DRUG STUDY

Prescribed and Recommended Dosage, Frequency, and route of Administration

Availability: >Ophthalmic solution: Quizin-0.5% (5 mg/ml) >Premixed solution for injection: 250 mg/50 ml, 500 mg/100 ml, 750 mg/150 ml >Solution for injection (concentrated): 500 mg/20 ml >Tablets: 250 mg, 500 mg, 750 mg Indications and Dosages >Acute bacterial exacerbation of chronic bronchitis Adults: 500mg I.V. or P.O. q 24 hours for 7 days >Community-acquired pneumonia Adults: 500 mg I.V. or P.O. q 24 hours for 7 to 14 days, or 750 mg I.V. or P.O. q 24 hours for 5 days >Nosocomial pneumonia caused by

Generic Name Brand Name Classifications

Levofloxacin Iquix, Levaquin, NovoLefloxacin, Oftaquiz, Quixin, Tavanic Pharmacologic Class: Fluoroquinolone Therapeutic Class: Anti-Infective Pregnancy risk category: C

Mechanism of Action
Inhibits the enzyme DNA gyrase in susceptible gramnegative and grampositive aerobic and anaerobic bacteria, interfering with bacterial DNA synthesis.

Indication

Contraindication

Adverse Reaction

Nursing Responsiblities
1. Avoid rapid or bolus I.V. administration, because this may cause severe hypotension. 2. Check v/s, specially BP. Too-rapid infusion can cause hypotension. 3. Closely monitor patients with renal insufficiency. 4. Assess for severe diarrhea, which may indicate pseudomembranous colitis. 5. Watch for hypersensitivity reaction. D/C drug immediately of rash or other s/sx occur. 6. Watch for s/sx of tendinitis or tendon rupture. 7. Tell patient to stop taking drug and contact prescriber if he experiences s/sx of hypersensitivity

>Acute bacterial exacerbation of chronic bronchitis >Community-acquired pneumonia >Nosocomial pneumonia caused by methicillin-susceptible strains of Stapylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli, Klebsiella pneumonia, Haemophilus influenza, or Streptococcus pneumonia; complicated skin and skin-structure infections >Acute bacterial sinusitis caused by S. pneumonia, H. influenza, or Moraxella catarrhalis >Uncomplicated skin and skin-structure infections >Complicated UTI >Chronic bacterial

Hypersensitivity to drug, its components, or other quinolones

CNS: seizures GI: pseudomembranous colitis Hematologic: lymphocytopenia Metabolic: hypoglycemia Other: Steven-Johnson syndrome

methicillin-susceptible strains of Stapylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli, Klebsiella pneumonia, Haemophilus influenza, or Streptococcus pneumonia; complicated skin and skin-structure infections Adults: 750 mg I.V. or P.O. q 24 hours for 7 to 14 days >Acute bacterial sinusitis caused by S. pneumonia, H. influenza, or Moraxella catarrhalis Adults: 500 mg I.V. or P.O. q 24 hours for 10 to 14 days or 750 mg P.O. or I.V. q 24 hours for 5 days >Uncomplicated skin and skin-structure infections Adults: 500 mg I.V. or P.O. q 24 hours for 7 for 10 days >Complicated UTI Adults: 250 mg I.V. or P.O. q 24 hours for 10 days or 750 mg P.O. q 24 hours for 5 days >Chronic bacterial prostatitis Adults: 500 mg I.V. or

prostatitis >Conjunctivitis >Corneal ulcers

reaction or severe diarrhea.. 8. Instruct patient to stop taking drug and notify prescriber immediately if tendon pain, swelling, or inflammation occurs.

P.O. q 24 hours >Conjunctivitis Adults and children ages 1 and older: one or two drops of 0.5% ophthalmic solution into affected eye q 2 hours while awake and one or two drops 2 4 hours while awake on days 3 to 7. >Corneal ulcers Adults and children ages 6 and older: On days 1 to 3, one or two frops of 1.5% ophthalmic solution instilled into affected eye q 30 minutes to 1 hour while awake and q 4 to 6 hours after retiring. Dosage adjustment: Renal impairment