UNIVERSITY OF LAGOS

University Road Lagos Mainland Akoka, Yaba, Lagos.

A REPORT ON

STUDENTS’ INDUSTRIAL WORK EXPERIENCE SCHEME

(SIWES)

DONE AT

EMZOR PHARMACEUTICAL INDUSTRIES LIMITED, LAGOS STATE, NIGERIA

WRITTEN BY

NWEDA EMMANUEL IKECHUKWU

190801533

SUBMITTED TO

DEPARTMENT OF BIOCHEMISTRY

FACULTY OF SCIENCE

IN PARTIAL FULFILMENT OF THE REQUIREMENT FOR THE AWARD OF

BACHELOR OF SCIENCE

IN BIOCHEMISTRY

ON

1
 13TH OF OCTOBER 2023.

CERTIFICATION
This is to certify that the Student Industrial Work Experience Scheme (SIWES) was carried out
by Nweda Emmanuel Ikechhukwu, with the matriculation number; 190801533 according to the
requirements of the Student's Industrial Work Experience Scheme (SIWES) at Emzor
Pharmaceutical Industries Limited.

------------------------- ------------------
Nweda Emmanuel Ikechukwu Date

-------------------------- ------------------
Dr R.A. Lawal Date
(Institution based supervisor)

2
 DEDICATION
This report is dedicated to my heavenly Father for his divine strength, health, and provision to
continue throughout the period of the Industrial Training and the will never to give up in life, and
also to my biological parents, for their prayers, love and support.

3
 REPORT OVERVIEW
This Report is a summary of all the work experience I have been able to gather during my
SIWES training program at EMZOR Pharmaceutical Industries Limited.
The pharmaceutical industry produces and markets drugs licensed for use as medications.
Pharmaceutical companies are allowed to deal in generic/brand medications and medical devices.
Products are formulated into various dosage forms e.g., syrups, suspensions, etc. The dosage
forms in which the medications would be administered determine the type of processing the raw
materials will undergo.
In this report, the various processes that raw materials undergo to produce the desired finished
products are outlined and properly defined from weighing of raw materials to compounding and
packaging. However, the operating conditions of the processes are determined by the
specifications for an individual drug.
In conclusion, this report also contains some of the tests that are carried out on drug samples by
the company to ensure that they are safe for the consumption and the procedures for the various
tests conducted on drug samples are shown.

4
Table of Contents
Certification 2
Dedication 3

Report overview 4
Table of Content 5-6

Chapter One- Introduction 6

1.1 Background of Study 7
1.2 Aim of the Students Industrial Work Experience Scheme 7

1.3 Description of Emzor Pharmaceutical Industries Limited 8

1.4 Location and brief history of Emzor Pharmaceutical Industries Limited 8
1.5 Organizational Chart of Emzor Pharmaceutical Industries Limited 9
1.6 Manufactured products and Indication/Use 9

Chapter Two 10
2.0 Departments/Units in the Organization and their Functions 10
2.0.1 Administration Department 10
2.0.2 Production Department 10
2.0.3 Quality Control Department 10
2.0.4 Quality Assurance Department 10
2.1 Quality Assurance/Quality Control in Pharmaceutical 11

5
2.2 Instrumentation/Equipment Utilized during SIWES 12
2.2.1 In-Process Laboratory Section 12
2.2.2 Chemistry Laboratory Section 13
2.2.3 Microbiology Laboratory Section 14

Chapter Three 16
3.0 Detailed work done, skills and knowledge acquired 16
3.1 Verification of raw materials weights 17
3.2 Line Clearance 17
3.3 Physiochemical analysis of finished products 17
3.4 Identification test of raw materials 17
3.5 Drug analysis (Assay) of raw materials 18
3.6 Preparation of some common reagents used in the Chemistry Lab 19

3.7 Finished product analysis 19

Chapter Four
4.0 Summary 20
4.1 Conclusion 21

4.2 Problems encountered during the program 21

6
CHAPTER ONE– INTRODUCTION

1.0 BACKGROUND OF STUDY

The student industrial work experience scheme (SIWES) is an approved skill training scheme
which forms part of the minimum academic standards in various degree scheme for all Nigerian
universities to acquire skills and experience in their various course of study. Student Industrial
Work Experience Scheme was established by the Industrial training Fund (ITF) in 1973 with the
aim of bridging the gap between the skills required by the labor market and those acquired by the
graduate students.
Since its introduction by the ITF in 1973 the Scheme has gone through series of reforms. Its
management, for instance, has changed hands from the ITF to the various regulatory agencies
such as; National Universities Commission (NUC), National board for Technical Education
(NBTE) and National Commission for College of Education (NCCE), and now back to the ITF
again. These are the major stakeholders in (SIWES). Consequently, SIWES Program was
introduced into the curriculum of tertiary institutions in the country as far back as 1974 with 748
students from 11 institutions of higher learning. However, the scheme has over the years
contributed immensely to the personal development and motivation of students to be able to
understand the important connection between the taught and learnt content of their academic
program and what knowledge and skill will be expected of them in professional practice after
graduation.
The Scheme was designed to expose students to the industrial environment and enable them
develop occupational experiences so that they can readily contribute their quota to national
economic and technological development after graduation.

7
Consequently, SIWES is a planned and structured program based on stated and specific career
objectives which are geared toward developing the occupational competencies of participants.

1.1 AIM OF THE STUDENTS INDUSTRIAL WORK EXPERIENCE SCHEME

This scheme was set out to bridge the gap between the theoretically trained students in tertiary
institutions and the practical application in the labor field. The student will be able to stand better
chance and advantage by acquiring practical skills to his or her theoretical knowledge than a
technical man. The scheme is also aimed at exposing students to work methods and techniques in
handling equipment and machinery that may not be in educational institutions and ensure the
proper training of the university students in preparing them for the world of industrial work.

1.4 DESCRIPTION OF EMZOR PHARMACEUTICAL INDUSTRIES LIMITED

Emzor Pharmaceutical Industries Limited is a private indigenous pharmaceutical manufacturing

group founded in 1984 by Dr. Stella C. Okoli in Lagos State, Nigeria. The Company
manufactures high quality pharmaceutical products and medical consumables.

1.5 LOCATION AND BRIEF HISTORY OF EMZOR PHARMACEUTICAL

INDUSTRIES LIMITED

Emzor Pharmaceutical Industries Limited is an Indigenous Pharmaceutical Industries owned by

Dr. Stella C. Okoli, she graduated from the University of Bradford as a Pharmacist, and obtained
a Master degree in Biopharmaceutical from the University of London, Chelsea College.

The Company is located at Plot 3C, Block A, Aswani Market Road, Oshodi/Osolo Expressway,
Lagos State, with three other branches. However, I worked with the branch at 10, Kolawole
Shonibare Street, Ajao Estate, Isolo Lagos State. The Company Started as a small pharmacy
retail shop “Emzor Chemist Limited” in January 1977 and became one of the leading

8
 pharmaceutical companies in Nigeria with over50 products since its incorporation in 1984 till
date.

1.6 ORGANIZATIONAL CHART OF EMZOR PHARMACEUTICAL INDUSTRIES

LIMITED

GROUP MANAGING DIRECTOR

QAM QCM SP TSM

As QAM PP (2)
ELECT ASTM MECH ASTM

PROD
SUP/OFFICERS
IPCO MICROBIOLOGIST ANALYST ELECT SUP/OFFICERS MECH SUP/OFFICERS

1.7 MANUFACTURED PRODUCTS AND INDICATION/USE

Emzor Pharmaceutical Industries Limited deals with the Production of Tablets, Capsule,
Suspension, and Syrup branded and generic and active ingredients.

9
Indications/Use OF SOME OF THE COMPANYS DRUGS
 Paracetamol Syrup (Paracetamol BP.125mg/5ml), Emcap Suspension (Paracetamol BP.
120mg/5ml), Emprofen Suspension (Ibuprofen BP. 100mg/5ml): used to relief pains,
feverish conditions, cold symptoms, toothache.
 Em-Vit.C (Ascorbic acid BP.100mg/5ml) is a nutritional supplement for good health and
also vital for the prevention and treatment of scurvy.
 Emzolyn Expectorant Syrup, Emzolyn Cough (Pediatrics) Syrup, Emzolyn 4 Way Syrup
they are known as Anti tussive(Cold Suppressants).

CHAPTER TWO
2.0 DEPARTMENTS/ UNITS IN THE ESTABLISHMENT AND THEIR FUNCTIONS
There are basically six departments in Emzor Pharmaceutical Industries Limited. Some of them
are briefly outlined below.

2.0.1Administrative Department: The department consists of Accounting, Audit, Sales and

marketing, and Human Resource.
(i) Account section is concerned with finances of the Organization.
(ii) Auditing examines the company financial records to check that they are correct.
(iii) Sales and Marketing deals with how the products produced gets to market.
(iv) Human Resource takes care of staff welfare in relation to the company’s policy.

2.0.2Production Department: This department is mostly known as active department of the

company because it’s responsibility in ensuring that products are always and readily available for
customer/consumer supply. Basically, they are responsible for the production and packaging of
drugs.
(i) Dispensary unit
(ii) Compounding/Fabrication unit
(iii) Filling/packaging unit
(v) Finished product warehouse:

2.0.3 Quality Control Department: This department is otherwise known as the heart of the
industry because it ensures the quality of materials used and the finished product sold out to
consumers for their consumption are up to the required standard. They are mostly concerned
with raw material, intermediate and finished product analysis in accordance with approved
specification. Quality Control is product oriented.
The quality control has the power and jurisdiction to approve or reject any component, after
adequate laboratory procedures.
The quality control department is divided into two units, they are;

10
(i) Chemistry Laboratory: This section/unit carries out series of test on different products,
they test for raw materials, finished drugs, running of assay of different drugs samples, etc.
This role is very vital for the effective functioning of the company in the area of quality and
standardization.
(ii) Microbiology Laboratory: This section caries out microbial control of production
environment, Microbial analysis of raw material, intermediate and finished products
(iii) Instrumentation room: A separate instrument room, so – called control room, is
preferred, otherwise serious corrosion may spoil the costly instrument, and electric supply to
the instruments is controlled by suitable voltage regulator and inverter.

2.0.4Quality Assurance Department: is a set of activities for ensuring quality in manufacturing

processes. In Emzor, Quality Assurance is subdivided into three units. It is process oriented.
(I) In-Process Control: is a sub-section where production/product in-progress is monitored.
Physical parameters such as pH, weight (wt./ml) etc. are carried out intermittently on products to
ensure uniformity. This unit also is responsible quality checks and assessment in the
manufacturing processes. It also ensures and enforces compliance to cGMP.
(ii) Documentation unit: this section takes care of the issuance of all BPRs, reference numbers,
and control of all sensitive documents, both of production and quality assurance.
(iv) Recovery unit: at the section, packaged products that were damaged due to handling
and storage before they are distributed are recovered.

2.1 QUALITY ASSURANCE AND CONTROL IN PHARMACEUTICAL UNIT

The term quality assurance and control are often used to refer to ways of ensuring the quality of a
service or products. For each analytical procedure, quality assurance and control is extremely
important. Quality assurance is process-oriented and it focuses on defect prevention while
quality control is product-oriented and focuses on defect identification.
However, the objectives of quality assurance and control program include:
 To document the procedures and methods of sample collections, preparations and
analysis.
 To provide assurance as to reliability of analysis using replicate samples and cross
laboratory checks.
 To provide assurance as to the accuracy from using recognized reference standards.
 To provide a chain of custody of samples.
 To provide assurance as to the precision and accuracy from the duplicate samples. Both
the quality assurance and control are after quality products and they function to see that
the products being produced are of high quality and standards by performing both
chemical and microbial tests to attest the potency of the products.

2.1.1 GOOD MANUFACTURING PRACTICES OF THE COMPANY (GMP)

Good Manufacturing Practice (GMP) aims primarily at diminishing the risk inherent in any
pharmaceutical production. Such risks include: cross contamination and mix-up caused by for
example, wrong labels being put on container.
GMP having evolved over time necessitated the need for the word ‘current’ to be added to it,
hence cGMP.

11
I will like to classify this in three forms:
(I) Personnel Hygiene
(II) Product handling/safety
(III) Operational System checking

2.1.3 LABORATORY SAFETY RULES OF EMZOR PHARMACEUTICAL

INDUSTRIES LIMITED
(i) Non laboratory staff is not allowed to touch any reagent or equipment in the laboratory.
(ii) Always put on your lab coat with cap and cover shoes while in the laboratory.
(iii) All laboratory staff must know how to use fire extinguisher.
(v) The entire storage containers must be labeled with name, concentration, dates and signature.
(vi)The entire unlabeled container should be discarded.
(v) No answering of phone calls in the laboratory.
(vi)Food or beverages are not to be stored or consumed in the laboratory.
(vii) All acids must be stored in a glass container.
(Viii) All materials not under use should be off the reagent desk.

2.2 INSTRUMENTATION/EQUIPMENT UTILIZED DURING SIWES

2.2.1 IN-PROCESS LABORATORY SECTION: This section deals mainly with the
physical parameters analysis on products at intervals during production to make sure that they
correspond to the company product specification. The Equipment used includes:

 pH Meter: A pH meter measures essentially the electro-chemical potential between a

known liquid inside the glass electrode and the unknown liquid outside.

Analytical Weighing Balance: This equipment used in weighing samples (in Kg, g or mg) such
as raw material or product.

UV-VIS Spectrophotometer: UV-visible spectrophotometer is one of the most frequently

employed equipment in pharmaceutical analysis. It involves measuring the amount of
ultraviolet or visible radiation absorbed by a substance in solution. The law that governs the
quantitative spectrophotometric analysis is the Beer-Lambert law which states that ‘the
quantity of light absorbed by a substance dissolved in a nonabsorbent solvent is directly

12
 proportional to the concentration of the substance and the wavelength of the light through the
solution”. This law is accurate for dilute solutions.

2.2.2 CHEMISTRY LABORATORY SECTION: This is a subsection of the Quality Control

Department where chemical analysis of both raw and finished pharmaceutical product is carried
out. Some of the Equipment’s used include:

 Electrical Distiller: This is used in distillation of water for analytical purpose. Distiller
functions using boiling, evaporation and condensation techniques. The water obtained is referred
to as distilled water. Distiller

 Analytical Weighing Balance: This equipment used in weighing samples (in gram or
mg) such as raw material or drugs and can also be used to determine average weight of drugs.

13
  pH Meter: A pH meter measures essentially the electro-chemical potential between a
known liquid inside the glass electrode and the unknown liquid outside.

 Moisture Analyzer: This equipment is used to determine the percentage moisture

content/weight loss on drying (L.O.D) of granules.

 Desiccator: A desiccator is a compartment used to store sample in order to keep them
away from moisture. It is made up of glass and has an air tight glass cover. A desiccator contains
an active desiccant which is responsible for keeping moisture away from samples put into it. The

desiccant in the desiccator requires periodic activation and this is done by heating
in the oven at 130 degrees Celsius for about 24 hours.

2.2.3 MICROBIOLOGY LABORATORY SECTION: This is Subsection of the Quality

Control Department where microbial analysis of clean in place sample, raw materials and
finished products are carried out. Some of the equipment used includes:

 Microscope: It an essential Instrument used in the Microbiology laboratory. It is used to

view the Microbial world.

14
  Autoclave: It is a pressurized device used to heat aqueous solutions above their boiling
point at normal atmospheric pressure to achieve sterilization. It is used to remove micro-
organisms (virus, bacteria, fungus etc.) and spores using high pressure and temperature. It is also
known as Wet Sterilization. It is used to sterilize contaminated materials.

 Refrigerator: It is used to preserve Microbiological media such as Stocks, Cultures and

Reference Organisms.

 Oven: It is also referred to as Laboratory Furnace. It is used to sterilize test-tubes, petri-

dishes and so on. It is also known as dry sterilization. It is also used for drying and heating.

 Colony counter: It is used to estimate a liquid culture's density of micro-organism by

counting individual colonies on a petri-dish, agar plate.

15
CHAPTER THREE
3.0 DETAILED/ACTUAL WORKDONE, SKILLS AND KNOWLEDGE ACQUIRED
The In-Process Laboratory, Chemistry Laboratory and Microbiology Laboratory
 In-Process Laboratory: All Pharmaceutical Units need an In-Process Laboratory for
evaluation of Production/Products in-progress is monitored. Various test such as analysis of
water, pH, weight/ml of Intermediate and Finished Products are carried out. These tests are
carried out on Syrups and Suspensions.

 Chemistry Laboratory: All Pharmaceutical Units need a Chemical Laboratory for

evaluation of raw material and finished products. A chemical laboratory can undertake majority
of the tests for raw material test like solubility, identification’s reaction, assay, moisture content,
pH, etc. Also, analysis of finished product and reagent preparation. These products are analyzed
to know if they are safe for human consumption. The kinds of test(s) to be carried out on syrup
and suspension. The following are the tests carried out on sample materials and Drugs:
(i) Identifications test (Qualitative analysis)
(ii) Assay analysis (Quantitative analysis)
(iii) Dissolution test Analysis

 Microbiology Laboratory: All pharmaceutical units need a microbiology laboratory for

evaluation of raw materials, intermediate and finished products. A microbiology laboratory
majorly in testing if there are microbes in the products, raw materials and clean-in-place (rinse
water sample).

3.1 VERIFICATION OF RAW MATERIAL WEIGHTS: The essence of verifying raw

material weights is to know if the weight of the raw material corresponds to the weight on the
worksheet before production/compounding takes place. This is done by In-Process personnel.

3.2 LINE CLEARANCE: This process is done by In-Process Personnel. The essence is to
make sure the filling and packaging lines are free from all previous products before a new

16
product and any substance that can likely be threat to the quality of the product. The environment
must be clean and temperature must be within specification.
The shippers, packets, caps are checked properly before packaging. The coding on the shippers
and packets must include batch number, manufacturing date, and expiring date.

3.3 PHYSIOCHEMICAL ANALYSIS OF FINISHED PRODUCTS

This test is also known as determination of physical parameters of a sample.
Under this test, the description of the physical properties of the sample (such as taste, flavor,
color, pH, appearance, and uniformity of weight etc.) is determined. This test is carried out on
syrups, and suspensions.
Regulatory agencies perform this test on drugs to know if such drug complies with the
acceptable standards of the British Pharmacopeia (B. P) or United States Pharmacopeia (U.S. P).
The test is also performed on drugs that are produced in order to check if the new batch still
complies with the U.S.P/B. P standards as the previous batch. If the drug fails the physical
parameters analysis, it means there is something wrong with the physical property(s) of the
product, depending on which parameter it fails.
The pH of the Products is determined using pH meter and the wt./ml is determined using the
analytical weighing balance.

3.4 IDENTIFICATION TEST OF RAW MATERIALS

These tests are carried out on samples to know whether the compounds used in manufacturing
the products as claimed by the manufacturers are present or not and also to know if the product
contains any harmful/impurities compound.
Analysis of raw materials is done on raw materials before they can be approved for production; it
has to undergo some chemical analysis both qualitatively and quantitatively. These analyses test
for its identity, potency, solubility etc. Examples of chemical analysis on certain raw material
include;
 Paracetamol Powder (C8H9NO2)
Aim: To ensure that the product is in accordance to the specifications given.
Action: Pain reliever (Analgesic)
Physiochemical properties: Paracetamol is a white crystalline powder.
Solubility Test: Paracetamol powder was dissolved in water, methylene chloride and 96%
ethanol.
Observation: It was sparingly soluble in water, very slightly soluble in methylene chloride and
freely soluble in 96% ethanol.

 Sodium Benzoate (C6H5NaO2)

17
Action: Microbial Preservative, used to preserve the product from microbes.
Physiochemical properties: Sodium Benzoate is a white crystalline powder.
Solubility Test: Sodium Benzoate was dissolved into water, 96% ethanol.
Observation: It dissolves completely in water and sparing soluble in 96% ethanol.
 Sodium Bicarbonate (NaHCO3)
Action and use: Antacid, used in treatment of electrolyte deficiency.
Physiochemical properties: A white crystalline powder. Solubility: Sodium Bicarbonate was
dissolved in water and 96% ethanol.
Observation: Soluble in water and practically insoluble in ethanol, when heated in the dry state
or in solution, it gradually changes into sodium carbonate.

3.5 DRUG ANALYSIS (ASSAY)OF RAW MATERIALS

The essence of this analysis is to qualify and quantify the presence of a given compound in a
supplied raw material. The Raw Materials used for the production of Some Emzor drugs
includes: Ascorbic acid, Diphenhydramine hydrochloride, Acetaminophen (paracetamol powder)
and so on.
 Ascorbic acid (C6H8O6)
Action: It is used in the treatment of vitamin C deficiency
Physiochemical properties: A white crystalline powder with an acidic taste.
Solubility: freely soluble in water, soluble in alcohol, practically insoluble in ether and in
light petroleum. Acidity: 5% solution has a pH of 3.0 to 3.5
Stability: Darkens slowly on exposure to air, moisture and light. Stored in a non-metallic
container
Assay:
- Reagent: 1M H2SO4, 0.05M Iodine solution, Starch solution, CO2 free water.
- Apparatus: titration set up, beaker, funnel, conical flask
- Procedure: 0.150g of ascorbic acid was weighed into a conical flask, 10ml of 1M
dilute H2SO4 was added then50ml of CO2 free water was also added. 1ml of starch
(indicator) was added. The solution was titrated against 0.05M iodine solution until a
persistent violet blue color was obtained.
- Equation and Calculation: Titre value was recorded
- %Assay=Titre Value X Equivalent Weight X 100 Weight of Ascorbic Acid

3.6 PREPARATION OF SOME COMMON REAGENTS USED IN CHEMISTRY

LABORATORY
The commonly used reagents in the laboratory include:
 Preparation of 0.1M NaOH used to analyze Paracetamol Syrup and Paracetamol drops.
Procedure: 8g of NaOH pellet was measured into 250ml beaker and was dissolved with
distilled water.

18
 The solution was transferred into 2000ml Volumetric Flask Distilled water was added to
make up the Solution.
Shake the solution carefully not to spill out any before transferring to the reagent bottle.

 Preparation of Emzolyn Mobile Phase used to Analyze Emzolyn Cough Syrup.

Procedure:500ml of distilled water was filtered and transferred into 1000ml volumetric
flask,
500ml of Acetonitrite was and transferred into the volumetric flask containing 500ml of
distilled water
5ml of triethylamine was added to the solution using pipette. The pH of the Solution was
adjusted to 6.5 Using Acetic acid before transferring the solution to the reagent bottle
with the name written boldly on it.

3.7 FINISHED PRODUCTS ANALYSIS

This test is carried out on drug sample in order to determine the weight per ml of the drug sample
(suspension and syrups), To determine if the amount of the active Ingredient complies with the
acceptable standards of the British Pharmacopeia (B. P) or United States Pharmacopeia (U.S. P).
The test is also performed on drugs that are produced in order to check if the new batch still
complies with the U.S.P/B. P standards as the previous batch. Check the S.O.P(standard of
procedure) for the method of analysis of the particular active ingredient being worked on.
- Prepare the solution of the drug sample following the method of analysis stated in the
S.O.P (which should contain the molar absorptive, or molarities of reagent in
titrimetric.)
- Find the weight taken by using the formula Weight taken = Average weight (mg) ×
equivalent weight (mg)× 100 Claim weight (mg)
- Calculate the dilution factor using the formula Dilution factor = a/100 × b/c ×
d/e......... Where a= First volume makes up b = Second volume make up c = No. of
mistaken from first volume make up d = No. of mistaken from second volume make
up e = Third volume make up
- Shake or sonicate the final solution if stated in the S.O.P.

FOR INSTRUMENTAL METHOD: Proceed to the UV-Visible Spectrophotometer. Blank

machine with the solvent used to prepare the solution of the sample. Then take at least 3
absorbance of the prepared solution of the drug sample. Then calculate the %Assay: %Assay =
Absorbance of sample × 100 Absorbance of standard.
FOR TITRIMETRIC METHOD: The method employed in volumetric analysis, in this method a
solution from graduated vessel (burette) is added to a known volume of a second solution until
chemical reaction between the two is just completed. This is shown by color change known as
end point or in an indicator. Then calculate the % Assay; %Assay = Titre value × eq. wt. × factor
× 100 Weight taken.

19
These are the list of finished products analyzed: Paracetamol Syrup, Paracetamol Drops, Em-
Vit.c Syrup, Em-Vit.c Drops, Zolat Suspension, Emzolyn Expectorant, Emzolyn Paed Cough
Syrup, Emtrim Suspension, Emgyl Suspension, Em-Vite Syrup, Em-Vite Drops and so on.

 Assay of Em-vite Syrup: (Active Ingredient is Ascorbic Acid) Titrimetric Method

Aim: To determine the amount of Ascorbic Acid in Em-vite Syrup
Material/Equipment: Em-vite Syrup, 250ml conical flask, titration set-up, 50ml measuring
cylinder,1ml graduated pipette, starch solution, 0.05M Iodine solution, 1M H2SO4, distilled
water.
Procedure:
Sample Preparation:
- 6.5g of Em-vite Syrup was weighed into 250ml Conical flask
- 30ml of distilled water was added to it
- 25ml of 1M H2SO4(Sulphuric Acid) was added to the solution.
- Titrate with 0.05M Iodine Solution to a dark brown color using 1ml of Starch solution as
Indicator added towards the end point.

Calculation:
Quantity of Active in Sample Weighed = Quantity Weighed / wt./ml × 50 / 5
% Assay = Titre value × Equivalent weight × Factor of Iodine / Quantity of active in sample
weighed × 100
Note: Equivalent weight = 1ml of 0.05M Iodine Solution is equivalent to 8.806g of Ascorbic
Acid.

CHAPTER FOUR

4.0 SUMMARY

Having gone through the necessary training involved in student industrial work experience
scheme (SIWES) with the experience gained for three months; it is highly expedient for me to
summarize my report on the platform of what I engaged in during this period. More so, I want to
recall that during my industrial attachment at Emzor Pharmaceutical Industries Limited, I was
exposed to series of tests and assays carried out on both raw materials and finished products
which has made me to appreciate the world of science and technology.

4.1 CONCLUSION

My Student Industrial Work Experience Scheme (SIWES) training with EMZOR Pharmaceutical
Industries Limited has provided an avenue for me to understand practical aspects of the
theoretical knowledge already acquired in some of the courses I have offered so far as an
undergraduate of Biochemistry Department through the necessary verification tests carried out
on raw materials, water and drugs to ensure that they are up to the expected standard for human
use.
SIWES has made me acquainted to the work environment.

20
 (i) I was exposed to handle various laboratory instruments / equipment with or with no
Supervision.
(ii) Ability to safe guard the work environment in industries even unfavorable ones
(iii) Ability to survive multi-tasking conditions.
The Training has given me an opportunity to understand some of the basic principles of
chemistry which will further enhance my knowledge of the course. This training also gave me
the opportunity to interact, share knowledge and ideas with other students from different
institutions. The industrial training program was successful and it gave me the opportunity to
understand some of the principles of biochemistry, in other to make me a productive member of
the society and boosted myself esteem to face future challenges that may arise.

4.3 PROBLEMS ENCOUNTERED DURING THE PROGRAM

Some of the problems I encountered before and during the course of my SIWES attachment
include:
(i) Inability to secure a place of attachment resulting in my nine weeks rather than twelve
weeks of training.

21