SOMOSOT PHARMA Paracetamol

Republic of the Philippines
Cebu Normal University

Osmeña Blvd., Cebu City, 6000, Philippines
College of Nursing
Telephone No.: (+63 32) 254 4837
Email: cn@cnu.edu.ph
Website: www.cnu.edu.ph
DRUG STUDY
Patient’s Initials: HK Date of Admission: NI Diagnosis: Complaint of fever and “moderate to sever dull, aching pain” in his left knee for the past month
Age: 60 years old Height: NI Weight.: NI Clinical Intervention: Relieve pain
Sex: M Ward: NI Bed No.:NI Name of Physician: NI
Drug Information Classification Mechanism of Action Indication Contraindications Side Effects Nursing Responsibilities
Generic Name: Pharmacologic Pharmacodynamics or General Paracetamol is • Rash or swelling Before Drug Administration:
Paracetamol Classification: Mechanism of Action: Indication/s: contraindicated for use • Flushing, low blood • Assess vital signs for baseline data
Analgesic and A para-aminophenol Commonly used to in patients with known pressure and a fast • Assess the patient for history conditions that may
Trade Name: antipyretic drugs derivative known as treat mild to hypersensitivity or heartbeat – this can contraindicate the drug to the patient
Perfalgan paracetamol has some moderate pain, idiosyncratic reaction to sometimes happen when • Assess the patient’s knowledge of drug therapy
Therapeutic analgesic, antipyretic, such as paracetamol (or any of paracetamol is given in • Check the doctor’s order before drug administration
Minimum Dose: Classification: and modest headaches, the other ingredients in hospital into a vein in your and ensure that everything is right (dose, frequency,
500 mg Pain reliever and anti-inflammatory toothaches, and the product). arm patient, etc.)
fever reducer properties. Its analgesic sprains, as well as Paracetamol should be • Blood disorders, such • Educate the patient to swallow medication with
Maximum Dose: effect may be caused by to lower fevers used with caution in as thrombocytopenia (low water.
4,000 mg inhibiting prostaglandin brought on by patients with impaired number of platelet cells) • Inform the patient that he can take the medication
synthesis in the central colds and the flu. hepatic function and and leukopenia (low with or without food.
Patient’s Dose: nervous system (CNS) Since it's generally impaired renal function. number of white blood
500 mg 1tab and, to a lesser extent, by safe to consume cells) During Drug Administration:
peripheral blocking of and has few side • Liver and kidney • Do not administer the drug together with other drugs
Route: pain-impulse generation, effects, damage, if you take too as it may cause drug- drug interactions especially
PO although the exact paracetamol is much (overdose) – this other drugs with paracetamol because it may lead to
mechanism is yet frequently can be fatal in severe overdose.
Frequency: unknown. By preventing suggested as one cases
q 4 hrs the hypothalamus of the initial After Drug Administration:
heat-regulating center therapies for pain.
College of Nursing
Telephone No.: (+63 32) 254 4837
Availability/Form: from functioning, it Patient’s • Instruct the patient not to change the dose or
• tablets or caplets. causes antipyresis. Indication: abruptly stop medication because it may lead to
• capsules Patient substance abuse.
• liquid – usually for Pharmacokinetics: experiences fever • Advise the patient not to drink any alcohol or large
children Absorption: Well and aching on the amounts of caffeine because this lessens the
• soluble tablets absorbed following oral left knee that is effectiveness of the drug.
(tablets that dissolve and rectal administration. described as • Monitor the patient’s reaction to the drug.
in water to make a Mainly absorbed in the moderate to • Encourage the patient to report if there are any
drink) small intestine with severely dull over adverse effects.
• suppositories minimal absorption from the past month. • Advise the patient to avoid engaging in activities that
(capsules inserted the stomach. Decreased require physical exhaustion and let them rest as much
into the back rate of absorption with as they can.
passage) food. Time to peak
• an injection given plasma concentration:
into a vein – Approx 30 minutes to 2
normally only used in hours (oral); approx 2-3
hospital hours (rectal); approx 15
minutes (IV).
Contents:
Maize starch, Distribution: Widely
potassium sorbate, distributed into most body
purified talc, stearic tissues except fat.
acid, povidone, and Crosses the placenta;
soluble starch. enters breast milk (small
amounts). Volume of
distribution: Approx 1
L/kg. Plasma protein
binding: 10-25%.
College of Nursing
Telephone No.: (+63 32) 254 4837
Metabolism: Metabolism
mainly in the liver into
sulfate and glucuronide
conjugates, while a small
amount is metabolised by
CYP2E1 to a minor
hydroxylated metabolite,
N-acetyl-p-benzoquinone
imine (NAPQI), which is
conjugated rapidly by
glutathione and
inactivated to non-toxic
cysteine and mercapturic
acid conjugates.
Undergoes first-pass
metabolism (oral).
Excretion: Mainly via

urine (60-80% as
glucuronide metabolites;
20-30% as sulfate
metabolites; approx 8%
as cysteine and
mercapturic acid
metabolites; <5% as
unchanged drug).
College of Nursing
Telephone No.: (+63 32) 254 4837
Elimination half-life:
Approx 1-4 hours.
References (at least 2):

1. Paracetamol: Indication, Dosage, Side Effect, Precaution. (n.d.). MIMS. Retrieved April 16, 2023, from https://www.mims.com/philippines/drug/info/paracetamol?mtype=generic
2. (n.d.). Paracetamol 500mg Tablets - Patient Information Leaflet (PIL) - (emc). Retrieved April 16, 2023, from https://www.medicines.org.uk/emc/product/5164/pil#gref
3. Preoperative paracetamol improves post-cesarean delivery pain management: a prospective, randomized, double-blind, placebo-controlled trial. (n.d.). PubMed. Retrieved April 16, 2023, from
https://pubmed.ncbi.nlm.nih.gov/27555133/
4. Paracetamol - Tests & treatments. (2022, November 4). NHS inform. Retrieved April 16, 2023, from
https://www.nhsinform.scot/tests-and-treatments/medicines-and-medical-aids/types-of-medicine/paracetamol
College of Nursing
Telephone No.: (+63 32) 254 4837
PRODUCT ASSESSMENT RUBRICS FOR DRUG STUDY
Student Name: ___________________________________ Year/Section: ____________________ Date: __________________ Score: ___/30

Directions: Please select the appropriate rating using the following descriptions.
Element Very Satisfactory Satisfactory Needs Improvement Comments
Drug ☐ Accurately presented all of the patient and drug information ☐ Accurately presented most of the patient and drug ☐ Accurately presented some of the patient and drug information
Information (name [brand & generic], dosage [patient’s dose; min. & max], information related to the case. 1 missing information or error related to the case. 2 or more missing information or errors noted.
(10%) frequency, route, availability, contents) related to the case. [3] noted. [2] [1]
Classification ☐ Accurately presented the classification (therapeutic and ☐ Accurately presented the classification related to the drug ☐ Inaccurately presented the classification related to the drug.
(10%) pharmacologic) related to the drug. [3] but with 1 irrelevant information or error noted. [2] Classification is not relevant to the drug. [1]
☐ Accurately presented the indication/s (general & ☐ Accurately presented the indication/s related to the drug ☐ Inaccurately presented the indication/s related to the drug.
Indication (10%)
patient-specific) related to the drug. [3] but with 1 irrelevant information or error noted. [2] Indication is not relevant to the drug. [1]
Mechanism of ☐ Accurately presented the mechanism of action ☐ Accurately presented the mechanism of action of the drug ☐ Inaccurately presented the mechanism of action of the drug.
Action (10%) (pharmacokinetics, pharmacodynamics) of the drug. [3] but with 1 irrelevant information or error noted. [2] Mechanism of action is not relevant to the drug. [1]
☐ Accurately presented all of the common contraindications ☐ Accurately presented most of the common ☐ Accurately presented some of the common contraindications
Contraindicatio related to the drug. [3] contraindications related to the drug. 1 missing information related to the drug. 2 or more missing information or errors noted.
n (10%) or error noted. [2] [1]
☐ Accurately presented all of the common side effects related to ☐ Accurately presented most of the common side effects ☐ Accurately presented some of the common side effects related
Side Effects
the drug. [3] related to the drug. 1-2 missing information or errors noted. to the drug. 3 or more missing information or errors noted. [1]
(10%)
[2]
Nursing ☐ Accurately presented all of the common nursing ☐ Accurately presented most of the common nursing ☐ Accurately presented some of the common nursing
Responsibilities responsibilities (before, during, and after) related to the drug. [9] responsibilities related to the drug. 1-2 missing information responsibilities related to the drug. 3 or more missing information
(30%) or errors noted. [7] or errors noted. [3]
☐ Presented at least 2 sources that are updated (within 5 years), ☐ Presented only one source that is updated (within 5 years), ☐ No source was presented. Sources are not updated (more than 5
References
relevant, and credible. [3] relevant, and credible. Other sources are not updated, credible years), relevant, and credible. [1]
(10%) or relevant. [2]
Sub-score = ____ = ____ = ____
Evaluated by:
College of Nursing
Telephone No.: (+63 32) 254 4837
_______________________________________
Signature over Printed Name of Clinical Instructor

SOMOSOT PHARMA Paracetamol

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Republic of the Philippines

Cebu Normal University

Excretion: Mainly via

References (at least 2):

PRODUCT ASSESSMENT RUBRICS FOR DRUG STUDY

Student Name: ___________________ Year/Section: Date: Score: _/30

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