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  • Alfa Blockers Illustration Atf

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    There are two types of alpha blockers: selective and nonselective. Selective alpha blockers like terazosin, doxazosin, and praxosin selectively block alpha-1 receptors. Nonselective alpha blockers like phentolamine and phenoxybenzamine block both alpha-1 and alpha-2 receptors. Selective alpha blockers are reversible inhibitors while phenoxybenzamine is an irreversible inhibitor. These drugs work by competitively inhibiting alpha receptors in smooth muscle cells to reduce blood pressure and relax smooth muscle.

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    Alfa blockers Illustration atf

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    There are two types of alpha blockers: selective and nonselective. Selective alpha blockers like terazosin, doxazosin, and praxosin selectively block alpha-1 receptors. Nonselective alpha blockers like phentolamine and phenoxybenzamine block both alpha-1 and alpha-2 receptors. Selective alpha blockers are reversible inhibitors while phenoxybenzamine is an irreversible inhibitor. These drugs work by competitively inhibiting alpha receptors in smooth muscle cells to reduce blood pressure and relax smooth muscle.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    5 views1 page

    Alfa Blockers Illustration Atf

    Uploaded by

    pnsscsny29
    There are two types of alpha blockers: selective and nonselective. Selective alpha blockers like terazosin, doxazosin, and praxosin selectively block alpha-1 receptors. Nonselective alpha blockers like phentolamine and phenoxybenzamine block both alpha-1 and alpha-2 receptors. Selective alpha blockers are reversible inhibitors while phenoxybenzamine is an irreversible inhibitor. These drugs work by competitively inhibiting alpha receptors in smooth muscle cells to reduce blood pressure and relax smooth muscle.

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    © All Rights Reserved
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    of 1

    Selective ( ) Blockers

    ✗
    Nonselective ( + ) blockers L La

    Mechanism of action Terazosin


    d
    MTM
    -R
    Irreversible Inhibitor MEJÍA Epi
    Ne
    Phenoxybenzamine
    (Allosteric Inh.) S/E’S
    Doxazosin Reversible Inhibitor Phentolamine
    Smooth muscle cell
    Ammán.
    .

    (Active site-I)
    Praxosin -R

    .nJaa
    ame?Ear h a%aEaM
    Phentolamine •

    :- R Eyaculatory
    Tamsulosin response
    }
    ° . Vas deferens
    Smooth muscle relaxation
    Afterload BP

    -÷÷
    Epi ✗ - Blocker "
    Ne Epi Effector ***ÉA Phentolamine
    EEEEE;ái:*.µ
    + +

    |
    Enzyme C - Blocker -R Phenoxybenzamine
    "
    Ne y

    wiii - R
    }
    -

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    -

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    ^
    G Retrograde
    • •
    a
    a

    Calmodulin P. Edema Pre-synaptic -R


    DAG IP C
    ++

    ATP Eyaculation
    Vasodilation GTP GDP Flushing neuron
    Vasoconstriction
    3
    Ne
    I. Fluid Relaxation of I.U.S. "

    Pago

    |
    cATP Near skin surface Vasodilation Pupil contriction
    Smooth muscle PK CAM-Kinase Bv Capillary
    Afterload T.P.R. Permeability *U. Frequency* Ap
    Muscle SNS Aortic sinus Miosis Post-synaptic Ap
    T.P.R. relax Contraction ' MLCK "
    MLCK Carotid sinus Cataract surgery U. Incontinence <

    neuron
    '
    Ap
    BP i
    P H:O BP (Hotn) ;
    .
    v

    HR Fluid leakage
    PP P P N Ne
    P (Reflex tach)
    Smooth muscle cell Iris prolapse
    Aldosterone P. Edema Interstitial fluid
    trough corneal : "

    ¥!
    jqr-E-j.ir
    A.T- II
    .

    U. Flow Incision
    Epi / Ne Urine Renin himno
    Reflex Tachycardia

    Tres 14*1 Internal uretaral sphincter


    ' ✗ - Blocker Relax I.U.S.
    •
    Intraoperative floppy Iris Syndrome

    .IE?EoLaÉ÷EÉkYB•
    .?' Epi / Ne
    (Semen)
    Ejaculate Érase JG

    iEa ariE rf@E.zE


    a. Cells Hr AV conduction
    I.U.S. contract Urine retention
    Prostatic Prostatic
    fluid muscle
    contraction

    Indications Contraindications
    Cheese
    Vasodilation Tamsulosin MAO-I + Tyramine

    :*
    Epi

    " ""⇐← U. Retention Wine Tamsucosin


    " Calculi in ureter Ne -

    T.P.R. ""

    .EE:1
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    µ
    Trazar1rem al
    Bp H Bp
    BP

    9←üEoa .ai→t#i.-%aar. aaaa..i


    Smooth muscle Hipertensive crisis
    A
    Mes
    Relax I.U.S. .
    . relax (>180/120) ^
    Pheocromocytoma

    :üµmaa•→Ez→¥
    →IÉ☒§g§ .fi?IFKE%aaaIaaL-y!÷EÜrBIawa•
    U. outflow :
    , Dilate Phenoxybenzamine
    Phentolamine
    ↳ 4K
    Relieve U. Retention ureter BB
    Hypertension Epi
    lumen Best 00 L -R
    * 2ND Line Anti-HTN Br
    z Ne

    Phentolamine
    O
    Phenoxybenzamine
    I.F.I.S. Urinary Incontinence

    Alpha blockers | mechanism of action, indications,


    adverse reactions, contraindications
    a
    *
    IÍúiq
    ?⃝

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