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  • Other Drugs For Angina

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    sujyotsharma
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    This document discusses four other drugs: Ivabradine which selectively inhibits the cardiac pacemaker current to lower heart rate; Trimetazidine which increases tolerance to ischemia by inhibiting fatty acid metabolism and stimulating glucose metabolism; Oxyphedrine which depresses coronary vessel tone to increase coronary circulation and oxygen uptake by the heart while also having positive inotropic and chronotropic effects; and Ranolazine which inhibits potassium current to delay action potential and prolong QT interval. Potential side effects of Ranolazine mentioned are dizziness, weakness, constipation, postural hypotension, headache, and dyspepsia.

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    Other Drugs For Angina(1)

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    This document discusses four other drugs: Ivabradine which selectively inhibits the cardiac pacemaker current to lower heart rate; Trimetazidine which increases tolerance to ischemia by inhibiting fatty acid metabolism and stimulating glucose metabolism; Oxyphedrine which depresses coronary vessel tone to increase coronary circulation and oxygen uptake by the heart while also having positive inotropic and chronotropic effects; and Ranolazine which inhibits potassium current to delay action potential and prolong QT interval. Potential side effects of Ranolazine mentioned are dizziness, weakness, constipation, postural hypotension, headache, and dyspepsia.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    5 views2 pages

    Other Drugs For Angina

    Uploaded by

    sujyotsharma
    This document discusses four other drugs: Ivabradine which selectively inhibits the cardiac pacemaker current to lower heart rate; Trimetazidine which increases tolerance to ischemia by inhibiting fatty acid metabolism and stimulating glucose metabolism; Oxyphedrine which depresses coronary vessel tone to increase coronary circulation and oxygen uptake by the heart while also having positive inotropic and chronotropic effects; and Ranolazine which inhibits potassium current to delay action potential and prolong QT interval. Potential side effects of Ranolazine mentioned are dizziness, weakness, constipation, postural hypotension, headache, and dyspepsia.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Other Drugs

    Drugs in this Class


    

    Ivabradine

    Trimetazidine

    oxyphedrine

    Ranolazine

    Pharmacology
    IVABRADINE - Ivabradine is a heart-rate-lowering agent that acts by selectively and specifically inhibiting the
    cardiac pacemaker current (If), a mixed sodium-potassium inward current that controls the spontaneous
    diastolic depolarization in the sinoatrial (SA) node and hence regulates the heart rate.
    TRIMETAZIDINE - Trimetazidine increases cellular tolerance to ischemia by inhibiting fatty acid metabolism
    and, secondarily, stimulating glucose metabolism.

    OXYPHEDRINE - Oxyphedrine depresses the tonicity of coronary vessels, increase the coronary circulation
    volume, the oxygen uptake by the heart and also to exert a positive inotropic and chronotropic action.

    RANOLAZINE - Ranolazine inhibits rapid delayed rectifier potassium current, thus delaying action potential
    and prolonging QT interval.

    Adverse Effects
    Side effects of Ranolazine are dizziness, weakness, constipation, postural hypotension, headache, dyspepsia.

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