Instruments 1

© Dept.OBGYN,GMCH Aurangabad.
SIM’S SPECULUM
James Marion Sims ( USA )
A) PARTS – a)Blades‐ Single /Double, Curved
b) Handle‐ Grooved
B) METHOD OF APPLICATION
Sim’s position / Dorsal position with buttocks
at the end of table
No need of anesthesia
Along with anterior vaginal wall retractor
Introduced in AP diameter , rotated in 90
degrees
C) USES
a) Gynecology
Routine examination, for visualization of cervix,
vagina.
Collect vaginal discharge for investigation
OPD procedures – IUCD insertion & removal, Pap
smear , IUI.
Diagnostic
Hysterosalphingography, Sonosalphingography
Operations
Minor – D & C, polypectomy, hysteroscopy
Major – Vaginal hysterectomy
b) Obstetrics
First trimester‐
, evacuation & curettage, MVA , suction evacuation of
vesicular mole
Second & third trimester‐
Evaluation of APH, cervical encirclage, intracervical
catheterization
Puerperal‐
Diagnosis & repair of cervical laceration
D)ADVANTAGES
Ideal for OPD examination
E)DISADVANTAGES
Needs AV retractor for better visualization, assistant
required ot procedures
F)CONTRAINDICATION
Unmarried
G)STERILISATION – Autoclaving , boiling
SIM’S ANTERIOR VAGINAL WALL
RETRACTOR
A) PARTS –Angulated fenestrated ends(15
degree angle)
After introducing Sim’s speculum, AV
retractor is held in right hand with angle of
fenestrum facing upwards
C) USES
With Sim’s speculum
D) STERILISATION
Autoclaving in OT, boiling in OPD
NOTE
Angulated
fenestrated tip
CUSCO’S BIVALVED SELF RETAINING
VAGINAL SPECULUM
A) PARTS – Two hinged blades, screw
Lubricated introduced in AP diameter of vagina,
rotated in 90 degrees, blade opened & fixed
with the help of screw
C) USES
Per speculum examination
OPD procedures – pap smear(Ideal speculum),
IUI, colposcopy
NOT used for major/ minor gynecological
operations
D) ADVANTAGES
Self retaining, assistant not required ,can be
used in any position, can be adjusted to the side
of vagina
E) DISADVANTAGES
Can not visualize anterior & posterior vaginal
wall
Space available is limited for carrying out
procedures
F) STERILISATION
Autoclaving
HEGAR’S DILATORS
A) PARTS –
Curved tip, single/ Double bladed
Set of 12 dilators cover all diameters from 3‐26 mm
Held in center between index finger below & thumb
upside
Dilatation with gradual number of dilators by to &
frow movements
C) USES
a) Gynaecology
As a part of D & C
Before hysteroscopy
Diagnosis of incompetent os‐ Passage of no 8 Hegar’s
dilator without resistance without causing pain or
discomfort
Therapeutic in cervical stenosis
In Fothergill’s operation before amputation of cervix
Drainage of pyometra/ Lochimetra
b) Obstetrics
Before curettage
Newton’s formula
Cervical dilatation= Gestational age (Wk)+ 0.5
D) COMPLICATIONS‐ Cervical lacerations, false passage,
uterine perforation, cervix incompetence
E) STERILISATION‐ Autoclaving
UTERINE CURETTE
A) PARTS –
Fenestrated loops(Single/ Double)‐ sharp/ blunt
Sizes 4‐10 mm
Serrated Handle
Held in center between index finger below & thumb
upside
Tip of index finger should be at a distance equal to
UCL
C) USES
a) Gynaecology (Sharp curette)
1) Diagnostic
Evaluation of DUB, TB endometritis, post menopausal
bleeding, infertility, Ca cx ( endocervical curettage)
With polypectomy, part of Fothergill’s repair
2)Therapeutic
In DUB , Asherman’s syndrome
b) Obstetrics
Blunt curettage for incomplete,missed,
inevitable, septic abortion
Puerperal curettage‐ Retained POCs
D)Sample to be sent in formalin bulb for HPE
TB‐ In Normal saline for culture & formalin for
HPE
E) COMPLICATIONS‐ Uterine perforation,
Hemorrhage
F) STERILISATION‐ Autoclaving
SHARP END OF CURETTE
BLUNT END OF CURETTE
UTERINE SOUND/ HYSTEROMETER
A) PARTS –
Handle & blunt olive tip
12 inches in length, 2 mm in diameter angulation
2.5 inch from blunt tip
Do PV examination before sounding
Do PS ,catch hold anterior lip of cx
Hold sound like pen with little finger extended to
prevent perforation
C) USES
To determine length & direction of uterocervical
canal before D & C, insertion of IUCD
Evaluation of misplaced CuT
To distinguish between chronic inversion &
pedunculated polyp
To manipulate uterine cavity during laparoscopy
Jakarta’s test – In suspected vesicular mole if
sound can be rotated all around in uterine cavity
& inserted for more than 11 cm test is positive
Clarke’s test‐ In endometrial carcinoma passage
of sound produces bleeding
D)CONTRAINDICATIONS‐ In suspected / confirmed
pregnancy
E) COMPLICATIONS‐ Uterine perforation,
Hemorrhage
F) STERILISATION‐ Autoclaving
NOTE
Olive tip
Angulation and serration(markings) on handle
BLADDER SOUND
A) PARTS –
Handle & blunt tip (No olive tip)
25cm in length, doesn’t have graduations
B) USES
To define limits of bladder during operations like
anterior colporrhaphy , Kellies stitch for SUI repair
To confirm suspected bladder injury during vaginal
hysterectomy
To determine length & direction of vesicovaginal
fistula
To sound foreign body in bladder
To differentiate bladder or urethral diverticulum
from anterior vaginal wall cyst
C) STERILISATION‐ Autoclaving
NOTE:
•Blunt end
•Smooth curve
•No serrations/markings
KOCHER’S PEDICLE CLAMP
A) PARTS –
Business end having transverse serrations on it with rat
teeth at its tip
B) USES
a) Gynaecology
To clamp pedicle during hysterectomy
(abdominal/vaginal)
To clamp pedicle of pedunculated fibroid in myomectomy
To clamp pedicle of ovarian tumour / cyst
To steady the uterus during abdominal hysterectomy
b) Obstetrics
To clamp pedicle during obstetric hysterectomy
Artificial rupture of membranes
Clamping of umbilical cord
NOTE
Transverse serrations and 2*1 tooth at tip
HEMOSTIC FORCEP
• It is called “peang” after Jules Emile Pean .
• TYPES: Straight, curved. Small ,medium ,large.
• PARTS : Business end :Tapering ands with transverse
serrations on inner side for hemostasis.
• Handle at proximal end with finger grip and catch with
3 ratchets first merely catches tissue, second clamps
tissue third crushes tissue creating hemostasis
• Blades with cross joint .
• Artery is the misnomer used.
• When holding structures on surface straight hemostat
is used, in deep pelvic cavity curved one is used.
NOTE
TRANSEVERSE SERRATIONS
Curved artery forceps being used for holding ends of suture material
USES
• To secure bleeder before ligation or cauterization
for hemostasis.
• To hold parietal / visceral peritoneum
• To hold ligatures to be kept long.
• Kelly’s hemostat is used as clamp.
• To crush the base of fallopian tube in tubal
ligation.
• Used to separate tissue planes e.g. to separate
myoma from pseudocapsule.
• Small peanut held at the tip is used for blunt
dissection of loose aereolar tissue : exposing
anterior longitudinal ligament in sling surgeries.
PUNCH BIOPSY FORCEP
• Parts: Business parts: Cup shaped in Gelhorns
and square jaw in Alligators types . Upper cup
has sharp cutting edge lower cup holds the
tissue.
• Proximal end : finger rings with handle at
right angle to shank.
• Shank: two arms with cross joint.
USES
• Cervical punch biopsy
• vaginal punch biopsy
• vulval punch biopsy
• Biopsy is taken from the edge of the ulcer or growth.It
should also include normally looking area. 2‐3 pieces
should be punched out from different areas.
• Centre of the growth is necrotic so not a good area for
biopsy.
• If bleeding occurs: apply pressure, cauterise, take
figure of 8 suture with chromic catgut.
ALLIS FORCEPS
• Parts : Business end: Tips are curved inside
and have 4‐5 rat teeth which fit in one
another for a firm grip of tissue.
• Proximal end: finger grips and ratchet lock .
• Shank: 2 arms with box joint.
• USES : To hold rectus sheath while opening
and closing the abdominal wall.
NOTE
Multiple teeth at the tip of forcep
Allis forceps used for holding angle of rectus sheath
• GYNECOLOGICAL: In anterior colporrhaphy, enterocele
repair, colpoperinearrhyphy
• In vaginal hysterectomy during opening of anterior and
posterior pouches , during closure of vagina.
• Fothergills repair
• Abdominal hysterectomy after opening vaginato
facilitate circumcising cervix and to draw up the cx
after opening the vault.
• Dissection of vaginal cuff in abdominoperineal repair.
• In the repair of vesicovaginal fistula/recovaginal fistula.
• To hold the cx in trachleorrhaphy.
• In vaginal hysterectomy to deliver fundus through
either of the pouches.
• Utriculoplasty while suturing the cut horns of uterus.
• OBSTETRICS: In cesarean section to hold the
angles of incision.
• To catch the apex of episiotomy incision while
suturing episiotomy.
• For correction of acute inversion of uterus by
abdominal operation.
• To hold quadrants of cervix during encirclage.
• OTHER : Marchetti test in stress incontinence
To hold vas deference in vasectomy.
BABCOCK’S FORCEPS
• Parts: business end: Semicircular fenestrated
atraumatic ends which when approximated
can hold a tubular structure.
• Proximal end: finger rings and ratchet lock.
• Shank: 2 arms with box joint
• 3sizes; small, medium, large.
USES :
• To hold fallopian tubes in tubal sterilization ,ruptured tubal
ectopic pregnancy, tuboplasty.
• Round ligaments in round ligament plication.
• Ovaries in conservative operations on ovaries like
adhesionolysis, ovarian biopsy, ovarian ectopic pregnancy,
cystectomy ,wedge resection.
• In wherthiem’s hysterectomy to hold ureters and pelvic
lymph nodes.
• To hold bowel in repair of rectovaginal fistula ,third degree
perineal repair.
• To hold bladder in repair of vesico vaginal fistula.
• OTHER: To hold vas in vasectomy
To hold appendix, ceacum
NOTE
Triangular tip with groove and fenestra
Babcocks forceps used for holding fallopian tube
Babcocks forceps used for holding round ligament
Babcocks forceps used for holding ovary
SPONGE HOLDING FORCEPS
• PARTS: Business end round fenestrated with
transverse serrations.
• Proximal end: finger rings with ratchet lock
• Shank : 2 arms cross joint .
• USES: General : Painting and preparing parts
preoperatively.
• Swab out vagina and pelvic cavity.
NOTE
round fenestrated with transverse serrations.
(non traumatic) © Dept.OBGYN,GMCH Aurangabad.
Sponge holding forceps used for painting before
operative procedures
USES IN GYNECOLOGY:
• To apply pressure by means of sponge over deep
bleeding point during pelvic surgery, to check
hemostasis.
• For packing away omentumand intestines out of
pelvis.
• Temporary clamping of infundibulopelvic
ligament during haemorrhage in myomectomy.
• Graduated sponge is used in POP‐Q quantification
of prolapse.
USES IN OBSTETRICS: To hold gravid cervix
during encirclage.
• To hold cervix for tracing cervical tear after
vaginal delivery.
• During cesarean section: To push down the
bladder, to hold the edges of uterus and to
swab out blood, muconium from abdomen.
• To deliver fallopian tubes in puerperial tubal
ligation.
OVUM FORCEPS
• Named after Haywood Smith
• Stainless steel
• PARTS: Business end: Cup shaped oval fenestrated
ends.
• Proximal end : finger rings and no catch.
• Shank:2 arms with cross joint
• USES: To remove products of conception when more
than 10 wks of incomplete/inevitable, missed abortion
.
• Evacuation of vesicular mole.
• To remove bits of placenta,membranes from gravid
uterus, foreign body from uterus.
• To twist off pedunculater polyp.
NOTE
Oval end with vertical serrations
GREEN ARMYTAGE FORCEPS
• PARTS:Business end: Flat, transverse triangular
with transverse serrations.
• Proximal end: Finger rings with ratchet lock.
• Shank : 2 arms with box joint
• TYPES : Straight, curved.
• USES:To grasp the lower edge of the lower
uterine segment in lscs.This achieves hemostasis
by compressing bleeding vessel.
• To trace cervical tear after vaginal delivery.
• Advantages: Atruamatic, hemostatic,can lift up
the edges of uterus fo easy suturing.
• Disadvantages: Sponge forcep is used now a days
for tracing cervical tear after vaginal delivery.//
NOTE
Flat, transverse triangular with transverse serrations at tip
Vulsellum
Features : long curved instrument which has tip
with multiple sharp rat teeth which gives firm
grip.
Uses : designed to hold lip of gynecological cervix‐
Anterior lip held in: endometrial biopsy, insertion of
IUD, intra uterine insemination, vaginal
hysterectomy, cauterization of cervix, cervix
biopsy.
Posterior lip held in : colpo‐puncture, culdoscopy,
posterior colpotomy, biopsy from anterior lip of
cervix.
Other uses: for grasping fibroids in myomectomy, to
hold cervical stumps after amputation of cervix.
NOTE
curved blades for better visuatisation© Dept.OBGYN,GMCH Aurangabad.
NOTE
Multiple teeth at tip © Dept.OBGYN,GMCH Aurangabad.
Tissue forceps(dissecting forcep/thumb forcep)
Features : serrations on handle for better grip
and handle with spring like action.
Uses :
1. Tooth forceps : to grasp tuogh structures like
rectus sheath fascia, vaginal wall.
2. Plain forceps : To grasp structures like
peritoneum and muscles.
3. To hold tissue in place while applying suture.
4. To hold suture ends while suture removal.
Plain forceps
Toothed forceps
Plain forceps for holding peritoneum
Toothed forceps for holding rectus sheath
SHIRODKAR’S UTERUS HOLDING FORCEPS
A) PARTS –
Curved transeverse blades, handle with ratchet lock
Opened blades are passed from top over the fundus
till they reach isthmus, which is clamped in
anteroposteriorly
C) USES
To steady & manipulate uterus in tuboplasty,
Shirodkar’s abdomonal tubal patency test,
conservative operations of adnexa e.g.
salphingectomy for tubal ectopic, ovarian surgery,
Moschowitz enterocoele repair,uterosacral ligament
plication
D) STERILISATION‐ Autoclaving
Bonney’s myomectomy clamp
Features : two sets of rings proximal and distal
Uses : for obliteration of B/L uterine artery
while,
• Abdominal myomectomy
• Utriculoplasty
When to release clamp‐
every 15 mins
Every 10 mins if ovarian ligament are clamped.
Contraindication: removal of cervical or ischemic
fibroid
Business end
Handle
NEEDLE HOLDER
A) PARTS –
Business end with inner surface with crisscross
serrations with a longitudinal groove, box joint
nearer to business end, handle with ratchet lock
B) METHOD OF USE
Curved needle held caught at a distance of 2/3 rd
from joint with needle held at a distance of 2/3 rd
from tip.
C) USES
To hold needle during suturing
Can be used as hemostat
D) STERILISATION‐ Autoclaving
NOTE
Crisscross serrations and longitudinal groove
Needle holder is used for holding needle while suturing tissue
TOWEL CLIP
Doyen’s cross action towel clip
• ‘g’ shaped .
• Curved blades cross near business end ending
in sharp teeth.
• When the handle with spring like action is
pressed the tips open out and on release of
pressure the teeth get approximated. Blades
are flat.
Figure of 8 towel
clip
Mayo’s towel clip
USES
• To drape the surgical area after paintingthe
parts in abdominal or vaginal procedure.
• To fix the suction tube, cautery wire or cords
to the drapes.
EPISIOTOMY SCISSORS
• It is a pair of angulated scissors.
• PARTS: Business end: Appointed end that goes
inside vagina and a blunt end that lies outside
vagina on perineal skin.
Proximal end :finger rings on same side.
Flat blades with cross joint. It is angulated to
keep hand away from perineum.
USES: To give episiotomy.
NOTE
Angulation at blades © Dept.OBGYN,GMCH Aurangabad.
NOTE
Blunt and sharp tips of blades
Operative vaginal delivery
Piper
Simpsons
Cephalic Curve
Pelvic Curve
Functions
Parts
Types of Vacuum
Classification of OVD
• Outlet
– Scalp visible @ introitus w/o separating labia
– Fetal skull @ pelvic floor
– Saggital suture in AP plane (or ROA/LOA)
– Fetal head at or on perineum
– Rotation < 45 degrees
• Low
– Leading point of fetal skull > or = +2 station
– Rotation < 45 degrees
– Rotation > 45 degrees
• Mid
– Station above +2 station but the head is engaged
• High
– Not included in classification
Indications for OVD
No indication is absolute
• Prolonged 2nd stage
– Nulliparous: lack of continuous progress
• >3hrs with regional anesthesia
• >2hrs w/o regional anesthesia
– Multiparous: lack of continuous progress
• >2hrs with regional anesthesia
• >1hr w/o regional anesthesia
• Fetal compromise
• Maternal benefit to shortened 2nd stage
Indications for forceps delivery
• Foetal indications: ‐
– Foetal distress in second stage when prospect of vaginal
delivery is safe: ‐
• Abnormal heart rate pattern
• Passage of meconium
• Abnormal scalp blood ph
– Cord prolapse in second stage
– Aftercoming head of breech
– Low birth wt. Baby
– Post maturity
Indications for forceps delivery
• Maternal indication: ‐
– Maternal distress
– Pre‐eclampsia
– Post caesarian pregnancy
– Heart diseases
– Intra partum infection
– Neurological disorders where voluntary efforts are
contraindicated or impossible
Safe practice: prerequisites for
instrumental delivery
• Fully dilated cervix

• One‐fifth or nil palpable abdominally
• Ruptured membranes
• Contractions present
• Empty bladder
• Presentation and position known
• Satisfactory analgesia
Insertion
Vacuum Placement
• Proper cup placement is the most important
determinant of success in vacuum extraction.
• The center of the cup should be over the sagittal
suture and about 3 cm in front of the posterior
fontanelle toward the face – median flexion point.
DOYEN’S RETRACTOR
• Parts: BUSSINESS END: Stout broad transverse
end curved with hollow towards handle.
• HANDLE: Finger grips are present with curved
end
• SIZES: Small,medium,large.
• METHODS: After opening peritoneal cavity,
doyens retractor covered with wet mop is
inserted to retrct the abdominal wall to avoid
trauma
• ADVANTAGES : Hemostatic function: the stout
blade compresses the edges of the abdominal
incision creating temonade effect.
• DISADVANTAGES: Does not retract bladder well.
• Space occupying when large size used.
Doyens retractor used for retraction of bladder in
lower segment cesarean section
Uses :
To retract lower abdominal wall.
• GYNECOLOGY : Abdominal hysterectomy ,
tuboplasty, Shirodkars sling, Purandare’s
cervicopexy, Virkuds composite sling, Khana
sling, exploratory laparotomy for ovarian
tumour myomectomy, Wertheims
hysterectomy
• OBSTETRICS: Cesarean section , exploratory
laparotomy in ruptured ectopic, cesarean
hysterectomy.
DEAVER’S RETRACTOR
• Business end:A narrow graduallycurved c
shaped blade with blunt end.
• Proximal end: Acutely curved tip for hand grip.
• Handle is straight.
• SIZES:Small, medium,large.
• METHOD:after openin peritoneal cavity,the
omentum and bowel are packedwith isolation
mops and deaver’s retractor covered with
mop is inserted to retract the intraperitoneal
structures.
USES
• To retract sides of abdominal incision and
intraabdominal structuresin procedures:
abdominal hysterectomy, Shirodkar’s sling
operation,Wirkud’s sling operation,exploratory
laparotomy for ovarian tumour, Werthiem’s
hysterectomy.
RIGHT ANGLE RETRACTOR
• Also named as Landon bladder retractor.
• It is L shaped.
• PARTS: Business end 2 cm broad flat blade
with curved or flat end. Curved end prevents
injury to bladder. Handle has circular opening
in centre for introduction of finer for better
grip
• Advanages: Blade being flat and narrow
occupies less space in the anterior pouch it is
good for vaginal surgeries.
USES
• To retract bladder away from uterus and
cervix during vaginal hysterectomy. It prevents
injury to bladder and ureter during clamping
of uterine vessels .
• To retract lateral anterior vaginal walls during
any vaginal operation.
Right angle retractor is used for abdominal wall
Roux’s ‘C’ shaped retractor
Feature: stout handle in middle and blades are
curved.
Uses :
To retract sides of anterior abdominal wall in
mini‐laparotomy and exploratory laparotomy.
SCALPEL HANDLE
A) TYPES
Disposable/ Non disposable(common)
Resharpenable/ with replaceable blades (common)
Flat handle( #3 & #4),rounded & flat(#7)
B) METHOD OF USE
a) Palmer grip/dinner knife‐
Handle held with second through fourth finger
Best for initial incision & larger cuts
b) Pencil grip‐
Handle held with tips of first & second & tip of the
thumb with the handle resting on fleshy base
Best for more precise cuts
Barb Parker’s handle and sugical blade is being used
for skin incision
SURGICAL BLADES
A) TYPES
# 10– curved cutting edge with flat back
# 11 ‐ triangular blade with sharp point & flat cutting
edge parallel to handle & flat back
# 15 – smaller version of #10
# 20 – large, broad
B) USES
# 10 , # 20 – for making skin incision
# 11 – for incision & drainage
# 15 – for making fine incisions
FOLEY’S CATHETER
A) PARTS –
40 cm length self retaining, from 12‐ 30 French
French represents diameter‐ external diameter in mm
is 1/3 of catheter number
Made up of latex/ silicon/ polythene
Two channels one for inflation of balloon other for
drainage of urine
B) METHOD OF USE
Introduced under all aseptic precautions till the bulb
is well inside bladder
Bulb inflated with normal Saline/ sterile water just
enough to retain it inside bladder.
Removed after deflating catheter, if can not be
deflated bulb ruptured by excessive deflation/
injecting NaHCO3 © Dept.OBGYN,GMCH Aurangabad.
B) USES
a) Obstetrics
To relieve retention of urine in retroverted gravid
uterus
For instillation of ethacrydine lactate solution for
second trimester MTP
To replace bulging membranes during cirvical
encirclage operation
Treatment of atonic PPH
Preoperative catheterization to avoid bladder injury
Mechanical method for induction of labour
b) Gynaecology
To relieve retention of urine in pelvic tumours
To perform hysterosalphingography
Conservative treatment of vesicovaginal fistula
( catheter for 3‐6 wks)
To test tubal patency during tuboplasty
paediatric foleys catheter is used
Treatment of Asherman’s syndrome
To improve visualisation of vesicovaginal fistula
apply traction to inflated catheter
To achieve hemostasis in myomectomy
C) COMPLICATIONS
Introduction of infection
Catheter fever
Reflex anuria
False passage
Urethral strictures after repeated
catheterisation
IUCD removal hook :
Features‐ handle with angulation and tip has
hook and sharp point of hook is directed
towards angled side of instrument.
Use :
1. Removal of embedded IUD from uterine
cavity
2. Removal tubal prosthesis from uterine cavity
Complications
Pain and perforation
NOTE
Angulation and hook at tip
Novak’s endometrial biopsy curette:
Features : tip with sharp serrations and proximal
end has Leur lock hub and a stillates to
remove endometrial strip and to clean the
curette.
Uses :
Endometrial biopsy.
Colwin’s cannula :
Features : spiral conical tip with proximal end
having Leur lock hub with stillete.
Uses : used only in multiparous cervix with
patulous os.
1. Hystero‐salpingography
2. Chromo‐ pertubation test in laparoscopy
3. Hydrotubation
Uterine manipulator (Hulka manupulator for
normal sized uterus)
Feature : it is a combination of vulsellum and
uterine sound.
Uses : manupulate uterus during‐
1. Laparoscopic tubal ligation
2. Mini laparotomy tubal ligation
3. Diagnostic laparoscopy
An Ayre and an Aylesbury spatula
Sampling the cervix. Note pointed Sampling the cervix using an

end of spatula in cervical os endocervical brush
A range of smear taking devices: Preparation of a cervical smear. Note
coplin jar containing fixative is
Endocervical brushes, wooden
immediately to hand to prevent air
spatulae, and broom drying
Collection of specimens
Specimens can be obtained in three ways
• Scraping the ectocervix with a modified spatula (the Ayre spatula or a
variation of it) for obtaining material for preparing conventional cervical
smears
• an endocervical brush.
• Using a broom like device which samples both endo and ectocervix.
Steps are essential to ensure the Pap test is performed correctly
• A speculum must be inserted into vagina to locate cervical os.
• The sampling device(s) used should be selected according to the shape and
size of the cervix and the location of the squamocolumnar junction. An Ayre
spatula is suitable for sampling the cervix in a parous woman ; however a
spatula and brush may be needed in a post menopausal woman where the
squamocolumnar junction lies within the endocervical canal.
• The pointed end of the spatula should be inserted into the cervical os in a
nulliparous cervix and the rounded end of the spatula inserted into
the patulous os of a parous woman. The device should be rotated 360
degrees to remove the cells from the region of the transformation zone,
squamocolumnar junction©and endocervical
Dept.OBGYN,GMCH canal.
Aurangabad.
• The material on the spatula or brush must be
transferred immediately to a glass slide which has been
previously labeled with the patient’s name and
registration number.
• The glass slide fixed immediately with an appropriate
fixative (95%alcohol) and the slides transported to
the cytology laboratory in a container for processing
together with the corresponding cytology request
form.
• Samples taken for Liquid Based Cytology should be
processed strictly in accordance with the
manufacturers instructions. After sampling the
cervix, the tip of the sampling device should be broken
off into the transport medium in the container
provided which should then be transported to the
laboratory for processing if the Surepath method is
being used. However if the Thinprep method is being
used it is of the upmost importance that the tip of the
sampling device is ©not included in the container
Dept.OBGYN,GMCH Aurangabad.
• Sampling the cervix using an endocervical brush
Sampling the cervix. Note pointed end of spatula in
cervical os An Ayre and an Aylesbury spatula
• Preparation of a cervical smear. Note coplin jar containing
fixative is immediately to hand to prevent air drying A
range of smear taking devices: Endocervical brushes,
wooden spatulae, and broom
Fixation of Pap smears
Proper fixation is an essential step in the preparation of
cervical smears. It ensures that the cells are well stained
and clearly displayed for microscopic analysis and
preserved for immediate and future review. Fixation can be
achieved by complete immersion of the slide in one of
alcohol fixatives listed below for 15‐20 minutes after
which the slide can be removed from the fixative and
transported to the laboratory for staining.
Alternatively,fixation can also be achieved by spray
fixation. Spray fixative consist of an alcohol base and
carbowax that provides a thin protective waxy coat over
the slide. The carbowax must be removed by immersion in
alcohol before staining© Dept.OBGYN,GMCH Aurangabad.
A satisfactory fixative has to meet several requirements.
1. It should penetrate the cell rapidly so that detailed cell
morphology is maintained.
2. Cell shrinkage should be minimal and uniform so that
morphological distortions do not occur .
3. It should allow permeability of dyes across the cell boundaries
and appropriate for the staining method used
4. It should permit cell adhesion to the glass microscope slide
5. It should be bactericidal, non toxic and permanent..
The following fixatives are suitable for the fixation of cervical smears
which are to be stained by the Papanicolaou method.
• 95% ethanol (for optimal fixation)
• 80% isopropanol
• 95% denatured alcohol (90 parts 95% ehanol, five parts absolute
methanol and five parts absolute isopropanol)
• Reagent grade alcohol (absolute methanol, 80%isopropanol,90%
acetone)
Fixation must be immediate . The smear must not be allowed to dry
before fixation
Classification
Suture material
Natural Synthetic
Absorbable Non absorbable Absorbable Non absorbable
Characteristics of an ideal suture material :
1. Its use should be possible in any operation the only
variable being its diameter as determined by its tensile
strength
2. It should allow easy and comfortable handling
3. Tissue reaction stimulator should be minimal and should
not be favorable to bacterial growth
4. The breaking strength should be high in small caliber
5. The knot should hold securely without fraying or cutting
6. Material should not shrink in tissues
7. Should have uniform physical property
8. Its material should be non electrolytic, non capillary, non
allergic and non carcinogenic
9. Should be sterile
10. Should be absorbed with minimal tissue reaction after it
has served its purpose
Catgut
• Made up of ribbons of sheep or beef intestinal
submucosa(collagen) spun into strands of varying size from 7‐
0 to 3.
• it is absorbed by tissue or cellular proteases.
• Knot configuration 1*2
Features Plain catgut Chromic catgut
Constitution Not treated with chromium salt Treated with 20% chromium salt in water
with 5 parts of glycerin for 1 to 96
hours.(true chromatisation/surface
chromatisation)
Absorption 7 days 4‐6 weeks

Advantages Ease of handling Ease of handling and knot security
Disadvantages Early loss of tensile strength and Variability in absorption
weak knot strength
Uses Ligating blood vessles & Uterine, peritoneal and subcutaneous
subcutaneuos tissue tissue closure, tubal ligation
POLYGALACTIN (910)/ VICRYL
Braided multifilament, coated with copolymer of lactide &
glycolide
Violet coloured, Sizes from 9‐0 to 3
Knot configuration 2+1+1+1
Suture is absorbrd by hydrolysis & non inflammatory cell
enzymatic degradation.
80 % tensile strength is lost by 21 days, absorption is minimal for
40 days & complete in 56‐70 days
TYPES
1) Coated vicryl‐ coated with calcium stearate it permits precise knot
placement & smooth tie down
2) Vicryl rapide – High initial tensile strenght absorbed rapidly in 14
days
Absorbed completely in 6 wks
Ideal for suturing episiotomy
3) Vicryl plus – Has coating made up of tricosan having antimicrobial
properties
Uses : uterine closure , to suture rectus sheath.
Polypropylene suture
Monofilament, composed of linear hydrocarbon
polymer
Non absorbable
Non capillary
Better knot security
High tensile strength least tissue reactivity can be
used in presence of infection.
2+1+1+1 knot configuration.
Use
for fascial closure in patients with high risk for
dehiscence
Fixation of prolene mesh
Surgical silk
Made up of twisted or braided fibers of raw protein thread
spun by silkworm larva.
Though classified as non absorbable, tensile strength lost in
1 yr and totally absorbed in 2 yrs. (very slowly absorbing
suture)
Untreated silk has capillary action but
treated(trupermanizing/surgical silk) is non capillary/
serum proof.
Twisted silk : non absorbable coating of tanned gelatin/ other
protein substance which prevents growth of tissue.
Virgin : several silk filaments are
twisted together to form fragile strand
of 8‐0, 9‐0 used in microsurgery.
Uses : fixation of drain
Linen
Made from long flax fibres twisted in strands
Size : 4‐0 to 2.
Tensile strength is inferior
Diameter is not uniform
Use : ligating bleeders, safety suture for stumps.
Magnesium sulphate
Class – Anticonvulsant and sedative
Category A
Mechanism of action‐
1. Reduces end plate sensitivity to acetyl choline
2. Reduces acetyl choline release
3. Blocks Ca++ channels
4. Direct depressant action on uterine muscle
Uses‐
• local‐ anti inflammatory.
• Parenteral‐ drug of choice in prevention and treatment of siezure in pre‐
eclampsia and eclampsia, tocolytic in preterm labour.
Contra‐indications‐ myesthenia gravis, impaired renal function.
Side effects‐
• Maternal : respiratory depression, muscular paresis, flushing, perspiration,
headache, rarely pulmonary edema.
• Fetal‐ lethargy, hypotonic, rarely respiratory depression.
Anti‐dote: inj. Calcium gluconate 10% 10 ml
© Dept.OBGYN,GMCH iv
Aurangabad.
Mechanism : Mgso4
Neuromuscular Neuronal
Abort
Conduction Burst
Convulsion
slowed Firing
N‐Methyl D‐
Ca++
Aspartate Abort
entry
Receptors Convulsion
blocked
Blocked
Ach secretion by Prevent

motor nerve end Convulsion
Prevent
Sensitivity of end Convulsion
plate to AchAurangabad.
© Dept.OBGYN,GMCH
Alternative regimens for
magnesium sulphate
Regimen Loading Dose Maintenance Total dose
dose
Pritchard 4 gm IV over 3- 5gm IM 4 hrly

5 min. followed in alternate
by 10 gm IM buttock. 30 gms in
deep. preeclampsia,
Zuspan 4 gm IV over 1-2 gm / hr IV Continued upto
15- 20 min. infusion. 24 hrs after
last convulsion
or delivery
whichever is
Low Dose 4 gm IV over 2 gm I.M /
later.
Regimen period of 3-5 diluted IV 3
min. hourly.
IV/IM Mgso4
When magnesium sulfate is admin
No evidence from the
IV, the onset of action is
Collaborative Trial of any
immediate and the duration of
difference between the
action is about 30 min.
intramuscular and
intravenous regimens. Following IM admin of the drug,
the onset of action occurs in
However intramuscular
about 1 hr and the duration of
injections are painful and are
action is 3-4 hr.
complicated by local abscess
formation in 0.5% of cases. Onset – IV < IM
Duration Of Action – IV < IM
Monitoring ---–
• The maintenance dose of Magnesium Sulphate is
given only after assuring that:
• Patellar reflex is present
• Respiration not depressed. ( RR > 16/min)
• Urine output during previous 4 h- exceeded 100 mL.
(25ml/hr)
Labetalol
Class‐ anti‐hypertensive
Category C
Mechanism of action‐ – β1+ β2+ α1 adrenergic
blocker with weak β2 agonist(5 times more
capable of locking B than α )
Uses‐ hypertension in pregnancy, hypertensive
crisis.
Contra‐indications‐ hepatic disorders, asthma,
CCF.
Side effects ‐ rash and liver damage, fetal
hypoglycemia.
T1/2‐ 4‐6 hrs
Regime –
• Orally 100mg tds upto 800 mg daily
• Intravenous starting with 20 mg iv bolus if
no response in 10 mins 40 mg iv bolus then 80 mg every 10
mins with total dose of 220 mg per episode.
Nifedepine
Class –dihydropyridine calcium channel blocker
Category C
voltage‐gated calcium channel blockage in
cardiac muscle and blood vessels(vasodilatation)
Uses‐
hypertension, angina pectoris, prevention of
preterm labour
Precausion ‐ use with MgSO4 can be hazardous
Side effects‐ flushing, hypotension, headache, tachycardia,
inhibition of labour.
T1/2 – 2 to 5 hrs
Regime
• 5‐20 mg bd/tds max dose 200mg
• prevention of preterm labour‐ 20‐30 mg stat and 10‐20 mg
every 6 hrly.
Alpha methyl dopa
Class –anti hypertensive
Category B
• Stimulates α receptors and decreases
sympathetic outflow from CNS
• Decreases peripheral vascular resistance
Uses‐ pregnancy induced hypertension
Max effect in 4 hrs, total duration of action is 8 hrs
Contra‐indications‐ hepatic disorders, psychiatric
disorders, CCF
Side effects‐ postural hypotension, sedation,
lethrgy, reduced mental capacity, dryness of
mouth.
Regime 250 mg tds max dose 2 gms
Phenobarbitone
Class – anti convulsant
Mechanism of action‐ acts by raising
threshold for electric stimulation of
motor cortex.(produces all degree of depression)
Uses‐
• Epilepsy
• Sedation for threatened abortion/during preoperative
preparation
• Neonatal jaundice
Side effects:
Maternal : excitement, nausea, vomiting, megaloblastic
aneamia, habituation.
Fetal : neonatal depression, coagulopathy, teratogenisity.
Regime : 15‐30 mg 3‐4 times a day
Oxytocin
(invented by du Vigneaud in 1953 and received noble
prize in chemistery in 1955)
Category C
Class – uterine stimulant
1. Acts through receptors and voltage mediated C++ channels
2. Stimulates amniotic and decidual PG production
Uses‐
1. Induction and augmentation of labour
2. Uterine inertia
3. Prevention and treatment PPH
4. Breast engorgement
5. Oxytocin challenge test
Contra‐indications‐ Pregnancy Labour Any time
Grand multipara As in pregnancy Hypovolemic state
Contracted pelvis Obstructed labour Cardiac disease
H/O CS or Inco‐ordinate
hysterotomy uterine contraction
Malpresentation Fetal distress

Side effects
• Maternal: uterine hyper stimulation, uterine rupture, water intoxication,
hypotension
• fetal : fetal distress
Plasma half life ‐ 3‐4 mins, duration of action 20 mins
Regime : High dose(4‐6 mIU/min),low dose(1‐4 mIU/min)
Oxytocin escalating doses‐(Anderson’s logarithmic method of titration)‐start
in a dose of 4 U in 500ml of RL and double the dose with every pint i.e. 8‐
16‐32 and so on upto max. of 100U.
Oxitocin regimen:
Oxitocin 2.5 U in 500 ml NS started at 10 drops/
min(2 – 2.5 mU/min), dose is raised every 30
mins till 4 contractions per 10mins each
lasting for > 40 seconds are obtained.
Set 1 ml = 20 drops Set 1 ml = 15 drops
10 drops/min = 2.5 mu/min 10 drops/min = 3.4 mu/min
20 drops/min = 5 mu/min 20 drops/min = 6.6 mu/min
30 drops/min = 7.5 mu/min 30 drops/min = 9.9 mu/min
40 drops/min = 10 mu/min 40 drops/min = 13.2 mu/min
50 drops/min = 12.5 mu/min
Methyl Ergometrine
Class‐ Uterine stimulant
Category C
• Blood vessel constrictor and smooth muscle agonist
• Acts directly on the smooth muscle of the uterus and
increases the tone, rate, and amplitude of rhythmic
contractions
Onset of action : Oral ‐ 10 min, im‐ 4‐7 mins, iv‐ 40 sec.
Uses‐
• routine management after delivery of the placenta; PPH;
• Subinvolution
• most commonly used to prevent or control excessive bleeding
• Uterine contractions to aid in expulsion of retained products
of conception © Dept.OBGYN,GMCH Aurangabad.
• Incomplete abortion
Side effects
Cholinergic effects such as nausea, vomiting, and diarrhea,
Cramping, dizziness, Pulmonary hypertension, Coronary
artery vasoconstriction, Severe systemic hypertension
(especially in patients with preeclampsia), Convulsions.
Contraindications‐ hypertension, toxemia of pregnancy; and
hypersensitivity, before second twin is born, heart disease,
Rh negative status, vascular disease.
Half life – 1‐2 hrs
Regime‐
parenteral : 1mL(0.2 mg) after delivery of the anterior
shoulder, after delivery of the placenta, or during the
puerperium. May be repeated as required, at intervals of 2‐
4 hours.
Oral : One tablet, 0.2 mg, 3 or 4 times daily in the
puerperium for a maximum of 1 week
Misoprost(PGE1)
Category X
• Binds to myometrial cells to cause strong myometrial
contractions.
• Cervical ripening with softening and dilatation of cervix
Uses‐
Abortion, induction and augmentation of labour, prevention of
PPH,
Cervical priming before gynecological procedures like D n C and
hysteroscopy.
[vaginal route‐ action is slow and sustained
Oral‐ action is rapid and short duration]
COMPLICATIONS :
› Uterine hyperstimulation.
› Uterine rupture.
› Fetal heart rate abnormalities.
› Amniotic fluid embolism.
› Retained placenta.
› Tachysystole, meconium passage
› Meconium aspiration syndrome.
T1/2‐ 1 – 2 mins
Antidote‐ 0.25 mg terbutaline sc
Clinical situations and dose
› For MTP use :
Ist trimester- 400mcg every 4 hrly ( max.1600mcg )
IInd trimester- 400mcg every 4 hrly
› For pre induction
Cx ripening use : 25-50 mcg 4-6 hourly.(max
dose 150 mcg)
› For IUD – 13-24 wks 200mcg/4hrly
late- 100 mcg/ 6-12 hrs
› For viable pregnancy : 25 mcg intravaginal 4 hrly
maximum doses 150 mcg
› For PPH : Prophylaxis 600 mcg / rectal

treatment 1000 mcg / rectal
Dinoprostone
Class – prostaglandin
• Binds to myometrial cells to cause strong myometrial
contractions.
Uses‐ induction of labour
Contra‐indications‐
• For induction of labour in women with ‐‐‐
› Scarred Uterus (pre.LSCS or Uterine surgery)
› Grand multiparae.
• Hypersensitivity
• Asthma
Side effects‐ nausea, vomiting, diarrhea, vaginal irritation,
hyperstimulation syndrome.
T1/2‐ contraction starts within 1 hrs & peak at 4 hr.
Regime‐ 0.5 mg(3ml) over 6 hrs with 3 doses in 24 hrs.
Antidote‐ 0.25 mg terbutaline sc
Carboprost
Class – prostaglandin
• Binds to myometrial cells to cause strong myometrial contractions.
Uses‐
• prophylaxis and treatment of PPH,
• IInd trimester MTP
• Ist trimester MTP for softening of cervix
• For induction of labour in women with ‐‐‐
› Scarred Uterus (pre. LSCS or Uterine surgery)
› Grand multiparae.
• Asthma
Side effects‐ nausea, vomiting, diarrhea, vaginal irritation, rupture of
uterus
Regime‐ 250 mcg im every 20 mins till bleeding stops or max 8
ampoules.
Mefipristone
Class – Anti‐progestine
Mechanism of action‐(Competetive anti‐progestational and anti‐
glucocorticoid.)
• Attenuate mid‐cycle Gn surge
• Prevents secretory change by progesterone
• Stimulates uterine contractions
• Blocks decidualisation
Uses‐
• Termination of pregnancy upto 7 weeks
• Cervical ripening
• Post coital contraceptive and once a month contraceptive
• Inaduction of labour
Contra‐indications ‐
Side effects‐ Nausea, Vomiting, Diarrhea,
Headache, dizziness, Chills or hot flushes,
Shivering, Fatigue
T1/2‐ 20‐36 hrs
Regime – 200 gm single dose
Ethacrydine lactate
Stripping of membranes with liberation of PGs
Uses‐
• antiseptic in solutions of 0.1%.
• second trimester abortion. Up to 150 ml of a 0.1% solution is
instilled extra‐amniotically using a foleys catheter
Contra‐indications‐ hypersensitivity
Side effects‐ anaphylactic reaction
Hypersensitivity, prolonged use delays wound healing
Regime 10 ml/gestational wk of 0.1% solution (max:
200 ml),
Iron Sucrose
Category B
[iron dextran(inferon), iron sorbitrate(jectofer),iron
dextrin(maltofer),sodium ferric gluconate complex,
iron saccharate, iron sucrose]
Composition : 100mg/5ml
Indications :
‐Iron deficiency
•Poor compliance to oral iron
•Inadequate absorption of oral iron
•Lack of response to oral iron
‐Anemia of those patients suffering from chronic
haemodialysis.
• Contraindications : Hypersensitivity, Iron
overload
• Safety Profile :
• Caution required in pregnancy, safety has not
been established to administer in nursing mother,
children and geriatric.
• Adverse Effects :
• Hypotension, anaphylactoid reactions,
musculoskeletal pain, diarrhoea, nausea
vomiting, abdominal pain, pruritus, elevated liver
enzymes, pain at injection site.
• Dosage :
• 100mg (5ml) one to three times per week.
• Expected rise in Hb‐ 0.7‐ 1 gms% /week
Oral iron(ferrous sulphate, ferrous gluconate,
ferrous fumarate, ferrous ascorbate, sodium
ferridatate, iron hydroxide polymaltose, ferric
amm.Citrate, carbonyl iron)
Class –Heamatinics
Uses‐ iron defficiency
aneamia prophylaxis and treatment,
megaloblastic aneamia
Side effects‐ epigastric pain, nausea, vomiting,
staining of teeth, metallic taste,bloating,
constipation.
Regime – 200mg(60mg elemental iron) tds
Folic acid
Class heamatinics
Category A
Uses‐ megaloblastic aneamia treatment and
prophylaxis, in methotraxate toxicity,
phenytoin toxicity, prevention of abruption.
Side effects‐ nontoxic
Folinic acid‐ used for prevention and treatment
of methotraxate toxicity within 3 hrs of
administration.
Regime – therapeutic‐ 2‐5 mg/day
prophylactic‐ 0.5 mg/day
Terbutaline
Class – tocolytic
Category B
Mechanism of action‐β2 adrenergic stimulant(↓
intracellular Ca++ →inhibits MLCK→inhibits interaction
of actin and myosin → smooth ms relaxation)
Uses‐
• prevention of preterm labour for atleast 48 hrs for
action of corticosteroids
• Antidote for prostaglandin induced uterine
hyperstimulation
Side effects‐
Maternal‐headache, palpitation, tachycardia, pulmonary
edema, hypotension.
Fetal‐ tachycardia, heart failure, IUFD.
Regime 0.25 mg SC every 3‐4 hrly.
Ritodrine
Class – tocolytic
Mechanism of action‐ β2 adrenergic stimulant(↓ intracellular
Ca++ →inhibits MLCK→inhibits interaction of actin and
myosin → smooth ms relaxation)
Uses‐
• prevention of pretem labour
• External cephalic version
Side effects
Maternal: tachycardia, hypotension, palpitation,
hyperglycemia, hypokaleamia, pulmonary edema.
Fetal : hyperkalemia, hypoglycemia, hypotension, respiratory
distress syndrome.
Regime: tablet 10 mg, 10mg/ml
0.05‐ 0.35 mg/min for 12 hrs increased by 50 mcg/min
every 10 mins, orals started ½ hr before discontinuation of
iv drip. Then tablet 2 hrly for first day and then 4‐6 hrly on
subsequent days. © Dept.OBGYN,GMCH Aurangabad.
Isoxsuprine
Class – Tocolytic
Mechanism of action: β2 adrenergic stimulant(↓ intracellular Ca++
→inhibits MLCK→inhibits interaction of actin and myosin → smooth
ms relaxation)
Uses‐
• prevention of pretem labour
• External cephalic version
Chronic cardiac disease, hyperdynamic
circulation, chorioamionitis, fetal demise, fetal malformation.
Side effects:
Maternal: tachycardia, hypotension, palpitation, hyperglycemia,
hypokaleamia, pulmonary edema.
Fetal : hyperkalemia, hypoglycemia, hypotension, respiratory distress
syndrome.
Plasma half life: 1.5‐ 3 hrs
Regime : 2 cc im every 8 hrly
10 mg bd/tds
Maternal Corticosteroids
(Betamethasone and Dexamethasone)
Betamethasone 2 doses 12 mg IM 24 hrs apart
Dexamethasone 4 mg IM every 6 hrs total 4 doses
Repeat or booster dose are not needed
Relative contraindication
‐may be used with caution in c/o severe preeclampsia
‐impaired GTT
‐severe arenal inssufficiecy between 28‐34 weeks
Dexa also used in HELLP syndrome

CORTICOSTEROIDS‐
Indicated between 28‐34 weeks
Contraindication‐1) diabetic mother
2)chorioamniotis
Cefotaxim
Class –cephalosporine (third generation‐parenteral)
Category B
Mechanism of action‐ inhibits bacterial cell wall
synthesis
Uses‐
1. respiratory, urinary and soft tissue infection
2. Surgical prophylaxis
3. Infections like meningitis, typhoid, gonorrhea, hospital
acquired infections
Side effects
Thromboplebitis, diarrhea, hypersensitivity.
T1/2‐ 1 hr but longer for deacetylated metabolite
Regime – 1‐2 gms iv 8‐12hrly
Metronidazol
Category B
Class – tissue amoebicide(nitroimidazole)
Mechanism of action‐ nitro group disrupts pyruvate
pathway energy metabolism in anearobes
Uses‐amoebiasis, giardiasis, Trichomonas vaginalis,
anearobic bacterial infection.
Contra‐indications‐ in neurological diseases, blood
discrasias, Ist trimester pregnancy,chronic
alcoholism.
Side effects‐anorexia, nausea, vomiting, metallic
taste, abdominal cramps.
T1/2‐ 8 hrs
Regime – orally 400 mg tds
parenterally‐ 500 mg/100 ml iv suspension tds
Ciprofloxacin
Class –Flouroquinolones
Category C
Mechanism of action‐ damages bacterial DNA→ damaged
DNA digested by endonuclease→cell lysis
Uses‐UTI, gynecological and wound infection, gonorrhea,
bacterial gastro enteritis, typhoid, MDR‐TB.
Contra‐indications‐ pregnancy and lactation.
Side effects‐
nausea, vomiting, bad taste, headache, anxiety, skin
hypersensitivity.
T1/2‐ 3‐5 hrs
Regime‐ oral:500 mg bd
iv: 200 mg bd
Clotrimazole
Class –anti fungal(azole)
Category B
Mechanism of action‐ inhibits cytochrome P450
→ cascade of membrane instability
Side effects‐ local irritation
Uses‐ vaginal candiasis
Regime – 1% lotion/cream
100 mg vaginal tablet
Clindamycin
Class – Lincosamide antibiotic
Category B
Mechanism of action‐ inhibits protein synthesis
Uses‐ Anearobic and mixed
infection(abdominal/lung/pelvic abcsess),
bacterial vaginosis.
Side effects‐ urticaria, abdominal pain, diarrhea
and psuedo‐membranous enterocolitis
Regime – 150‐300 mg qid orally or
200‐600mg iv 8 hrly
Fluconazole
Class – tri‐azole anti‐fungal
Category C
Mechanism of action‐ inhibits cytochrome P450
→ cascade of membrane instability
Uses‐cryptococcal meningitis, systemic/ local
candidiasis, recurrent candiasis.
Side effects‐ nausea, vomiting, abdominal pain,
rash.
T1/2‐ 25‐30 hrs
Regime‐ 150 mg single dose for vaginal candidiasis
Nevirapin
Class – anti retroviral[non‐nucleoside reverse transcriptase
inhibitor (NNRTI)]
Category C
Mechanism of action‐ inhibits non‐nucleoside reverse
transcriptase an essential viral enzyme which transcribes
viral RNA into DNA. Active only against HIV 1 infection
Uses‐
• triple combination therapy has been shown to suppress viral load
effectively in HIV‐AIDS
• Prevention of vertical transmission‐ single dose of nevirapine given
to both mother and child reduced the rate of HIV transmission by
almost 50%
Side effects‐
• mild or moderate rash, Stevens‐Johnson syndrome, toxic
epidermal necrolysis and hypersensitivity
• severe or life‐threatening liver toxicity.
Dosing of Nevirapine
Adult
Immediate‐release (IR) tablet or oral suspension: 200 mg
QD for 14 days, then 200 mg BID
Extended‐release (XR) tablet:
• 400 mg QD If initiating treatment with nevirapine: start
with IR tablet, 200 mg QD for 14 days; then change to
XR tablet, 400 mg QD If switching from nevirapine IR
formulation (200 mg BID) to XR formulation: start XR
tablet, 400 mg QD (without lead‐in dosage adjustment)
• Pediatric Age 15 days‐adolescence 150 mg/m2 QD for
the first 14 days, then 150 mg/m2 BID; maximum total
daily dose: 400 mg
• Prevention of Mother‐to‐Child Transmission single
dose 200 mg in active labour
Aspirin
Class – NSAID
Category if < 150 mg/day‐ C,
in standard dose D
Mechanism of action‐ nonselective inhibition of
COX‐2 enzyme
Uses‐ analgesic, antipyretic, post MI/ stroke, pre‐
eclampsia.
Contra‐indications‐peptic ulcer, liver disease,
diabetic.
Side effects – nausea, vomiting, epigastric pain,
hypersensitivity.
Regime: low dose ‐ 75 mg od.
Heparin
Class – anti coagulant
Acts indirectly by activating plasma antithrobin III →
binds and inactivates clotting factors (Xa and IIa)
of intrinsic and common pathway of coagulation
Contra‐indications‐bleeding disorders, severe
hypertension, threatened abortion, piles, GI
ulcers, sub acute bacterial endocarditis.
Side effects‐ bleeding, thrombocytopenia, alopecia,
osteoporosis, hypersensitivity.
Regime‐ low dose 5000 U sc every 8 hrly.
Low molecular weight heparin
Class – anticoagulant
Category C
Mechanism of action‐ selectively inhibit factor Xa and not
IIa.
Uses‐
Prophylaxis and treatment of DVT
Unstable angina
Maintain patency of indwelling canulae and shunts
In treatment of APLA syndrome
Advantages over unfractionated heparin
Better subcutaneous Bioavailability, longer t 1/2, aPTT
and clotting time not increased.
Regime‐ pamparin: 0.6 ml sc OD.
Antidote‐ protamin sulphate 1 mg for every 100 U of
heparin © Dept.OBGYN,GMCH Aurangabad.
Methotraxate
Class –anti‐metabolite
Category X
Mechanism of action‐ inhibits dihydrofolate
reductase→ blocks DNA synthesis
Uses‐ invassive mole, choriocarcinoma,
leukemias, rheumatoid arthritis, psoriasis.
Side effects‐ : ulcerative stomatitis, low white blood cell
count and thus predisposition to infection, nausea, abdominal
pain, fatigue, fever, dizziness and rarely pulmonary fibrosis
teratogenic, bone marrow depression, renal tubular necrosis.
Regime – 1 mg/kg
100 mg/ m2 body suface area
Metformin
Class – Oral hypoglyceamic(Biguanides)
Category B
• Suppress hepatic gluconeogenesis and glucose output from
liver
• Enhances insulin mediated glucose disposal in muscle and fat
• Retards glucose absorption in GIT
• Enhances peripheral glucose utilization
Contra‐indications‐hypersensitivity, hypotension,
CVS, RS, hepatic and renal disturbance.
Side effects‐ abdominal pain, anorexia, metallic
taste, tiredness, lactic acidosis.
Regime – 0.5 – 2.5 gms, 2‐3 doses.
Cabergoline
Class – D2 agonist
Category B
Mechanism of action‐ long‐acting dopamine D2‐receptor agonist
(decreases prolactine secreation by activating dopaminergic
receptors)
Uses‐
prevention of lactation
hyperprolactanemia
Contraindication
• Severely impaired liver function or cholestasis
• Cautions: severe cardiovascular disease, Raynaud's disease,
gastroduodenal ulcers, active gastrointestinal bleeding,
hypotension.
Side effects‐ Nausea, vomiting, stomach upset, constipation, dizziness,
lightheadedness or tiredness.
Regime – 2.5 mg stat for breast supression
Tetanus vaccine
Class – Toxoids
Category C
Uses‐
• Routine immunization of children and mothers
• After injury that might lead to intriduction of tetanus bacilli
Side effects‐ local pain, erythema, induration,
fever chills, malaise.
Regime – 0.5 ml single dose im.
Anti Rh immunoglobuline
Class – vaccine
Category C
Mechanism of action‐ masks Rh antigen on fetal RBC,s
after feto maternal bleed hence prevents maternal
sensitization
Uses‐ prevention and prophylaxis of post delivery or post
delivery Rh isoimmunisation
Should be given with in 72 hrs of delivery
T1/2: 22‐28 days but action lasts till 42 days
Regime‐ 300 mcg post delivery
150 mcg post abortion
(10mcg/ ml of whole blood or 20 mcg/ml of PRC feto‐
maternal bleed)
Tranexemic acid
Class –anti fibrinolytic
Category B
Mechanism of action‐ binds to lysin
binding site on plasminogen and
prevents its combination with fibrin.
Uses‐
• DUB
• Cu‐t menorrhagia
Side effects‐ nausea, diarrhea, headache, giddiness,
thrombophlebitis.
Contraindications‐ severe renal insuficiency,
hematuria.
Regime – 10‐15 mg/ kg 2‐3 times a day
Clomiphene citrate
Class –anti‐estrogenic
Category X
Mechanism of action‐ induces gonadotropin secreation by blocking
estrogenic feedback inhibition.
Uses‐
• sterility due to failure of ovulation
• aid in‐vitro fertilization,
• PCOD
• Anovulatory DUB
• oligospermia.
Contra‐indications‐ ovarian cyst, ovarian failure, hepatic dysfunctions and
occurrence of visual symptoms.
Side effects‐ poly‐cystic ovaries, multiple gestation, hot flush, risk of ovarian
tumor increases, ovarian hyper stimulation syndrome
Clomiphene resistance‐ absent ovulation with 100 mg clomiphene for 5 days
in 3 cycles
Clomiphene failure‐ absence of pregnancy even after ovulation with CC
T1/2‐ 6 days
Regime – 50 mg once a day for 5 days starting from 5th day of cycle.(max
200mg /day.)
Drotaverine
Class –antispasmodic
Mechanism of action‐ selective inhibitor of
phosphodiesterase 4, and has no anti‐
cholinergic activity
Uses‐
• treating renal colic.
• It has also been studied in accelerating labor by
speeding up cervical dilation
Contra‐indications‐ severe hepatic or renal failure
hypersensitivity
Side effects‐nausea, vomiting, headache, allergic reaction
Regime (1 amp contains 20 mg)
Acute renal colic‐ 40‐80 mg iv
Micronised progesteron
Ind‐luteal phase support
‐threatened abortion
‐preterm labour
‐secondary amenorrhea
‐DUB
Dose‐100mg,200mg,300mg,400mg
Route‐Oral,Injectable,Vaginal
‐preparation of endometrium for blastocyst implantation
‐promotes follicular cyst development
‐acts as immune system mainly by affecting cytokine synthesis
and function of NK cell
‐decreses uterine contractility
‐helps in development of fetal brain by multimodal effect
‐prevents preterm labour
ESTROGEN
Female sexual hormone & growth hormone for mullerian
system
SYNTHESIS OF ESTROGEN
Steroidal hormone derived from lipid precursor
cholesterol in graffian follicle, corpus luteum & placenta
Androstenedione Estrone (E1) Estriol (E3)
Ring A aromatisation
Testosterone Estradiol (E2)
A)NATURAL ESTROGENS
Etsradiol( 17β‐Etradiol/ E2) is the major estrogen secreted
by ovary
Estrone(E1)
Estriol(E3)
Principle estrogen before menopause – Estradiol, after
menopause – Estrone © Dept.OBGYN,GMCH Aurangabad.
CH3OH CH3 O CH3OH
OH
HO HO
HO
Estradiol Estrone Estriol
B) SYNTHETIC ESTROGENS
Natural estrogens are inactive orally & have shorter
duration of action due to rapid metabolism in liver
To overcome these shortcomings synthetic estrogens
have been introduced
However currently introduced micronised estradiol
preparations are orally active
a) CONJUGATED STEROIDAL ESTROGENS
Estrone sulphate, Estradiol valerate, Estradiol benzoate,
Estradiol succinate or hemisuccinate
b) NON CONJUGATED SYNTHETIC ESTROGENS
17α ‐Ethinyletsradiol, Mestranol
c) NON STEROIDAL
Diethylstilbesterol( oral), Hexosterol, Dienesterol
(topical)
d) ESTROGEN ANALOGOUES
Clomiphene, Tamoxiphene, Raloxiphene, Ormiloxiphene,
Chlorotrianesene
MECHANISM OF ACTION
2 types of receptors ERα & ERβ
Most tissues express both subtypes but ERα
predominates in uterus, vagina, breast,
hypothalamous & blood vessels while ERβ
predominates in prostate gland
Binding of agonist to receptor causes dimerisation of
receptor & its interaction with ‘Estrogen Responsive
Elements’(EREs) of target genes
Gene transcription is promoted through certain
coactivator proteins
In case of antagonist binding the receptor assumes a
different conformation & interacts with corepressor
proteins inhibiting©gene transcription
Dept.OBGYN,GMCH Aurangabad.
PHYSIOLOGICAL ACTIONS
Stimulates development of vagina, uterus, breasts
Development of secondary sexual characters
Redisribution of fat to hips & breasts
Responsible for accelerated growth phase &
epiphyseal closure of long bones at puberty
Maintainance of normal structure of skin & blood
vessels
Stimulates hepatic synthesis of many proteins like
transcortin, thyroxine binding globulin, sex hormone
binding protein, transferrin, renin substrate, fibrinigen
causing increased circulating levels of thyroxin,
estrogen, testosterone, iron & copper
Decrease in resorption of bone by antagonising
effects of PTH
Increased coagulability of blood by increasing
concentrations of factors II, VII, IX, X & increased
plasminogen & decreased platelet adhesiveness
Increase HDL cholesterol & triglycerides & decrease
total & LDL cholesterol
Facilitate movement of fluid from the plasma to the
extravascular space
USES
1)HRT‐
Estradiol the safest estrogen
If osteoporosis is a risk best treated with tibolone
Estradiol if necessary may be considered in doses 1
mg/day
If cardiovascular risk is predominant tibolone is most
suited ,
Estradiol if necessary may be considered in doses 1
mg/day © Dept.OBGYN,GMCH Aurangabad.
For those with risk of of breast & endometrial cancer
tibolone is best , estradiol is better avoided
Those with vasomotor symptoms & neuroendocrine
deficits estradiol is best
Those at risk of venous thromboembolism & hot
flushes should avoid raloxiphene
Oophorectomised subjects should be on estradiol
from immediate postoperative period & may be
shifted to tibolone after few months
2) Oral contraceptive pills
Estrogen of choice is 17α ethinyl estradiol
Usual dose range from 50mg to 10 mcg
Dose of 20‐30 mcg has been found to be most
optimal in combination with progestin
3)Senile vaginitis
Effective in both preventing & treating atrophic
vaginitis , topical preparations are commonly used
3) Delayed puberty in girls
4) Can also be used in acne, hirsuitism, palliative
treatement of carcinoma prostate
5) Tamoxiphene is the first choice hormonal therapy in of
breast cancer in both pre & post menopausal women
ADVERSE EFFECTS
Increased risk of endometrial carcinoma
Increased incidence of breast carcinoma
Increased incidence of gallstones & benign
hepatomas
Increased risk of thromboembolic phenomenon
Stilbesterol given to pregnant women cause increased
incidence of vaginal & cervical carcinoma in the
female offspring
Migraine & endometriosis may be worsoned
PROGESTINS
Progestin= favoring pregnancy
Steroidal hormone derived from cholesterol, secreted by
corpus luteum in early pregnancy & later by placenta
Progesterone is a 21 carbon compound ,is the natural
progestin
Progesterone means only good things to women &
doesn’t cause any harm
Unfortunately clinical usefulness is limited by poor
absorption from oral route
Orally active progestins in clinical practice are micronized
progesterone, esters of progesterone & 19‐ norsteroid
progestins O
CH
C H3 3
CH3
O
A)CLASSIFICATION
Progesterone derivatives
a)Derived from pregnane ring
1.Micronised progesterone
Oral, transdermal, IM, vaginal & rectal applications
( Prometrium, Utrogestan, Crinon)
2. Derivatives of progesterone
Restroprogesterone dydrogesterone –oral application
(Duphastone)
3. Esters of progesterone
Pregnane steroids(21 carbon compounds)
Hydroxyprogesterone derivatives :
Medroxyprogesterone acetate oral& paprenteral
application (Provera, Farlutal)17α
hydroxyprogesterone 17‐n‐ caproate (Proluton
injectable)
b) Progestins derived from androsten ring (19 carbon
compounds)
4. Androstene steroids
Testosterone derivatives: Ethisterone , Dimethisterone,
Danazol‐ oral application
c) Progestins derived from estrane ring
5. Estrane steroids (18 carbon compounds) 19 nor
testosterone derivatives
Norethisterone, Norethisterone acetate, Allylstrenoloral
application ( Orgametril, Pregmate, Lyndiol, gestin)
d) Progestins derived from gonane ring
6. Gonane steroids (19 carbon compounds)
Structural modification of estrane & ethyl group at
position 13
Norgestrel( primovular)
7. Newer gonane steroids (19 carbon compounds)
Structural modification of gonane & methylene group at
position 11
Desogestrel, Gestodene ,Norgestimate (Novelon,
Femilon)
MECHANISM OF ACTION
Unlike other steroid receptors Progetserone
receptors(PR) have limited distribution in body mostly
confined to female genital tract, breasts, pituitary &
CNS
PR exists in 2 isoforms PR A&B
After binding to progesterone it undergoes dimerisation
attaches to progesterone responsive element &
regulates transcription through coactivators
Natural progesteron is inactive orally, most of the
synthetic progestins are active orally
PHYSIOLOGICAL ACTIONS
Brings about secretory changes in estrogen primed
endometrium
Brings about decidual changes in endometrium
Converts watery cervical secretions into viscid scanty
secretion
Acting along with estrogen prepares mammary gland
for lactation
Weak inhibitor of Gn secretion from pituitary
Causes rise in basal body temperature by 0.5 degree
centigrade
It also has respiratory stimulant & CNS depressant
effect
USES
Progestin Indication
19 norsteroids Contraception
(norgestrel, desogestrel, norgestimate)
19 norsteroids Hemostatic progestins (DUB)

(norethisterone, norethisterone acetate)
Dydrogesterone LPD, PMS, DUB, endometrial protection,

(short acting progesterone like) menopause
Esters of progesterone Long term contraception, endometrial

(medroxyprogesterone) protection
Micronised progesterone LPD, PMS, DUB, endometrial protection,

menopause
19 norsteroids Menopausal support

(tibolone) Bone & CVS protection
ADVERSE EFFECTS
Breast engorgement, headache, rise in
body temperature, esophageal reflux,
acne mood swings
Irregular bleeding & amenorrhoea
19 nor testosterone derivatives lower HDL
levels & may promote atherogenesis
Blood sugar levels may rise & diabetis
may be precipitated by long term use of
agents like levonorgestrel
If given in early pregnancy may cause
masculanisation of female foetus
Intramuscular injections are painful
This is a specimen of uterus along with cervix and bilateral
adnexal structures. Fungating cauliflower like growth arising
from cervix appears to be fragile suggestive of carcinoma
cervix.
Different Types of The Lesion
Clinical :
1) Exophytic;
2) Ulcerative and
3) Infiltrative.
Histopathological
1) Squamous cell carcinoma (85-90%);-Large cell
keratinizing, Large cell non keratinizing, Small cell
2) Adenocarcinoma (10-15%).
3) Adenosquamous
4) Sarcoma
5) Malignant melanoma
6)Nuroendocrine ca
Risk Factors
1)Human papilloma virus infection in 70-90 % of cases-

common types 16,18,6,11,31,33,45
2)Coitus before age of 18,multiple and high risk sex
parteners
3)Delivery of 1st baby before 2o yrs,multiparity with poor
birth spacing
4)Poor personal hygiene and low socioeconomic status
5)STDs,HIV infection, HSV-2
6)Immunosupressed individual
7)Smoking,alcohol
8)OC pills and Progestogens
Symptoms
• Post coital, intermenstrual and post
menopausal bleeding
• Offensive vaginal discharge, lower pelvic pain,
referred pain to legs, frequency of micturation,
hematuria, tenesmus, rectal bleeding
CIN
It is cervical intraepithelial neoplasia in which a part
or full thickness of stratified squamous
epithelium is replaced by dysplastic cells but
basement membrane is intact.
1)CIN1 (Mild dysplasia) ‐lower 1/3 of epithelial
thickness
2)CIN2 (Moderate dysplasia)‐lower 2/3 rd of
epithelial thickness
3)CIN3 (Severe dysplasia/Carcinoma in situ)‐entire
thickness of epithelium with intact basement
membrane
Preventive Measures
Primary prevention
(a) Identifying high risk factors
(i) Early sexual intercourse; (ii) Early age of first
pregnancy; (iii) Too many births and too frequent
births; (iv) Poor local hygiene; (v) STD - HPV
and HSV type II infection.
(b) Secondary prevention
(i) Screening against carcinoma cervix : cytology,
HPV testing, colposcopy and biopsy
(ii) "Down staging screening" by WHO - intends to
diagnose the disease early and to minimise cancer
death. © Dept.OBGYN,GMCH Aurangabad.
FIGO staging of carcinoma cervix
Stage I
Stage I is carcinoma strictly confined to the cervix; extension to the uterine corpus should
be disregarded. The diagnosis of both Stages IA1 and IA2 should be based on microscopic
examination of removed tissue, preferably a cone, which must include the entire lesion.
Stage IA: Invasive cancer identified only microscopically. Invasion is limited to measured
stromal invasion with a maximum depth of 5 mm and no wider than
7 mm.
Stage IA1: Measured invasion of the stroma no greater than 3 mm in depth and no wider
than 7 mm diameter.
Stage IA2: Measured invasion of stroma greater than 3 mm but no greater than 5 mm in
depth and no wider than 7 mm in diameter.
Stage IB: Clinical lesions confined to the cervix or preclinical lesions greater than Stage
IA. All gross lesions even with superficial invasion are Stage IB cancers.
Stage IB1: Clinical lesions no greater than 4 cm in size.
Stage IB2: Clinical lesions greater than 4 cm in size.
Stage II
Stage II is carcinoma that extends beyond the cervix, but does not extend into the pelvic
wall. The carcinoma involves the vagina, but not as far as the lower third.
Stage IIA: No obvious parametrial involvement. Involvement of up to the upper two thirds
of the vagina.
Stage IIB
: Obvious parametrial involvement, but not into the pelvic sidewall.
Stage III
Stage III is carcinoma that has extended into the pelvic sidewall. On rectal examination,
there is no cancer‐free space between the tumour and the pelvic sidewall. The tumour
involves the lower third of the vagina. All cases with hydronephrosis or a non‐functioning
kidney are Stage III cancers.
Stage IIIA: No extension into the pelvic sidewall but involvement of the lower third of the
vagina.
Stage IIIB: Extension into the pelvic sidewall or hydronephrosis or non‐functioning kidney.
Stage IV
Stage IV is carcinoma that has extended beyond the true pelvis or has clinically involved
the mucosa of the bladder and/or rectum.
Stage IVA: Spread of the tumour into adjacent pelvic organs.
Stage IVB: Spread to distant organs.
Advantages of Surgery Over Radiotherapy
(i) Thorough surgico-pathological staging during

surgery.
(ii) Accurate prediction of survival rate by para-
aortic and pelvic node ass ment surgically.
(iii) Preservation of ovarian function when desired,
(iv) Retention of more functional and pliable
vagina.
(v) Transposition of ovaries when needed for
consideration of full radiotherapy.
(vi) Psychological benefit of the woman.
Treatment
• I A 1 – Simple Hysterectomy
• I A2, I B – Wertheims Hysterectomy
• II A –
Schoutas operation
Primary Radio therapy
Combine surgery + Radio therapy
• II A onwards – Radio therapy
Consisting of brachy therapy
Followed by external radiation
Questions
Q. Clinically what are the different types of the lesion ?
Q. Histopathologically what are the different types of carcinoma cervix ?
Q. What are the different modes of spread in carcinoma cervix?
Q. What are predisposing risk factors?
Q. What is CIN?
Q.What are 4 cardinal signs & symptoms?
Q. What is natural history of Ca Cx?
Q. Screening methods for Ca Cx ?
Q. What are the preventive measures against carcinoma cervix ?
Q. What are the advantages of surgery over radiotherapy ?
Q. What is neoadjuvant chemotherapy and what are the benefits ?
Q. What is concurrent chemoradiation ?
Q. How a woman with carcinoma cervix in pregnancy can be managed ?
Q. What is the overall 5 years survival rate following therapy in a woman* carcinoma
cervix ?
Q. What are the aims of palliative treatment ? What different palliative treat-ments can
be given to a woman with carcinoma cervix ?
Q. Vaccines for Ca Cx ?
FIBROID UTERUS
This is cut & mount specimen of uterus around 8‐10
wks size. External surface shows serosal fold.
Evidence of circular mass of 2 x 3anterior wall of
uterus. Cervix normal.
Etiology
• Age – 35 – 40 yrs
• Nulliparity
• Racial & Genetic factors – african
• Hyperoestogenaemia – obesity, estrogen, secreting ovarian
tumours.
Types of Fibroid
• Submucous (15%)
• Interstitials (75%)
• Subserosal (10%)
Symptoms
• Menstrual disturbances – menorrhagia, spasmodic
dysmenorrhoea, irregular bleeding.
• Pressure symptoms – dyspepsia, retention of urine,
constipation, varicusities.
• Infertility
• Recurrent abortions
• Pain
• 50% patients are asymptomatic
D/Ds
• Pregnancy
• Hematometra
• Pyometra, hydrometra
• Retained POCs
• Adenomyosis
• Endometrial polyps
• Endometriosis
• Chronic PID
• Benign / malignant ovarian tumour
• Ca endometrium
• Pelvic kidney © Dept.OBGYN,GMCH Aurangabad.
Bi t t
Investigations
• Hb, Bld Group
• Ultrasound – Number, Location, size of Fibroid
• Hysterosalpingography – for submucous fibroid
• Hysteroscopy – guided polypectomy can be done
• D & C – to rule out Ca endometrium
• Laparoscopy
• Radiography – calcification. D/Ds – ovarian tumour, TB mass,
calcified mucocele of appendix, bone tumour
• CT scan is not very helpful
• MRI is having definite role in identifying adenomyosis &
sarcomas
• IVP – for broad ligament fibroid – for anatomy & pathology of
Treatment
• Asymptomatic fibroid – follow up for 6 months.
• Symptomatic fibroid
a) Medical – for anaemia
‐ Control of menorrhagia – mifepristone
GnRh analogue danazole
b) Minimally invasive surgency :
Currettage, myometrial aspiration polypectomy,
vaginal myomectomy
c) Surgery – Abdominal myomectomy, Laparoscopic
myomectomy, myloysis, embolotherapy,
h t t
Questions
1) What is cause of menorrhagia in fibroid?
2) What is cause of recurrent abortion in fibroid?
3) Which is most common complication of fibroid in pregnancy?
4) What is the role of D & C in fibroid uterus c/o menorrhagia?
5) Enumerate complications of fibroid?
6) Incidence of sarcomatous change in fibroid?
7) What is used for embolisation of uterine artery?
8) What is most common fibroid undergoing torsion?
9) What is wandering fibroid?
10) Mention the contraindication of myomectomy?
11) How will you differentiate between
© Dept.OBGYN,GMCH fibroid & adenomyosis ?
Aurangabad.
UTERO‐CERVICAL PROLAPSE
Uterine length
Cervical length
This is wet and mounted specimen of uterus

with cervix. There increased uterocervical length
and presence of vaginal tag, Mostly suggestive of
genitourinary prolapse.
Classification of prolapse
1)Anterior vaginal wall
Upper two third‐cystocele
Lower one third‐urethrocele
2)Posterior vaginal wall
Upper one third‐enterocele
Lower two third‐rectocele
3)Uterine descent‐
First degree‐descent of cervix into vagina Second
degree‐descent of cervix upto introitus
Third degree‐descent of cervix outside introitus
4)Procidentia‐all of uterus outside introitus
Note cervical descent upto Note cervical descent beyond
introitus – II degree UV prolapse introitus‐ III degree UV prolapse
Symptoms
• Something coming out of introitus

• Dragging pain in lower abdomen
• Difficulty in voiding,walking,defecating,coitus
• Urinary frequency and urgency
• Mucosal irritation and discharge
Risk Factors
• Pregnancy, vaginal child birth,

• Menopause‐ aging, hypoestrogenism
• Chronically increased intra abdominal pressure
• COPD, Constipation, obesity
• Pelvic floor trauma
• Race, connective tissue disorder
Different Types of Surgery
1) Repair of cystourethrocele
2) Repair of rectocele and enterocele
3) For uterovaginal prolapse
a. Vaginal hysterectomy with pelvic floor repair
b. Manchester(Fothergills) operation
c. Le Forts operation
d. Abdominal repairs
‐Sling operation
‐Abdominal sacrocolpopexy
Management in pts who wants reproductive
functions depends on,
• Supravaginal elongation
• Ant and post vag wall prolapse
If present If absent
Fothergill’s operation Sling operation
• Perimenopausal completed family,
Mayowards operation(vaginal hysterectomy
with anterior colporrhaphy with post
colpoperiniorrhaphy)
• Patients not fit for surgery(old patients),
Ring pessary insertion
Dani’s stitch(introital tightening)
Le Fort’s operation
Supports of The Uterus
Supports of the uterus are described in a three tier system.
A. Upper tier : Indirect support

to maintain the anteverted position of uterus. Supporting structures are:
• Endopelvic fascia • Round ligaments
• Broad ligaments with intervening pelvic cellular tissues.
B. Middle tier : Direct and strongest support.

• Endopelvic fascia • Pericervical ring of fascia
• Mackenrodt's ligaments • Uterosacral ligaments
• Pubocervical ligaments
C. Inferior tier — Indirect support

• Pelvic floor muscles (levator ani). • Levator plate
• Perineal body • Urogenital diaphragm • Endopelvic fascia
Differential Diagnosis
• Cervical polyp
• Cyst of Bartholin’s gland
• Cyst of Skene’s duct
• Pedunculated fibroid
• Vaginal cyst
• Inversion of uterus
Questions
Q. Classification of prolapse?
Q. What are symptoms?
Q. What are risk factors associated with prolapsed?
Q. What are the urinary symptoms in a case of G‐U prolapse ?
Q. What other associated pathologies must be excluded during examination?
Q. What is decubitus ulcer ?
Q. What is the change in the vaginal and in the supra‐vaginal part of the cervix ?
Q. What are the anatomical changes in the urinary system in a case of G‐U
prolapse ?
Q. How you can clinically differentiate a third degree uterine prolapse from a
second degree one ?
Q. What is Fothergill's Stitch ?
Q. What is the common operation for congenital or nulliparous prolapse?
Q. What are the complications of vaginal hysterectomy with pelvic flow i
operation ?
Q. What important factors are generally considered before deciding the
appropriate treatment for prolapse ?
Q. What are differential diagnosis?
MUCINOUS CYSTADENOMA OF OVARY
It is specimen of large tumor of size 17x15x14 cm in size external surface
smooth, lobulated, thin capsule with no areas of hemorrhage, necrosis, adhesions,
few dilated vessels are seen. Fallopian tubes are seen on lateral aspects of tumor
& are normal hence it is benign ovarian cyst.
Etiology
• Racial factor –common in white population
• High economic status
• Use of ovulation induction agents
• BRCA‐ genetic familial association
• Nulligravida , early menarchae, late menopause
Routes of transmission
• Direct
• Haematogenous
• Transcoelomic
• Lymphalic
Symptoms
• Distention of abdomen
• Pressure symptoms
• Menorrhagia, amenorrhea
• Pain in abdomen & discomfort
• Dyspepsia like symptoms
Investigations:
• Routine investigation
• USG
• USG Doppler
• CT / MRI
• FNAC for Histological diagnosis
Treatment
• TAH with BSO
• Ovariotomy
• Ovariocystecomy
• Laparoscopy or USG guided aspiration of cyst.
Chemotheraphy
• DOC ‐ B+E+P regimen
• Bleomycin, etoposide, cystplatin
• Symptomatic Rx ‐ Ascitic tap.
Complications
• Torsion of cyst
• Rupture
• Hemorrhage
• Malignant change
FIGO surgical staging system for ovarian cancer
Stage surgical – pathological findings
IA growth limited to one ovary
IB Growth limited to both ovaries
IC Tumor limited to one or both ovaries, but with disease on

surface of one or both ovaries or capsule ruptured or with
malignant Ascites or positive peritoneal washings
IIA Extension &/or metastasis to uterus & /or tubes
IIB Extension to other pelvic tissues
IIC Tumor limited to genital tract or other pelvic tissue with disease
on surface of one or both ovaries, or with capsule ruptured or
with malignant ascites or positive peritoneal surfaces.
• Figo surgical staging system for ovarian cancer
Stage surgical – pathological findings
IIIA Tumour grossly limited to true pelvis with negative nodes but
with histologically, confirm microscopic seeding of abdominal –
peritoneal surface.
IIIB Abdominal implants < 2 cm with negative nods
IIIC Abdominal implants at least 2 cm & or positive pelvic paraaortic,

inguinal nodes
IV Distant metastases including malignant pleural effusion or

parenchyma liver metastasis
Questions :
1. What is most common histological type of ovarian tumor ?
2. What are the causes of pain in ovarian tumor ?
3. Which are hormone secreting tumors?
4. Which are differential diagnosis of ovarian tumour?
5. What is Meig’s syndrome?
6. Describe teratoma?
7. What is rokitanskis protruberence ?
8. What is struma ovari ?
9. Most common ovarian tumour seen in pregnancy?
Questions :
10. Symptoms & management of torsion of ovarian tumor in
pregnancy
11. Enumerate tumor markers in ovarian tumour.
12. Describe significance of Ca‐125 ?
13. Which are other condition where CA 125 is seen?
14. Call exrer’s boolies are seen in which ovarian tumour?
15. What is krukenbeigs tumours?
16. Management of benign ovarian tumour?
17. Mention clinical features of malignant ovarian tumor
VESSICULAR MOLE
• This is specimen of vesicular mole showing bunch of
grape like structures each vesicle 2x5 mm in size.
• Vesicle is gray translucent containing clear fluid. There
is no any foetal tissue or placenta.
Spectrum of G.T.D.
• Complete mole
• Partial mole
• Persistent gestational trophoblastic placental site
trophoblastic disease tumor
• Choriocarcinoma
Vessicular mole
• Definition‐ Abnormal condition of placenta in which
partial degenerative & partially proliferative changes in
young chorionic villi.
Differences
Complete mole Partial mole
1.Embryo or foetus Absent Present
2.Hydrophic degeneration Diffuse Focal
of villi
3.Trophoblastic hyperplasia Diffuse Focal
4.Uterine site More than date Less than date
5.kariotype 46xx/46xy Triploid
6.BHGC >50,000 <50,000
7.Risk of persistent GTD 20% 5%
8.Scalloping of villi Absent Present
9.Trophoblastic stromal Absent Present
inclusion
Etiology
• Age <20 & >35 years.
• Race & ethnic groups.
• Vit A & carotene deficiency.
1) Increase r‐globulin in absence of hepatic
disease.
2)AB blood group.
• ABO antibodies absent.
• History of prior H. mole
Signs & Symptoms:
• Abnormal bleeding P.V leading to anemia.
• Abnormal uterine growth.
• Preeclampsia – early onset <20 weeks.
• Hyperemesis gravidarum
• Hyperthyroidism
• Absent foetal parts, no ballotment
Management
INVESTIGATION :
1) CBC
2) USG‐Characteristics show storm appearance
3) USG doppler . Increase vascularity
4) CT
5) MRI
6) B.HCG . prognostic AND diagnostic marker
TREATMENT :
• Suction evacuation .
• Supportive IV for anemia and infection
• Counseling for regular follow up.
Management
• For treatment purpose patients are categories into 2 groups :
• Group A‐ favourable CX & V mole is in process of expulsion .
suction evacuation should be done.
• Group B‐ unfavourable cervix prior to suction evacuations
• Cervix should be dilated with laminaria tent and T‐misoprost
400 micro gram PV.
• CHEMOTHERAPHY:
• DOC‐ methotrexate.
Questions
• Definition of gestational trophoblastic disease.
• What is thyroid storm ? what are predisposing conditions & what the
treatment?.
• What is recurrence rate of vesicular mole.?
• What is incidence of vesicular mole.?
• What are the causes of pain in vesicular mole.?
• What is most common site of metastasis in GT.N. & describe
characteristic appearance.?
• What is cell of origin of vesicular mole.?
• Enumerate differential diagnosis of vesicular mole.
• Enumerate complications of vesicular mole.
• Enumerate risk factors for malignant change in vesicular mole.
• What is folinic acid & What is its use.?
HYDRO‐CEPHALOUS
This is a specimen of newborn fetus showing enlarged head as
compared to rest of the body suggestive of hydrocephalus
HYDROCEPHALUS
(greek word hydros‐ water ,cephalos‐ head) is a condition
characterised by excessive accumlation of CSF in ventricles
associated with thinning of brain matter .
• CSF volume ‐ 0.5L‐1.5L
• Incidence‐ 1 in 2000 deliveries
• Classification: According to pathology‐
1) Obstructive
2) Non‐Obstructive
According to cause –
1) Congenital
2) Non Congenital
• Obstretic clinical findings:
1) FHS is high up
2) Head cannot be pushed into pelvis
3) Breech presentation is more common
Q&A
• Which is most common anamoly associated with hydrocephalus?
Open spina bifida
• USG findings
Dialation of ventricles,dangling choroid plexus, thinning out of cerebral cortex
• Most common syndrome associated
Parinaud syn. Leading to abducent nerve palsy
• Most common malformations associated
Arnold Chiari malformation, Dandy Walker malformation
• Enlargement of skull is seen upto
3yrs of age
• Management during labour
Induction done beyond 36wks and during labour decompression of head is done
with sharp pointed scissors
• Sites for shunts
Peritoneal cavity , Pericardial cavity
• Obstretic complications
Obstructed labour, rupture of uterus
• PV findings
CONJOINT TWIN
ANENCEPHALY
This is a jar mounted specimen of baby with
deficient development of vault of skull and
brain tissue suggestive of anencephaly.
• Incidence‐ 70% females mostly in Elderly mothers
• P/A examination‐ head not palpable
• P/V examination‐ face or brow presentation
Q&A
• Glands most commonly affected
Adrenal glands, pituitary gland
• USG findings
Absence of cranial vault, angiomatous brain tissue, frog sign.
• Which wk USG findings are confirmatory
13 wks
• Complications seen
Hydramnios, malpresentation, premature labour, tendency of
prolonged pregnancy, shoulder dystocia, obstructed labour.
• Confirmation by raised alpha fetoprotein level
• For prevention‐ folic acid supplementation
• Difference between enencephaly and anencephaly
ECTOPIC PREGNANCY
This is a laparoscopic view of unruptured tubal ectopic pregnancy mostly in ampullary region of
fallopian tube.
Definition:
It is defined as the pregnancy in which the fertilised ovum is implanted and
develops outside the normal uterine cavity
Frequency:
has increased due to chronic pid, ovulation induction, use of iucd
Etiology:
factors delaying migration of fertilized ovum in the uterine cavity
factors facilitating nidation of fertilized ovum in tubal mucosa
iatrogenic
Implantation sites :
1.uterine‐a)cervical
b)angular
c)corneal
2.extra uterine‐a)tubal(97%)
b)ovarian(0.5%)
c)abdominal
tubal is again divided into 4 parts:
a. ampulla(55%)
b. isthmus(25%)
c. infundibular(18%)
d. interstitial(20%)
Clinical features:
triad of amenorrhea, abdominal pain, vaginal bleeding
signs‐pallor ,shock, tense tender abdomen
Differential diagnosis:
Acute appendicitis, perforated peptic ulcer, twisted ovarian tumour
Investigations :
Hb, blood group, culdocentesis, βhcg level, color Doppler
Management ‐
anti shock treatment, laparotomy‐for acute ruptured ectopic.
For unruptured‐
a)medical‐
methotrexate,
potassium chloride
hyperosmolar glucose
b)surgical
Questions and answers
1.most common site of ectopic
Fallopian tube
2.in that most common
Ampullary region 55%
3.other sites
Cervical, abdominal, angular, corneal, ovarian
4.iatrogenic causes of ectopic
Iud ,pop, sterilization operation
7.clinical varieties of ectopic
Acute, unruptured, chronic or old
9.ring of fire
Seen on trans vaginal color sonography
ORAL CONTRACEPTIVE PILLS
• ESTROGEN PROGESTERON COMBINED PILLS
Uniphasic multiphasic
• LOW DOSE PILLS
• PROGESTERON ONLY PILLS [mini pill]
Mechanism of action
• SUPPRESSION OF OVULATION : ovulation os inhibited by
action of estrogen on FSH and progesteron on LH surge .
• Thickening of cervical mucus making it immpermeable to
sperms
• Endometrium is out of phase to ovulation so that
implantation does not occur
BENEFITS OF ORAL CONTRACEPTIVE
• Reduces menstrual blood loss and aneamia
• Fewer premenstrual complaints
• Decreases chances of ectopic pregnancy
• Decreases dysmenorrhoea associated with endometriosis
NON CONTRACEPTIVE BENIFITS

• Decreases incidence of ovarian and endometrial carcinoma
• Increases bone mineral density
• Prevention of atherogenesis
• Decreases activity of rheumatoid arthritis
• Decreases incidence of benign breast diseases
• Decreases size of liomyoma
• Decreases hirsuitism and acne in hyperandrosteronism
ABSOLUTE CONTRAINDICATIONS
• Stroke
• Thrombophebitis
• coronary occlusion
• Thromboembolic disease
• Liver malignancy
• Pregancy,lactation
• Undiagnosed vaginal bleeding,premalignant or
malignant conditionsof uterusor vagina
• Breast carcinoma,past breast cancer
• Uncontrolledhypertention,migrain,heavy
smokers,hyperlipidemia.
RELATIVE CONTRAINDICATIONS
• Age more than 40 yrs
• Smokers more than 35 yrs of age
• History of jaundice
• Heaadache of nonneurological origin
• Unexplained vaginal bleeding
• Caner cervixor precancerous lesions
• Breast feeding more than 6 mts postpartum
LOW DOSE PILLS
• Ethynyl estradiol dose has been reduced to

30mgm or less and biochemical structure of
progesteron was changed to reduce
androgenic side effects
PROGESTERON
• Types of progesterons used:1st generations
: no longer used now
• 2nd generation: norgestrel,ethinodiol
diacetate,norethindrone,levonorgestrel.
• 3rd generation:norgestimate,desogestrel
• Spironolacton derivative:drospirenone
PROGESTERON ONLY PILLS
• OVERETTE:NORGETREL75mgm
• MICRONOR:NORETHINDRONE35MG
• NOR‐QD35mg
• Mechanism of action : thickening of cervical mucus
making it hostile for sperms,endometrial
hyperplasia, decreased tubal mobility,abnormal
luteal function.
ADVANTAGES OVER COMBINED ORAL CONTRACEPTIVE
Can be used in patients with,
• Breast feeding mother
• undiagnosed vaginal bleeding
• severe artery disease
• liver tumours
• the rare disease porphyria
• a history of breast cancer (with certain exceptions).
Loestrin 24 : (Fe and Yaz)
(drospirenone 3mg +
EE 20 mcg)
‐ 24 days hormones and
4 days hormone free pills.
‐ estrogen free
interval shortened
‐ decreased number of
withdrawl episodes.
Seasonale [EE 30mcg + levonorgestrel 0.15mg]
Seasonique [EE 30mcg + levonorgestrel
0.15mg]+[EE 10 mcg (7)]
‐13 wks cycle (12 wks hormonal and 1 wk
hormone free)
Lybrel (EE 20 mcg + levonorgestrel 0.09mg)
• Once daily for 365 days.

• break through bleeding and spotting is likely
while taking Lybrel. However, for the majority
of women this usually decreases over time.
Methods of use
• Quick start‐ started any day regardless of
cycle
• FIRST DAY START‐ within the first 24 hrs of
your period. if delayed 7 days back up is
required.
• Sunday start‐started on first Sunday
following menses.
FAILURE RATE: 0.3(PERFECT USE) 8(TYPICAL USE)
They are of two types‐
• (1) Progestogen‐only formulations that
contain a progestogen hormone and are
effective for 2 or 3 months; and,
• (2) Combined formulations that contain both
a progestogen and an estrogen and are
effective for 1 month
INJECTABLE PROGESTINE CONTRACEPTIVE
Depo‐subQ provera 104 –
subcutaneous preparation every 3 months.
absorbed slowly than im
Advantages
‐Therapeutic levels within 24 hrs.
‐No additional contraceptives if given within 5
days of menses.
‐convenient.
‐no iron defficiency aneamia..
PROGESTERONE ONLY
Name Active Duration of Common
ingredients effect trade
names
DMPA 150 mg Depo-
(progestogen- medroxyprogesterone 90 days
Provera,
only) acetate in an aqueous
microcrystalline Depo-
suspension Clinovir,
others
NET-EN 200 mg 60 days Noristerat,
(progestoge norethisterone Norigest,
enanthate Doryxas, and
n-only)
in an oily preparation others
CONTRACEPTIVE BENEFITS
• High effectiveness esp with enzyme inducing drugs
• Minimizes the forget ability
• Highly convenient non intercourse related.
• Fully reversible
• Coitus independent
• Pt has ovulatory cycles
NON CONTRACEPTIVE BENEFIT
Decrease in menstrual problems
‐less heavy bleeding and less anemia –used for TREATMENT FOR DUB
‐less dysmenorrhia
‐less PMS
Less PID
Less extra‐uterine pregnancies
Less endometriosis
Reduction in growth of fibroids only if oligo‐ is obtained.
NON‐COC BENEFITS
Benefit in sickle cell disease
Lactation not suppressed
Lunelle
• Monthly injection (Estradiol cypionate +

Medroxyprogesterone)
• Efficacy: 97 % Typical use
• Side effects: similar to OCPs
• Compliance: > OCPs
VAGINAL CONTRACEPTIVE RING
First marketed in US by the name NUVA RING

• It is a flexible transparent,colourless vaginal ring measuring 2
inches in diam made of ethylene vinyl acetate copolymer
15ug of EE and 120 ug of etonogestrel(active metabolite of
desogestrel) © Dept.OBGYN,GMCH Aurangabad.
• Worn usually within 5 days of menses.
• Worn for 3 weeks and then discarded
• New ring is inserted a week later.
The ring can be placed any where in the vagina
with no specific fit. There is no wrong way to
insert the ring. if it lies comfortably in the
vagina it is right.
• Ring should be worn at all times in a cycle. intercourse should
be tried with the ring in‐situ first and be removed only if it is
troublesome but should be replaced within 3 hrs.
• If ring slips or is kept out for >3 hrs then a back up
contraceptive should be used for 1wk.
• Estrogen & progestin levels in week 4 are only slightly lower
than weeks 1‐3
• If ring is left in > 3 wk but < 4 wk
– Remove ring; insert new one after a 1 wk break; no back‐up
needed
• If ring is left in > 4 wk
– Insert new ring; use back‐up for 7 days
ADVANTAGES OF THE NUVA RING
• High patient compliance
• Easily inserted and removed.
• Vaginal adm precludes GI interface with absorption.
• No hepatic first‐pass metabolism of progestins.
• Low and steady levels of research result in little
spotting and irregular bleeding.
DISADVANTAGES OF THE RING
• No protection against STDs
• Local device side effects
‐vaginal discharge
‐inflammation(vaginitis)
‐irritation
• Same contraindications as with COC
FAILURE RATE: 8(PERFECT USE) 0.3(TYPICAL USE)

CONTRACEPTIVE PATCH
• Contraceptive patch is a new transdermal product

containing norelgestromin(active metabolite of
norgestimate) and Ethinyl estradiol.
• It is usually 4.5 cm2 in size and has 3 layers
‐outer protective layer of polyester
‐medicated middle adhesive layer
‐a clear polyster release liner that is removed before
the patch is applied
• Patch contains 6mg of norelgestromin and 0.75mg of
EE releasing
• ‐120ug of norelgestromin and 20ug of EE everyday.
SIDE EFFECTS
• Breakthrough bleeding or spotting
approximately the same as with pill.
• Breast symptoms are initially worse with patch,
comparable to pill by 5th cycle
( ~1% discontinuation).
• May not relieve dysmenorrhea to same extent as pill.
• 20% Skin irritation‐2% leave cos of skin irritation
• Failure rate ~ 1% per year.
• Less effective in women who weigh > 90 kg (198 lbs)
• Pregnancy can occur if the patch loosens or falls of for
more than 24 hrs or the patch is kept for more than
one week
• Detachment < 2%
• Lint ring
Sites of patch
• Buttocks
• Lower abdomen
• Outer upper arm
• Upper torso excluding breasts
• If patch falls off new patch should be applied within
48 hrs
• If >48 hrs‐additional protection like condom is
required till next menses
• Patch is not affected by heat,humidity and exercise.
• Generally users have better compliance with patch
than with pill (88% vs. 78%).
• About 2% of patches completely detach with activity.
• 2‐3% discontinue treatment due to application site
reaction.
NORPLANT
‐levonorgestrel in six silasic rods implanted
subdermally
• Made of 6 silastic capsules each 34*2.4mm
• Contains 36 mg of LNG
• Release 30 ugm daily
• Implanted subdermally
• Action for 5 years
• Compliance: high!!
• Problems: irregular bleeding, surgical removal
Jadelle
• Similar to norplant (norplant2)
• 2 rod system
• For 3 yrs
• Shortens implant removal time
IMPLANON
• Made of 1 rod of ethynele vinyl acetate‐4cm*2mm
• Contains 68mg of etonogestrel(3‐keto‐desogestrel)
• Releases 60 ugm daily initially & later 30ugm.
• Action for 3 years
• Placed in arm 6‐8 cms from elbow in biseps groove
with in 5 days of menses.
• It is not radio‐opague
• Most frequent side effect prolonged and frequent
bleeding
Copper‐T
• It is the type of intrauterine contrceptive device.
• It is effective ,reverssible and long term method
of contraception
• In these copper wire of surface area 200 to 380
mm is wrapped round the vertical stem of
polypropylene frame.
• IT is inserted near the end of normal
menstruation with help of spetial inserter by
WITHDRAWAL METHOD
Types of copper T
• Copper T 200
• Copper 7
• Multiload Copper T 250
• Copper T 380 A –Paraguard –stem is wound with 314 mm
of fine copper wire arms have 33 mm of copper bracelets
about 50 ug of copper eluted daily in the
uterus
life span of 10 years
1 year failure rate is 0.6 in perfect usera and 0.8 in typical
users
• Copper T 220
• Nova T‐Silver added to copper wire
Mechanism of action
• Interfers with succesful implantation of fertilised ovum.
• Prevention of fertilisation
• Spermicidal due to intense local inflamatory response leading
lysosomal actvation
Adverse effect
• Uterine perforation ‐1 in per 1000 apperant
• or clinically silent during insertion
• Cramping and bleeding minimised by NSAIDS
• Menorrhagia‐blood loss is doubled 10 to 15 % of women have
to be removed the devise.
• Infection‐e.g septic abortion ,Tubo ovarian abcess
major risk of infection is during insertion and up to next 20
days.
• Pregnancy with retained IUD‐ abortion rate is 54% with device
in situ compared with 25% if removed promtly.
• Ectopic Pregnancy‐provides less protection against extrauterine
pregnanacy
Contraindications
• GENERAL‐
Pregnancy or suspiction of pregnanacy
Distorted uterine cavity
Acute pelvic inflammatory disease
Postpartum endometritis or septic abortion
Uterine or cervical neoplasia
Genital bleeding
Acute cervisitis or vaginitis
Women having multiple Sexual partner
h/o ectopic pregnanacy
Genital actinomycosis
• PARAGUARD 380A
Because of Copper content
Wilsons Disease
Copper Allergy
LNG‐IUS(MIRENA) SYSTEM
• It is a plain Nova‐T device with
silastic reservoir impregnated The levonorgestrel intrauterine system
with levonorgestrel attached to Hormone cylinder
Rate-controlling
vertical arm and covered with a membrane
rate limiting silastic membrane. Levonorgestrel
intrauterine
• Contains 52 mg of LNG system
• Releases 20 ug/day. Detail
• Approved lifetime is 5 years.

Uterine Section of
wall system
MECHANISM OF ACTION
• Main effects are local –low daily dose gives high conc in
the endometrium only.
• Blood levels are a quarter of peak level of POP and so
ovarian function is less altered.
• In endometrium‐suppresion and anti proliferatIve action
• Cervical mucos becomes thick,scanty and impermeable.
• It activates GLYCODELIN A in the endometrium which
inactivates the sperms
Most women continue to ovulate and in most adq estrogen
is produced.
ABSOLUTE CONTRAINDICATIONS(WHO 4)
• Immediate post‐septic abortion

• Unexplained vg bleeding
• Cervical/endometrial cancer
• Uterine fibroids with distortion of cavity
• Current PID/STD
• Pelvic tuberculosis
• Current breast cancer
RISKS OUTWEIGHT ADVANTAGES
(WHO 3)
• Postpartum 48 hrs to <4 wks
• AIDS
• Present/past h/o ischaemic heart disease
• Viral hepatitis /cirrhosis
• Liver tumours
INSERTION OF MIRENA
It should be inserted within 7 days of a normal cycle as it is not an
effective anovulant or post coital contraceptive.
Correct placement in the fundus is very important to deliver the
steroid over the whole endometrium and suppress it.
The device is enclosed within the insertion tube and the side arms are
released when tip of tube has crossed the internal os.
If the side arms are released too high in the cavity they are unable to
open and can result in break through bleeding.
Removal of Mirena
• During menses
• “7 Day Rule”‐advice in advance to abstain or use a barrier for 7 days
before any IUD is removed
HEALTH BENEFITS
• REDUCTION OF BLEEDING‐
Decreases blood loss by 97% at one year. it is a cost
effective alternative to hysterectomy in DUB.
• Decreases incidence of endometriosis.
• No effect on lipid metabolism, carbohydrate
metabolism, coagulation factors or lipid profile.
• Return of normal menstruation and fertility within a
mth after removal of IUS.
Minor side effects include
• Acne
• Nausea, headache
• Depression
• Breast tenderness
• Weight gain-2.5 kgs in 5 years
• 12% of the people dev functional ovarian cysts of which most
resolve spontaneously.
Main reasons for premature removal were
• Bleeding problems 5.4 % -freq light bleeding lasting for upto 4
weeks but rarely longer.
• Amenorrhea 1%
• Pain 2.5%
• Acne 1%
Frameless IUD
• IUD that doesn't have the rigid, or semiflexible, plastic frame
• GyneFix (and the GyneFix mini) consists of six (four for the mini)
small copper sleeves threaded on a suture strings.
• A small anchoring knot at the fundal end is inserted measurig 9‐
10 mm into the myometrium by a special stylet passed through
an inserter
• Better tolerated, less likelihood of expulsion
• decreased incidence of menorrhagia and dysmenorrhea
FibroPlant
• consists of a small rod ( 3cms) that
contains hormone
• levonorgestrel released at
14mcg/day, for three years.
Advantages :
• Reduced incidence of cramping
and pain.
• Decreased blood loss
• Fewer disturbances in the bleeding
pattern
• Useful for women unable to tolerate
other types of IUD, menorrhagia or
fibroid.
Essure Contraception
• available in Australia since February 2001.
• performed under local anaesthetic.
• takes less than 10 minutes.
• titanium nickel and stainless steel micro coil, is
passed through the telescope and placed in the first
part of each fallopian tube. The device springs open
to stay in place and the telescope is removed.
• next 3 months the device causes tissue to grow and
block the first part of the fallopian tube
• no effect ovulation or hormones.
• 3% of women complained of menstrual changes
Advantages of Essure
• Performed under local anaesthetic
• Rapid recovery
• No incision or stitches required
Disadvantages of Essure
• Failure rate 2 in 1000 women
• 3 month wait before it can be relied on
• Not reversible and IVF may be less successful
• It may restrict the use of some intrauterine operations
• Inability to place one or both devices in 2% of women
Complications
• bleeding (risk 3%)
• infection and uterine or tubal perforation (risk 1%)
flexible inserts into each fallopian tubes
inserts to form a natural barrier within fallopian

tubes that prevents sperm from reaching eggs
Hysterosalpigography performed after

3 months
CONDOM
• TYPES: dry type: nirodh, duracap, kohinoor
• Pre‐lubricated:
• Spermicidal condoms
• Failure rate : 2to 12 pregnancies %
• Advantages : effective when used correctly and
consistently. Widely available, inexpensive. simple to
use with no local or systemic side effects
• Disadvantages : unattractive appearance, loss of
pleasurable sensation, erectile difficulty may be
increased, motivation needed.
Non contraceptive benefit
• Protection from STDS
• Protection from HIV infection
• Male partner contributing for contraception
‘Femshield’
• flexible female condom.
• loose‐fitting sheath and two
rings.(polyurethane)
• protect from sexually transmitted infection and
pregnancy.
Cervical cap
• It blocks sperm from entering the uterus and
prevents fertilization. After intercourse, it should
be left in place for 8 hours. Put spermicidal jellies
or creams that kill sperm into the cap before
inserting it into your body.
Insertion
Use one hand to separate vulva. The other hand can
squeeze the rim of cervical cap and insert the cap
far inside vagina. Use a finger to push it over
cervix.
Advantages
• Can be inserted many hours before sex play.
• Easy to carry around, comfortable.
• Does not alter the menstrual cycle.
• Does not affect future fertility.
• May help you better know your body.
Disadvantages
• Does not protect against HIV/AIDS.
• Requires a fitting in a clinic.
• Not able to fit with all women.
• Can be difficult to insert or remove.
• Can be dislodged during intercourse.
• Poses a danger of possible allergic reactions.
MYOMA SCREW
A myoma is a benign (non‐cancerous) tumour in the

muscle of the uterus. This myoma screw is used in
surgery to remove such fibroids. It can be done
abdominally or via the vagina. The fibroid is ‘screwed’
and clamped before removal. The myoma screw is
almost crude in its simplicity. It has a straight shaft with
an oval handle and a corkscrew head. It was made by
Liverpool‐based instrument makers Alexander and
Fowler towards the end of the 1800s.
• LAPAROSCOPIC AND HYSTEROSCOPIC MYOMA SCREWS
INTENDED USE
• Used to stabilize and manipulate non‐degenerating myomas or
fibroids, or other tissues during
• laparoscopic and hysteroscopic procedures.
CONTRAINDICATIONS
• Use of these devices is contraindicated in the presence of infection,
pregnancy or a degenerating myoma or fibroid.
WARNINGS
• None known
PRECAUTIONS
• The Laparoscopic Myoma Screw and the Hysteroscopic Myoma Screw are
intended for use by physicians trained and experienced in laparoscopic
and hysteroscopic procedures.
• The potential effects of phthalates on pregnant/nursing women or
children have not been fully characterized and there may be concern for
reproductive and developmental effects.
INSTRUCTIONS FOR USE
Laparoscopic Myoma Screw
• 1. Insert the laparoscopic myoma screw into the abdomen through a 5 mm or
larger access port.
• 2. Place distal tip in contact with tissue to be anchored.
• 3. Anchor device by turning the handle clockwise and applying slight pressure.
• 4. Manipulate and/or dissect attached tissue.
• 5. Remove device from patient and dispose of properly.
Hysteroscopic Myoma Screw
• CAUTION: Deflection of hysteroscope can damage this device.
• 1. Insert device into a 2 mm or larger scope channel.
• 2. Place distal tip in contact with tissue to be anchored.
• 3. Anchor device by turning the handle clockwise and applying slight pressure.
• 4. Manipulate and/or dissect attached tissue.
• 5. Remove device from scope and dispose of properly.
HOW SUPPLIED
• Supplied sterilized by ethylene oxide gas in peel‐open packages. Intended for one‐
time use. Sterile if package is unopened or undamaged. Do not use the product if
there is doubt as to whether the product is sterile. Store in a dark, dry, cool place.
Avoid extended exposure to light. Upon removal from the package, inspect the
product to ensure no damage has occurred.
Mixter forceps, also
known as the right angle
Mixter Forceps clamp, is a surgical
instrument used primarily
by general, vascular, and
cardiothoracic surgeons,
as well as in certain
gynecological procedures.
They come in a variety of
lengths and sharpness of
angle. The shape of the
clamp is ideal for
occluding blood vessels,
assisting in dissection and
passing sutures around
structures.
Uses of mixter forceps
1.Occluding Blood Vessels
Most surgical clamps are curved to around 45 degrees. This makes accessing
blood vessels and structures more ergonomic; however, certain structures are
either too deep, or in too awkward a position to properly occlude with these
clamps. The 90‐degree‐curved mixter forceps allows these structures to be
occluded more effectively.
2. Dissecting
The mixter forceps aids in dissection in a few
ways. Because of its angle, it can reach around
potential vessels and other important
structures when other clamps and forceps
cannot. An example of this is the cystic duct
and artery during a gallbladder operation. A
right angle clamp is most often used to expose
those structures because they are hidden and
require being exposed on all sides.
3. Passing sutures: Sutures must sometimes be

passed underneath
© Dept.OBGYN,GMCH Aurangabad.a structure to be tied around it
Laparoscopic Grasping Forceps
Laparoscopic Grasping Forceps
• Lightweight 1‐piece design eliminates timely

disassembly/reassembly and potential for mis‐matched or lost
components . Insulated sheath for added safety for the medical
professional . Ergonomic ratchet handle with 360º finger rotation
knob which allows for single‐handed operation and smooth,
consistent rotation which helps to reduce hand fatigue . Rotation
lock/brake feature engages when the handle is in fully closed
position to maintain firm control of grasped tissue . 5 mm OD and
35 cm shaft for extra length and greater instrument versatility for
larger patients . Luer lock flush port for optimized cleaning of the
inner lumen. Extra screw‐on and lanyard caps provided as standard
. REF 35‐110 available with standard non‐ratchet handle,
monopolar HF port and fully insulated sheath and handle* . Ideal
for precise manipulation and firm grasp of varying types of tissue .
10 popular patterns available, all having dual action jaws for
increased tissue access
Laparoscopic Dissecting Forceps
Laparoscopic Dissecting Forceps
• Lightweight 1‐piece design eliminates timely

components . Ergonomic standard free‐moving handle with 360º
finger rotation knob which allows for single‐handed operation and
smooth, consistent rotation which helps reduce hand fatigue .
Rotation lock/brake feature engages when the handle is in fully
closed position to maintain firm control of grasped tissue . 5 mm
OD and 35 cm shaft for extra length and greater instrument
versatility for larger patients . Luer lock flush port for optimized
cleaning of the inner lumen. Extra screw‐on and lanyard caps
provided as standard . Monopolar HF hook‐up port for optional
electrosurgical use combined with insulated sheath and handle for
added safety for the medical professional .
• Ideal for precise dissection and separation of varying types of
tissue . 6 popular patterns available, all having dual action jaws for
increased tissue access
Laparoscopic Needle Holders ‐
Tungsten Carbide
Laparoscopic Needle Holders ‐
Tungsten Carbide
• Lightweight ergonomic 1‐piece design eliminates timely
components .
• Tungsten Carbide jaws provide firm grip on needles minimizing
slippage and are less susceptible to wear .
• In‐line ring handle design places surgeon’s hand in line with the
needle to help facilitate natural suturing motion . German stainless
steel with gold‐plated finger rings for easy identification .
• Luer lock flush port for optimized cleaning of the inner lumen. Extra
screw‐on and lanyard caps provided as standard . 5 mm OD and 35
cm shaft for extra length and greater instrument versatility for
larger patients .
• 3 popular patterns available (left, right, straight)
Laparoscopes (Autoclavable)
Laparoscopes (Autoclavable)
• Rod‐lens system and technology which provides brilliant

high‐definition image and outstanding optical quality . 5
mm & 10 mm OD patterns available with various direction
of view angle options . Stainless steel with all possible
leakage paths laser welded and/or solder‐sealed . Distal
and proximal ends made from scratch resistant sapphire
glass . Triple tube (lumen) design provides added resistance
to bending and lens cracking . Each laparoscope comes
equipped with special lens polishing paste and three
standard light‐source adapters: ACMI/British Standard,
Richard Wolf & Storz/Olympus . High quality German‐
crafted instruments are fully Autoclavable at 132º C .
• 4 popular patterns for a range of procedures

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© Dept.OBGYN,GMCH Aurangabad.

BLUNT END OF CURETTE

Toothed forceps for holding rectus sheath

• Fully dilated cervix

Sampling the cervix. Note pointed Sampling the cervix using an

Absorbable Non absorbable Absorbable Non absorbable

Absorption 7 days 4‐6 weeks

Ach secretion by Prevent

Pritchard 4 gm IV over 3- 5gm IM 4 hrly

Duration Of Action – IV < IM

• The maintenance dose of Magnesium Sulphate is

given only after assuring that:

• Patellar reflex is present

• Respiration not depressed. ( RR > 16/min)

• Urine output during previous 4 h- exceeded 100 mL.

Contracted pelvis Obstructed labour Cardiac disease

Malpresentation Fetal distress

10 drops/min = 2.5 mu/min 10 drops/min = 3.4 mu/min

20 drops/min = 5 mu/min 20 drops/min = 6.6 mu/min

30 drops/min = 7.5 mu/min 30 drops/min = 9.9 mu/min

40 drops/min = 10 mu/min 40 drops/min = 13.2 mu/min

50 drops/min = 12.5 mu/min

› For PPH : Prophylaxis 600 mcg / rectal

Dexa also used in HELLP syndrome

Estradiol Estrone Estriol

19 norsteroids Hemostatic progestins (DUB)

Dydrogesterone LPD, PMS, DUB, endometrial protection,

Esters of progesterone Long term contraception, endometrial

Micronised progesterone LPD, PMS, DUB, endometrial protection,

19 norsteroids Menopausal support

1)Human papilloma virus infection in 70-90 % of cases-

(i) Thorough surgico-pathological staging during

This is wet and mounted specimen of uterus

• Something coming out of introitus

• Pregnancy, vaginal child birth,

Fothergill’s operation Sling operation

A. Upper tier : Indirect support

B. Middle tier : Direct and strongest support.

C. Inferior tier — Indirect support

IA growth limited to one ovary

IB Growth limited to both ovaries

IC Tumor limited to one or both ovaries, but with disease on

IIA Extension &/or metastasis to uterus & /or tubes

IIB Extension to other pelvic tissues

Stage surgical – pathological findings

IIIB Abdominal implants < 2 cm with negative nods

IIIC Abdominal implants at least 2 cm & or positive pelvic paraaortic,

IV Distant metastases including malignant pleural effusion or

NON CONTRACEPTIVE BENIFITS

• Ethynyl estradiol dose has been reduced to

• Once daily for 365 days.

FAILURE RATE: 0.3(PERFECT USE) 8(TYPICAL USE)

• Monthly injection (Estradiol cypionate +

First marketed in US by the name NUVA RING

FAILURE RATE: 8(PERFECT USE) 0.3(TYPICAL USE)

• Contraceptive patch is a new transdermal product

• Approved lifetime is 5 years.

• Immediate post‐septic abortion

inserts to form a natural barrier within fallopian

Hysterosalpigography performed after

A myoma is a benign (non‐cancerous) tumour in the

3. Passing sutures: Sutures must sometimes be

• Lightweight 1‐piece design eliminates timely