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10/4/2023

Anatomy of The Nervous


System

By: DR.Ndukui James G, Ph.D.


For: BSc. Nursing

The Nervous System


“The right half of the brain controls the left
half of the body. This means that only left
handed people are in their right mind.”

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Objectives
• Name the major divisions of the nervous system, both anatomical and
functional
• Describe the functional and structural differences between gray matter and
white matter structures
• Name the parts of the multipolar neuron in order of polarity
• List the types of glial cells and assign each to the proper division of the
nervous system, along with their function(s)
• Categorize the major neurotransmitters by chemical type and effect
• Identify the anatomical and functional divisions of the nervous system
• List the basic functions of the nervous system
• Describe the basic structure of a neuron
• Identify the different types of neurons on the basis of polarity
• List the glial cells of the CNS and describe their function
• Name the major regions of the adult nervous system
• Locate regions of the cerebral cortex on the basis of anatomical landmarks
common to all human brains

• Describe the regions of the spinal cord in cross-section


• List the cranial nerves in order of anatomical location and provide the central and
peripheral connections
• List the spinal nerves by vertebral region and by which nerve plexus each supplies
the glial cells of the PNS and describe their function
• Describe the components of the somatic nervous system
• Name the modalities and sub-modalities of the sensory systems
• Distinguish between general and special senses
• Describe regions of the central nervous system that contribute to somatic functions
• Explain the stimulus-response motor pathway
• Describe the components of the autonomic nervous system
• Differentiate between the structures of the sympathetic and parasympathetic divisions
in the autonomic nervous system
• Name the components of a visceral reflex specific to the autonomic division to
which it belongs
• Predict the response of a target effector to autonomic input on the basis of the
released signaling molecule
• Describe how the central nervous system coordinates and contributes to autonomic
functions
• Describe the major sections of a neurological exam!

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Functions of the Nervous System


1. Sensory input – gathering information
 To monitor changes occurring inside and
outside the body (changes = stimuli)
2. Integration –
 to process and interpret sensory input
and decide if action is needed.
3. Motor output
 A response to integrated stimuli
 The response activates muscles or glands
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The Nervous System


• What Two Organ Systems Control
All the Other Organ Systems?
– Nervous system characteristics
• Rapid response
• Brief duration
– Endocrine system characteristics
• Slower response
• Long duration

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Structural Classification of the


Nervous System

 Central nervous system (CNS)


 Brain
 Spinal cord
 Peripheral nervous system (PNS)
 Nerve outside the brain and spinal cord

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Functional Classification of the


Peripheral Nervous System
 Sensory (afferent) division
 Nerve fibers that carry information to the
central nervous system

Figure 7.1
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Functional Classification of the


Peripheral Nervous System
 Motor (efferent) division
 Nerve fibers that carry impulses away from
the central nervous system

Figure 7.1
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Functional Classification of the


Peripheral Nervous System
 Motor (efferent) division
 Two subdivisions
 Somatic nervous system = voluntary
 Autonomic nervous system = involuntary

Figure 7.1
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Organization of the Nervous


System

Figure 7.2

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Nervous Tissue: Support Cells


(Neuroglia or Glia)
 Astrocytes
 Abundant, star-shaped cells
 Brace neurons
 Form barrier
between capillaries
and neurons
 Control the chemical
environment of
the brain (CNS)
Figure 7.3a

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Nervous Tissue: Support Cells


 Microglia (CNS)
 Spider-like phagocytes
 Dispose of debris
 Ependymal cells
(CNS)
 Line cavities of the
brain and spinal cord
 Circulate
cerebrospinal
fluid
Figure 7.3b, c
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Nervous Tissue: Support Cells

 Oligodendrocytes
(CNS)
 Produce myelin
sheath around
nerve fibers in the
central nervous
system Figure 7.3d

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Neuroglia vs. Neurons


• Neuroglia divide.
• Neurons do not.
• Most brain tumors are “gliomas.”
• Most brain tumors involve the neuroglia
cells, not the neurons.
• Consider the role of cell division in cancer!

Support Cells of the PNS


 Satellite cells
 Protect neuron cell bodies
 Schwann cells
 Form myelin sheath in the peripheral
nervous system

Figure 7.3e

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Nervous Tissue: Neurons

 Neurons = nerve cells


 Cells specialized to transmit messages
 Major regions of neurons
 Cell body – nucleus and metabolic center
of the cell
 Processes – fibers that extend from the
cell body (dendrites and axons)

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Neuron Anatomy

 Cell body
 Nucleus
 Large
nucleolus

Figure 7.4a

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Neuron Anatomy
 Extensions
outside the cell
body
 Dendrites –
conduct
impulses toward
the cell body
 Axons – conduct
impulses away
from the cell
body (only 1!)
Figure 7.4a

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Axons and Nerve Impulses

 Axons end in axonal terminals


 Axonal terminals contain vesicles with
neurotransmitters
 Axonal terminals are separated from the
next neuron by a gap
 Synaptic cleft – gap between adjacent
neurons
 Synapse – junction between nerves
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Nerve Fiber Coverings

 Schwann cells –
produce myelin
sheaths in jelly-roll
like fashion
 Nodes of Ranvier –
gaps in myelin
sheath along the
axon
Figure 7.5

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Application
• In Multiple Scleroses the myelin sheath is
destroyed.
• The myelin sheath hardens to a tissue called
the scleroses.
• This is considered an autoimmune disease.
• Why does MS appear to affect the muscles?

Neuron Cell Body Location

 Most are found in the central nervous


system
 Gray matter – cell bodies and unmylenated
fibers
 Nuclei – clusters of cell bodies within the
white matter of the central nervous system
 Ganglia – collections of cell bodies
outside the central nervous system
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Functional Classification of
Neurons
 Sensory (afferent) neurons
 Carry impulses from the sensory receptors
 Cutaneous sense organs
 Proprioceptors – detect stretch or tension
 Motor (efferent) neurons
 Carry impulses from the central nervous
system
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide
7.14a

Functional Classification of
Neurons

 Interneurons (association neurons)


 Found in neural pathways in the central
nervous system
 Connect sensory and motor neurons

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7.14b

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Neuron Classification

Figure 7.6

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Structural Classification of Neurons


 Multipolar neurons – many extensions
from the cell body

Figure 7.8a

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7.16a

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Structural Classification of Neurons


 Bipolar neurons – one axon and one
dendrite

Figure 7.8b

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7.16b

Structural Classification of Neurons

 Unipolar neurons – have a short single


process leaving the cell body

Figure 7.8c

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7.16c

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How Neurons Function


(Physiology)
 Irritability – ability to respond to stimuli
 Conductivity – ability to transmit an
impulse
 The plasma membrane at rest is
polarized
 Fewer positive ions are inside the cell than
outside the cell

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Starting a Nerve Impulse

 Depolarization – a
stimulus depolarizes the
neuron’s membrane
 A deploarized
membrane allows
sodium (Na+) to flow
inside the membrane
 The exchange of ions
initiates an action
potential in the neuron
Figure 7.9a–c
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The Action Potential


 If the action potential (nerve impulse)
starts, it is propagated over the entire
axon
 Potassium ions rush out of the neuron
after sodium ions rush in, which
repolarizes the membrane
 The sodium-potassium pump restores
the original configuration
 This action requires ATP
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Nerve Impulse Propagation

 The impulse
continues to move
toward the cell body
 Impulses travel
faster when fibers
have a myelin
sheath
Figure 7.9c–e

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Continuation of the Nerve Impulse


between Neurons
 Impulses are able to cross the synapse
to another nerve
 Neurotransmitter is released from a nerve’s
axon terminal
 The dendrite of the next neuron has
receptors that are stimulated by the
neurotransmitter
 An action potential is started in the dendrite
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How Neurons Communicate at


Synapses

Figure 7.10
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The Reflex Arc


 Reflex – rapid, predictable, and
involuntary responses to stimuli
 Reflex arc – direct route from a sensory
neuron, to an interneuron, to an effector

Figure 7.11a

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Simple Reflex Arc

Figure 7.11b, c

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Types of Reflexes and Regulation


 Autonomic reflexes
Smooth muscle regulation
Heart and blood pressure regulation
Regulation of glands
Digestive system regulation
 Somatic reflexes
Activation of skeletal muscles
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 7.25

Central Nervous System (CNS)

 CNS develops from the embryonic


neural tube
 The neural tube becomes the brain and
spinal cord
 The opening of the neural tube becomes
the ventricles
 Four chambers within the brain
 Filled with cerebrospinal fluid
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Regions of the Brain

 Cerebral
hemispheres
 Diencephalon
 Brain stem
 Cerebellum Figure 7.12

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Cerebral Hemispheres (Cerebrum)

 Paired (left
and right)
superior parts
of the brain
 Include more
than half of
the brain
mass
Figure 7.13a

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7.28a

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Cerebral Hemispheres (Cerebrum)

 The surface
is made of
ridges (gyri)
and grooves
(sulci)

Figure 7.13a

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7.28b

Lobes of the Cerebrum

 Fissures (deep grooves) divide the


cerebrum into lobes
 Surface lobes of the cerebrum
 Frontal lobe
 Parietal lobe
 Occipital lobe
 Temporal lobe
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7.29a

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Lobes of the Cerebrum

Figure 7.15a

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7.29b

Specialized Areas of the Cerebrum

 Somatic sensory area – receives


impulses from the body’s sensory
receptors
 Primary motor area – sends impulses to
skeletal muscles
 Broca’s area – involved in our ability to
speak

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Sensory and Motor Areas of the


Cerebral Cortex

Figure 7.14

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Specialized Area of the Cerebrum

 Cerebral areas involved in special


senses
 Gustatory area (taste)
 Visual area
 Auditory area
 Olfactory area

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7.32a

Specialized Area of the Cerebrum

 Interpretation areas of the cerebrum


 Speech/language region
 Language comprehension region
 General interpretation area

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7.32b

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Specialized Area of the Cerebrum

Figure 7.13c

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7.32c

Layers of the Cerebrum

 Gray matter
 Outer layer
 Composed
mostly of neuron
cell bodies

Figure 7.13a

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7.33a

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Layers of the Cerebrum

 White matter
 Fiber tracts
inside the gray
matter
 Example:
corpus callosum
connects
hemispheres
Figure 7.13a

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7.33b

Layers of the Cerebrum


 Basal nuclei – internal
islands of gray matter
 Regulates voluntary
motor activities by
modifying info sent to
the motor cortex
 Problems = ie unable
to control muscles,
spastic, jerky
 Involved in
Huntington’s and
Parkinson’s Disease
Figure 7.13a

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7.33c

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Diencephalon

 Sits on top of the brain stem


 Enclosed by the cerebral heispheres
 Made of three parts
 Thalamus
 Hypothalamus
 Epithalamus

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7.34a

Diencephalon

Figure 7.15

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7.34b

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Thalamus

 Surrounds the third ventricle


 The relay station for sensory impulses
 Transfers impulses to the correct part of
the cortex for localization and
interpretation

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Hypothalamus

 Under the thalamus


 Important autonomic nervous system
center
 Helps regulate body temperature
 Controls water balance
 Regulates metabolism

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7.36a

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Hypothalamus

 An important part of the limbic system


(emotions)
 The pituitary gland is attached to the
hypothalamus

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7.36b

Epithalamus

 Forms the roof of the third ventricle


 Houses the pineal body (an endocrine
gland)
 Includes the choroid plexus – forms
cerebrospinal fluid

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Brain Stem

 Attaches to the spinal cord


 Parts of the brain stem
 Midbrain
 Pons
 Medulla oblongata

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7.38a

Brain Stem

Figure 7.15a

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7.38b

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Midbrain

 Mostly composed of tracts of nerve


fibers
 Reflex centers for vision and hearing
 Cerebral aquaduct – 3rd-4th ventricles

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Pons

 The bulging center part of the brain


stem
 Mostly composed of fiber tracts
 Includes nuclei involved in the control of
breathing

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Medulla Oblongata
 The lowest part of the brain stem
 Merges into the spinal cord
 Includes important fiber tracts
 Contains important control centers
 Heart rate control
 Blood pressure regulation
 Breathing
 Swallowing
 Vomiting
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Cerebellum

 Two hemispheres with convoluted


surfaces
 Provides involuntary coordination of
body movements

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7.43a

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Cerebellum

Figure 7.15a

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7.43b

Protection of the Central Nervous


System
 Scalp and skin
 Skull and vertebral column
 Meninges

Figure 7.16a

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7.44a

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Protection of the Central Nervous


System
 Cerebrospinal fluid
 Blood brain barrier

Figure 7.16a

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7.44b

Meninges

 Dura mater
 Double-layered external covering
 Periosteum – attached to surface of the
skull
 Meningeal layer – outer covering of the
brain
Folds inward in several areas

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7.45a

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Meninges

 Arachnoid layer
 Middle layer
 Web-like
 Pia mater
 Internal layer
 Clings to the surface of the brain

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7.45b

Cerebrospinal Fluid

 Similar to blood plasma composition


 Formed by the choroid plexus
 Forms a watery cushion to protect the
brain
 Circulated in arachnoid space,
ventricles, and central canal of the
spinal cord

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Ventricles and Location of the


Cerebrospinal Fluid

Figure 7.17a

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7.47a

Ventricles and Location of the


Cerebrospinal Fluid

Figure 7.17b

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7.47b

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Blood Brain Barrier


 Includes the least permeable capillaries
of the body
 Excludes many potentially harmful
substances
 Useless against some substances
 Fats and fat soluble molecules
 Respiratory gases
 Alcohol
 Nicotine
 Anesthesia
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Traumatic Brain Injuries


 Concussion
 Slight brain injury
 No permanent brain damage
 Contusion
 Nervous tissue destruction occurs
 Nervous tissue does not regenerate
 Cerebral edema
 Swelling from the inflammatory response
 May compress and kill brain tissue
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Cerebrovascular Accident (CVA)

 Commonly called a stroke


 The result of a ruptured blood vessel
supplying a region of the brain
 Brain tissue supplied with oxygen from
that blood source dies
 Loss of some functions or death may
result

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Spinal Cord
 Extends from the
medulla oblongata to
the region of T12
 Below T12 is the cauda
equina (a collection of
spinal nerves)
 Enlargements occur in
the cervical and lumbar
regions
Figure 7.18

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Alzheimer’s Disease
 Progressive degenerative brain disease
 Mostly seen in the elderly, but may
begin in middle age
 Structural changes in the brain include
abnormal protein deposits and twisted
fibers within neurons
 Victims experience memory loss,
irritability, confusion and ultimately,
hallucinations and death
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Spinal Cord Anatomy


 Exterior white mater – conduction tracts

Figure 7.19

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7.53a

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Spinal Cord Anatomy


 Internal gray matter - mostly cell bodies
 Dorsal (posterior) horns
 Anterior (ventral) horns

Figure 7.19

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7.53b

Spinal Cord Anatomy


 Central canal filled with cerebrospinal
fluid

Figure 7.19

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7.53c

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Spinal Cord Anatomy

 Meninges cover the spinal cord


 Nerves leave at the level of each
vertebrae
 Dorsal root
 Associated with the dorsal root ganglia –
collections of cell bodies outside the central
nervous system
Ventral root

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Peripheral Nervous System

 Nerves and ganglia outside the central


nervous system
 Nerve = bundle of neuron fibers
 Neuron fibers are bundled by
connective tissue

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The Peripheral Nervous System


• What are the Twelve Pairs Of
Cranial Nerves?
– Olfactory (CN I)
• Sense of smell
– Optic (CN II)
• Sense of vision
– Oculomotor (CN III)
• Eye movement

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BRIEF summary of the 12 cranial nerves


Number Sensory,
(Roman Name of nerve Motor, or Type of information
numeral) Both?
1 (I)
2 (II)
3 (III)
4 (IV)
5 (V)
6 (VI)
7 (VII)
8 (VIII)
9 (IX)
10 (X)
11 (XI)
12 (XII)

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Cranial nerve mnemonic #1:nerve names


Number Saying Nerve Name
1 Oh
2 Oh
3 Oh --
4 To
5 Touch
6 And
7 Feel
8 Very
9 Good
10 Velvet --
11 Ah,
12 Heaven!

Cranial nerve mnemonic #2: sensory, motor, or both?

Number Saying Sensory, Motor, Both?


1 Some
2 Say
3 “Money
4 Matters”
5 But
6 My
7 Brother
8 Says
9 “Big
10 Brains
11 Matter
12 More!”

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Cranial Nerve Mnemonic #3: functions


http://www.noteflight.com/scores/view/7dc90d51c8730d5c36f51d18aa774fbf5b844ac9
Nerves correspond to notes 1 (lowest) to 12 (highest). Nerves 7 & 9 are grouped together; so are nerves 3, 4, & 6.

Processing sensory info


• Recall earlier slides about synapses between
neurons, tracts connecting parts of the brain
with each other, cranial nerves coming into
and out of the brain….

• Examples of the brain processing sensory


info:
– Responding to bright light
– Localizing sounds in space

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Processing sensory info: responding to bright light


• Background info on the eye (10th Martini, Figures 17-5 & 17-6)

Processing of sensory info: responding to bright light

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Processing sensory info: localizing sounds in space


• Background info on the ear (10th Martini, Figure 17-21)

Processing sensory info: localizing sounds in space

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The Peripheral Nervous System


• What are the Cranial Nerves? (continued)
– Trochlear (CN IV)
• Eye movement
– Trigeminal (CN V)
• Eye, jaws sensation/movement
– Abducens (CN VI)
• Eye movement
– Facial (CN VII)
• Face, scalp, tongue sensation/movement
– Vestibulocochlear (CN VIII)
• Hearing, balance

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The Peripheral Nervous System


• What are the Cranial Nerves? (continued)
– Glossopharyngeal (CN IX)
• Taste, swallowing
– Vagus (CN X)
• Autonomic control of viscera
– Accessory (CN XI)
• Swallowing, pectoral girdle movement
– Hypoglossal (CN XII)
• Tongue movement

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The Peripheral Nervous System


• The Cranial Nerves

Figure 8-25(a)

The Peripheral Nervous System


• The Cranial Nerves

Figure 8-25(b)

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The Peripheral Nervous System


•Key Note
•The 12 pairs of cranial nerves are responsible
for the special senses of smell, sight, and
hearing/balance, and control movement of the
eye, jaw, face, tongue, and muscles of the
neck, back, and shoulders. They also provide
sensation from the face, neck, and upper chest
and autonomic innervation to thoracic and
abdominopelvic organs.

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The Peripheral Nervous System


• Nerve Plexus—A complex, interwoven
network of nerves

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The Peripheral Nervous System


•Peripheral
Nerves and
Nerve Plexuses

Figure 8-26

The Peripheral Nervous System


• Reflex—An automatic involuntary motor
response to a specific stimulus

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Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

REFLEX
Receptor ARC
Stimulus

Effector Ventral
root Information
processing
in CNS
Response Activation of a
by effector motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)

Figure 8-27
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Arrival of
stimulus and
activation of
receptor

Stimulus

Figure 8-27
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Dorsal
Arrival of Activation of a root
stimulus and sensory neuron
activation of
receptor

Receptor
Stimulus

KEY
Sensory neuron
(stimulated)

Figure 8-27
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Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

Receptor
Stimulus

Information
processing
in CNS

KEY
Sensory neuron
(stimulated)
Excitatory
interneuron

Figure 8-27
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Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

REFLEX
Receptor ARC
Stimulus

Ventral
root Information
processing
in CNS
Activation of a
motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)

Figure 8-27
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Dorsal Sensation
Arrival of Activation of a root relayed to
stimulus and sensory neuron the brain by
activation of collateral
receptor

REFLEX
Receptor ARC
Stimulus

Effector Ventral
root Information
processing
in CNS
Response Activation of a
by effector motor neuron
KEY
Sensory neuron
(stimulated)
Excitatory
interneuron
Motor neuron
(stimulated)

Figure 8-27
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Stretching of muscle tendon


stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch

Spinal
cord
REFLEX
ARC

Contraction

Activation of motor
neuron produces reflex
muscle contraction
Figure 8-29
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Stretching of muscle tendon


stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch

Spinal
cord

Figure 8-29
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Stretching of muscle tendon


stimulates muscle spindles
Muscle spindle
(stretch receptor)
Stretch

Spinal
cord
REFLEX
ARC

Contraction

Activation of motor
neuron produces reflex
muscle contraction
Figure 8-29
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The Peripheral Nervous System


• The Flexor Reflex, a Type of Withdrawal
Reflex

Figure 8-30

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The Peripheral Nervous System


•Key Note
•Reflexes are rapid, automatic responses to
stimuli that “buy time” for the planning and
execution of more complex responses that are
often consciously directed.

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The Peripheral Nervous System


•The Posterior Column
Pathway

Figure 8-31

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The Peripheral Nervous System


•The Corticospinal
Pathway

Figure 8-32

The Peripheral Nervous System

Table 8-4

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Structure of a Nerve

 Endoneurium
surrounds each fiber
 Groups of fibers are
bound into fascicles
by perineurium
 Fascicles are bound
together by
epineurium
Figure 7.20
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Classification of Nerves

 Mixed nerves – both sensory and motor


fibers
 Afferent (sensory) nerves – carry
impulses toward the CNS
 Efferent (motor) nerves – carry impulses
away from the CNS

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Spinal Nerves

 There is a pair of spinal nerves at the


level of each vertebrae for a total of 31
pairs

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Spinal Nerves

Figure 7.22a
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Autonomic Nervous System

 The involuntary branch of the nervous


system
 Consists of only motor nerves
 Divided into two divisions
 Sympathetic division
 Parasympathetic division

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Comparison of Somatic and


Autonomic Nervous Systems

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The Autonomic Nervous System


• What Is The Autonomic Nervous
System?
• Branch of nervous system that
coordinates cardiovascular, digestive,
excretory, and reproductive functions

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The Autonomic Nervous System


• What are the Two Divisions of the ANS?
– Sympathetic division
• “Fight or flight” system
– Parasympathetic division
• “Rest and digest” system

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The Autonomic Nervous System


•Key Note
•The two divisions of the ANS operate
largely without our awareness. The
sympathetic division increases alertness,
metabolic rate, and muscular abilities; the
parasympathetic division reduces metabolic
rate and promotes visceral activities such as
digestion.

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The Autonomic Nervous System


•The Somatic and
Autonomic Nervous
Systems

Figure 8-33(a)

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The Autonomic Nervous System


•The Somatic and
Autonomic Nervous
Systems

PLAY The Organization of


the Somatic and
Autonomic Nervous
System Figure 8-33(b)

The Autonomic Nervous System


• The Sympathetic Division

Figure 8-34

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The Autonomic Nervous System


• What are the Effects of Sympathetic
Activation?
– Generalized response in crises
– Increased alertness
– Feeling of euphoria and energy
– Increased cardiovascular activity
– Increased respiratory activity
– Increased muscle tone

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The Autonomic Nervous System


• The Parasympathetic Division

Figure 8-35

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The Autonomic Nervous System


• What are the Effects of Parasympathetic
Activation?
– Relaxation
– Food processing
– Energy absorption
– Brief effects at specific sites

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Aging and the Nervous System


• What are Age-Related Changes?
– Reduction in brain size and weight
– Loss of neurons
– Decreased brain blood flow
– Changes in synaptic organization of the brain

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Anatomy of the Autonomic Nervous


System

Figure 7.25

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Autonomic Functioning

 Sympathetic – “fight-or-flight”
 Response to unusual stimulus
 Takes over to increase activities
 Remember as the “E” division = exercise,
excitement, emergency, and
embarrassment

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7.74a

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Autonomic Functioning

 Parasympathetic – housekeeping
activites
 Conserves energy
 Maintains daily necessary body functions
 Remember as the “D” division - digestion,
defecation, and diuresis

Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide


7.74b

Development Aspects of the


Nervous System

 The nervous system is formed during


the first month of embryonic
development
 Any maternal infection can have
extremely harmful effects
 The hypothalamus is one of the last
areas of the brain to develop
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Development Aspects of the


Nervous System

 No more neurons are formed after birth,


but growth and maturation continues for
several years (new evidence!)
 The brain reaches maximum weight as
a young adult
 However, we can always grow
dendrites!
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69

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