Mechanism of action Indications ADRS

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Factor II (Thrombin) Factor X inhibitors

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Inhibitors

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Argatroban Rivaroxaban Petechiae
Gingival bleeding Ant. Epistaxis Purpura
(IV)
Bivalirudin Apixaban (PO) Ee Lakhan
.

Bivalirudin
Argotraban
Can’t take Heparin Acute P. Embolim
Dabigatran (po) Edoxaban P. C . C. A . T. III
c/s X
Argatroban Hematemesis II VII IX
,

Bivalirudin ah
Dabigatran NN

(II - I)
Idarucizumab
a

Acute DUT (Antidote)

Argatroban
un Prophylaxis
DUT / PE
µ
Fe Anemia
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Dabigatran CBC
X (II - I)
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VII Bivalirudin Rivaroxaban FOBT Factor X - I " "

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VII
v.

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I I
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I Apixaban
0044 Hematochezia Y Andexanet Alfa
(Antidote)

÷
Prothrombin Thrombin Melena
(II) (II )
a Hematuria Vaginal Bleeding
Edoxaban
PF
V
a

Factor
X X CVA
Contraindications
X -I Fibrinogen Fibrin
VIII Prosthectic Valve X -I

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IX IX a

XIII XIII
Renal infarct II - Inhibitors
a

MI
/
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GRAMANET
XI a
XI Bivalirudin
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Fibrin Mesh Used when PC’s can’t take •

EÜÜ D
Argatroban Heparin (HIT)

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Dabigatran
XII a
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Non-Valvular Uncontrollable Recent ischemic CVA

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AFIB Bleeding
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Splenic infarct
1 Rate control °

X - inhibitors "Costly" a. aaaa

BP
Nstemi

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2 Rhythm control
(Cardiovert) Stemi "Mesenteric
XII Ischemia" Rivaroxaban
: A. Dissection
. .

A. Aneurysm
"Ischemic colitis" Apixaban Used in place of Warfarin
3 Argatroban
A
Bivalirudin
Doxaban Drug interacting
a. • µ

Rivaroxaban
Apixaban Monitor PT / INR Constantly
asi .
Long time to kick on

"Limb gangrene"
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Direct-acting oral anticoagulants (DOACs) | Mechanism of
action, indications, adverse reactions, contraindications *
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