CLOXACILLIN

By: Edamarie B. Cabasa

 CLOXACILLIN

Brand Name: Cloxapen

Classification: Antibiotic
 Dosage, Route, Frequency
ADULT
Upper Respiratory Tract Infection:
250 mg orally every 6 hours for 7 to 14 days.

Pneumonia:
500 mg orally every 6 hours for up to 21 days,

Skin and Structure Infection:

500 mg orally every 6 hours for 7 days, or until 3 days
after acute inflammation resolves
 Dosage, Route, Frequency
Cystitis:
250 mg orally every 6 hours for 3 to 7 days,
PEDIA:
Pneumonia, Upper Respiratory Tract In
fection, Skin and Structure Infection:
>= 1 year to 18 years: 50 to 100 mg/kg/day
orally divided every 6 hours.
 MECHANIS OF ACTION
Exerts bactericidal activity via
inhibition of bacterial cell wall synthe
sis
Exerts bacterial autolytic effect by
inhibition of certain PBPs
 INDICATION
Treatment of bacterial infections including:
endocarditis, pneumonia, bone and joint
infections, skin and soft-tissue infections,
and sepsis that are caused by susceptible
strains of penicillinase-producing staphylo
cocci.
 CONTRAINDICATION

Penicillin and cephallosporin

hypersensitivity
 SIDE EFFECTS
• Upset stomach,
• nausea,
• vomiting,
• gas and
• mouth sores
You may develop a black, "hairy" tongue while taking
this medication. This effect is harmless and usually
goes away after treatment.
 DRUG-DRUG INTERACTION
Contraceptives - decreased contraceptive
effectiveness
Live Typhoid Vaccine - decreased immunological
response to the typhoid vaccine

Probenecid - increased cloxacillin levels

Warfarin - decreased anticoagulant effectiveness
 NURSING RESPONSIBILITIES
1. Perform skin testing before giving the
medication
2. Administer drug, do not leave client unless
drug is taken
3. Explain to the client that antibiotic therapy
lasts for 7 days will take the drug without any
miss
NURSING RESPONSIBILITIES
4. Make sure that the client takes the drug
at the same time of the day.
5. Provide rest and comfort

6. Assess for any signs of hypersensitivity r

eaction such as purpura, rash, urticarial,
exfoliative dermatitis, itching.