DRUG STUDY

PENICILLIN G SODIUM
PENICILLIN V
PENICILLIN G SODIUM
NAME OF DRUG AND DOSAGE, ROUTE, MECHANISM OF INDICATION
CLASSIFICATION FREQUENCY ACTION
GENERIC NAME Moderate to severe Bactericidal against Neurosyphilis
PENICILLIN G systemic infections- microorganism by
SODIUM Adults: 1.2 to 24 million inhibiting cell wall
BRAND NAME units daily I.M. or I.V., synthesis during active
CRSTAPEN divided into doses given multiplication. Bacteria
CLASSIFICATION every 4 hours resist penicillin by
PENICILLIN Children: 25,000 to producing
300,000 units/kg daily penicillinases.
I.M. or I.V., divided into
doses given 4 hours.
Endocarditis
prophylaxis for dental
surgery-
Adults: 2 million units
I.V. or I.M. 30 to 60
minutes before
procedure, then 1
million units 6 hours
later.
CONTRAINDICATION ADVERSE EFFECT DRUG – DRUG NURSING
INTERACTION RESPONSIBILITIES
 Contraindicated in CNS: neuropathy, Aminogylcosides:  Before giving drug,
patients seizures, agitation, Physically and ask patient about
hypersensitive to anxiety, confusion, chemically allergic reactions to
drug or other depression, dizziness, incompatible. penicillin.
penicillins and in fatigue, hallucination, Colestipol: May  Obtain specimen
those on sodium- lethargy decrease penicillin G for culture
restricted diets CV: heart failure, sodium level. sensitivity test
 Use cautiously in thrombophlebitis Hormonal before giving first
patients with other GU:nephropathy contraceptives: May dose.
drug allergies, Hematologic: hemolytic decrease hormonal  Injection may be
especially anemia contraceptives painful, but ice
cephalosporins, Musculoskeletal: effectiveness. applied to the site
because of possible arthralgia Oral anticoagulants: may help alleviate
cross-sensitivity Other: hypersensitivity May increase risk of discomfort.
reactions bleeding.  Observe the patient
Probenecid: May closely.
increase penicillin level.  Tell the patient to
report adverse
reaction promptly.
PENICILLIN V
NAME OF DRUG DOSAGE, ROUTE, MECHANISM OF INDICATION
AND FREQUENCY ACTION
CLASSIFICATION
GENERIC NAME Tablets: 250 mg, 500 Bactericidal against  To prevent
PENICILLIN V mg microorganism by recurrent
BRAND NAME Oral suspensions: inhibiting cell wall rheumatic fever
Apo-pen VK, 125 mg/5 ml, 250 synthesis during  To prevent
Novopen VK, Pen mg/5 ml active multiplication. inhalation anthrax
Vee K Bacteria resist after possible
CLASSIFICATION penicillin by exposure
PENICILLIN producing
penicillinases.
CONTRAINDICATION ADVERSE EFFECT DRUG – DRUG NURSING
INTERACTION RESPONSIBILITIES
 Contraindicated in CNS: neuropathy Hormonal  Before giving drug,
patients GU:nephropathy contraceptives: May ask patient about
hypersensitive to Hematologic: hemolytic decrease hormonal allergic reactions to
drug or other anemia, contraceptives penicillin.
penicillins and in thrombocytopenia, effectiveness.  Obtain specimen
those on sodium- leucopenia Probenecid: May for culture
restricted diets Musculoskeletal: increase penicillin level. sensitivity test
 Use cautiously in arthralgia before giving first
patients with other Other: hypersensitivity dose.
drug allergies, reactions overgrowth of  Instruct patient to
especially nonsusceptible take entire quantity
cephalosporins, organisms of drug exactly as
because of possible prescribed, even
cross-sensitivity after he feels
better.
 Instruct the patient
to take drug with
food if stomach
upset occurs
THANK YOU