm
pio oup (LPa)
ha
ha
ha
ald e m vethco
lP
lP
lP
Houzatal
lu eh inl
el
el
el
clocRuiA
w
w
re
re
(-Auciclockwt
Ca
Ca
LPG louwts priond go) is on hoizota liu
Work Kerenue (oppoiwhe2
(chang
Rough R
a
a
rm
rm
rm
(cha R
ha
ha
ha
lP
lP
lP
Pevers
el
el
el
w
w
re
re
Ca
Ca
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 20 of 26
lP
lP
lP
el
el
el
w
Readion of Chiral MOeoles
re
re
- Ciral MolkuJly hosA orgavc CDpound whth has four
Ca
Ca
ditfocnt abmlqroup
a attachd wih Carbon
- Racomic
ixtul E T equimolormixtut of DeXo (D)/
ond Yeow wo (L) Substanu is callud
mixtw
a
a
Racanic
rm
rm
rm
Chirad Mole wls Ahow eyps of reodions
ha
ha
ha
Thverum
lP
lP
lP
1) Racan saton
I)
el
el
el
Relenion
w
w
Tnesim ^
Thiu au thos reoution tin whith chrol moleolu
re
re
chonga tmeir natual atttl Hodim, (Mven
Ca
DLXo (ompdmds 's'[LJ

Ca Levo Conupounds
'R (o)
'S (L LewO compomds R [o] Cxo (ompoumds
SN veouhon show tu ínveryon coehm.

a
a
rm
rm
rm
ha
ha
ha
OH
C - ..cl
lP
lP
lP
Ho - -
el
el
el
aH Transition
w
Ba
re
re
Ca
Ca
CH
Ho C CH
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 21 of 26
lP
lP
lP
el
el
el
11) Kacem sation-
w
Eawhon, u
re
re
opticol athive A (ompound
Ca
Ca
Converted ind optically inactive cowpound oftoL thu
Teaion.
C -
H
a
a
(H H
rm
rm
rm
H
ha
ha
ha
lP
lP
lP
R 'S-opHall
el
el
el
S2-thloo bulant inadhe
w
w
( LOmpomdJ
re
re
n YeDchion, 'cl'*plau H Ondpm a MLAO
Ca
opthicall inaive
Ca
(ompovnd,wdh
ophisally auie ae
Raceisa1m
S Optitally iradhwe
Conpond
(OMpovn
a
a
u)
rm
rm
rm
Rerention
reDchion chiral Moluwwcompomd remain
ha
ha
ha
COnsta(SAnt (Owfiquwation) afto Y2Ochon.
lP
lP
lP
el
el
el
w
CaHh-- Br+U
re
re
CaHn C
Ca
Ca
CaMs
H
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 22 of 26
lP
lP
lP
el
el
el
w
'Raumic Modifiaton and Resolution of Yacemic mixtu
re
re
Racemic ModificaliM
Ca
Ca
AMso knoun as Racomit mixtue
Fepesenttd au (DL, RS, t, dl )
-u equal amount of Leavo (-) 0Md dexbo (t) foms
optically inadtive mixturt known ab rAcomic Modificahin.
a
a
-Equal amoun enociomurs.
rm
of
rm
rm
bom
O.4
ha
ha
ha
-Caunl arvoun
lP
lP
lP
ofboH
el
el
el
Dexo (+ Levd C- RaamiC mixtun
E)
w
w
re
re
Resoluhion
of Kaemic muxtun
Ca
Ca
is tu protas of separation fa racwmc
Modificahm Iuto is enantiomus ConstituenA.
-Hso n tis process ophcally inachi COpound convta

optical active COmpounds.
a
a
jntd
rm
rm
uHhods ycd for esoluhtonM-

rm
ha
ha
ha
)Mechanital muthod ngstallzahion nunodJ
lP
lP
lP
Chromaldoraphy
el
el
el
) Bíological muhod
w
w
re
re
w) Chumital uhod
Ca
Ca
Muchanal muhod (utallizodiom muhod)-

n tis muHno
d, fsHy Cstallizd ha
boH tantrioms in rOcomc mixtu
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 23 of 26
lP
lP
lP
el
el
el
Now h have differen Aapls eom eoh Ors.
w
re
re
SO, tuuy ak Supavales by magnifyun Lwns and orceps.
Ca
Ca
is muhonial Sepavohon (manval) ven
given Louss
Poussewr
in gU8.
This muhod is applicabla only o racomic COolo mwats
affiniy
I u molwus of th sUbstana nawe qheat
s
a
a
for Sama emntiomurs ham fo ppositt on).
rm
rm
rm
TL MuHod is economc bu Hma con suming
ha
ha
ha
apy
lP
lP
lP
11 Chowatog
Optically adive SvbSfanct an be resolvéd by tromato-
el
el
el
grapmy
w
w
re
re
Tn tu procos ta racomc Mixtu is rn Hhrouan a
Ca
ColuMn,whidh is-fild wim a optially

Ca actte adsovont
(a dhinl Subsanu).
Tha enantiomrs will ineadr difenty um tu
chval substant ud eluts ar differnt routes.
a
a
-(tmOVE
rm
rm
opticaluy active svbApnL aR selechvely

rm
ha
ha
ha
In this
adsorbed byopticall acrive adsorhet on t basus
lP
lP
lP
of their affinu
qciv
el
el
el
e fmin resolved via Acyladion by opically acid dloridus.

w
w
re
re
) Biologiol Mhod
Ca
Ca
n this uhod Certaln miUcorqamlsm (bockeia,
fungi ,enzymus ek.)a allbw to gow in Racemic
ixtun.
Thy duspoy ou of t eSS impovtaut enawtiomurs
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 24 of 26
lP
lP
lP
el
el
el
a fastrli- (ompart o othr
w
can be
re
re
Hent,
Hentt, tha Undhongtcd (othur) enanthomur retain and
Ca y
Ca
isolatd -fradhonodl Cystallization or chromatogap
Posewr in 19s8
is duvelopac by
enaionu acrifiad. and f mixtut s
Drawback ont
tOxt than uy kill miooorqnsm
a
a
rm
rm
rm
be Ued Emove 0- ammonlum
Peniullivm Can
Ommonum rtara0
racomic
ha
ha
ha
tarali tom mixtumixtuH of
lP
lP
lP
Chumicol mumo
iv
el
el
el
modificahon is conveakd
i mhoda YacemC
w
w
diastexomr Onotur Compomds.
re
re
(Mto a mixtUR Of of
Ca
MHrd
enavtiomar is dficult
Ca becausu of
-Ta sepavahom of
SamA physica propertie
FhautiomY toutd wih optally ochive compoumds to

rm
a
a
diaseroMLrs.
rm
rm
rm
twun,
diastotoisomuK b SLparalea dut to
ha
ha
ha
CO
poperties and fler Separatiom

lP
lP
lP
diffeonu in tuir physi cal
nd enanhoms Dy addug
el
el
el
HMLLy
ae HConverted
w
rujwra aud (H*)

re
re
Acd Ras Cachon oflen usedfo esoluhm

Ca
Ca
Of vacmuc alkaloids ik quiwone mophina et

a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 25 of 26
lP
lP
lP
el
el
el
w
HymMM Suynhnts
is
re
re
In Hs Muhod, Optically athe Compound
Ca
Ca
Compound
durecHy pepae om On opti cally inathive
oF othr opthicolly acHve

undu inflvonu Som
Substwnc&L
aphically
a
a
Rauic phcally
rm
rm
rm
Athrt
Mixtu ache
ha
ha
ha
Ophically
optically inachive
lP
lP
lP
achut
oY. Dexbo +
el
el
el
DExho/wvo
CUAyout
w
w
re
re
OR (inacive)
Ca
we on sauy thaF SummuiC molw Ca

Conveted inp acummuhc Molewles(ative).
is dieHy
CHO
Ophical
Opticad
nacne D Active
(H H
H
a
a
rm
rm
rm
ChOH Asummum
Symmu
ha
ha
ha
Conbon
Conbm LSymmsic Cfty mmuic
TMOLwlus Moletulus J
lP
lP
lP
el
el
el
typus
w
w
re
re
Syuuthuus
Ponliad Abselu fAummeic
Ca
Ca
) Ao solu Aymmic symus

OPTIUA LLY TNAtTIVEAsymmebic OPTICALLY fave
COMPOUND Synthesis CDMpoUN DS
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll
a
a
rm
rm
rm
ha
ha
ha
Page 26 of 26
lP
lP
lP
el
el
el
Paxhial frymmubic syuthu
w
re
re
a mmuic Sundhuus Boh (+) and
Ca
Ca
enantiomus an fomad bu OL
obtainud in Owou
SO Boh an o in eqval omoun and acF as a
optically ackive Compound aud pass plan polaid
a
a
ec
rm
rm
rm
lugh GlucoL
Dptiially
ha
ha
ha
so5X
lP
lP
lP
ophically
Racu
el
el
el
C
Mixt
ahve
w
w
re
re
1+bsolurfsymmuMc sythuis 8-
Ca
In his symuus, kacemic Ca

mixtuu (ymmumc
MolAw) Is Complaty Convtur into ophcally ache
Cowpoundu
Dexo bR LVO-uAy o
n Dnly onn nantiomar Coun founud tonplehy

a
a
n u, py sical
rm
rm
rm
0My agtnl is used.
ha
ha
ha
lP
lP
lP
,CoOGH H
C=C H00
el
el
el
C-COD H
w
H00C BH H
re
re
Ethyl fumualc] CD- dieyl taruic aud]

Ca
Ca
Et fumualr d hO2 undu iuflven of dexo votatdy,

give C+)
dieyl tauaic acio
a
a
rm
rm
rm
ha
ha
ha

P
P
ll
ll
ll

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a

Taulameism 1 Optical Geomerical

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formula and also

Ophrical acive (ormpount whidh has pOwento voal th

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Ligt prism anhclockuL

Lugh passus Hhrovgh

pass tii Ligh fom polamimuler

filled a sdlution whith w have to

PPL qots unaffecked o staigk th soluhn

o Conmpou nd is opticolly inactive but f th pPL

(ompound (solutin) ic opticall achive"

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Dextro otatoy" as "D"

F PPL rotales auticlotkwisL diretion. thu soluhm is

"Levo rotalon denoe a L Or

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mpoable Mirror imag Of each ae Callad

"enautiomer" and pocess of omatton of

Enautioms dife rom On OMothy in thhee dimnsi

Speufic of plan polaajsd

towads ophicol achiut. A) Levo (-

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atlesF two Stereotenhs

HO-C-H Ho- C-H

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) Plan oFF Summihy

equal disanu t tonb

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plam poloiud lugk

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Chia Mole CUlAs also have "du'ral coxte" or

Bu tu a ophicol inacive moleculus whjch an

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Thes A 3D epecenahion of MaleColes.

These Onr VSLd or bolh thial f adjval Molecule

s tL D lepr suntahion of moleculo

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Coufiqnahm of ole cules

Tn his, 20 choctu o motecul is (onveat fujo

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Rosanoff arovnd 1900.

This Mehod is USed or phital adtve Ompound.

whihwhidh coRwisA rotuhon

In tis onfiqurattom, "Glyuraldmyde

proptr fischur projehion formula of mouul.

) tigmat oxidiuo goup must bon top.(f not Hhun

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4OH h0H Cho

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R Rectus Ceight, whidh yotal PPL dodkws

1.. hig afomic nUmbtL wih vM

sFo NC H , thei at.umb l6) a) s)=96) 1.

wo or MOK otoms/gnoup oftahud to tu chiral

Centre R SAm tun qive priouhy accoding to then

T owes piou om/aoup musF b on bottom 4

top of vetille ins.

SoMLtmdionol goup wih th poioium ondu

-T) -r)-u) sH)- F oR) -on) - No) NH-cch

(ou -cooR) LoDH- CHo -4oH -ce9-C=l7

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