REPUBLIC of the PHILIPPINES

City of Makati
COLLEGE OF ALLIED HEALTH STUDIES
J. P. Rizal Extension, West Rembo, Makati City 1215
Telephone No. : (+632) – 881 – 1571
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DRUG STUDY
Drug Name Mechanism of Action Indication Side Effects/Adverse Effect Contraindication Nursing Consideration
Generic Name: Cefoxitin inhibits bacterial cell wall Prophylaxis of surgical Hypersensitivity reactions (e.g. Hypersensitivity to cefoxitin - Assess the 12 Rights in Giving Medication
Cefoxitin synthesis by binding to 1 or more of infections maculopapular or and other cephalosporins.
Brand Name: the penicillin-binding proteins erythematous rash, exfoliative - Monitor renal function periodically when used in combination
Cefovex (PBPs) which in turn inhibit the final dermatitis, pruritus, urticaria, w/ other nephrotoxic drugs; prothrombin time. Observe for signs
Dosage transpeptidation step of eosinophilia, fever, and symptoms of anaphylaxis during 1st dose.
Intravenous peptidoglycan synthesis in bacterial angioedema); elevated serum - Special precautions to patients w/ history of penicillin allergy,
Prophylaxis of surgical cell walls, thus inhibiting cell wall creatinine and/or BUN GI disease (particularly colitis) and seizure disorder. Renal
infections biosynthesis and arresting cell wall concentrations, anaemia; impairment. Pregnancy and lactation. encephalopathy.
Adult:  2 g 30-60 min prior assembly resulting in bacterial cell transient increase in serum Pregnancy and lactation
to surgery, then 6 hrly for death. AST (SGOT), ALT (SGPT), - Evaluate therapeutic response.
not more than 24 hr. For LDH and alkaline phosphatase
caesarean section: 2 g as levels; jaundice;
a single dose as soon as thrombophlebitis. Rarely,
the umbilical cord is oliguria, renal toxicity,
clamped; a further 2 g Reference: neutropenia, transient
dose 4 hr and 8 hr after MIMS 151st Edition 2017 leucopenia, granulocytopenia,
the initial dose may be DRUG REFERENCE: thrombocytopenia, bone
given if necessary. https://www.mims.com/ marrow depression; GI effects
(e.g. nausea, vomiting,
diarrhoea).

Potentially Fatal: Anaphylaxis,
pseudomembranous colitis.