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Question N1 When the entire CBC is suppressed due to either anemia, infection, or hem
orrhage is called?

Answer: Pancytopenia

Point: 0.5

Question N2 An increased production of RBCs in the bone marrow is seen in the periphe
ral smear as?

Answer: increased reticulocyte count

Point: 0.5

Question N3 Erythropoietin-a glycoprotein secreted by the kidneys that stimulates the p

roduction of red blood cells.

Answer: 1

Point: 0.5

Question N4 101. A 55 years old woman comes to your office complaining about increas
ed menstrual flow, days of her period became more and amount of lost blood increased.
Taking medical history you discover that she has such kind of complains almost a year,
but nowadays she gets tired very easily and almost fainted prior Saturday. She works int
o office, has sedentary lifestyle, almost no physical activity, has two grown up children. I
n her anamnesis she remembers some kind of “benign” medications received during
pregnancy, cannot recall names. She had no serious medical problems in the past. Physi
cal exam reveals little pallor of the face and increased heart rate. 1. What is the diagnosi
s? 2. What tests would you make? 3. What tests would reveal? 4. Treatment (common as
pects)

Answer:

1- The diagnosis : iron deficiency anemia, caused by high blood loss during menstruatio
n.

2 -What test would you make : CBC , peripheral blood smear , serum ferritin level , seru
m iron .

3- What test would reveal :

CBC ; low hemoglobin concentration

peripheral blood smear; microcytic hypochromic

serum ferritin level; low

serum iron; low

4- treatment : supplementation ( PO, IM , IV )

NOTE: IM ( 5ML/100MG) . IV (during 10 days )

Point: 5.00

Question N5 In Polycythemia Vera, the Hgb, Hct, and RBC count and red cell mass are?

Answer: elevated

Point: 0.5

Question N6 The term "shift to the left" refers to?

Answer: immature cell forms in the peripheral blood

Point: 0.5

Question N7 The predominant symptoms of anemia are based on the severity of the dis
ease rather than thespecific etiology.

Answer: 1

Point: 0.5

Question N8 Iron-deficiency anemia is anemia with diminished red blood cell productio
n and an MCV <80characterized by hypochromic cells and low levels of stored iron in the
body.

Answer: 1

Point: 0.5

Question N9 Inducing a remission means a removal of over 99.9% of the leukemic cells i
n the body and theelimination of peripheral blasts in circulation.

Answer: 1

Point: 0.5

Question N10 The most common symptoms of chronic myelogenous leukemia are fatig
ue, night sweats, andlow-grade fever.

Answer: 1
Point: 0.5

Question N11 During acute leukemia most common presentation results from the effect
s of the leukemia blastcells crowding out the normal marrow cells, resulting in symptom
s of pancytopenia even if the totalwhite blood cell count is normal.

Answer: 1

Point: 0.5

Question N12 Platelets-smallest cells in the blood, formed in the red bone marrow; min f
unction is to assist inthe clotting of blood from a wound for healing.

Answer: 1

Point: 0.5

Question N13 Write down five main compositions of CBC

Answer:

11- Hemoglobin concentration.

22- Erythrocytes number.

33- Leukocytes number.

44- Hematocrit.

55- MCV .

Point: 2.00

Question N14 Allergic reactions are frequently associated with an increase in the presen
ce of ?

Answer: Eosinophils

Point: 0.5

Question N15 Which single feature of normal RBC's is most responsible for limiting their
life span?

Answer: Increased flexibility of the cell membrane

Point: 0.5

Question N16 During aplastic anemia patients most commonly present with bleeding fr
om thethrombocytopenia
Answer: 1

Point: 0.5

Question N17 Platelets-smallest cells in the blood, formed in the red bone marrow; min f
unction is to assist inthe clotting of blood from a wound for healing.

Answer: 1

Point: 0.5

Question N18 Injured blood vessel releases ADP, which attracts platelets (PLT)

Answer: 1

Point: 0.5

Question N19 Calcium ions Are required for promotion and acceleration of almost all blo
od clotting reactions

Answer: 1

Point: 0.5

Question N20 Increased production of platelets is caused by autoimmune disease.

Answer: 1

Point: 0.5

Question N21 Hemophilia A (lack of F VIII) and B (lack of F IX) are transmitted genetically
and affect onlyfemales.

Answer: 1

Point: 0.5

Question N22 The expected range for clotting time is 4-10 mins.

Answer: 1

Point: 0.5

Question N23 Write down five main compositions of CBC.

Answer:

1- Hemoglobin concentration

2- Erythrocytes number

3- Leukocytes number
4- Hematocrit

5- MCV

Point: 2.00

Question N24 The term "shift to the left" refers to?

Answer: immature cell forms in the peripheral blood

Point: 0.5

Question N25 The best source of active bone marrow from a 20-year old would be:

Answer: Iliac Crest (hip)

Point: 0.5

Question N26 Write down three main causes of Iron-deficiency anemia

Answer:

The three main causes of iron deficiency anemia are :

11- Menstrual blood loss.

22- Pregnancy.

33- Gastrointestinal blood loss.

There also sub-reasons such as vit B12 and folic acid deficiency.

Point: 2.00
Question N27 Vitamin B12 and folic acid have simillar adverse effects, but what separete
s one from theother?:

Answer: No neurological symptoms in folic acid

Point: 0.5

Question N28 What is the main function of neutrophils?

Answer:

The primary function of neutrophils is phagocytosis (the ingestion and destruction of mi

croorganisms).

immune defense.
Point: 2.00
Question N29 The Hodgkin's disease patient described in the question above undergoes
a lymph nodebiopsy fordefinitive diagnosis. If the diagnosis of Hodgkin's disease were c
orrect, which of the followingcellswould the pathologist expect to find?

Answer: Reed-Sternberg cells.

Point: 0.5

Question N30 The polypeptide chains of hemoglobin A are composed of:

Answer: 2 alpha, 2 beta

Point: 0.5

Question N31 Write down three main causes of Iron-deficiency anemia

Answer:

The three main causes of iron deficiency anemia are :

11 -Menstrual blood loss.

22- Pregnancy.

33- Gastrointestinal blood loss.

There are also sub-reasons such as vit B12 and folic acid deficiency.

Point: 2.00
Question N32 What is the lifespan of Red blood cells (RBC).

Answer: 120 Days

Point: 0.5

Question N33 NHL can start anywhere in the body there is lymph tissue.

Answer: 1

Point: 0.5

Question N34 Myeloid Stem cells: Generate myeloid cells:

Answer: Granulocytes

Point: 0.5

Question N35 Myeloid Stem cells: Generate myeloid cells:

Answer: Granulocytes

Point: 0.5

Question N36 Lymphoid Stem cells generate:

Answer: Lymphocytes: T type mainly

Point: 0.5

Question N37 Leikemia is infection of the red blood cells:

Answer: 0

Point: 0.5

Question N38 GM-CSF IS :

Answer: this is a growth factor and regulates vascular dysfunction.

Point: 0.5

Question N39 GM-CSF IS :

Answer: this is a growth factor and regulates vascular dysfunction.

Point: 0.5

Question N40 GM-CSF IS :

Answer: this is a growth factor and regulates vascular dysfunction.

Point: 0.5

Question N41 GM-CSF IS :

Answer: this is a growth factor and regulates vascular dysfunction.

Point: 0.5

Question N42 GM-CSF IS :

Answer: this is a growth factor and regulates vascular dysfunction.

Point: 0.5

Question N43 How many types of iron you now in the body?

Answer: heme iron,non-heme iron.

Point: 0.5

Question N44 an acute infection would show up in a blood count as Leukocytosis:

Answer: 1
Point: 0.5

Question N45 Treatment Of iron deficiency

Answer: Intravenous iron products transfused.

Point: 0.5

Question N46 Fecal occult blood Test (FOBT) which looks for blood in stool samples

Answer: 1

Point: 0.5

Question N47 How is serum epo (erythropoietin)-level in diagnosed polycythemia vera?

Answer: Decreased

Point: 0.5

Question N48 A 55-year-old male has a myocardial infarction requiring admission to the
hospital. He is being treatedwith an anticoagulant. The healthcare provider would be m
ost concerned about which of thefollowing:

Answer: .Nausea

Point: 0.5

Question N49 The process by which platelets and plasma proteins react to convert fibrin
ogen into fibrin:

Answer: Coagulation .

Point: 0.5

Question N50 Platelets undergo changes when there is a break in the endothelial lining
of the blood vessels:

Answer: Platelet factors

Point: 0.5

Question N51 3 prognostic factors in ALL 1.age (<30 better)2. blast count (>30 worse)3. c
ytogenetics - hyperdiploidy is good, t(9;22) is bad

Answer: 1

Point: 0.5

Question N52 Lymphoid Stem cells generate:

Answer: Lymphocytes: T type mainly

Point: 0.5

Question N53 Hydroxyurea increase hemoglobin production and decrease reticulocyte c

ells:

Answer: 1

Point: 0.5

Question N54 What is the fourth system in hemostasis:

Answer: Fibrinolysis

Point: 0.5

Question N55 Which of the following is an example of a macrocytic anemia?

Answer: Pure red cell aplasia

Point: 0.5

Question N56 1.Compression and Vasoconstriction 2. Formation of a platelet plug 3. Blo

od Coagulation 4. Clotretraction and thrombus dissolution are the steps involved in he
mostasis?

Answer: 1

Point: 0.5