Republic of the Philippines

Cebu Normal University

Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: cn@cnu.edu.ph
Website: www.cnu.edu.ph

DRUG STUDY

Patient’s Initials: Date of Admission: October 20, 2023 Diagnosis: G P (2002) PU delivered a live, full term, female neonate, cephalic presentation via NSVD, BW 2450 grams, AS 8,9
2 2

Age: Height: 152 cm Weight: 63 kg Clinical Intervention: Postpartum Care

Sex: Ward: OB Ward Bed No.: 6 Name of Physician: Dr. Angelene Meriel V. Escatron

Drug Information Classification Mechanism of Action Indication Contraindications Side Effects Nursing Responsibilities

Generic Name: Pharmacologic Pharmacodynamics or Co-amoxiclav is Hypersensitivity to the Amoxicillin Side Effects (Major Before Drug Administration:
Co-Amoxiclav Classification: Mechanism of Action: indicated for the (Duoclav)/clavulanate potassium to any of the & Minor): • Check doctor’s orders before drug
Beta lactam and Amoxicillin treatment of the penicillins or to any of the excipients of CNS: anxiety, administration and ensure that
Trade Name: Beta Lactamase competitively inhibit following Duoclav. confusion, agitation, everything is right (dose, frequency,
Duoclav inhibitor penicillin binding infections due to dizziness, reversible patient, etc.)
(Penicillin) proteins, leading to susceptible History of a severe immediate hypersensitivity hyperactivity, • Perform hand hygiene before coming in
Minimum Dose: up regulation of strains of reaction (eg, anaphylaxis) to another β-lactam anxiety, insomnia, , contact with the patient.
125 mg autolytic enzymes and sensitive agent (eg, a cephalosporin, carbapenem or weakness, • Make sure to wear the appropriate PPE
Therapeutic inhibition of cell wall organisms: monobactam). numbness, unusual before approaching the patient.
Maximum Dose: Classification: synthesis. Amoxicillin • Lower thoughts or • Verify patient identity.
625 mg Antibiotic has a long duration of respiratory History of cholestatic jaundice/hepatic behavior, seizure • Assess patient’s health to check for
action as it is usually tract infections - dysfunction due to Duoclav. (convulsions) conditions that may contraindicate her
Patient’s Dose: given twice daily. bronchitis, with the drug of choice. (Especially renal
1 tab 625 mg Pregnancy Amoxicillin pneumonia, Drug to Drug Interaction GI: diarrhea that is impairment)
Category: B has a wide bronchiolitis • Oral anticoagulants watery or has blood • Obtain specimen for culture and
Route: therapeutic range as • Otitis media Oral anticoagulants and penicillin antibiotics in it, nausea, sensitivity tests before giving first dose.
Oral mild overdoses are not (middle ear have been widely used in practice without vomiting, upper Begin therapy while awaiting results.
associated with infection) reports of interaction.However, in the stomach pain, clay- • Ask patient about allergic reactions to
Frequency: significant toxicity. • Sinusitis literature there are cases of increased colored stools, loss penicillin. A negative history of penicillin
BID Patients should be • Skin and skin international normalised ratio in patients of appetite allergy is no guarantee against allergic
counseled regarding structure maintained on acenocoumarol or warfarin and reaction.
Availability/Form: the risk of anaphylaxis, infections - prescribed a course of amoxicillin. If co- GU: interstitial • Discuss the importance of the drug
 Republic of the Philippines
Cebu Normal University
Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: cn@cnu.edu.ph
Website: www.cnu.edu.ph

Drug Information Classification Mechanism of Action Indication Contraindications Side Effects Nursing Responsibilities
Oral suspension Clostridium difficile cellulitis administration is necessary, the prothrombin nephritis, given prior to administration.
(125mg/ infections, and (infection of the time or international normalised ratio should nephropath, dark • Advise patient to take prescribed
31.25mg)/5mL bacterial resistance. dermis and be carefully monitored with the addition or colored urine medicine on time.
(200mg/28.5mg)/ subcutaneous withdrawal of amoxicillin. Moreover, • Inform patient on possible side effects.
5mL Pharmacokinetics tissue), adjustments in the dose of oral anticoagulants Hematologic: • Obtain the patient’s vital signs and
(250mg/62.5mg)/ Absorption: erysipelas may be necessary. agranulocytosis, baseline data.
5mL Amoxicillin is (infection of leukopenia,
(400mg/57mg)/ approximately 60% dermis • Methotrexate thrombocytopenia, During Drug Administration:
5mL bioavailable. Well hypodermi), Penicillins may reduce the excretion of thrombocytopenic • Administer drug within the prescribed
(600mg/42.9mg)/ absorbed from folliculitis methotrexate causing a potential increase in purpura, anemia, time periods following reconstitution.
5mL duodenum (75-90%) (inflammation of toxicity. eosinophilia, • Administer right drug and right dose.
More resistant to acid the hair follicles), hemolytic anemia. • Never administer a drug later than the
Tablet inactivation than other furuncles (boils), • Probenecid expiration date.
250mg/125mg penicillin. Carbuncle, Concomitant use of probenecid is not IS: pale or yellowed • Administer drug orally to patient
500mg/125mg abscesses, recommended. skin,easy bruising or preferably after meals.
875mg/125mg Distribution: impetigo (large Probenecid decreases the renal tubular bleeding, skin rash,
Diffuses readily into vesicles or secretion of amoxicillin. Concomitant use of bruising, severe After Drug Administration:
Tablet, extended the most body tissues honey-crusted probenecid may result in increased and tingling, numbnes, • Make sure to continue monitoring the
release and fluids. CFS sores), infected prolonged blood levels of amoxicillin but not of severe skin reaction patient’s vital signs
1000mg/62.5mg penetration increased ulcers, infected clavulanic acid -- fever, sore throat, • Record administration in the patient’s
when meninges burns, and other. swelling in your face record.
Tablet, chewable inflamed. Crosses • Mycophenolate mofeti or tongue, burning • Monitor patient reactions to the drug.
200mg/28.5mg Placenta; enters • Urinary tract In patients receiving mycophenolale mofetil, in your eyes, skin • Encourage patient to report distressing
400mg/57mg breast milk in small infections (UTI) - reduction in pre-dose concentration of the pain, followed by a adverse reactions.
amounts. The central infections of the active metabolite mycopnenolic acid of red or purple skin • Instruct discontinuation of medication if
Contents: volume of distribution kidneys,ureters, approximately 50% has been reported rash that spreads adverse effect occurs.
250mg of of amoxicillin is bladder and following commencement of oral amoxicillin (especially in the • Make sure to perform hand hygiene
amoxicillin (as 27.7L.4 urethra plus clavulanic acid the change in pre-dose face or upper body) after contact with the patient and the
trihydrate) and level may not accurately represent changes in and causes patient’s surroundings.
125mg clavulanic Metabolism: Patient’s overall MPA exposure. blistering and
acid (as potassium Incubation with human Indication peeling. PATIENT TEACHING
clavulanate). liver microsomes has Prophylactic • Hormonal contraceptives • Instruct patient to take drug with food.
 Republic of the Philippines
Cebu Normal University
Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: cn@cnu.edu.ph
Website: www.cnu.edu.ph

Drug Information Classification Mechanism of Action Indication Contraindications Side Effects Nursing Responsibilities
(These ingredients led to the detection of measures to May decrease contraceptive effectiveness. Other: anaphylaxis, • Tell patient to take entire quantity of
together are 7 metabolites. The M1 prevent Advise use of additional form of contraception hypersensitivity drug exactly as prescribed, even after
known as Co- metabolite has postpartum during penicillin therapy. reactions, fever feeling better.
amoxiclav). undergone infections. • Space doses evenly.
hydroxylation, M2 has • Live-virus vaccines Adverse Effects: • Take with meals if GI upset occurs.
undergone oxidative May decrease effectiveness of live-virus GI: diarrhea, • Report rash, diarrhea, other new
deamination, M3 to M5 vaccines. Concurrent use isn't recommended. nausea, vomiting, symptoms.
have undergone abdominal pain,
oxidation of the • Warfarin Gastritis, stomatitis,
aliphatic chain, M6 has May enhance anticoagulant effect. Use glossitis, black hairy
undergone together cautiously. tongue, enterocolitis
decarboxylation,and and
M7 has undergone Drug-Herb Interaction pseudomembranous
glucuronidation. • Khat colitis.
May decrease antimicrobial effect.
Excretion: Discourage khat chewing, or tell patient to IS: skin rashes,
70% are excreted take drug 2 hours after khat chewing. urticaria and
unchanged in the urine erythema
Drug to Food Interaction multiforme, vaginitis,
Half-life: Avoid co-administration of antibiotics with milk abnormal taste,
1 to 1½ hours (7½ products which are rich sources of divalent
hours in severe renal ions, such as calcium and magnesium that CNS: headache,
impairment). complex with some antibiotics and prevent dizziness, tiredness
their absorption. Dairy products such as milk, and hot flushes.
yogurt and cheese decrease the absorption of
antibiotics.
References (at least 2):
 CO-AMOXICLAV 625MG TABLETS. (n.d.). Drugs.com. https://www.drugs.com/uk/co-amoxiclav-625mg-tablets-leaflet.html
 Clavulanic acid. (n.d.). Go.drugbank.com. https://go.drugbank.com/drugs/DB00766
 Duoclav Side effects, Contraindications. (n.d.). Ndrugs. Retrieved October 23, 2023, from https://www.ndrugs.com/?s=duoclav&t=side%20effects
 Drug Study - CoAmoxiclav | PDF | Rtt | Drugs. (n.d.). Scribd. https://www.scribd.com/document/434022735/Drug-Study-CoAmoxiclav
 Republic of the Philippines
Cebu Normal University
Osmeña Blvd., Cebu City, 6000, Philippines

College of Nursing
Telephone No.: (+63 32) 254 4837
Email: cn@cnu.edu.ph
Website: www.cnu.edu.ph

PRODUCT ASSESSMENT RUBRICS FOR DRUG STUDY

Student Name: Jay Ann Joy C. Peruda Year/Section: 2/B Date: March 14, 2024 Score: ___/30

Directions: Please select the appropriate rating using the following descriptions.
Element Very Satisfactory Satisfactory Needs Improvement Comments
Accurately presented all of the patient and drug Accurately presented most of the patient and drug Accurately presented some of the patient and drug
Drug
information (name [brand & generic], dosage information related to the case. 1 missing information or information related to the case. 2 or more missing
Information
[patient’s dose; min. & max], frequency, route, error noted. [2] information or errors noted. [1]
(10%) availability, contents) related to the case. [3]
Accurately presented the classification Accurately presented the classification related to the Inaccurately presented the classification related to
Classification
(therapeutic and pharmacologic) related to the drug. drug but with 1 irrelevant information or error noted. [2] the drug. Classification is not relevant to the drug. [1]
(10%) [3]
Accurately presented the indication/s (general & Accurately presented the indication/s related to the drug Inaccurately presented the indication/s related to the
Indication (10%) patient-specific) related to the drug. [3] but with 1 irrelevant information or error noted. [2] drug. Indication is not relevant to the drug. [1]
Accurately presented the mechanism of action Accurately presented the mechanism of action of the Inaccurately presented the mechanism of action of
Mechanism of
(pharmacokinetics, pharmacodynamics) of the drug. drug but with 1 irrelevant information or error noted. [2] the drug. Mechanism of action is not relevant to the
Action (10%) [3] drug. [1]
Accurately presented all of the common Accurately presented most of the common Accurately presented some of the common
Contraindication contraindications related to the drug. [3] contraindications related to the drug. 1 missing contraindications related to the drug. 2 or more
(10%) information or error noted. [2] missing information or errors noted. [1]
Accurately presented all of the common side Accurately presented most of the common side effects Accurately presented some of the common side
Side Effects
effects related to the drug. [3] related to the drug. 1-2 missing information or errors effects related to the drug. 3 or more missing
(10%) noted. [2] information or errors noted. [1]
Nursing Accurately presented all of the common nursing Accurately presented most of the common nursing Accurately presented some of the common nursing
Responsibilities responsibilities (before, during, and after) related to responsibilities related to the drug. 1-2 missing responsibilities related to the drug. 3 or more missing
(30%) the drug. [9] information or errors noted. [7] information or errors noted. [3]
Presented at least 2 sources that are updated Presented only one source that is updated (within 5 No source was presented. Sources are not updated
References (within 5 years), relevant, and credible. [3] years), relevant, and credible. Other sources are not (more than 5 years), relevant, and credible. [1]
(10%) updated, credible or relevant. [2]
Sub-score = ____ = ____ = ____

Evaluated by:

Signature over Printed Name of Clinical Instructor