The daughter of the color-blind man marries the son of other color-blind man, and these spouses

distinguish colors normally. What is the greatest probability of appearance of color-blindness in their
children?
Color blindness is X-linked recessive disease.

As stated color blindness is an X recessive disease and both of the grandparents that are male are
colorblind. That means that both of them have one recessive x that is the carrier gene of the
colorblindness and obviously Y chromosome since they are male. Grandparent females do see the
colours normally but there is still a possibility of them to be carriers of the colorblindness gene so
their genotypes can be either xX or XX. The female parent genotype is Xx so she is an carrier of the
gene but does not show it since she is not colorblind. The male parent does not carry the recessive x
that is linked to the colorblindness since he would be colorblind if he would have it. So only one
parent can or can not carry the recessive x. The odds for the mother to carry an recessive x is 100%
since she has had to inherit the recessive x from the father. So in conclusion mother has one
recessive x and father has none. The child if female can inherit with 50% odds either the recessive x
or the dominative x and from the father she will inherit the dominative X which will anyways make
her a carrier but not colorblind. If the child is a male, he will inherit the Y chromosome from the
father and with 50% odds an recessive chromosome or an dominant chromosome from the mother
so there is a 50% chance for a male child to be colourblind.

In conclusion, all male children have a 50% chance to be colorblind and all female children have a 0%
chance to be colorblind.