PEDIATRIC DOSAGES

Acebrophylline

2 mg/kg/day in 2 divided doses

Gastritis, vomiting

Tab 100 mg, SR Tab 200 mg Syrp-100 mg, 50 mg/5 ml

Acetazolamide

T.125 mg, 250 mg INJ: 500 mg vial

10-30mg/kg/day in 3-4 div doses PO

Acidosis, hypokalaemia, Steven Johnson syndrome, Bone marrow suppression

ACTH

Inj 5 mL vials 60 IU/mL

20-40 units IM OD X 2 weeks

Acyclovir

T.200 mg, 400 mg, 800 mg, Inj 250 mg vial ,Susp. 400 mg/5 ml

15-20 mg/kg/dose over 1 hr I/V as infusion in D. or NS QgH for 14-21 days. Neonatal HSV20 mg/kg/dose
BD/Q8 hrs Oral - Herpes simplex - 10 mg/ kg/dose Q8 hrs for 7 days Varicella – 20 mg/kg/dose Q6 hrs
oral 10 mg/kg Q8H IV

Nephrotoxicity, rashes, thrombocytosis, thrombophlebitis and tissue necrosis if extravasation

Adenosine

INJ: 3 mg/ml ampoules

0.1 mg/kg I/V push along 3 mL saline simultaneously by a 3-way, increase the dose by 0.1 mg/kg every 2
min until clinical response occurs. Max: 0.3 mg/kg (administration must be to a large proximal vein and
saline push immediately after drug administration)

Bronchoconstriction, heart block, bradycardia, hypertension, needs continuous ECG monitoring

Adrenaline

1 mL amp of 1:1000 solution (1 mg/1 mL)

0.01 ml/kg/dose S/C. Do not exceed 0.5 mL/dose may repeat after 5 min. Give IM in anaphylactic shock.
Nebulisation: 0.2 ml/kg diluted in 3cc NS.

Ventricular premature contraction, Atrial arrhythmias prolonged QT interval.

Albendazole

T.400 mg Suspension:400 mg in 10 mL

>2 yrs – 400 mg PO single dose 1-2 yrs – 200 mg PO single dose

High doses can cause sore throat and fever, worm migration in heavy infestation

Albumin

10,50,100 mL vials of 20% volume

0.5-1 g/kg/dose IV infusion over 1-2 hr at a rate of 0.1 g/min

Rapid infusion may cause human albumin hypersensitivity reactions

Allopurinol

T. 100 mg, 300 mg; Inj 500 mg

10 mg/kg/24 hrs in 2–3 divided doses

Rashes, renal toxicity, hepatic toxicity, peripheral neuropathy

Amikacin

INJ: 100,250 mg 500 mg/2mL

15 mg/kg/day I/V OD/ 2 div. doses

Ototoxicity nephrotoxicity
Aminophylline

Arrhythmias, seizures

T. 100 mg INJ: 250 mg In 10 mL amp.

5 mg/kg/dose diluted with double volume of dextrose 1/V slow push or added to 5% dextrose drip to
run over 6 hrs x 4 doses Total daily dose should not exceed 20 mg/kg/day.

Amiodarone (CORDARONE)

T: 100 mg, 200 mg INJ: 50 mg/ mL (Long-acting antiarrhythmic drug)

Oral<1 yr 600-800 mg/1.73m2/dayin 2 div doses>1 yr: 10–15 mg/kg/day in 2 div dosesl/V DosesLoad 5
mg/kg over 30 min, then continuous infusion of 5–15 microgram/kg/min (max 15 mg/kg over 24 hrs)

Arrhythmia, hyperglycaemia, hypothyroidism, pulmonary toxicity, hepatotoxicity, hypersensitivity,

pneumonitis.

Amlodipine

T:2.5 mg, 5 mg, 10 mg

Peripheral edema, hypotension

Starting dose: 0.06 mg/kg/day up to 5 mg/day ODMax dose: 0.6 mg/kg/day up to 10 mg/day

Amoxicillin

Diarrhoea, skin rash

DT: 125 mg, 250 mg. Dry syp or 50 mg/kg/day / 2 or 3 PO Higher dose ready made suspension (125, of
80–90 mg/kg/day in 2–3 div doses may 250 mg/5 ml, drops 100 mg/mL). be used

Amoxicillinclavulanate

Oral(per 5 mL): 200/28.5 400/57 Tab: 625(500+125) 375(250+125) 1.V: 600 (500Amoxicillinclavulanat

Oral: 50 mg/kg/day BD higher dose 80-90 mg/kg/day may be usedl.V.: <3 mo/<4 kg - 30 mg/kg/dose q
12 hrs Ã3m/>4 kg - 30 mg/kg/dose q 8 hrs

Anaphylactic reaction, dose adjustment in renal and hepatic impairment

Amphotericin-B

50 mg vial

Hypotension, fever, chills

0.25-1 mg/kg/single daily dose (1 mg/10 mL conc) as slow I/V infusion in dextrose over 2-6 hrs as slow IV
Test dose - 1 mg in 20 mL D5 over 30 min. Liposomal amphotericin - 2.5-5 mg/kg OD in 5% Dx over 1 hr

Pruritus, maculopapular rashes.

Ampicillin

C: 250, 500DT: 125, 250Dry syp: 100-200 mg/kg/day-4dd. PO, I/V, 1/Min 125,250 mg/5mL INJ: 500 mg,
1g Meningitis 300–400 mg/kg/day

150 mg/kg/24 hrs I/V, 1/M-3-4 doses

Pruritus, maculopapular rashes

Ampicillin + Sulbactam

INJ: 1.5 g vial 1g Ampicillin + 500 mg

AAmrinon

20 mL ampoule, 1 mL=5 mg

Loading dose 0.75mg/kg IV over 3 min followed by infusion at 3–10 mcg/kg/min (should not be mixed
with dextrose).

Arrhythmia, hypotension, thrombocytopenia

Anti-haemophilic factor (factor VIII)

300 units/ vial strength may vary

25 U/kg/dose every 12–24 hrs. Units required = wt in kg x 0.5 x desired % increase in factor

Tachycardia, flushing blood borne diseases

Aspirin

Angioedema, Urticaria, anaphylactoid reaction

T. 75 mg, 100 mg, 150 mg, 350 mg Rheumatic fever 75 mg/kg 124 hrs PO into

4 div doses.Anti platelet dose: 3-5 mg/kg / 24 hrs OD, POAnalgesic:10 mg/kg/dose x 4PO

Ascorbic aaci

T.100/500 mg;drops 100 mg/ml

10 mg/kg/day; 2–3 div doses

Risk of renal stone formation higher doses

Artemether

INJ: 80 mg/1 ml/amp C.40 mg

3.2 mg/kg IM followed by 1.6 mg/kg dailyx 7days

Headache, dizziness, fever, chills

Arginine hydrochloride

IV 200 mg/kg over 90 min in 25 ml/kg 10% Dx followed by daily oral same dose

Extravasation can lead to skin necrosis

Artesunate

60 mg/amp

2.4 mg/kg 0, 12, 24 hrs foll. by ODx7d.

Fever, rashCardiotoxicity in hig doses

Atenolol

T. 25 mg, 50 mg

1 mg/kg/24hrs OD POMax dose:2 mg/kg/ day up to 100 mg/day

Bradycardia, headache, wheezing & hypoglycaemia

Atropine

INJ: 1 mL amp (0.6 mg/mL)

0.01 mg/kg I/V or 1/M. Higher doses for organo phosphorous poisoning.

Dry mouth, blurred vision, urinary retention, tachycardia, mydriasis

Azathioprine

T.50 mg

1-3 mg/kg/day PO

Leukopenia, hepatotoxicity, thrombocytopenia

Azithromycin

Dry Syp: 100 mg, 200 mg/5 ml, DT 100 mg, T. 250 mg. 500 mg, Inj 500 mg

10 mg/kg up to 500 mg on first day. Then 5 mg/kg/day up to 250 mg on days 2 through 5

Gastric upset

Aztreonam

INJ: 500 mg, 750 mg, 2 g

Dose correction in renal failure

100 mg/kg/day div into 3–4 doses; In newborn 30 mg/kg/dose Q12 hrs.Can be given IM (diluted)

Baclofen

T: 10 mg, 20 mg

15 mg/day in 3 div doses, max 40 mg/ day PO

Drowsiness vertigo, hypotonia, ataxia

Bisacodyl

Suppository 5 mg, 10 mg Tab - 5 mg, 10 mg

Suppository < 2 yr-5 mg, > 2 yrs 10 mgTab -> 6 yrs – 5 mg PO HS

Beclomethasone

Inhaler 100 or 200 mcg/ puff. Also available as Rota caps and as nasal spray for allergic rhinitis

100-200 mcg x 4 in 24 hrs and titrate depending on response

Oral candidiasis, irritation of nasal mucosa

Betamethasone

0.2 mg/kg/24 hrs div into 2–3 PO

T. 0.5 mg, inj. 4 mg/ml, 0.1% eye drops, skin cream and oral drops containing 0.5 mg/ml

GI bleed, Cushing features, osteoporosis

Biotin

I,C 5 mg

5-10 mg/day PO/IV MCD

Budesonide

1-2 puffs BD

MDI 100, 200 mcg/puffDPI 100, 200 mcg rotacaps 500 mcg / respule solution

Oral, thrush, dysphonia

Budesonode + Formoterol

Budesonide 100/200 mcg + Formoterol 6 mcg MDI

1-2 puffs BD

Oral, thrush, dysphonia

Caffeine

20 mg/ml

Loading 20 mg/kg of citrate PO/IV maintenance - 5–7.5 mg/kg 9 6 hrs

Gastritis, blood in stools, seizure

Calcium gluconate

10 mL amps of 10% IIN

I/V only. 0.5 mL 10% solution/kg/dose slow I/V diluted in NS

Bradycardia on rapid infusion

Calcitriol

Cap 0.25 mcg, 0.5 mcg INJ: 1 mcg/mm

Children 0.05-0.08 mcg/kg/day Premature infants 0.05 mcg/kg/day

Hypercalcaemia, vitamin D toxicity

CCaptopri

T.12.5, 25 & 50 mg

Start with 0.5 mg/kg/24 hrs div x 3 PO may increase to 0.5 mg/kg/dose. Maximum doses is 5 mg/kg/24
hrs. Neonates 0.1 mg/kg/dose every 8-12 hrs.

Hyperkalaemia, altered taste, rashes, neutropenia cough, oliguria, etc

CCarbamazepin

T. 100 200 mg. Susp. 100, mg/ 5 mm

10 mg/kg/day - 2PO may increase up to 20 mg/kg/day

Sedation, blurred vision, Bone marrow depression, Steven Johnson syndrome

Carnitine

T.330 or 500 mg, Syp 500 mg/ 5 mL,INJ: 1 g/5 ml

50–100 mg/kg/dose div into 2–3 PO 50 mg/kg/dose Q4-6 hrs IV

Abdominal cramps, body odor

Carvedilol

6.25 mg,

T. 3.125 12.5 mg & 25 mg

Start with 0.05 mg/kg twice daily and build upto max dose of 0.40.5 mg/kg/day over 1 week.

Postural hypotension, dizziness, fatigue, GI disturbances

40 mg/kg/24 hrs div into 2–3 PO

Nausea, epigastric pain, vomiting

Cefaclor

Cap 250 mg, Dry syp or readymade susp 125 or 187 mg/ 5 ml. Drops 50 mg/mL

Cefadroxil

30 mg/kg/24 hrs div into 2 PO

Nausea, epigastric distress, vomiting skin, rashes

SAT TREATMENT GUIDELINES FOR SICK CHILDREN

DT 125 mg & 250 mg, susp 125 or 250 mg/5 mL and Drops 100 mg/ml

Cefazolin

50-100 mg/kg/24 hrs div into 4 IM, IV.

Vials of 125 mg, 250 mg, 500 mg and 1 g

Skin rashes pruritus, diarrhoea, drug fever,

Cefdinir

Susp: 125 mg/5 mLCap: 300 mg

14 mg/kg/day q12h

Allergy, bloody diarrhoea

Cefepime

INJ: 500 mg, 1 g vials

100–150mg/kg/day 3 div doses I/V or l/M

Skin rash, eosinophilia, nausea, candidiasis

CCefixim

Skin rash, eosinophilia

Tab 200 mg, 100 mg Syrp 50 mg, 100 mg/5 mL

8–10 mg/kg/day 2 divided doses 20 mg/kg/ day for enteric fever

Cefoperazone

INJ. 1 g & 2 g vvial

100–150 mg/kg/24 hrs divinto 2–3 doses. IV /IM

Skin rash, drug fever, anaphylaxis, diarrhoea

Cefotaxime

INJ: 250, 500 mg 1 g vials

150–200 mg/kg/day, 3-4 doses I/V or 1/ MNewborn: 50 mg/kg/dose Q 12 hrs

Skin rash, drug fever, anaphylaxis, diarrhoea

Ceftazidime

INJ: 250, 500 mg, 1 g vial

150 mg/kg/day 3 div doses I/V or l/M

Skin rash, eosinophilia, urtic local pain

Cefpodoxime

T: 100 mg 200 mg Dry: Syp:50/ 100 mg/5 ml

10 mg/kg/day 2 div doses PO

Diarrhoea nausea vomiting

Ceftriaxone

INJ: 250 mg, 1 g

50–100 mg/kg/day div into 2 1/4, 1/M

Diarrhoea, skin rash, urticaria, eosinophilia

Cefuroxime

mg, Inj. Vials

Skin rash eosinophilia

T. 250 mg,

500 250 mg/750 mg & dry Syp 125 mg/5 ml.

IM/ IV 150 mg/kg/24 hr. div into 3. In meningitis 240 mg/kg/day div into 3 IVPO 30 mg/kg/day div. Into
2–3

Cephalexin

C.250 mg, 500 mgDT: 125 mg/ 5 ml 1 g vials

50-100 mg/kg/day div into 4 PO

Renal function impairment

Cetrizine

Syp-5 mg/5 ml Tab – 10 mg

<5 yrs – 2.5 mg OD/BD> 5 yr - 5 mg OD

Chloram-phenicol

C.250 mg, 500 mg Susp.125mg/ 5 ml 1 g vials

50–100 mg/kg/day in 4 divided doses PO / I/

Skin rashes, epigastric diseases, Bone marrow depression, grey baby syndrome in newborn
Chlorpheniramine maleate

Tab 4 mg Syrp 2 mg/5 ml

0.1 mg/kg/dose QOH

Drowsiness, urinary retension

Chloroquine

250 mg T contains 150 mg of chloroquine base INJ: vial contains 64.5 mg of chloroquine base

PO: 10 mg/kg of base per kg on day 1 & 2 followed by 5 mg/kg on day 3

Hypotension, Gl upset, rash, peripheral neuropathy

Ciprofloxacin

T.250 mg, 500 mg, 750 mg and IV infusion 200 mg in 100 mL

20–30 mg/kg/24 hrs div into 2 P020 mg/ kg/24 hrs div into 2 IV

Nausea, epigastric distress, dizziness

Chorionic gonadotropin

INJ: 200, 500,1000, 2000 Units/ml Children:Prepubertal cryptorchidism

1000–2000 units/m²/dose 3 times/wk Hypogonadotropic hypogonadism 500-1000 units dose 3 times

/week x 3 weeks.

Mental depression, tiredness, precocious puberty, premature closure of epiphysis

Cisapride

Syp 1 mg/ml T: 10 mg

0.15-0.3 mg/kg/dose 3-4 times a day 20 min before feeds

QT prolongation, cardiac arrhythmias

Clarithromycin

T: 250 mg Dry Syp: 125 mg/5 mL

15 mg/kg/PO for 10–14 days

est

Clindamycin

Cap 150, 300 mg

con

I.V : 30 mg/kg/day q8 hrs Oral: 10–30 mg/ kg/day q8 hrs

Hypotension, agranulocytosis, CDAD

Clobazam

T.5,10,20 mg

0.25–1 mg/kg/day 2 div doses PO

Dizziness, fatigue, weight gain, ataxia

Cloxacillin

C.250, 500 mg Dry syp. 125 mg/ 5 mLInj: 250 mg, 500 mg

100 mg/kg/day up to 200 mg/kg/day PO, I/, 1/M

ThrombophlebitisAnaphylaxis, rash
Colistin

Inj. 1 million U/vial

50,000-75,000 1.U/kg/day q8 hrs

ATN, neuromuscular blockade

Cotrimoxazole

(Trimethoprim + Sulphamethoxazole)T.80 mg TMP+400 mg Ped T. 20+100 mg/TabSyp: 40+200 mg/5 ml

In terms of Trimethoprim 6–10 mg /kg/day 2 div doses PO

Skin rashes, Steven Johnson syndrome, fixed drug eruption

Colony stimulating factor G-CSF

Inj 300 mcg/ml

5–10 mcg/kg/day OD.S/C or IV for usually for 3–14 days.

Haematuria, proteinuria

Cyclophosphamide

T 50 mg Inj 200,500 mg

Nephrotic syndrome: 3mg/Kg/Day OD PO

Leukopenia, H’gic cystitis.

Cyclosporine

C.25, 50, 100 mg Inj: 100 mg/ml

3-6 mg/kg/day (higher doses may be used in aplastic anaemia)

Hypertension, diabetes nephrotoxicity, gingival hypertrophy, hirsutism

Daptomycin

350 mg/vial

2-6 yr 9 mg/kg/day OD7- 11 yr 7 mg/kg/ day OD12 – 17 yrs 5 mg/kg/day ODas infusion over 1 hr.

Rash, renal failure, headache, anaemia

INJ: 500 mg

Desferrioxamine

Local pain & induration, flushing,

Acute iron overload: IV - 15 mg/kg/hr (Max 6 g/24 hrs) 90 mg/kg/dose Q8H IM

Desmopressin

Fluid retention, hyponatremia

INJ: 4 mcg/ml Nasal spray 10 mcg/ml

Diabetes insipidus : 5–10 mcg/24 hrs intranasally OD or Div into 2 doses. Nocturnal enuresis: 20mcg at
bed time nasal spray

Dexamethasone

INJ: 4 mg/mL T.0.5 mg Drops 0.5 mg/ml

Cerebral oedema: 0.6–1 mg/kg loading dose foll by 1 mg/kg/day div into 4 antiinflammatory: 0.2
mg/kg/day

Hyperglycaemia, fatigue, glycosuria, Cushing's disease

Dexmeditomidine

Inj 100 mcg/ml

0.2-0.7 mcg/kg/hr

bradycardia, hypotension
Diazepam

T.2,5,10 mg INJ:5 mg/mL SYP: 2 mg/5 mL

Oral:0.2-0.3 mg/kg/day div into 3 PO IV: 0.3 mg/kg/dose slowly in 2–3 mins Rectal: 0.5 mg/kg/dose

Respiratory depression, Sedation, Nausea

Dicyclomine

T. 20 mg, Syp 10 mg/5 ml

0.5 mg/kg/dose

Bladder & Bowel retention, Tachycardia

Diethylcarbamazine

Drowsiness, anorexia, vor

T.50 mg, 100 mg, syp.50 mg/5 ml 6 mg/kg/day div into 3 doses x 14-21

days Tropical eosinophilia 10 mg/kg/day

Digoxin

T.0.25 mg INJ: 0.5 mg/2mL paediatric Elixir 0.05 mg/mL

Loading dose: 0.02 mg/kg start;0.01 mg/ kg at 8 hrs; 0.01 mg/kg at 16 hrs & 0.01 mg/kg OD. Dose of
paediatric elixir: If weight of infant is n kg - dose is O.n mL BD, i.e., for 8 kg child it is 0.8 ml BD.

Nausea, cardiac arrhythmias, Vomiting, ECG changes

Diltiazem

T. 30 mg, ampoules of 5 mL

IV:0.25 mg/kg bolus. Oral: 1–2 mg/kg/ day div into 3 doses.

Exanthematous pustulosis, alopecia, arrhythmia, headach

Dobutamine

50 mg/1 mL inj titrate

Start with 6 mcg/kg/min & titrate infusion

Tachycardia, ectopic heart

Domperidone

Syrp/drps - 1 mg/mL & 10 mg/ mL available

0.2-0.3 mg/kg/dose

Dry mouth, diarrhoea

Dopamine

200 mg/5 ml

6–20 mcg/kg/minute 6 X Body Wt mg of Dopamine is taken in 100 mL 5% dextrose & this can be given as
n micro drops / minute = n mcg//kg/minute.

Tachycardia, ventricular arrhythmias tissue necrosis

Doxofylline

T 400 mg, Syp 100 mg/5 mL

12 mg/kg/day in 2 div doses. Maximum 18 mg/kg/day

Gastritis, Irritability, tachycardia

Doxycline

Tab 100 mg

2-5 mg/kg/day in 2 divided doses

Gastritis, teeth staining, photosensitivity

Enalapril

T:2.5, 5, 10, 20 mg

Cough, hypotension

Starting Dose: 0.1 mg/kg/day OD Max dose: 0.4 mg/kg/day up to 40 mg/day

Erythromycin

T.250 mg, 500 mg Susp: 125 mg 40 mg/kg/day div into 4 doses PO & 250 mg/5 ml Drops: 100 mg/ml

Abdominal pain, vomiting

Erythropoietin

Inj: 2000U/mL 4000U/mL

100—400 IU/kg 3 times a week

Hypertension, headache

Ethambutol

T.200, 400 mg, 800 mg

25 mg/kg/day OD PO

Optic neuritis, Color blindness, Rash

Faropenem

T. 150 mg,

200 mg, 300 mg

15–30 mg/kg/day q8 hrs

Diarrhea

Fludrocortisone

T0.1 mg

0.05-0.1 mg 24 hrs PO, OD

Hypertension, Edema, Congestive heart failure, headache

Flumazenil

Inj 0.1 mg/ml

0.005-0.01 mg/kg load infusion. 0.005–0.01 mg/kg/hr (max 1 mg)

Arrhythmia ,seizures
Fluconazole

T. 150 mg

6–12 mg/kg/day OD or BD, PO/ IV

flu-like symptoms, rash, liver dysfunction

Fosphenytoin

Inj 75 mg/ml

Hypotension, neutropenia,

30 mg/kg loading dose IV, followed by 7.5 mg/kg/day maintanance dose Can be given IM.

Frusemide

T.40 mg INJ: 20 mg/2mL

1-2 mg/kg/dose PO 0.5-1 mg/kg/dose IN, 1/M (max: 5–10 mg/kg/dose)

Electrolyte imbalance, may precipitate hepatic coma if used during pre-coma

Fluticasone

MDI: 50, 125, mcg/puffNasal spray: 27.5 mcg/ spray 50mcg/spray

MDI: 50–250 mcg BDNasal spray-1 puff each nostril OD

Dysphonia, oral thrush, adrenal suppression

Fluticasone + Salmeterol

50–250 mcg of fluticasone BD

Dysphonia, oral thrush, adrenal suppression

Fluticasone 50/125/250 mcg+ Salmeterol 25 mcg MDI IDPI – Flu 125/250 mcg + Salmeterol 50 mcg
rotacaps
Gentamicin

INJ: 10 mg/mL, 40 mg/mL0.3% eye/ear drops

5-7.5 mg/kg/day- OD I/I/M Newborn: 2.5 mg/kg/dose Q12 hrs

Skin rashes, nephrotoxicity, ototoxicity

Glucagon

1 mg=1 unit

0.02-0.03 mg/kg/dosel/V, 1/M, S/C

Nausea, vomiting, hypersensitivity

Granisetron

Syp 1 mg/5 mL;Inj. 1 mg/ml

20 mcg/kg/dose; IV 10 mcg/kg/dose

Diarrhoea, dizziness

G-CSF

Inj:300 mcg/mL

5-10 mcg/kg/day OD, SC/IV till count improves for 1-2 weeks

Bone pain, redness at injection site

Haloperidol

T.0.25 mg, 1.5 mgSyp: 2 mg/ ml Inj: 5 mg/ml

0.1 mg/kg/day Div into3 or 4 doses In Chorea > 5 yrs 0.25 mg x 3 PO

Use carefully in children with epilepsy & in less than 3 yrs

Hyaluronidase

INJ: 150u/mL, 1500 u/mL

150 U S/C or 1/D at 5 times (Q.2 mL to each) at the leading edge of extravasations
Tachycardia, Hypotension, Erythema

Hydrocortisone

Vial 100 mgT.20 mg

Shock-10 mg/kg I/V bolus go up to 50 mg/ Hyperglycaemia, Hypertension, kg followed by same dose Q 6
hrs x 2–4 days Peptic ulcer, Cushing's Status Asthmatics - 10 mg/kg stat

syndrome dose followed by 4 mg/kg/dose Q6H Physiologic-replacement 20 mg/m2PO (0.75

mg/kg/day)23 in the morning 13 in the evening

Hydroxyzine

T:10,25 mg Syp: 10 mg/5 ml

2 mg/kg/day q 6-8 hrs

Anaphylaxis

Ibuprofen

T.200 mg, 400 mg Susp: 100 mg/ 8–10 mg/kg/dose x 3 or 4 PO 5 ml

Abdominal pain, nausea, vomiting

Ipratropium bromide

Dryness of mouth, tachycardia

MDI 20/40 mcg/dose, Neb soln 250 mcg/mL Neb respule 500 mcg/ respule

2-4 puffs per dose Neb soln - 0.5 mL <1 yr, 1 mL> 1 yr every 20 mins for 3 doses then 6–8 hrly

Iron

3-6 mg / kg/ day

drops – 25–30 mg/mLSyp 80 mg/5 ml different strengths available

abdominal pain, gastritis

Isoniazid

T.100 mg 300 mgSyp: INH 300 mg/5 ml

10 mg/kg/day OD PO

Hepatitis, Peripheral neuritis, GI upset

Labetalol

T: 100, 200, 300 mg

Starting dose: 2–3 mg/kg/dayMax Dose: 10–12 mg/kg/day up to 1.2 g/day

Edema, blurred vision, wheezing

Lactulose

10 g/15 ml

Constipation-1 ml/kg/dose BD-QID Hepatic Bloating encephalopathy 10–90 ml/day so as to produce 2–3
soft stools

Lansoprazole

C15 mg, 30 mg

1 mg/kg OD

Rash ,headache protienuria

Leuprolide

Inj:5 mg/ml

1/M Depot0.15-0.3 mg/kg/dose every 28 days.

Weight gain, hot flashes, depression, nausea, vomiting, myalgia

Levamisole

T.50, 150 mg Susp: 50 mg/5 mL

3 mg/kg/day PO single dose; 2 mg/kg on alternate days for nephrotic syndrome

Neutropenia in prolonged use

Levosimendan

Inj 12.5 mg/5 mL

0.05-0.2 mcg/kg/min (infusion in D5)

Hypotension

Levitracetam

100 mg/mL Syrpt. 250, 500,

30-60 mg/kg/day q12 hrs.load-60 mg/kg in status

Behavioral changes sedation

Levocetrizine

T.5 mg, Syp - 2.5 mg/5 ml

<5 yrs - 1.25 mg OD/ BD> 5 yrs – 2.5 mg OD

sedation

LLevosalbutamo

headache, tremor, tachycardia

T.1 mg, 2 mg Syrp - 1 mg/5 ml MDI 50 mcg, 100 mcg Respule - 0.31/0.63/1.25 mg

Oral - 0.05 mg/kg/dose X 3–4 POMDI 2-6 puff/ dose sosRespule -Infants - 0.31 mg, Child -0.63 mg
LLimari

C 70 mg, 140 mg Syp 35 mg/5 ml 10–20 mg/kg/day q 8-12 hrs

Mild laxative effect

Linezolid

T 600 mg, susp 20 mg/mL,Inj100 mL,200 mL (20 mg/mL)

10 mg/kg/dose 12 Hourly. P010 mg/ kg/dose 8

12 Hrly IV

Myelosupression, Rash, Headache, Thrombocytopenia

Losartan

T: 25, 50, 100 mg

Edema, hypotension

Starting dose: 0.75 mg/kg/day up to 50 mg/day ODMax. dose: 1.4 mg/kg/day up to 100 mg/day

Lorazepam

INJ: 1 mg, 2 mg/1 mL

0.1mg/kg 1/V bolus. Can be repeated after 15-20 mins.

Sedation, anorexia, amnesia

Lornithine Laspartte

5 g sachet, 60 mg/mL syp, 5g/10 mL amp

1-2 sachet tid,5–10 ml bd, 2–8 amp daily

Mannitol

20% solution, 100, 250, 350 mL

Headache, nausea, vomiting

2.5-5 ml/kg/dose I/V infusion over 30 min lower doses used frequently (4-6 hrly) avoid rebound.
Mebendazole

T.100 mg; Susp: 100 mg/5 ml

100 mg bd x 3 daysIrrespective of age

migration of worms, urticaria

Meropenem

Inj.500 mg, 1 g

20mg/kg 9 8 hrs, meningitis 40 mg/kg q8 hrs Seizure, leucopenia, rash

Methyl prednisolone

T4 mg, 16 mg, INJ: vial 500 mg, 1g

a/c Asthma - 2 mg/kg foll by 1mg/kg q 8hrs, Hypertension, oedema, pulse- 30 mg/kg OD x 3 days as
infusion pseudotumour cerebri in D5/NS

Metoclo promide

0.1 mg/kg/dose

T.10 mg, Syp 5 mg/5 ml Inj: 5 mg/5 ml

Extrapyramidal reaction:

Mefloquine

T 250 mg

Nausea, dizziness

15-25 mg/kg as a single dose (Dose above 15 mg/kg may be split into 2 doses) 15 mg/kg followed 8 hrs
later by 10 mg/kg

Methylene blue

T 65 mg, Inj. 10 mg/ml

1 mg/kg/dose IV as 1% sol over 5 min May be repeated after 1 hr

Urine and feces turn blue green, anaemia

Metoprolol

1-2 mg/kg/day

T 25 mg, 50 mg, 100 mg Inj. 1 mg/ml

Bradycardia, hypotension, cardiac failure

Metronidazole

T. 200,400 mg Syp: 200 mg/5 mL 1/V infusion 500 mg in 100 mL

30–50 mg/kg/day q 8hrs PO; IV-7.5 mg/kg/ dose q 8 hrs

Metallic taste, Vomiting, dizziness

Methotrexate

T.2.5 mg

5-15 mg/m2/wk

Nausea, vomiting, blood dyscrasias

Midazolam

Inj 1mg/mLor 5 mg/ml

Respiratory depression

loading dose of 0.15 mg/kg continuous infusion of 1mcg/kg/mnt (in 5%D/NS step up as per response
every 15 mins (max 2mg/kg/hr)

Milrinone

10 mg/10 mL amp, premixed inf- 200 mcg/ml

50–75mcg/kg over 15 mins then contn infusion 0.5-0.75 mcg/kg/min

Ventricular arrhythmia, hypokalemia, headache bronchospasm

Montelukast

T.4 mg, 5 mg, 10 mg 4 mg/mL syp, 4 mg sachet

6 months -5 yr: 4 mg OD 6-14 yr: 5 mg OD>14 yrs:10 mg OD

headache, tiredness.

Morphin

T 30 mg, 10 mg, Syp 5 mg/ml, inj 10 mg/ml

0.1-0.2 mg/kg/dose IM,IV,SC inf 0.025–0.05 mg/kg/hr

Hypotension, bradycardia

N-acetyl cysteine

Stomatitis, Urticaria Rapid IV push may cause Hypotension

Solution as Sodium 10%100 mg/ Infants 2-4 mL as inhalation, Children mL (4mL, 10 mL, 30mL) 20% 6-10
mL, Adolescents: 10mL 200 mg/mL (4mL, 10mL,30mL, Acetaminophen over dose-140 mg/kg 100mL)

loading followed by 70 mg/kg Q 4 hrs x17 doses PO 150 mg/kg IV in 5% Glucose over 15-30 min followed
by 50 mg/kg over 4 hrs then 100 mg/kg over 16 hrs. Rapid IV can cause hypotension.

Naloxone

0.02 mg/mL, 0.4 mg/mL

0.1 mg/kg/dose IV (max 2mg) IV/IM/S/C

Gl irritation, renal dysfunction

Nalidixic acid

T-500 mg Syp 300 mg/5 ml

50–55 mg/kg/day div x 3–4 doses PO

Pseudotumour cerebri, skin rashes

Naproxen

T.250, 500 mg

10–15 mg/kg/day q 8-12 hrs

Gl irritation

Neostigmine

0.5 mg/ml

0.01-0.04 mg/kg/dose q2 hrs-4 hrs SC,IMIV; Bradycardia, abd. Cramps, urinary NDNM .025-1
mg/kg/dose (Max.5 mg)PO incontinence 0.5 mg/kg/doseq 6 hrs

Nevirapine

T200 mg

For eMTCT 2 mg/kg OD for 6 weeks

Rash ,steven Johnson, Gl upset

Nifedipine

C-5 mg,

10 mg SR:T-10,20,30 mm

0.5 mg/kg/dose PO q 4-6 hrs

Tachycardia, Flushing & Odema

Nimodipin

T30 mg, inj. 10 mg/50 mL

5–10 mcg/kg/min (max 30 mcg/kg/min)

Nitazoxanide

Syp:100 mg/5 ml

1-3 yr: 100 mg bid 4-11 yr: 200 mg bid

Nausea, diarrhea, abdomir pain

Octreotide

Inj: 0.05,0.1,0.2,0.5, 1 mg/mL vials

1-10 mcg/kg IV/SC q 12 hrs May be given as contn infusion NS/D5

Mild transient hypo or hyper glycaemia

Ondansetron

T 4 mg, 8 mg Syp 2 mg/5mL

0.1 mg/kg/dose

Headache, hypokalaemia, bronchospasm

Oseltamivir

C. 75 mg, Syp - 12 mg/ml

2 mg/kg/ dose BD for 5 days

gastritis, dizziness, diarrhoea

Pantoprazole

Inj.40 mg/mL T. 20 mg, 40 mg

Diarrhea, nausea, muscle pain

1 mg/kg OD PO, IV- reconstitute in NS dil in 100 mL NS/ D5 over 15mins , (Hep. dysfn max 20 mg/day,
renal dysf- max.40 mg/day)
Pancuronium

Inj. 2 mg/ml

0.05-0.1 mg/kg/dose IV may be repeated after 30 mins

Prolonged hypotonia, transient hhypotension

Paracetamol

T 500 mg,650mg Susp 125, 250 mg/5 ml,inj.150 mg/mL

mg, 10–15mg/kg/dose q6 hrs Suppository -30 mg/kg/dose -

Nausea,>150 mg/kg liver cell failure

Pencillamine

C.125 mg, 250 mg, 250 mg

WILSON DISEASE 20 mg/kg/day POq 6-12 hrs (mx.1 gm/day) LEAD INTOXICATION 30-40 mg/kg/day Q8
hrs/Q12 hrs RHEUMATOID ARTHRITIS 3 mg/kg/day PO12 hrs increasing by 3 mg/kg every 2–3 months to
max 10 mg/kg/day

Rash, Pruritus, SLE Like syndrome, nephrotic syndrome, bone marrow suppression, hem.anemia

Pencillin-G

5 lakhs, 10 lakhs

2–3 lakh unit/kg/day q 4-6 hrs I/M, I/V

Anaphylaxis

Penicillin-V

250 mg

25-50 mg/kg/day divided 6-8 hrs

Rash, gasritis
Pentazocine

INJ: 30 mg/ml

0.5 mg/kg/dose I/V1 mg/kg/dose IM,SC

CNS depression & vomiting

Pentoxyfylline

T400 mg, inj 100 mg/5 ml

NB 5 mg/kg/hr for 6 hrs x 3-5 days 20 mg/ kg/24 hrs PO q8 hrs

Hypotension, tachycardia

Pheniramine maleate

0.5 mg/kg/day q 8 hrs

T 50 mg,

25 mg; inj.22.5 mg/mL, syp 15 mg/ 5 mL

Drowsiness, dry mouth

Phentolamine

Inj.50 mg/ml

5 mg in 10 mL NS (Mx.0.1 mg/kg)S/c

Hypotension, headache

Pheno barbitone

T. 15, 30, 60 mg Inj: 200 mg/ mlElix: 20 mg/5 ml

3-5 mg/kg/day q 12-24 hrs Loading dose 15-20 mg/kg Slow I/V

Sedation, Hyperactivity, ataxia

Phenytoin

T: 100 mg Syp: 30 or 125 mg/5mL Inj: 50 mg/ml

5-8 mg/kg/day q 12–24 hrs Loading 15-20 mg/kg slow I/V at a rate 1 mg/kg/ min

Bradycardia, Arrhythmia, Hirsuitism, rash, Gum hyper trophy

Phenylephrine

Inj. 10 mg/ml

5–10 mcg/kg IV

Hypertension, bradycardia,

Piperacillin Tazobactum

INJ. 2 gm, 4 gm

300-400 mg/kg/day IV q6 hrs – 8 hrs

Rash, transient rise of liver enzymes.

Piperazine citrate

SYP: 750 mg/5 ml,1.500 mg

75–100 mg/kg OD at bed times x2d

Nausea, vomiting, Skin rashes

Piroxicam

DT: 20 mg, C.10,20 mglnj: 20 mg/ml

0.2 mg/kg OD PO max. 15 mg/kg/day

G.l. upset

Powder 1 gm/gm
Poly ethyline glycol (PEG)

1 g/kg made into solution

cramps, bloating, rash

Prazocin

Capsule: 1, 2,5 mg

Starting dose: 0.05-0.1 mg/kg/day PO divided q8 hrs Max dose: 0.4 mg/kg/day

Dizziness, Drowsiness, Headache, Weakness

Propofol

Inj. 10 mg/mL, 20,50 & 100 mL vials

1.5–3 mg/kg/dose IV1-2 min

Hypotension ,bradycardia

Prednisolone

T.5, 10, 20 mg Syp:5 mg/mL

1-2 mg/kg/day X 2–4 div doses

Gastric upset, Hypertension, Psychosis

Primaquine

1.2.5, 7.5 & 15 mg(of base)

0.3 mg/kg OD x 5-14 days

Nausea, vomiting,
Promethazine

T.10,25 mg Pediatric Elixir: 5 mg/5mL Inj: 25 mg/mL

0.5-1 mg/kgdose 1/M, I/V1mg/kg/dose PO

Dizziness, dry mouth

Propranalol

T.10, 20,40, 80 mg Inj 1 mg/ml

1-2 mg/kg/day 96-8 hrs PO (mx.4 mg/kg/day)Bradycardia I/V 0.01–0.1 mg/kg/dose over 10 mins

Prostaglandin E1 (Alprostadil)

Inj 500 mcg/mL, 1 mL amp

0.1 mcg/kg/min

Hypotension, bradycardia

Pyrantelpamoate

T.250 mg Susp:250 mg/5mL

11 mg/kg/day single dose PO x 1 day rpt for pinworm after 2 wks

Skin rash

Pyrazinamide

T.500 mg,

750 mg Susp: 300 mg/5mL

30–35 mg/kg/day PO q 12–24 hrs

Hepatotoxicity, Gl upset
Quinine

T.100 mg,

300 mg, 600 mg

10 mg/kg/dose x 3 PO X 7-10 days. I/V loading dose infusion 20 mg/kg over 4 hrs in 10mL/kg of DNS
followed by infusion 10 mg/kg after 12 hrs

Vertigo, tinnitus, blurred vision, cardiac arrhythmia

Inj: 300 mg/ml

Ranitidine

T.150, 300 mg, Syp - 75 mg/ 5 mL INJ: 25 mg/mL

2 mg/kg/dose PO 12 hrs, 1-2 mg/kg/dose I/V q 8-12 hrs

Skin rashes

Ribavirin

SYP: 50 g/5 MLC:100,200 mg

10 mg/kg/24 hrs

Nausea, anemia

Rifampicin

C.150, 300, 450g, 600 mg Syp: 100 mg/5 mL

10–12 mg/kg/dayOD PO on empty stomach

Hepato toxicity, Flu like syndrome

Nausea, vomiting, Skin rashes

Roxithromycin

DT.50 mg,T.150 mg Syp.50 mg/5mL 5–8 mg/kg/24 hrs q 12 hrs

Salbutamol

Fine tremor, Palpitation, Tachycardia

T.2 mg, 4 mg Syp: 2 mg/5 ml Rotacap: 200 mg Aerosol: 100 mcg/puff; Repulses2.5 mg, Respirator

0.1 mg/kg/dose X 4 PO Nebulisation: 0.5ml (<5 yrs),1 mL (>5 yrs) respirator solution with 2.5 mL NS over
20 mins solution 5 mg/mL

1-2 puff: 12 hourly

Tachycardia

Salmetrol (only with steroid)

25 mcg/puffRotacaps 50 mcg 7 сар

Sildenafil

T 25,50,100 mg,

Convulsions, allergic reactions

PPHN 0.4 mg/kg bolus over 3 hrs followed by 1.6mg/kg/hr as continuous infusion over 24 hrs

Sodium benzoate

Abdominal pain, blurred vision

Oral preparation available in grocery stores

250 mg/kg over 90 mins in 25 ml/kg 10% Dx followed by daily oral same dose

Sodium phenyl acetate

Abdominal pain, blurred vision

250 mg/kg over 90 mins in 25 ml/kg 10% Dx followed by daily oral same dose
Sodium nitroprusside

Inj: 50 mg/vial

0.5–10 mcg/kg per min

Check cyanide level >72 hrs use/ renal failure

Sodium valproate

T.200, 300,500 mg Syp: 200 mg/5 mL

Hepatotoxicity

20-60 mg/kg/day PO / IVq 8-12 hrs, Status 40 mg/kg st at 5 mg/kg/min

Spironolactone

T.25,50, 100 mg

2–3 mg/kg/day q 8-12 hrs

Hyperkalemia, gynaecomastia

SStreptomyci

INJ: 0.75g, 1g vials

15 mg/kg/day IM

8th Nerve damage & nephrotoxicity

Teicoplanin

INJ: 200, 400 mg vials

Loading dose: 10 mg/kg a 12 hrs for 3 doses followed by 6–10 mg/kg/day Neonates: Loading dose: 16
mg/kg on the 1st day, followed by 8 mg/kg/day

Pain, phlebitis at the site of injection

Terbutaline

T 2.5 mg, 5 mg Syp 1.5 mg/ 5ml

Palpitation, tremor

Oral – 0.05 – 0.1 mg/kg/doseS/C5 mcg/kg/dose(0.01 ml/kg/dose) IV 2-10 mcg/kg/hr

Theophylline

C.125,250 mg Syp:100 mg/5 ml

5 mg/kg/dose not to exceed 20 mg/kg/day apnea 6 mg/kg/day q 6-8h

Gl disturbances nausea, vomiting

Thiamine

100 mg, 100 mg/ml

10–50 mg/day IV/PO OD or BD

IV cardiovascular collapse

Thyroxine

T: 25 mcg, 50 mcg, 75 mcg,

Palpitation, Loss of weight

New born 10mcg/kg Child4-6 mcg/kg PO OD

100 mcg

Tigecycline

50 mg/vial

1.2 mg/kg IV q 12 hrs (max-50 mg 9 12 hrs)

nausea, vomiting, cholestasis, pancreatitis

Topiramate

T25 mg, 50 mg, 100 mg

2–10 mg/kg/dayq 8–12 hrs status-10 mg/kg/ Ataxia, anorexia, epistaxis day q 12 hrs x2 days then 5
mg/kg/dayq 12 hrs

Triclofos

SYP: 500 mg/5 ml

0.5 ml/kg/dose

Skin rash

Tramadol

T: 50 mg

1–2 mg/kg/dose q 4-6 hrs, max 400 mg/day Constipation, nausea

Tranexamic acid

INJ: 100 mg/mLT.500 mg

10 mg/kg I/V immediately before surgery then oral 10–25 mg/kg/dose q 8-12 hrs

Hypotension, Thrombo embolic complications

Urso deoxycholic acid

T.150 mg, 300 mg

Neonates 10–15 mg/kg/day PO Infants 30 mg/kg/day q 8-12 hrs

Dyspepsia, diarrhoea, biliary pain, headache

Vancomycin

INJ: 500 mg vial

45-60 mg/kg/day div into 3 or 4 IN infusion over 1 hrs NS or 5% Dextrose

Ototoxicity, Nephrotoxicity

Vasopressin

20U/mm

0.2U-0.3U/kg/dose in 2ml/kg Dx over 20 mins, 0.010 /kg/min IV infusion DI 2.5–100 im/sc 2–4 times
daily

Abd cramp, HR changes, water intoxication,

Vecuronium

10 mg/vial,20mg/vial

0.05-0.1 mg/kg may be rptd hrly

Myopathy, neuropathy

Verapamil

40 mg,80mg,

SR120,240

1–3 mg/kg/dose q 8-12 hrs PO

Cl in infants

Zidovudine

T300 mg,C150 mg Syp 50 mg/5mL NB 2 mg/kg/dose q 6 hrs PO IV 1.5 mg/kg/dose q 8 hrs

Anemia, thrombocytopenia
Zinc sulphate

20 mg/mL drops, 20 mg/ml syrp,

20 mg Tab

Diarrhea <6 mo-10 mg, >6 mo 20 mg x14 d acrodermatitis 6 mg/kg/day,def. 1mg/kg

Metallic taste, vomiting