12/11/2018 Drugs that cause or prolong delirium - UpToDate

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Drugs believed to cause or prolong delirium or confusional states*

Analgesics Corticosteroids
NSAIDs Dopamine agonists
Opioids (especially meperidine) Amantadine
Antibiotics and antivirals Bromocriptine

Acyclovir Levodopa

Aminoglycosides Pergolide

Amphotericin B Pramipexole

Antimalarials Ropinirole

Cephalosporins Gastrointestinal agents
Cycloserine Antiemetics
Fluoroquinolones Antispasmodics
Isoniazid Histamine­2 receptor blockers
Interferon Loperamide
Linezolid
Herbal preparations
Macrolides
Atropa belladonna extract
Metronidazole
Henbane
Nalidixic acid
Mandrake
Penicillins
Jimson weed
Rifampin
St. John's Wort
Sulfonamides
Valerian
Anticholinergics
Hypoglycemics
Atropine
Hypnotics and sedatives
Benztropine
Barbiturates
Diphenhydramine
Benzodiazepines
Scopolamine

Trihexyphenidyl Muscle relaxants

Anticonvulsants Baclofen

Cyclobenzaprine
Carbamazepine

Levetiracetam Other CNS­active agents
Phenytoin Disulfiram

Valproate Cholinesterase inhibitors (eg, donepezil)

Vigabatrin Interleukin­2

Antidepressants Lithium

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12/11/2018 Drugs that cause or prolong delirium - UpToDate
Mirtazapine Phenothiazines

Selective serotonin reuptake inhibitors

Tricyclic antidepressants

Cardiovascular and hypertension drugs
Antiarrhythmics

Beta blockers

Clonidine

Digoxin

Diuretics

Methyldopa

NSAID: nonsteroidal antiinflammatory drugs; CNS: central nervous system. 
* Not exhaustive, all medications should be considered.

Graphic 70449 Version 6.0

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