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Ravisankarfatsolublevitamins 151009132900 Lva1 App6891
Ravisankarfatsolublevitamins 151009132900 Lva1 App6891
Vitamin - A Diterpenoid
Pro-vitamin A β-carotene
CH2OH
RETINOL
CHO
RETINAL(Vitamin A aldehyde)
COOH
RETINOIC ACID
Vitamin A, D, E, K
Retinol
Milk, butter, cheese, cream, eggs, liver
Lycopene
Lumisterol
Cisergocalciferol
Ergocalciferol
C2H5
Cholecalciferol Sitocalciferol
Vitamin D5
Vitamin D - Cholecalciferol
• Vitamin D is a cholesterol-like
molecule
• Important to bone and calcium
Ergocalciferol regulation
Diet
– Acts more like a steroid
hormone rather than a enzyme
cofactor
• Cholecalciferol (D3) has two sources:
Cholecalciferol – Diet
• plants have ergocalciferol (D2), which
synthesis in skin
easily becomes D3
• animal flesh has ready-made D3
– Sunlight (UV)
• Converts 7-dehydrocholesterol into
D3 in the skin
Vignan Pharmacy College, Vadlamudi,
10/9/2015 7-dehydrocholesterol E.A. DENNIS 2010 ©
Guntur
Vignan Pharmacy College, Vadlamudi,
10/9/2015
Guntur
25
Table 2: Recommended Dietary Allowances (RDAs) for Vitamin D [1]
Age Male Female Pregnancy Lactation
0–12 months* 400 IU 400 IU
(10 mcg) (10 mcg)
1–13 years 600 IU 600 IU
(15 mcg) (15 mcg)
14–18 years 600 IU 600 IU 600 IU 600 IU
(15 mcg) (15 mcg) (15 mcg) (15 mcg)
19–50 years 600 IU 600 IU 600 IU 600 IU
(15 mcg) (15 mcg) (15 mcg) (15 mcg)
51–70 years 600 IU 600 IU
(15 mcg) (15 mcg)
>70 years 800 IU 800 IU
(20 mcg) (20 mcg)
• Stabilize reactions or
situations that typically
produce free radicals
– Nucleic acid and protein
metabolism
– Mitochondrial metabolism
– Supplementation may
increase antibody
production
– When supplemented prior
to slaughter, helps maintain
meat quality (shelf life,
10/9/2015
color) Vignan Pharmacy College, Vadlamudi,
37
Guntur
Vitamin E - Deficiency
• Rare – typically associated with fat malabsorption or
excessive intake of polyunsaturated fatty acids
(PUFAs)
– Erythrocyte hemolysis and hemolytic anemia
• Red blood cell breaks open and spill the contents, perhaps due to
PUFA oxidation
• Observed among newborns of several species
• Vitamin E treatment resolves hemolytic anemia
– Prolonged deficiency causes neuromuscular dysfunction;
affects the spinal cord and the retina
• Degeneration of nerve cells (poultry)
• Factors contributing for free radical genaration in the body include smoking and exposure to Uv-
radiations.
• Tocopherols (Vitamin E) are equipped to perform a unique function. They can interrupt free
radical chain reactions by capturing the free radical; this imparts to them their antioxidant
properties.
• The free hydroxyl group on the aromatic ring is responsible for the antioxidant
properties. The hydrogen from this group is donated to the free radical, resulting in a
relatively stable free radical form of the vitamin.
• Deficiency
• Heart Disease and Vitamin K deficiency go hand in hand!
• Deficiency severe enough to affect blood clotting is
extremely rare.