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Zantac SF Assessment - Team ABC and A - Q4 2016

1. The primary role of stomach is to receive and store ingested food for onward release into the
duodenum, and to initiate digestion.

 (a) True
o (b) False

If choice a is selected set score to 1.

2. Which is NOT the part of Gastrointestinal Tract.

o (a) Rectum & Anal Canal


o (b) Pharynx
 (c) Trachea
o (d) Small & Large Intestine

If choice c is selected set score to 1.

3. ____________________ is a potent stimulator of gastric secretion. It is thought to be the final link in


stimulation of a parietal cell by other excitatory factor.

o (a) Gastrin
 (b) Histamine
o (c) Acetylcholine

If choice b is selected set score to 1.

4. Parietal cells contain a large number of smooth-walled vesicular or tubular membranes known as
tubulovesicles. The inactive proton pumps are present on the tubulovesicular membrane.

 (a) True
o (b) False

If choice a is selected set score to 1.

5. __________________________is an intracellular membrane structure, which has a few stubby


microvilli lining the extracellular face.

 (a) Canaliculus
o (b) Tubulovesicles

If choice a is selected set score to 1.

6. What are the factors for the control of gastric secretion?

o (a) Excitatory Factor Only


o (b) Inhibitory Only
 (c) Inhibitory & Excitatory Factors Both
o (d) None of All

If choice c is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

7. The mucus provides lubrication and forms a physical barrier to acid damage, while the bicarbonate
neutralizes any acid that penetrates below the surface of the mucus.

 (a) True
o (b) False

If choice a is selected set score to 1.

8. During the process of digestion, strong muscular mixing movements help to reduce food particles to
semi-liquid chyme, while the gastric acid, together with enzymes such as
___________________begins the process of chemical breakdown into essential nutrients.

 (a) Pepsin
o (b) Amylases
o (c) Lysozymes
o (d) Phospholipase

If choice a is selected set score to 1.

9. The physiologic stimulation of acid secretion has classically been divided into three interrelated
phases: Cephalic, Gastric and Intestinal.

 (a) True
o (b) False

If choice a is selected set score to 1.

10. ___________provides lubrication and forms a physical barrier to acid damage, while the
__________ neutralizes any acid that penetrates below the surface of the __________

o (a) Bicarbonate, Bicarbonate, Mucus


o (b) Mucus, Bicarbonate, Skin
o (c) Mucus, Mucin, Skin
 (d) Mucus, Bicarbonate, Mucus

If choice d is selected set score to 1.

11. At least WEEKLY heartburn or Acid regurgitation is __________________

 (a) GERD
o (b) PEPTIC ULCER
o (c) DYSPEPSIA

If choice a is selected set score to 1.

12. In ____________________, Pain is more common at night, when it may prevent the patient from
getting to sleep.

o (a) Gastric Ulcer


o (b) Duodenal Ulcer
o (c) Dyspepsia

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Zantac SF Assessment - Team ABC and A - Q4 2016

 (d) GERD

If choice d is selected set score to 1.

13. ___________________ulcers are located in the stomach.

 (a) Gastric
o (b) Duodenal

If choice a is selected set score to 1.

14. ___________________ulcers are found at the beginning of the small intestine known as the
duodenum.

o (a) Gastric
 (b) Duodenal

If choice b is selected set score to 1.

15. In Duodenal Ulcer, pain does not follow consistent pattern & Ingestion of food sometimes
exacerbates the symptoms rather relieves the pain that rarely occur at night.

o (a) True
 (b) False

If choice b is selected set score to 1.

16. Two predominant causes of peptic ulcer disease are_______________ & ________________

o (a) Helicobacter pylori & Smoking


o (b) Smoking & Spicy foods
o (c) Coffee & Smoking
 (d) Helicobacter pylori & NSAIDs

If choice d is selected set score to 1.

17. Patients who relapse more than three times in any one year are likely to be considered candidates
for maintenance.

 (a) True
o (b) False

If choice a is selected set score to 1.

18. Vomiting & Nausea are the key symptoms of DYSPEPSIA.

o (a) True
 (b) False

If choice b is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

19. Emotional stress, Smoking, Diet, Regularity and spacing of meals, NSAIDs are the contributing
factors in Dyspepsia.

 (a) True
o (b) False

If choice a is selected set score to 1.

20. Idiopathic dyspepsia is a Category of dyspepsia, where Specific causes can be identified.

o (a) True
 (b) False

If choice b is selected set score to 1.

21. _________________bind to the H2 receptor on the basolateral membrane of the gastric parietal cell,
thereby blocking the action of histamine on the parietal cells.

 (a) H2RAs
o (b) PPI
o (c) Gastrin
o (d) Acetylcholine

If choice a is selected set score to 1.

22. Secretion of gastric juices occurs in three phases: A cephalic (reflex) phase, A local (gastric) phase,
_______________phase.

o (a) Duodenal
o (b) Positive Feedback
o (c) Negative Feedback
 (d) Intestinal

If choice d is selected set score to 1.

23. Parietal cells secrete ______________ & ____________

 (a) HCL & Intrinsic Factor


o (b) HCL & Gastrin
o (c) HCL & Histamine

If choice a is selected set score to 1.

24. HCL functions to break up cells, to denature proteins for easier digestion, to kill many ingested
bacteria and to convert pepsinogen to pepsin.

 (a) True
o (b) False

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

25. Pepsinogen is secreted by gastric chief cells into the lumen and is converted to its active form
Pepsin in the presence of HCL.

 (a) True
o (b) False

If choice a is selected set score to 1.

26. Pepsin is an enzyme that breaks down Carbohydrates.

o (a) True
 (b) False

If choice b is selected set score to 1.

27. ______________ cells secrete histamine.

 (a) Enterochromaffin
o (b) G Cells
o (c) Somatostatin

If choice a is selected set score to 1.

28. Mucus is secreted by mucous neck cells in the epithelium of the stomach. It is useful for lubrication
and protection of gastric epithelial cells from the effects of the strongly acidic environment in the
lumen.

 (a) True
o (b) False

If choice a is selected set score to 1.

29. Which of the following is the characteristic feature of Parietal cells?

o (a) Exhibit 3 phases


 (b) Secrete large quantities of acid at a high concentration
o (c) Located in gastric glands present in the inner lining of the duodenum
o (d) All are correct

If choice b is selected set score to 1.

30. NSAIDs damage the gastro-duodenal mucosa by inhibiting the COX II enzyme, thereby inhibiting the
production of prostaglandins that are important protective factors.

 (a) True
o (b) False

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

31. Gastrin, Acetylcholine & Histamine are collectively known as Secretagogues responsible for Parietal
Cell stimulation.

 (a) True
o (b) False

If choice a is selected set score to 1.

32. Which of the following step is not true in the Mechanism of Acid Secretion (HCl) by Parietal Cells?

o (a) Combination of H+ ions with Cl- ions in the secretory cannaliculus to form HCL
o (b) Activation of parietal cells
o (c) Translocation of proton pumps from tubulovesicles to the membrane of secretory cannaliculus
 (d) Stimulation of parietal cells by histamine, dopamine, and/or gastrin

If choice d is selected set score to 1.

33. Following are the Acid Inhibitory Factors in Stomach.

o (a) Low pH in the stomach, reduced vagus nerve activity, Presence of stimulating factors
o (b) High pH in the stomach, Increased vagus nerve activity, Absence of stimulating factors
 (c) Low pH in the stomach, reduced vagus nerve activity, Absence of stimulating factors

If choice c is selected set score to 1.

34. Gastrin, a hormone released in response to the presence of certain types of food, such as Green
Vegetables.

o (a) True
 (b) False

If choice b is selected set score to 1.

35. Nerve stimuli received from the brain via the vagus nerve, triggered by the sight or smell of food.

 (a) True
o (b) False

If choice a is selected set score to 1.

36. The control of stomach pH is mediated by interplay between factors that excite gastric section, and
those that inhibit gastric secretion.

 (a) True
o (b) False

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

37. There are several possible ways to either reduce the acidity of the gastrointestinal contents or to
protect against the damaging effects of excess acid using pharmacological agents (drugs) and
interventions. The principal methods are:

o (a) Acid Neutralization & Suppression of Acid Secretion


o (b) Enhanced Mucosal protection
o (c) Enhanced gastrointestinal motility
 (d) All are Correct

If choice d is selected set score to 1.

38. Choose the main factors that have been found to contribute to Gastroesophageal reflux.

o (a) Incompetence of the lower functional oesophageal sphincter


o (b) Impaired mucosal defence
o (c) Decreased peristaltic clearance of refluxed material.
 (d) All are Correct

If choice d is selected set score to 1.

39. Which factor is NOT responsible for Incompetence of the lower functional oesophageal sphincter?

o (a) Damage to the vagus nerve


o (b) Hiatus hernia
 (c) Exercise
o (d) Drugs that affect parasympathetic nerve activity e.g. anticholinergics

If choice c is selected set score to 1.

40. Resting & Activated Phases are TWO key factors involved in Control of Acid Secretion?

o (a) True
 (b) False

If choice b is selected set score to 1.

41. GERD stands for :

o (a) Gross Expenditure on Research and Development


 (b) Gastro Esophageal Reflux Disease
o (c) Gastric, Esophagous, Regurgitating Disorders

If choice b is selected set score to 1.

42. NERD stands for:

 (a) Non Erosive Reflux Disease


o (b) Non Erosive Regurgitating Disease

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

43. NUARD stands for:

o (a) Non Ulcer Acid Rebound disorder


 (b) Non ulcer acid-related dyspepsia

If choice b is selected set score to 1.

44. PPI stands for:

o (a) Protein Pump Inhibitors


 (b) Proton Pump Inhibitors

If choice b is selected set score to 1.

45. Unusual high levels of gastrin in the blood is called __________gastrinaemia

 (a) Hyper
o (b) Hypo

If choice a is selected set score to 1.

46. In __________ ulcer, Normal secretion of HCL & corrosive effect of HCL surpasses the diminished
resistance of the gastric mucosa.

o (a) Duodenal
 (b) Gastric
o (c) Peptic

If choice b is selected set score to 1.

47. ______________ ulcer is the most important organic gastrointestinal disease.

o (a) Duodenal
o (b) Gastric
 (c) Peptic

If choice c is selected set score to 1.

48. Study of changes of normal mechanical, physiological and biochemical functions either caused by a
disease or resulting from an abnormal syndrome is called __________________.

 (a) Pathophysiology
o (b) Algology
o (c) Gerontology

If choice a is selected set score to 1.

49. ___________________ phase is activated by the thought, taste, smell and site of food, and
swallowing. It is mediated mostly by the vagus nerve which secretes acetylcholine.

o (a) Intestinal

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Zantac SF Assessment - Team ABC and A - Q4 2016

o (b) Gastric
 (c) Cephalic

If choice c is selected set score to 1.

50. The______________phase is due to the chemical effects of food and distension of the stomach.

o (a) Intestinal
 (b) Gastric
o (c) Cephalic

If choice b is selected set score to 1.

51. Which of these factor do not contribute to GERD?

 (a) Fruits
o (b) Decreased peristalsis
o (c) Impaired mucosal defence
o (d) Incompetence of the lower functional oesophageal sphincter

If choice a is selected set score to 1.

52. Which of these is NOT the diagnostic/Investigational technique for GERD?

 (a) Colposcopy
o (b) Endoscopy
o (c) X-ray using a barium (contrast)

If choice a is selected set score to 1.

53. Which of these is NOT the key aspect to ulcer management?

 (a) Gastric Resection


o (b) Treatment of the acute episode or exacerbation
o (c) Maintenance therapy to prevent recurrence

If choice a is selected set score to 1.

54. Ulcer patients who relapse more than three times in any one year are likely to be considered
candidates for ___________________________

 (a) Maintenance
o (b) X-Ray
o (c) Surgery
o (d) Endoscopy

If choice a is selected set score to 1.

55. Which of the following is not the characteristic feature of Gastric Carcinoma.

o (a) Dyspepsia and weight loss

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Zantac SF Assessment - Team ABC and A - Q4 2016

o (b) Coffee-ground vomit


o (c) Loss of appetite
 (d) Insomnia

If choice d is selected set score to 1.

56. Stopping _____________is probably the single most important lifestyle change a patient can make
in order to help treat an acid-related disorder.

o (a) Alcohol
 (b) Smoking
o (c) Spices
o (d) weight control

If choice b is selected set score to 1.

57. Drop in pH<4 for at least 1 continuous hour is a pharmacological phenomenon termed nocturnal
gastric acid breakthrough (NAB).

 (a) True
o (b) False

If choice a is selected set score to 1.

58. Zantac prevents clinically important gastrointestinal bleeding in up to _________of patients.

o (a) 88%
o (b) 96%
o (c) 100%
 (d) 98%

If choice d is selected set score to 1.

59. Acid related disorders such as GERD & Peptic Ulcers are _____________ , _____________
conditions.

o (a) Chronic, deadly


o (b) Acute, Progressive
o (c) Acute, Relapsing
 (d) Chronic, Relapsing

If choice d is selected set score to 1.

60. Mortality rates in patients who bleed as a result of Stress Related Mucosal disease area as high as
________%

o (a) 65%
o (b) 77%
 (c) 57%
o (d) 80%

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Zantac SF Assessment - Team ABC and A - Q4 2016

If choice c is selected set score to 1.

61. According to literature, Reported prevalence of GERD in Pakistan ranges from _____% to _____%

o (a) 24% & 28%


 (b) 22.2% & 24%
o (c) 20.2% & 22.2%

If choice b is selected set score to 1.

62. According to literature, PEPTIC Ulcer may lead to potentially life threatening complications like
heamorrhage and perforation.

 (a) True
o (b) False

If choice a is selected set score to 1.

63. According to literature, Profound acid suppression leads to rebound acid HYPOSECRETION from
the second week after treatment, and lasts till ECL cell mass is normalized, i.e., 2-3 months after
stopping treatment.

o (a) True
 (b) False

If choice b is selected set score to 1.

64. According to literature, Strong gastric Acid inhibition has risk


of:____________________,_______________________. Thus, an optimal inhibition of gastric acid
secretion has to be found.

o (a) Hypergastrinaemia with the possibility of ECL cell hyperplasia


o (b) Risk of bacterial overgrowth in the proximal digestive tract
 (c) All are Correct
o (d) None is correct

If choice c is selected set score to 1.

65. Which of the following is NOT the advantages of H2RAs.

 (a) Rapidly converted into metabolites


o (b) Faster onset of action
o (c) No interaction with clopidogel
o (d) No need to time administration with meals

If choice a is selected set score to 1.

66. According to literature, PPIs appear to be associated with an elevated risk of MI in the general
population; and H2 blockers show no such association.

 (a) True

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Zantac SF Assessment - Team ABC and A - Q4 2016

o (b) False

If choice a is selected set score to 1.

67. According to literature, H2RAs modestly increased the risk of hip, spine and any-site fractures.

o (a) True
 (b) False

If choice b is selected set score to 1.

68. According to literature, PPIs use is associated with significantly higher risk of incident of Chronic
Kidney Disease whereas H2RAs are not associated with CKD.

 (a) True
o (b) False

If choice a is selected set score to 1.

69. According to literature, The 2013 American College of Gastroenterology Guidelines recommends
that H2RAs can be added to daytime PPI therapy for effective relief of night time reflux.

 (a) True
o (b) False

If choice a is selected set score to 1.

70. According to literature, NAB was shown to occur in more than ____% of patients on PPI therapy, but
can be _________by adding a ______at bedtime.

o (a) 70%, decreased, Antacids


o (b) 70%, Increased, H2RA
o (c) 80%, decreased, H2RA
 (d) 70%, decreased, H2RA

If choice d is selected set score to 1.

71. Following are the most common symptoms of GERD, EXCEPT one

o (a) Heartburn
o (b) Regurgitation
 (c) Cough

If choice c is selected set score to 1.

72. Which of the following step is not true in the Mechanism of Acid Secretion (HCl) by Parietal Cells?

o (a) Combination of H+ ions with Cl- ions in the secretory cannaliculus to form HCL
o (b) Secretion of H+ ions into the secretory cannaliculus by the proton pump in exchange for K+
o (c) Activation of parietal cells
 (d) Stimulation of parietal cells by histamine, dopamine, and/or gastrin

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Zantac SF Assessment - Team ABC and A - Q4 2016

If choice d is selected set score to 1.

73. Following are the secretagogues for the production of HCl, Except one:

o (a) Histamine
o (b) Gastrin
o (c) Acetylcholine
 (d) Dopamine

If choice d is selected set score to 1.

74. The __________ is the part of the GI tract where 90% of the digestion and absorption of food
occurs, the other 10% taking place in the stomach and large intestine. The main function of this
portion is absorption of nutrients and minerals from food.

o (a) Duodenum
 (b) Small Intestine
o (c) Stomach
o (d) Jejunum

If choice b is selected set score to 1.

75. The control of stomach pH is mediated by interplay between factors that excite gastric section, and
those that inhibit gastric secretion.

 (a) True
o (b) False

If choice a is selected set score to 1.

76. The gastrointestinal __________is brought into repeated contact with potentially corrosive gastric
acid throughout the day, every day.

o (a) walls
 (b) Mucosa
o (c) sphincter
o (d) tract

If choice b is selected set score to 1.

77. Factors such as delaying gastric emptying may also contribute to damage the lining of the stomach,
because the highly acidic chyme is retained in the stomach for longer than usual.

 (a) True
o (b) False

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

78. The muscular walls of the lower part of the oesophagus form a __________that normally provides a
physical barrier to reflux.

o (a) Tissue Mass


 (b) Sphincter
o (c) Barrier

If choice b is selected set score to 1.

79. Drugs that affect parasympathetic nerve activity e.g. anticholinergics may NOT affect the
Incompetence of the lower functional oesophageal sphincter.

o (a) True
 (b) False

If choice b is selected set score to 1.

80. The GERD Pain may be provoked by stooping or bending, and is sometimes relieved by sitting up or
standing.

 (a) True
o (b) False

If choice a is selected set score to 1.

81. Which of the following is not an example of PPIs?

o (a) Esomeprazole
o (b) Omeprazole
o (c) Lansoprazole
 (d) Misoprostol

If choice d is selected set score to 1.

82. PPI are unable to control acid secretion over the complete 24-hrs period with a single dose.

 (a) True
o (b) False

If choice a is selected set score to 1.

83. Antacids are class of medications that act by directly ________________gastric acid.

o (a) Reducing
 (b) Neutralizing
o (c) Inhibiting
o (d) Increasing

If choice b is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

84. ______________provide temporary relief of heartburn (lasting 30 to 60 minutes) and thus may
require frequent dosing; acid suppression is not maintained throughout the night even if they are
given at bedtime and diarrhea or constipation.

 (a) Antacids
o (b) PPIs
o (c) H2RAs

If choice a is selected set score to 1.

85. aglandins & Alginates enhance the natural mucosal defences against acid.

 (a) True
o (b) False

If choice a is selected set score to 1.

86. _______________ is the transection of part of the vagus nerve to reduce nervous system
stimulation of acid secretion.

 (a) Vagotomy
o (b) Gastric Resection

If choice a is selected set score to 1.

87. _________________adhere selectively to ulcerated tissue, protecting it from acid attack.

 (a) Sucralfate
o (b) Colloidal Bismuth
o (c) Prostaglandins
o (d) H2RAs

If choice a is selected set score to 1.

88. Acid suppression has been shown to lead to elevated Serum gastrin in many individuals may even
lead to enterochromaffin-like cell hyperplasia, is the key disadvantage of using _____________

o (a) Antacids
 (b) PPI
o (c) H2RAs

If choice b is selected set score to 1.

89. Bedtime Histamine-2 receptor antagonists can control NAB in patients who are on PPI twice daily
therapy better compared with an additional bedtime dose of PPI.

 (a) True
o (b) False

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

90. __________________is an appropriate choice either for acute treatment or for maintenance
therapy.

 (a) Zantac
o (b) Omeprazole
o (c) Esomperazole
o (d) Lansoperazole

If choice a is selected set score to 1.

91. Which of the following is the dose of Zantac in Long-term management of reflux oesophagitis
(GERD)?

 (a) 150mg bid


o (b) 150mg OD
o (c) 300mg OD
o (d) 300mg bid

If choice a is selected set score to 1.

92. A unique property of Zantac is, it is extensively metabolized.

 (a) FALSE
o (b) TRUE

If choice a is selected set score to 1.

93. What is the dose of Zantac for the prophylaxis of NSAID induced ulcer?

 (a) 150mg bid / 300mg nocte


o (b) 300mg bid
o (c) 150mg OD

If choice a is selected set score to 1.

94. Ranitidine has a relatively long duration of action and so a single 150 mg oral dose effectively
suppresses gastric acid secretion for _______ hours.

o (a) 24
o (b) 18
o (c) 6
 (d) 12

If choice d is selected set score to 1.

95. Which of the following is the recommendation for the administration of ZANTAC intravenous
Injection?

o (a) A slow (over 1minutes) intravenous (i.v.) injection of 50 mg, diluted to a volume of 20 ml
o (b) A slow (over 2 minutes) intravenous (i.v.) injection of 50 mg, diluted to a volume of 2 ml
o (c) A slow (over 2 minutes) intravenous (i.v.) injection of 50 mg, diluted to a volume of 5 ml

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Zantac SF Assessment - Team ABC and A - Q4 2016

 (d) A slow (over 2 minutes) intravenous (i.v.) injection of 50 mg, diluted to a volume of 20 ml

If choice d is selected set score to 1.

96. Which of the following is NOT the Indication of Zantac Oral?

o (a) Prophylaxis of stress ulceration in seriously ill patients


 (b) Prophylactic Treatment of Gastrointestinal Motility
o (c) Prevention of non-steroidal anti-inflammatory drugs (including aspirin) associated duodenal
ulcers.
o (d) Treatment of duodenal and benign gastric ulceration including that associated with non-
steroidal inflammatory agents.

If choice b is selected set score to 1.

97. Usual dose of ZANTAC in children is 2mg/kg to 4mg/kg twice daily to a maximum of 300 mg per day.

 (a) TRUE
o (b) FALSE

If choice a is selected set score to 1.

98. Which one of the following is the Contraindication of Zantac?

 (a) In patients known to have hypersensitivity


o (b) Treatment with Zantac may mask symptoms of gastric carcinoma
o (c) Ranitidine is excreted via kidney and so plasma levels of the drug are increased in patients
with severe renal impairment.

If choice a is selected set score to 1.

99. Zantac is Contraindicated in Pregnancy.

o (a) TRUE
 (b) FALSE

If choice b is selected set score to 1.

100. Which of the following is the adverse reaction of Zantac?

o (a) Hepatomegaly
 (b) Leucopenia
o (c) Asthma
o (d) Pneumonia

If choice b is selected set score to 1.

101. The dosage regimen of Zantac for Nocturnal Acid Breakthrough is__________________

o (a) 300mg nocte


 (b) 150mg Nocte

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Zantac SF Assessment - Team ABC and A - Q4 2016

o (c) 150mg bid

If choice b is selected set score to 1.

102. The standard dosage regimen of Zantac for duodenal or benign gastric ulcer
is__________________

 (a) 150mg bid / 300mg nocte


o (b) 300mg bid
o (c) 150mg OD

If choice a is selected set score to 1.

103. For the long-term management of duodenal or benign gastric ulcer the usual dosage regimen of
Zantac is__________

o (a) 150mg bid


 (b) 150 mg nocte
o (c) 300mg bid
o (d) 300mg nocte

If choice b is selected set score to 1.

104. What is the treatment regimen of Zantac for NSAID associated peptic ulceration?

o (a) 8 to 12 weeks treatment may be necessary with 150 mg OD


o (b) 4 to 6 weeks treatment may be necessary with 300 mg nocte.
 (c) 8 to 12 weeks treatment may be necessary with 150 mg twice daily or 300 mg nocte.
o (d) 4 to 6 weeks treatment may be necessary with 150 mg twice daily or 300 mg nocte.

If choice c is selected set score to 1.

105. What is the treatment of Zantac for Moderate to Severe Oesophagitis (GERD) patients?

o (a) 150mg four times daily for up to 8 weeks


o (b) 150mg bid for up to 12 weeks
 (c) 150mg four times daily for up to 12 weeks

If choice c is selected set score to 1.

106. What is the dosage regimen of Zantac for symptomatic relief in GERD patients?

o (a) 150mg bid for 4 weeks


o (b) 150mg bid for 8 weeks
 (c) 150mg bid for 2 weeks
o (d) 150mg OD for 2 weeks

If choice c is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

107. What is the standard dosage regimen of Zantac Injection for the prophylaxis of mendelson's
syndrome?

o (a) 25 mg by I.M. or slow I.V. injection 45 to 60 mins before induction of general anaesthesia
 (b) 50 mg by I.M. or slow I.V. injection 45 to 60 mins before induction of general anaesthesia
o (c) 75 mg by I.M. or slow I.V. injection 45 to 60 mins before induction of general anaesthesia
o (d) 100 mg by I.M. or slow I.V. injection 45 to 60 mins before induction of general anaesthesia

If choice b is selected set score to 1.

108. Each 2ml of Aqueous solution of Zantac Injection contains 50 mg of Ranitidine as Ranitidine
hydrochloride B.P (25mg/ml)

o (a) FALSE
 (b) TRUE

If choice b is selected set score to 1.

109. Ranitidine is excreted via __________

o (a) Saliva
 (b) Kidneys
o (c) Liver
o (d) Sweat

If choice b is selected set score to 1.

110. Zantac should be avoided in patients with the history of porphyria.

o (a) FALSE
 (b) TRUE

If choice b is selected set score to 1.

111. Ranitidine at usual therapeutic doses potentiate the actions of drugs which are inactivated by
cytochrome P450 enzyme system.

o (a) TRUE
 (b) FALSE

If choice b is selected set score to 1.

112. Ranitidine does not cross Placenta and is not excreted via breast milk.

 (a) FALSE
o (b) TRUE

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

113. Ranitidine has long duration of action so a single 150mg oral dose effectively suppresses gastric
acid secretion for _________ hours.

o (a) 16
 (b) 12
o (c) 24
o (d) 18

If choice b is selected set score to 1.

114. Following oral administration of 150mg Ranitidine maximum plasma concentration occurred
after_______ hours.

 (a) 1 to 3
o (b) 4 to 6
o (c) 2 to 4

If choice a is selected set score to 1.

115. Absorption of Ranitidine after IM injection is rapid & peak plasma concentrations are usually
achieved within 30 minutes of administration.

 (a) FALSE
o (b) TRUE

If choice a is selected set score to 1.

116. Zantac film coated tablets should be stored at a temperature below_________celcius

o (a) 20
o (b) 2 to 8
o (c) 18
 (d) 30

If choice d is selected set score to 1.

117. Zantac injection is compatible with the following I.V Infusion fluids.

o (a) 4.2% bicarbonate


o (b) 4% & 5% Dextrose
o (c) 0.9% Sodium Chloride & 0.18% Sodium Chloride
 (d) All are correct

If choice d is selected set score to 1.

118. Unused admixtures of Zantac should be discarded 24 hours after preparations.

 (a) TRUE
o (b) FALSE

If choice a is selected set score to 1.

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Zantac SF Assessment - Team ABC and A - Q4 2016

119. There is No evidence of an interaction between oral Ranitidine with amoxicillin and
metronidazole.

 (a) TRUE
o (b) FALSE

If choice a is selected set score to 1.

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