DRUG STUDY

MEDICATION MECAHNISM INDICATION SIDE EFFECTS CONTRAINDICATION/ ADVERSE EFFECTS NURSING CONSIDERATION/
OF ACTION DRUG TO DRUG Patient Teaching
INTERACTION
GENERIC NAME: Inhibits cell- Adults and CONTRAINDICATIONS ADVERSE REACTIONS NURSING CONSIDERATIONS
Amoxicillin wall synthesis Children Common side effects of & CAUTIONS CNS: seizures, anxiety, • If large doses are given or if therapy
BRAND NAME: Amoxil during weighing 40kg • Contraindicated in confusion, agitation, is pro- longed, bacterial, or fungal
DRUG CLASS bacterial or more: 500 amoxicillin include: patients dizziness, reversible superinfection may occur, especially
Therapeutic class: multiplication. mg PO every hypersensitive to hyperactivity, anxiety, in elderly, debilitated, or
Antibiotics 12 hours or  acute allergic drug or other insomnia, behavioral immunosuppressed patients.
Pharmacologic class: 250 mg every reaction penicillin. changes. • CDAD, ranging from mild diarrhea
Aminopenicillins 8 hours.  anemia • Use cautiously in Gl: diarrhea, nausea, to fatal colitis, has been reported with
*DOSAGE:  elevated liver patients with other pseudomembranous nearly all antibacterial agents,
500mg/250mg enzymes drug allergies colitis, vomiting. including amoxicillin. Evaluate patient
*FREQUENCY: Every  persistent super
(especially to GU: interstitial if diarrhea occurs.
12hrs 500mg or cephalosporins) nephritis, nephropathy. • Amoxicillin usually causes fewer
ficial infections
250mg PO every 8 because of possible Hematologic: cases of diarrhea than ampicillin.
hours. of the skin cross-sensitivity. agranulocytosis, • Look alike-sounds alike: Don't
*ROUTE: PO  diarrhea • Use cautiously in leukopenia, confuse amoxicillin with amoxapine.
 headache those with thrombocytopenia, PATIENT TEACHING
 nausea mononucleosis thrombocytopenic • Tell patient to take entire quantity
 vomiting because of high risk purpura, anemia, of drug exactly as prescribed, even
 rash of maculopapular eosinophilia, hemolytic after feeling better. Instruct patient to
 antibiotic-
rash, Dialyzable drug: anemia. take drug with or without food. • Tell
Yes. Other: anaphylaxis, patient to notify prescriber if rash,
associated
Overdose S&S: hypersensitivity fever, or chills develop. A rash is the
inflammation of Oliguric renal failure. reactions, overgrowth most common allergic reaction,
the colon PREGNANCY- of nonsusceptible especially if allopurinol is also being
 serum LACTATION- organisms. taken.
sickness-like REPRODUCTION: • Tell parent to place drops directly
reactions Use during on child's tongue for swallowing or
pregnancy only if add to formula, milk, fruit juice,
clearly needed. water, ginger ale, or other cold drink
• Drug appears in for immediate and complete
human milk. Use consumption.
cautiously in
breastfeeding
women.

INTERACTIONS
Drug-drug. Hormonal
contraceptives: May
decrease
contraceptive
effectiveness. Advise
use of additional
forms of
contraception during
penicillin therapy.
Live-virus vaccines:
May decrease
effectiveness of live-
virus vaccines.
Concurrent use isn't
recommended.
Methotrexate: May
increase
methotrexate serum
concentration.
Monitor patient
closely for toxicity.
Probenecid: May
 increase levels of
amoxicillin and other
penicillins.
Probenecid may be
used for this
purpose.
Tetracyclines: May
reduce therapeutic
action of penicillins.
Avoid administering
together.
Warfarin: May
enhance the
anticoagulant effect.
Use together
cautiously. Drug-
herb.
Khat: May decrease
antimicrobial effect.
Discourage khat
chewing or tell
patient to take drug 2
hours after khat
chewing.
 Choose 1 dosage, frequency, and route
 For the nursing responsibilities and patient teaching, choose only those related to the route chosen