DRUG STUDY
Name of Drug Classification
Generic Name: Pharmacologic Class:
Ibuprofen Nonsteroidal anti-inflammatory
drug (NSAID), propionic acid
Trade/Brand Name: derivative
Advil, Motrin
Therapeutic Class:
Analgesic, antipyretic, anti-
inflammatory
Pregnancy Risk:
Category C (first & second
trimesters), Category D (third
trimester)
Sources:
Jones & bartlett learning 2018
nurse’s drug handbook (7th ed.).
(2018). Jones & Bartlett
Learning.
Kizior, R.J. & Hodgson, K.J.
(2019). Saunders nursing drug
handbook 2019 (27th ed.).
Elsevier.
Skidmore-Roth, L. (2019).
Mosby’s 2019 nursing drug
reference (32nd ed.). Elsevier.
Vallerand, A.H. & Sanoski,
C.A. (2019). Davis’s drug guide
for nurses (16th ed.). F.A. Davis
Company.
Mechanism of Action Indication Contraindication Side Effects
This drug blocks activity of  For relief of pain 1. Hypersensitivity to drug, CNS
cyclooxygenase, the enzyme associated with aspirin, iodides, or other 1. Headache
needed to synthesize rheumatoid arthritis, NSAIDs 2. Dizziness
prostaglandins, which mediate osteoarthritis, and 3. Drowsiness
inflammatory response and juvenile arthritis 2. Perioperative use in 4. Nervousness
cause local pain, swelling, and coronary artery bypass graft 5. Aseptic meningitis
vasodilation. By inhibiting  For relief of mild to surgery
prostaglandins, this NSAID moderate pain CV
3. Pediatric heart surgery
reduces inflammatory 1. Hypertension
 For pain relief in (before and after)
symptoms and relieves pain. 2. Arrhythmias
primary dysmenorrhea
Ibuprofen’s antipyretic action 4. Pregnant women starting
probably stems from its effect  For fever reduction at 30 wk gestation EENT
on the hypothalamus, which (premature closure of the 1. Amblyopia
increases peripheral blood  For relief of moderate ductus arteriosus) 2. Blurred vision
flow, causing vasodilation and to severe pain as an 3. Tinnitus
encouraging heat dissipation. adjunct to opioid 5. Patients with recent MI or
analgesics severe heart failure GI
1. Nausea
Sources:  For treatment of Precautions 2. Vomiting
Jones & bartlett learning 2018 patent ductus arteriosus Use with extreme caution in 3. Constipation
nurse’s drug handbook (7th ed.). patients with: 4. Dyspepsia
(2018). Jones & Bartlett 5. Abdominal discomfort
Learning. Sources: 1. History of GI bleeding or 6. GI bleeding
Jones & bartlett learning ulcer disease
Kizior, R.J. & Hodgson, K.J. 2018 GU
(2019). Saunders nursing drug nurse’s drug handbook (7th 2. Hypertension 1. Cystitis
handbook 2019 (27th ed.). ed.).
2. Hematuria
Elsevier. (2018). Jones & Bartlett 3. Advanced age (elderly
3. Azotemia
Learning. patients)
4. Renal failure
Skidmore-Roth, L. (2019).
Mosby’s 2019 nursing drug Kizior, R.J. & Hodgson, K.J. 4. Long-term ibuprofen
reference (32nd ed.). Elsevier. therapy Hematologic
(2019). Saunders nursing
drug 1. Anemia
Vallerand, A.H. & Sanoski, handbook 2019 (27th ed.). 2. Prolonged bleeding time
C.A. (2019). Davis’s drug guide Elsevier. Sources: 3. Aplastic anemia
for nurses (16th ed.). F.A. Davis Jones & bartlett learning 2018 4. Neutropenia
Company. Skidmore-Roth, L. (2019). nurse’s drug handbook (7th 5. Pancytopenia
Mosby’s 2019 nursing drug ed.). 6. Thrombocytopenia
7. Leukopenia
reference (32nd ed.). Elsevier.
Vallerand, A.H. & Sanoski,
C.A. (2019). Davis’s drug
guide for nurses (16th ed.).
F.A. Davis Company.
(2018). Jones & Bartlett 8. Agranulocytosis
Learning.
Hepatic
Kizior, R.J. & Hodgson, K.J. 1. Hepatitis
(2019). Saunders nursing drug
handbook 2019 (27th ed.). ENDO
Elsevier. 1. Hyperglycemia
2. Hypoglycemia
Skidmore-Roth, L. (2019).
Mosby’s 2019 nursing drug
Respiratory
reference (32nd ed.). Elsevier.
1. Bronchospasm
Vallerand, A.H. & Sanoski,
C.A. (2019). Davis’s drug Skin
guide for nurses (16th ed.). 1. Rash
F.A. Davis Company. 2. Pruritus
3. Urticaria
4. Stevens-Johnson syndrome
Other
1. Edema
2. Allergic reactions including
anaphylaxis
Sources:
Jones & bartlett learning 2018
nurse’s drug handbook (7th ed.).
(2018). Jones & Bartlett
Learning.
Kizior, R.J. & Hodgson, K.J.
(2019). Saunders nursing drug
handbook 2019 (27th ed.).
Elsevier.
Skidmore-Roth, L. (2019).
Mosby’s 2019 nursing drug
reference (32nd ed.). Elsevier.
Vallerand, A.H. & Sanoski,
C.A. (2019). Davis’s drug guide
for nurses (16th ed.). F.A. Davis
Company.