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Medi Call FCPS – 1 | AUG 2023 PAPERS

and incomplete closure of pubic svmphsis.Most likely


condition is - ID : 2296

Ⓐ Bladder exstrophy

Gynae 23 Aug 2023 (M) Ⓑ Incomplete cephalocaudal folding


Ⓒ Incomplete lateral folding
Ⓓ Failed reinforcement of the cloacal membrane by underlying
mesenchyme
1. Which is true about bile ? - ID : 340
Ⓐ Bladder exstrophy (also known as ectopia vesicae) is a
Ⓐ Bound to glycine and taurine congenital anomaly that exists along the spectrum of the
Ⓑ Unconjugated Ⓒ Not contain cholesterol exstrophy-epispadias complex
Ⓓ Recirculated from large intestine
8. 40 yr lady presented with features of
Ⓐ Liver ➜ Cholesterol is ( Bile precursor ) converted to cholic acid hypothyroidism.On examination swelling was noted
infront of neck. Endrocrinologist advised FNAC which
or chenodeoxycholic acid ➜ These acids in turn combine with ➜
showed increase lymphocytes.Likely cause would be - ID :
mainly Glycine and to a lesser extent with Taurine ➜ form Bile 2804
Acids ➜ salts of these acids then secreted in the bile
✦ Guyton, Pg. 829 Ⓐ Thyroid lymphoma Ⓑ Follicular adenoma
Ⓒ Hashimoto thyroiditis
2. The process of apoptosis is loss during the carcinogenic
activity. Which of the following is a tumour supressor gene Ⓒ ✪ Hashimoto’s thyroiditis ☛ combination type 2 and type 4
and Antiapoptotic factor ? - ID : 370
hypersensitivity reaction
Ⓐ Ras Ⓑ Bcl2 ◉ Type 2 ☛ Anti-TSH receptor antibodies are formed that inhibit
Ⓒ ABL Ⓓ AFP thyroid hormone release
◉ Type 4 ☛ CD8+ Cytotoxic T lymphocytes attack epithelial cells
Ⓑ Bcl-2 keeps the mitochondrial membrane of Thyroid ➜ Hypothyroidism
impermeable ➜ preventing cytochrome C release ➜ ↓ ✦ Harsh Mohan, Pg. 805
activation the caspase family of proteases ( primary trigger leading
9. Fetal Hb has which characteristics - ID : 4045
to the onset of apoptosis ) ➜ ↓ Appoptosis
Bcl-2 normally☛ Antiapoptotic , But become proapoptotic when Ⓐ 2 Alpha and 2 gamma chains
cell become mutated whose DNA can not be repaired Ⓑ 2 Alpha and 2 beta chains
✦ First Aid, Pg. 208,224, 208,224, 208,224 ✦ Robbins, Pg. 47 ✦ Pathoma, Pg. 27 Ⓒ 2 Beta and 2 gamma chains
Ⓓ 2 Beta and 2 delta chains
3. GH is related to Somatomedin. Which of the following
releases this peptide involved in bone growth? - ID : 725
Ⓐ ✪ Fetal ( HbF ) ☛ 2 Alpha+ 2 Gamma chains.
Ⓐ Liver Ⓑ Brain ✪ Adult ( HbA1 ) ☛ 2 Alpha + 2 Beta chains.
Ⓒ Kidney Ⓓ Lungs ✪ Adult ( HbA2 ) ☛ 2 Alpha + 2 delta chains.
✪ Sickle ( HbS ) ☛ 2 Alpha + Reduced Beta chains ( mutant HbA
Ⓐ Somatomedins ( secreted by liver in response to GH ) ☛
).
have potent effect of increasing all aspects of bone growth. ✦ First Aid, Pg. 404, 422
✦ Guyton, Pg. 944
10. In Normocytic, normochromic anemia , MCV would
4. HSV is associated with which of the following condition? remain normal in which one of the following - ID : 4049
- ID : 787
Ⓐ Acute blood loss after 2 days
Ⓐ CA cervix Ⓑ CA vulva
Ⓑ Resection of terminal ileum
Ⓒ Vaginal wart Ⓓ Vulval papules
Ⓒ Gastrectomy
Ⓓ Women in pregnancy not taking multivitamins
Ⓓ ✪ HSV-2 ☛ Tender vesicular papules and necrotizing lesions of
cervix vagina and vulva.
Ⓐ Normocytic, normochromic ☛ MCV, MCH and MCHC normal
✪ HPV ☛ CA cervix, CA vulva, Vaginal wart.
✦ Harsh Mohan, Pg. 177
➜ e.g. after acute blood loss, haemolytic anaemias, bone marrow
failure.
5. Resistance to tension is the main function of? - ID : 1482 ✦ Harsh Mohan, Pg. 271

Ⓐ Collagen type1 Ⓑ Collagen type2 11. Halothane is given as a general anesthetic and poor
Ⓒ Collagen type3 Ⓓ Collagen type7 analgesia. Which of the following drugs can be used in
combination to maximize the effect of halothane? - ID :
Ⓐ ◉ Type I collagen provide Resistance to tension being thick 4089

fibers, stiff and having strong high tensile strength Ⓐ Thiopentone. Ⓑ Nitric oxide.
✦ Goljan, Pg. 61, 60
Ⓒ Enfluran. Ⓓ Ketamine
6. Which is most likely to cause mutation of proto
oncogens - ID : 1643 Ⓑ Nitric acid ☛ analgesic properties ➜ combined with halothane (
analgesia may not be adequate if used alone ).
Ⓐ Chemicals Ⓑ Viruses
Ⓒ Ionizing radiations Ⓓ None of above 12. If a Female breast feeds her child what would happen
due to continuous suckling - ID : 4716
Ⓒ Ionizing Radiation☛ Cause point mutation of proto-oncogene-
Ⓐ Failure of primordial follicle to mature
> Drive carcinogenesis
Ⓑ Decreased prolactin Ⓒ Increase dopamine
✦ Robbins, Pg. 231, 201
Ⓓ Increase primordial cell maturation
7. Mother brought her Baby with complaints of some red
structure coming out above pubic svmphasis and Ⓐ Nervous signals from breasts to hypothalamus ➜ ↓ secretion of
frequently getting wet Examination reveal epispadiasis GnRH ➜ ↓ FSH ➜ Failure of primordial follicle to mature.

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✦ Guyton, Pg. 1068


Ⓐ ✪ Insulin ☛ shuttles glucose (carbohydrates), amino acids and
13. Lung function that cannot be measured by spirometry fats into cells.
and prevent lung from collapsing? - ID : 4997 ✪ Excess carbohydrates are stored as glycogen in liver
and muscles.
Ⓐ Residual volume Ⓑ ERV
✪ Remaining excess carbohydrates are converted into fats
Ⓒ Vital capacity Ⓓ Tidal Volume
and stored in adipose tissue.
Ⓔ IRV
✪ Insulin promotes amino acid uptake by cells and converts these
Ⓐ Spirometer records the volume movement of air into amino acids into protein.
✦ Guyton, Pg. 988, 983
and out of the lungs like VC,TV, IRV, ERV
Any volume that includes RV ( FRC, RV, TLC ) ➜ cannot be 20. Progress to grade 4 hepatic encaphelopathy is caused
measured with a spirometer because air in residual volume by - ID : 8620
of lungs cannot be expired
Ⓐ Alcohol Ⓑ Uremia
✦ Guyton, Pg. 503
Ⓒ Paracetamole Ⓓ Diuretics
14. In a tumor involving ligamentum arteriosum which is
most likely damaged - ID : 5320 Ⓓ Grade 4 Hepatic encaphelopathy is caused by
Ⓐ Right recurrent laryngeal nerve Paracetamol while progress to grade 4 is caused by
Ⓑ Left recurrent laryngeal nerve Diuretics.
Ⓒ Right phrenic nerve Ⓓ Left phrenic nerve
21. Vitamins used in synthesis of acetyI e Co-enzyme A -
Ⓑ Left recurrent laryngeal nerve (After splitting from the left ID : 8871

vagus) hooks around lower border of ligamentum arteriosum so in Ⓐ Riboflavin Ⓑ Thiamine


its tumor RLN will be involved Ⓒ Cobalamin
✦ SNELL, Pg. 98
Ⓓ Pantothenic acid (vit b5)
15. Muscle that arises from lumbar region and passes
through pelvis - ID : 5507 Ⓓ ✪ Animals require pantothenic acid in order to synthesize
coenzyme-A (CoA) which is used for the synthesis of fatty acids
Ⓐ Iliacus Ⓑ Psoas ✦ Harper's, Pg. 482
Ⓒ Lattismus dorsi Ⓓ Pyramidalis
22. Which of the following steroid synthesis step reduce
Ⓑ Psoas ☛ arises from lumbar region and extends through pelvis prostate hypertrophy and responsible for decrease in
to femur. prostrate size? - ID : 8993
✦ SNELL, Pg. 136
Ⓐ Contains testosterone 17,20 hydrolase deficiency
16. Genital tubercle in females gives rise to - ID : 6455 Ⓑ Increase cholesterol desmolase
Ⓒ Inhibition of 5 alpha-reductase
Ⓐ Labia majora Ⓑ Labia minora
Ⓓ All of these
Ⓒ Clitoris Ⓓ Vestibular glands
Ⓒ 5d-reductase inhibitor drug finasteride inhibits the conversion of
Ⓒ Genital tubercle ☛ develops around week 4 ➜ by week 9
testosterone to DHT which causes prostatic enlargement leading
becomes either clitoris or penis. to BPH.
✦ First Aid, Pg. 623

23. Best method to check bone density is - ID : 9346


17. True Regarding fibrinogen is - ID : 6639
Ⓐ CT scan spine Ⓑ MRI spine
Ⓐ Effects ESR
Ⓒ Calcium Level Ⓓ Dexa scan of spine
Ⓑ Decreases in liver disease
Ⓒ Takes part in clot formation
Ⓓ Bone density measurement ☛ Dual energy X-ray
Ⓓ Increase in DIC
absorptiometry (DEXA) scan, and it can be performed with devices
Ⓒ ✪ Fibrinogen is converted to fibrin to form secondary platelets that measure bone density in the hip and spine, or smaller
plug peripheral devices to measure bone density in the wrist, heel, or
✦ Robbins, Pg. 77 finger
✦ CMDT, Pg. 1166
18. Which among the following muscles have dual nerve
supply from median and ulnar nerve: - ID : 6973 24. A resident has done 2 successful Adrenalectomies. The
head of surgery doesn't let him do Adrenalectomy on this
Ⓐ Flexor digitorum profundus patient because he implies it might be difficult for him to
Ⓑ Palmaris longus Ⓒ Adductor pollicis perform surgery on right adrenal. What relation of right
Ⓓ Abductor pollicis adrenal makes it difficult ? - ID : 10806

Ⓐ Posterior relation to lower rib


Ⓐ Flexor digitorum profundus➜ ●medial part☛ant. interosious
Ⓑ Right renal artery Ⓒ IVC
nerve(median nerve) ●lateral part☛ulnar nerve Ⓓ Aorta
Palmaris longus➜ median nerve
Adductor pollicis➜ deep branch of ulnar nerve Ⓒ Due to the adrenal glands' anatomic location in the upper
Abductor pollicis➜ recurrent branch of median nerve retroperitoneum, extensive dissection of surrounding structures is
✦ KLM, Pg. 749 sometimes needed. The right adrenal gland in particular is also
19. Hormone that stores carbohydrates, lipids and partially retrocaval. It is drained by a short vein into the inferior
proteins in cells is also known as hormone of abundance: - vena cava posterolaterally. This can be avulsed easily and can be
ID : 8315 difficult to control. The left adrenal gland, on the other hand, has a
longer vein that drains into the left renal vein. ( Ref : KLM + NCBI
Ⓐ Insulin Ⓑ Cortisol
USA )
Ⓒ Thyroid Hormone Ⓓ Estrogen
25. Anterolateral system has - ID : 12251

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Medi Call FCPS – 1 | AUG 2023 PAPERS

Ⓐ Rubrospinal Ⓑ Spinobulbar 32. A patient came in emergency with diplopia, occipital


Ⓒ Reticular Ⓓ Spinothalamic tracts headache describe it as "Worst headache" and
deteriorating counscious level. Examination reveals neck
Ⓓ Components of Anterolateral system: stiffness. CT scan shows brain hemorrhage. CSF is blood
✪ Spinal cord ☛ Anterior spinothalamic and lateral spinothalamic stained. What is the diagnosis? - ID : 15278
tracts. Ⓐ Subdural hematoma Ⓑ Arachnoid hematoma
✪ Brain stem ☛ Reticular nuclei of brain stem. Ⓒ Spinal hematoma Ⓓ Subarachnoid haemorrhage
✪ Thalamus ☛ Reticular nuclei of brain stem.
✦ Guyton, Pg. 617, 617 Ⓓ Subarachnoid hemorrhage ☛ Bleeding due to trauma, or
26. A patient having fallopian tube ligation ligature slipped rupture of an aneurysm (such as a saccular aneurys or
result in bleeding and patient become hemodynamically arteriovenous malformation. Rapid time course. Patients complain
unstable bleeding result from which of these: - ID : 12822 of “worst headache of my life.” Bloody or yellow (xanthochromic)
lumbar puncture.
Ⓐ Branches of uterine artery ✦ First Aid, Pg. 513
Ⓑ Ovarian artery Ⓒ Vasical artery
33. The epinephrine causes vasoconstriction through
Ⓓ External iliac artery
which receptors? - ID : 15490
Ⓐ Uterine artery plays essential role unilateral hysterectomy, tubal Ⓐ B2 receptors Ⓑ M2 receptors
ligation Ⓒ V1 receptors Ⓓ Alpha 1 adrenergic
Ⓔ Alpha 2 adrenergic
27. Iron in body is stored as: - ID : 12974

Ⓐ Hemosiderin Ⓑ Transferrin Ⓓ Epinephrine ( In High concentration ) acts on an alpha 1-


Ⓒ Ferritin Ⓓ All of the above receptor on the vessel walls and results in Vasoconstriction and
raised blood pressure. The α1-adrenoceptors are the predominant
Ⓒ Storage of iron ☛ principally as ferritin mainly α-receptor located on vascular smooth muscle . In Low
in reticuloendothelial system and liver parenchymal cells. concentrations it has more affinity with Beta receptors on vessels
✦ Guyton, Pg. 450
and cause Vasodilation. ( Ref : Guyton + Wiki + NCBI )
28. Blood supply of heart depends upon: - ID : 12976 34. A 50 years Female patient is undergoing chemotherapy
Ⓐ Co2 levels Ⓑ Oxygen requirement due to CA breast. She is now presented with mouth sores
Ⓒ Hormones Ⓓ Neurotransmitters and white color membrane on oral mucosa. Causative
Organism in this patient would be - ID : 15510
Ⓑ ↑ Workload ➜ ↑ O2 demand ➜ local metabolites (adenosine) Ⓐ Herpes Ⓑ Staph aureus
dilates vessels ➜ ↑ coronary blood flow (fivefold during exercise) Ⓒ HPV Ⓓ Candida
✦ Oxford, Pg.

29. T test used to compare - ID : 13994 Ⓓ Candida albicans is the most common cause of ulcers in the
mouth is immunocompromised patients. Ulcers are typically white
Ⓐ Mean of Two categories Ⓑ Two propotional colored. Nystatin oral drops are the drop of choice for the ulcers
Ⓒ Shows relation between 4 pairs
Ⓓ Shows relation between odd numbers 35. Most common location of receptors for IgE is: - ID :
15517

Ⓐ T test is always related to two groups(remember t for 2) and it Ⓐ Eosinophils Ⓑ Plasma cells
will involves means of two groups like comparing of blood pressure Ⓒ Mast Cells Ⓓ Basophils
of men and women whereas chi-square will check differences
between two or more percentages or proportions.not mean Ⓒ Mast Cells > Basophils
values.e.g percentage of members of 3 different ethnic groups ✦ Harsh Mohan, Pg. 142

who have essential Htn 36. A Child having tumor with blue cells secretes
30. Due to which type of ischemia, patient has pale infarct catecholamines and caused by gene amplification and N -
- ID : 13997 MYC gene mutation in children? - ID : 15528

Ⓐ Venous infarct Ⓑ Hyperemia Ⓐ Retinoblastoma Ⓑ Neuroblastoma


Ⓒ Arterial infarct Ⓓ Thrombotic Ⓒ Glial glioma Ⓓ Wilms tumor

Ⓒ ✪ White infarcts (Pale ) ☛ occur with arterial occlusions in Ⓑ N-MYC oncogene ☛ Mutation due to amplification cause
solid organs with end-arterial circulations (e.g. heart, spleen, and Neuroblastoma (most common extracranial solid tumor of
kidney), childhood that secretes catecholamines)
✦ Robbins, Pg. 115 ✦ Reference, Pg. ✦ Harsh Mohan, Pg. 210

31. Incoordination with Pendular reflexes knee jerk and 37. A patient had an RTA and 1L of blood was lost. What
hypotonia, intentional tremors, jerky eye movement is type of anemia you can expect after 2 days of blood loss in
seen in? - ID : 14526 this patient? - ID : 15579

Ⓐ Cerebellar disease Ⓐ Microcytic hypochromic Ⓑ Macrocytic


Ⓑ Upper motor neurons lesion of cerebrum Ⓒ Anemia of chronic disease
Ⓒ Lower motor neuron lesion of spinal cord Ⓓ Normocytic Normochromic
Ⓓ Paralysis of quadriceps muscles
Ⓓ ✪ Normocytic, normochromic ☛ MCV, MCH and MCHC normal
Ⓐ Signs of cerebellar disease: ➜ e.g. after acute blood loss, haemolytic anaemias, bone marrow
Scanning speech, Intention tremor, nystagmus, asthenia, failure, ACD.
ataxia/drunken gait, atonia, dysdiadochokinesia, dysmetria, ✪ Microcytic, hypochromic ☛ ↓ MCV, ↓ MCH, ↓ MCHC ➜ e.g iron
pendular knee jerk, vertigo. deficiency anaemia and in certain non iron deficient anaemias (
sideroblastic anaemia, thalassaemia, anaemia of chronic disorders

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). hours of surgery. The structure most likely to have been


✪ Macrocytic ☛ ↑ MCV ➜ e.g megaloblastic anaemia. ligated is - ID : 16016
✦ Robbins, Pg. 443 ✦ Harsh Mohan, Pg. 271
Ⓐ Pudendal vein Ⓑ Ureter
38. Myelocytes are differentiated through - ID : 15623 Ⓒ Kidney Ⓓ Pudendal artery
Ⓔ Overian artery
Ⓐ Nucleus morphology Ⓑ Staining of granules
Ⓒ Cytoplasm staining Ⓓ RER shape
Ⓑ ureter is in danger of being inadvertently clamped (crushed),
ligated, or transected during a hysterectomy or other
Ⓑ Specific granules ☛ synthesized during Myelocyte stage.
✦ Sceincedirect Elsevier, Pg.
gyenacological procedures while ligating uterine artery passes as
ureter passes immediately inferior to it
39. 6 years old boy presented with apathy, less than 30%
energy, peripheral edema, dry sparse hair, scaly ✦ KLM, Pg. 361
hypopigmented skin lesions, albumin decrease, distended
abdomen due to Hepatomegaly and Anemia. Probable 45. What makes Autosomal dominant different form
disorder ? - ID : 15681 autosomal recessive? - ID : 16020

Ⓐ Marasmus Ⓑ Kwashiorkor Ⓐ Homozygous affected Ⓑ Hetero not affected


Ⓒ Vit C deficiency Ⓓ Rickets Ⓒ Hetrozygous is affected Ⓓ Least understood

Ⓑ ✪ Kwashiorkor ☛ Only protein malnutrition ➜ Anemia , edema Ⓒ ✪ Disorders of autosomal dominant inheritance are manifested
of hands, feet and Belly, enlarged liver donot have any effect on in the heterozygous state, so at least one parent in an index case
mental ilness usually is affected
✦ Robbins, Pg. 246
✪ Marasmus ☛ Deficiency of All Nutrients(Calories) ➜ weight
loss, dehydration, stomach shrinkage 46. What is symetrical distribution In Biostatics ? - ID :
✦ Harsh Mohan, Pg. 245 16074

40. Diabetic patient with Ischemic heart disease and Ⓐ Median= mode Ⓑ Mean= median
Myxedema with B.P. 180/100 mmHg. Which Ⓒ Sensitivity= specificity
Antihypertensive is best for that patient: - ID : 15709 Ⓓ Mean Median mode coincide in normal distribution

Ⓐ Verapamil Ⓑ Captopril Ⓓ A distribution in which the values of mean, median and mode
Ⓒ Propranolol Ⓓ Labetalol
coincide (mean = median = mode) is known as a symmetrical
distribution Conversely when values of mean, median and mode
Ⓑ ACE Inhibitors ( Captopril ) ☛ hypoglycemic effect ➜ ↓ blood
are not equal the distribution is known as asymmetrical or skewed
glucose by increasing muscular glucose disposal rate in
distribution.
hypertensive diabetic patients.
47. Where are the the Clara cells present? - ID : 16195
41. Jaundiced Patient presents with decrease haptoglobin,
bilirubin 6, direct bilirubin 0.9, Retics count 10, ALT 17, Ⓐ Distal bronchioles
ALP 75 , Hb 7 and Coombs +ve. Cause ? - ID : 15789 Ⓑ At bifurcation of trachea
Ⓒ Both a and b Ⓓ Terminal bronchioles
Ⓐ Macrocytic anemia Ⓑ Pernicious anemia
Ⓒ Anemia of chronic disease
Ⓓ Clara cells are most abundant in the terminal bronchioles,
Ⓓ Hemolytic anemia
where they make up about 80 % of the epithelial cell lining ➜
Ⓓ Features of Hemolytic Anemia secrete several distinctive proteins important for Surfactant
✦ Kaplan Anatomy, Pg. 62
◉ Macrophages phagocytoses ➜ Hb breakdown ➜ Heme ➜
Protoporphyrin ➜ Unconjugated bilirubin ➜ Jaundice 48. Anterior 2/3rd of tongue general pain sensation
carried by which of the following nerve? - ID : 16216
◉ ↑ RBCs destruction ➜ ↓ Hb ➜ ↓ tissue O2 levels ➜ ↑
erythropoietin ➜ ↑ reticulocytes. Ⓐ Facial nerve Ⓑ Vagus nerve
◉ Antibodies that attack red blood cells ➜ Coombs +ve Ⓒ Occulomotor nerve
✦ Goljan, Pg. ✦ Robbins, Pg. 443 Ⓓ Mandibular division of trigeminal nerve (lingual)
42. Pyruvate is the link between - ID : 15876
Ⓓ Anterior 2/3rd of tongue ➤
Ⓐ Glucose and acetyl CoA Ⓑ Lactate Special sensory ➜ Facial nerve
Ⓒ Alanine Ⓓ Glycolysis general sensory ➜ TrigeminalNote :- Pain/temp is general
sensation , taste is special sensation
Ⓐ It is the output of the metabolism of glucose known as
glycolysis. One molecule of glucose breaks down into two 49. A pateint presented with gestational ammenorhea of
molecules of pyruvate, which are then used to provide further 32 weeks having complaints of itching and vaginal
energy discharge.on examination there is pseudohyphae on the
cervix.which of the following organism is involved - ID :
43. Which of the following has the Shortest half life? - ID : 16296
16004
Ⓐ Staph. aureus Ⓑ Trichomonas
Ⓐ GH Ⓑ GnRH Ⓒ Amebiasis Ⓓ Candida
Ⓒ FSH Ⓓ LH
Ⓓ Candida albicans ☛ Vaginal Candidiasis
Ⓑ ✪ GnRH ☛ 2-4 minutes ( shortest half life ) ➜ degraded by ➤ Predisposing Factor ☛ Pregnancy, DM and use of Broad-
peptidases ➜ cleared by glomerular filtration. spectrum antibiotics.
✪ GH ☛ 20 min ✪ LH ☛ 60 min ✪ FSH ☛ 170 min ➤ Symptoms ☛ Pruritis, vulvovaginal erythema, Curd-like
✦ Williams Endocrinology, Pg. 578 ✦ Ganong, Pg. 401
discharge.
44. A 50-year-old woman had a hysterectomy for uterine ➤ Microscopy: Yeast and pseudo-hyphae with 10% KOH prep.
fibroid. She develops colicky right lumbar pain within 24 ✦ CMDT, Pg. 781 ✦ Levinson, Pg. 626

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50. You are working as a house officer in gynae OPD. Your 57. Anterior epithelium of cornea is: - ID : 17602
registrar is examining a 60-year-old female with
Ⓐ Stratified squamous keratinized
Uterovaginal prolapse. The patient is having 2nd-degree
prolapse, what is the major uterine support - ID : 16305 Ⓑ Simple squamous Ⓒ Simple columnar
Ⓓ Stratified Squamous non keratinized
Ⓐ Round ligament Ⓑ Coper
Ⓒ Longitudinal ligament Ⓓ Anterior cornea ☛ stratified squamous non keratinized ➜
Ⓓ Transverse cervical ligament protects against frictional rub.

Ⓓ The transverse cervical (cardinal) ligaments, which attach the 58. Which type of collagen present in skin - ID : 17648
cervix and upper end of the vagina to the lateral pelvic walls. It Ⓐ1 Ⓑ2
imparts lateral stability to the cervix and is an important support Ⓒ3 Ⓓ4
of the uterus.
✦ BD Chaurasia, Pg. 397 ✦ RJ Last, Pg. 466
Ⓐ Skin ☛ type 1 collagen ( ~ 90% of all collagen ).
51. Growth hormone maximum secretion in - ID : 16307
59. 40 years male presents with productive cough with
Ⓐ Strenuous exercise Ⓑ At noon yellow sputum.Chest xray show bilateral lung infiltrates
Ⓒ In morning Ⓓ NREM sleep and left upper lobe consolidation with air fluid level.ln
sputum neutrophils are present.Most likely organism
Ⓐ ✪ Maximum increase in strenous excercise. responsible - ID : 17662
Excercise >Hypoglycemia > Sleep. Ⓐ Mycoplasma Ⓑ Staph Aureus
✪ During excercise ☛ Insulin goes inside the cell ➜ Ⓒ Aspergillus Ⓓ Adenovirus
hypoglycemia ➜ ↑ Growth Hormone ➜ hyperglycemic effect.
✦ Guyton, Pg. 945 Ⓑ Bacterial Pneumonia ☛ ● Cough producing Mucopurulent
52. Failure rate of Intrauterine Contraceptive Device sputum ● High fever ● shaking chills ● occasional hemoptysis ●
(IUCD) is - ID : 16348 pleuritic pain ● Lobar consolidation ● Neutrophilia
Agents ☛ S. pneumoniae > H. Influenza > S. Aureus
Ⓐ 0.02 Ⓑ Less than 2% ✦ Robbins, Pg. 523 ✦ Davidson, Pg. 582
Ⓒ Less than 1% Ⓓ Less than 3%
60. New antihypertensive drug going to be tested by
Ⓒ ✪ Copper devices ☛ have a failure rate of about 0.8% which technique - ID : 17838
✪ Hormonal (levonorgestrel) devices ☛ fail about 0.2% of the Ⓐ Sequential trial Ⓑ Simple random
time within the first year of use. Ⓒ Stratified random Ⓓ Case control

53. The antibody released on re-exposure - ID : 16441


Ⓐ It is a statistical analysis where sample size is not fixed in
Ⓐ Ig G Ⓑ Ig M advance.Sequential trials are pre-planned repeated series of
Ⓒ Ig D comparisons that are stopped as soon as decision can be made as
to whether one treatment can be regarded as superior to
Ⓐ IgG is predominant Ab in 2ndry response another,or that both are equally effective.
Second encounter with same Ag ➜ rapid and higher and longer
61. In a patient of horner"s syndrome which of the
IgG antibody response than primary
following is true? - ID : 17992
✦ Levinson, Pg. 526

54. Levator ani supplied by: - ID : 16469 Ⓐ Exophthalmos Ⓑ Bilateral ptosis


Ⓒ Increase sweating Ⓓ Ipsilateral ptosis
Ⓐ Pudendal nerve Ⓑ Popliteal nerve
Ⓒ Cranial nerves Ⓓ Ulnar nerve Ⓓ Horner's syndrome is characterized by ipsilateral ptosis and
anhydrosis
Ⓐ Levator ani is supplied by Perineal branch of fourth sacral nerve
and from perineal branch of pudendal nerve. 62. The First Heart sound is produced due to ? - ID : 18060
✦ SNELL, Pg. 248
Ⓐ Hpovolumic contraction Ⓑ Isovolumic contraction
55. In older women breast overlies: - ID : 16506 Ⓒ Isovolumic relaxion Ⓓ Hypovolumic relaxation

Ⓐ Pectoralis major Ⓑ Isovolemtric contraction ➜ left ventricular pressure to rise


Ⓑ Superficial pectoral fascia
above atrial pressure ➜ Closure of A-V valves ➜ S1
Ⓒ Pectorlais minor Ⓓ Lattismis dorse ✦ Guyton, Pg. 116, 114

Ⓑ Breast lies on deep fascia (pectoral fascia)covering pectoralis 63. Enteropeptidase enzyme deficiency causes
major unavailability of which of the following enzymes in
✦ BD Chaurasia, Pg. 35 intestine during digestion? - ID : 18423

56. A 5 year old girl presented with pallor, lethargy and Ⓐ Trypsin Ⓑ Amylase
fatigue. CBC showed pigmented Hb, MCV 8 and MCHC 35, Ⓒ Lipase Ⓓ Elastase
microcytic anemia. The mother gives history of her
daughter eating mud regularly. The treatment shall be? - Ⓐ Enteropeptidase is an enzyme produced by cells of the
ID : 16758 duodenum and is involved in digestion in humans and other
Ⓐ Follow up Ⓑ Vit. D animals Enteropeptidase converts trypsinogen into its active form
Ⓒ Iron therapy Ⓓ Vitamin B12 injections trypsin, resulting in the subsequent activation of pancreatic
digestive enzymes.
Ⓒ ✪ IDA ☛ Microcytic anemia ➜ MCV < 80 µm3
64. A young group of boys living in daycare service, all of
✪ ↓ MCHC ( Hb conc. in RBCs ) ➜ ↓ RBC synthesis of Hb ➜ as in them are having malaise and weakness and restlessness
IDA ➜ treated with iron supplements. during night, they cant properly sleep due to perianal
✦ Goljan, Pg. 318, 319 itching. What is the cause of their symptoms? - ID : 18518

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Ⓐ Pin worm (Entrobius vermicularis)


70. Which of the following is Most potent Anabolic
Ⓑ Huge worm Ⓒ Thread worm
hormone ? - ID : 20466
Ⓓ Hook worm
Ⓐ Testosterone Ⓑ DHEA
Ⓐ The symptoms of a pinworm infection frequent and strong Ⓒ Progestrone Ⓓ DHT
itching of the anal area. restless sleep due to anal itching and
discomfort. pain, rash, or other skin irritation around the anus. the Ⓐ ✪ Testosterone ☛ Most potent Anabolic.
presence of pinworms in the area of your child's anus. the ✪ DHT ☛ Poor Anabolic, but most potent.
presence of pinworms in stools. ✪ Overall Potency ☛ DHT > Testosterone > Androstenedione.
65. A 68-year-old woman with uterine carcinoma ☢ DHT is potent overall, but when asked anabolic potent, it`s
undergoes surgical resection. This cancer can spread testosterone.
directly to ' the labia majora in lymphatics that follow ✦ Guyton, Pg. 1085, 636

which of the following structures? - ID : 18577 71. Source of Progesterone and estrogen during the last
Ⓐ Broad ligament Ⓑ Cardinal Ligament trimester? - ID : 20562
Ⓒ Quadrate ligament Ⓓ Uterine ligament Ⓐ Placenta Ⓑ Uterus
Ⓔ Round ligament of the uterus Ⓒ Ovary Ⓓ Chorionic villus

Ⓔ The round ligament of the uterus runs laterally from the uterus Ⓐ ◉ In the luteal phase following ovulation, estrogen and
through the deep inguinal ring, inguinal canal, and superficial progesterone are secreted by ➜ corpus luteum which involutes
inguinal ring and becomes lost in the subcutaneous tissues of the
slowly after ➜ 13th to 17th week of gestation
labium majus. Thus, carcinoma of the uterus can spread directly to
◉ After that onwards, syncytial trophoblast cells of Placenta
the labium majus by traveling in lymphatics that follow the
secretes progesterone and estrogens to maintain pregnancy.
ligament.
✦ First Aid, Pg. 625 ✦ KLM, Pg. 212
◉ Placental Estrogen is formed by ➜ DHEA and 16 -hydroxy-DHEA
➜ both formed in mother’s and Fetus' Adrenal glands
66. HIV patient developed reddish lesions on his skin. One ✦ Guyton, Pg.
of his sex partners has similar lesions too, Most common
skin cancer in HIV/AIDS patients are: ( may also be asked 72. A lady suffering from CA breast undergoes a total
in case of homosexuals ) - ID : 19477 mastectomy and axillary lymph node dissection and
develops edema of the right arm which of the following
Ⓐ Lymphoma Ⓑ Kaposi sarcoma can be the reason for this edema? - ID : 20661
Ⓒ Lymphogranuloma venarum Ⓓ Warts
Ⓐ Lymphatic obstruction
Ⓑ Kaposi sarcoma is a neoplasm of endothelial cells. it is seen in Ⓑ Increase vascular permeability
HIV/AIDS ( hint:homosexual male) and transplant patients. it Ⓒ Decrease oncotic pressure
presents as dark/violaceous plaques or nodeuls representing Ⓓ Increase hydrostatic pressure
vascular proliferations. Ⓔ Endothelial damage

67. Adhesion molecule present on leukocyte after Ⓐ Mastectomy ➜ Removal of LN ➜ Lymphatic obstruction ➜
margination at which of the following ? - ID : 20153 Edema
✦ Robbins, Pg. 98
Ⓐ LFA-1 Ⓑ ECAM
Ⓒ C5a Ⓓ None of above 73. Which of the following spread through Feco oral route
and cause severe Viral infection in pregnancy ? - ID : 20884
Ⓐ ✪ LFA-1 integrin ➜ Upregulate on leukocytes ➜ Interact with
Ⓐ Hep B Ⓑ HHV
ICAM on endothelium ➜ Transmigration
Ⓒ Hep E Ⓓ Hep C
✦ Robbins, Pg. 63

68. The Blood supply of uterus is ? - ID : 20291 Ⓒ Hep E spread Through feco-oral route during pregnancy,
especially in the third trimester, is characterized by a more severe
Ⓐ Ovarian + uterine artery Ⓑ Only uterine artery
infection that sometimes results in fulminant hepatitis, increasing
Ⓒ Femoral artery Ⓓ External iliac
maternal and fetal mortality and morbidity
Ⓐ Arterial supply to the uterus ● Chiefly by two uterine arteries ● 74. Superficial inguinal ring is traversed by which nerve ? -
partly by ovarian artery ID : 20914
✦ BD Chaurasia, Pg. 389 ✦ SNELL, Pg. 287
Ⓐ Ilioinguinal nerve Ⓑ Iliohypogastric
69. Medial wall of ischiorectal fossa is formed by ? - ID : Ⓒ Superficial inguinal Ⓓ Cremasteric
20343

Ⓐ Levator Ani muscles Ⓑ Puborectalis Ⓐ ✪ Ilioinguinal nerve passes forward in inguinal canal and
Ⓒ Obturator Ⓓ None of above emerges through superficial inguinal ring.
✪ iliohypogastric nerve pierces the external oblique aponeurosis
Ⓐ Ischiorectal Fossae is Fat-filled, wedge-shaped recesses on above superficial inguinal ring
either side of anal canal : ✦ SNELL, Pg. 125

Roof ➜ obliquely coursing levator ani muscle 75. GFR increases due to which of the following Conditions
Floor ➜ deep transverse perineal fascia ? - ID : 21236
Medial wall ➜ external anal sphincters/anal canal; levator ani
Ⓐ Decreased oncotic pressure
muscle
Ⓑ Increased oncoticpressure
Lateral wall ➜ ischial tuberosity; obturator internus muscle; Ⓒ Decreased hydrostatic pressure
obturator fascia Ⓓ None of above
Apex ➜ intersection of the levator ani and obturator internus
muscle Ⓐ ✪ ↓ Oncotic pressure ☛ more fluid moves out ☛ ↑ GFR
✪ ↓ Hydrostatic pressure ☛ less fluid moves out ☛↓ GFR
✦ Reference, Pg.
✦ Guyton, Pg. 337, 337

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76. Normal quiet expiration is brought about by recoil of - 83. In dehydration water is mainly absorbed from ? - ID :
ID : 21404 22537

Ⓐ Diaphragm Ⓐ DCT Ⓑ Collecting ducts


Ⓑ Elastic tissue in thoracic and lung wall Ⓒ Loop of Henle Ⓓ PCT
Ⓒ Abdominal muscles Ⓓ Sternicleidomastoid
Ⓓ ✪ Role of Aquaporins in Kidneys. Majority of water reabsorption
Ⓑ Normal expiration ☛ passive Elastic recoil of lungs expells air that occurs in the nephron is facilitated by the AQPs. Most of fluid
Forced expiration ☛ Elastic Recoil + Abdominal Recti > Internal that is filtered at the glomerulus is then reabsorbed in the PCT and
intercostals the descending limb of LOH
✦ Guyton, Pg. 497 ✪ <1 % water reabsorb in CD under the influence of ADH which
77. Boxer punched, TMJ Damaged. Patient is unable to secreted in dehydration
✦ Guyton, Pg. 378
chew and close mouth, muscle involved would be ? - ID :
22087 84. Polychromasia in RBCs is due to ? - ID : 22580
Ⓐ Lateral pterigoid Ⓑ Medial pterigoid Ⓐ Hb and ribosomes Ⓑ Hb
Ⓒ Masseter Ⓓ SCM Ⓒ Ribosomes and ER Ⓓ ER and golgi complex

Ⓐ Lateral pterygoid ☛ when it contracts, pulls condyle of TMJ Ⓐ Polychromasia ☛ bluish color on Wright-Giemsa stain of
anteriorly ➜ This allows mouth to open ➜ If it's damaged, mouth reticulocytes ( contain Hb ) represents residual ribosomal RNA.
could be stuck closed, and chewing would be impaired. ✦ First Aid, Pg. 407

Masseter ☛ plays a crucial role in mastication (chewing) and


85. Rectus sheath forms Posteriorly between umblicus and
closing mouth, but damage to it would typically present with xiphoid process? - ID : 22761
difficulty in closing mouth, not inability to open it.
Ⓐ Internal oblique and transverse abdomen
78. The most specific test to diagnose SLE is ? - ID : 22127 Ⓑ Internal oblique
Ⓐ Anti SMA Ⓑ Anti GGD Ⓒ External oblique and external oblique
Ⓒ Anti ds DNA Ⓓ ANA Ⓓ Transverse abdomen

Ⓒ ✪ Anti Ds-DNA ➜ 60%, Anti sm ➜ 30% ☛ Both are specific for Ⓐ Posterior wall of rectus Sheath ➜ ● Posterior lamina of internal
SLE oblique ● aponeurosis of transversus muscle
✦ BD Chaurasia, Pg. 209
✪ ANA ➜ Sensitive > 90%
✦ CMDT, Pg. 854, 854 86. The Indicative of the Ovulation in female is ? - ID :
22775
79. Tall man with normal external genitalia married but
had no kids. He had normal ejaculation period but semen Ⓐ Inc cervical mucous Ⓑ Dec mucous
analysis showed azoospermia, cause may be due to defect Ⓒ Low BP Ⓓ Hypothermia
in which sturcture? - ID : 22154
Ⓐ After ovulation the hormone progesterone causes cervical
Ⓐ Vas deference Ⓑ Sertoli cells
mucus to become sticky and thick This stops sperm and any other
Ⓒ Rete testes Ⓓ Semniferous tubules
foreign substance from getting through to the uterus
Ⓔ Adrenal cortex
87. Which of the following drugs causes tachycardia and
Ⓑ Azoospermia is associated with defect in sertoli cells respiratory distress, increases cardiac output in
therapeutic dose? - ID : 23199
80. Mechanism of action of local anesthesia is ? - ID : 22265
Ⓐ Pethidine Ⓑ Beta blocker
Ⓐ Block Cl channel Ⓑ Block K channel
Ⓒ Propranolol Ⓓ None of above
Ⓒ Block Ca channel in ionized form
Ⓓ Block Na channels in ionized form
Ⓐ ✪ Most opioids ☛ no direct effects on heart and other than
Ⓔ Works in unionized form
bradycardia, no major effects on cardiac rhythm.
✪ Meperidine / Pethidine ☛ exception to this generalization ➜
Ⓓ Local anesthetics ☛ reversibly binding to and inactivate Na
antimuscarinic ➜ tachycardia.
channels ➜ blocking conduction in peripheral nerves.
✦ Katzung, Pg. 561
✦ Medscape, Pg.

88. Specific granules are produced in ? - ID : 23211


81. Which test is important before starting Oral
anticoagulant ( warfarin ) and for its Monitoring ? - ID : Ⓐ Myelocyte Ⓑ Promyelocyte
22427
Ⓒ Metamyelocyte Ⓓ Osteocytes
Ⓐ APTT Ⓑ PT
Ⓒ Platelet count Ⓓ ESR Ⓐ ✪ Primary ( azurophilic ) granules ☛ appear during
promyelocyte stage.
Ⓑ ✪ Warfarin Monitoring is done by prothrombin time (PT) ✪ Secondary ( specific ) granules ☛ synthesized during
✪ Heparin Monitoring is done by APTT levels Myelocyte stage.
✦ Davidson, Pg. 1000 ✦ Sceincedirect Elsevier, Pg.

82. Haploid chromatin, Haploid DNA seen in ? - ID : 22495 89. Which of the following is microscopic feature of
malignant tumor? - ID : 23255
Ⓐ Spermatids Ⓑ Secondary oocyte
Ⓒ Both a and b Ⓓ None of above Ⓐ Pleomorphism Ⓑ Invasion
Ⓒ Metastasis Ⓓ High NC ratio
Ⓐ Spermatids ☛ haploid (1C) after two rounds of division
spermatogonia and sec. spermatocytes ☛ diploid (2C) Ⓑ ✪ Microscopic feature ☛ Invasion > Pleomorphism > ↑ NC
Primary spermatocytes ☛ tetraploid (4C) ratio
✦ Guyton, Pg. 1022,1055, ✪ Diag feature ☛ Metastasis > Invasion

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✦ Robbins, Pg. 195 ✦ N.I.H USA, Pg.

90. Which of the following intermediate filament is 96. Which of the following will decrease in strenuous
present in muscle cell ? - ID : 23289 exercise? - ID : 26304

Ⓐ Keratin Ⓑ Vimentin Ⓐ CO ⒷSv


Ⓒ Desmin Ⓓ Nestin Ⓒ TPR Ⓓ MAP

Ⓒ ◉ Desmin ☛ intermediate filament (IF) protein occurring Ⓒ ↓ in TPR is result of ↓ vascular resistance in skeletal muscle
exclusively in muscle and endothelial cells ➜ present throughout vascular beds ➜ leading to ↑ blood flow to cardiac and skeletal
smooth, cardiac and skeletal muscle cells muscle ➜ exercise hyperemia
◉ Nestin and Vimentin ☛ not unique to muscles ✦ Guyton, Pg. 206

✦ N.I.H USA, Pg.


97. Compliance Of treatment depends upon - ID : 26539
91. The Glomerulus supply is by which of the following
Ⓐ Doctors perception of disease
artery? - ID : 23292
Ⓑ Family's perception of disease
Ⓐ Arcute Ⓑ Interlobular Ⓒ Patient's perception of disease and its severity
Ⓒ Vesa recta Ⓓ None of above
Ⓒ Patient compliance/noncompliance depends on the duration,
Ⓑ Interlobular arteries arise from the arcuate arteries and ascend frequency, and complexity of the required behaviors
into the cortex, where they divide into afferent arterioles that ✦ Sceincedirect Elsevier, Pg.

supply blood to the glomerular capillaries. After traversing the 98. G6 p5 develop rigors chills sudden lower abdominal
renal corpuscle, the glomerular capillaries reform into a second pain, and white watery vaginal discharge most suitable
arteriolar network, the efferent arterioles. Diagnose is: - ID : 27901
92. A 9-month-old girl who was vaccinated 2 weeks ago Ⓐ Chorioamnionitis Ⓑ UTI
now has a rash all over her body and a fever. She Ⓒ Toxoplasmosis Ⓓ Pyelonephritis
experienced gum bleeding once 3 months ago. Her CBC
report shows a hemoglobin level of 13, WBC count of Ⓐ Chorioamnionitis ☛ infection of placenta and amniotic fluid ➜
6×10^9/L, and decreased platelets. Her peripheral smear
happens when amniotic sac is broken ➜ presents with fever, fast
shows large platelets, and her BT is prolonged, while PT
heart rate, painful uterus and amniotic fluid that smells bad.
and APTT are normal. What is the most likely diagnosis? -
ID : 23894 99. Anti sera agglutinates with A and D and plasma has
Ⓐ ITP Ⓑ TTP Anti B antibodies what’s blood group? - ID : 33715
Ⓒ Anemia Ⓓ Thalassemia Ⓐ A -ve Ⓑ A + Ve
Ⓒ O –ve Ⓓ B +Ve
Ⓐ ✪ ITP ☛ ↓ Platelets ➜ petechial haemorrhages, easy bruising,
and mucosal bleeding. Ⓑ ✪ Blood Group A ☛ has Anti B antibodies and agglutinates with
✪ MMR Vaccine ☛ reported to cause ITP in children. A agglutinins.
✦ Harsh Mohan, Pg. 311 ✦ Researchgate, Pg.
✪ Rh +ve ☛ agglutinates with D agglutinins.
93. First Pass effect is avoided and Bioavailibilty is ✦ Guyton, Pg. 477,479, 477,479, 477,479

improved if drug is given - ID : 24399 100. MOA of cabergoline: - ID : 33772


Ⓐ Sublingual Ⓑ Per rectal Ⓐ D1 Agonist Ⓑ D2 Agonist
Ⓒ Oral Ⓓ Intramuscular Ⓒ D1 Antagonist Ⓓ D2 Antagonist
Ⓔ I/V
Ⓑ Cabergoline ☛ long-acting dopamine receptor agonist ➜ high
Ⓔ Max Bioavailability due to less First Pass effect ➤
affinity for D2 receptors.
IV > SL > IM > per rectal > Oral
101. Which is the type of endocytosis that occurs in
94. Transposition of great vessels most commonly - ID : Lysosomes? - ID : 33920
25086
Ⓐ Pseudopods mediated Ⓑ Phagocytosis
Ⓐ Aorta arises from Right side
Ⓒ Pinocytosis Ⓓ Cell lysis
Ⓑ Pulmonary trunck from right side
Ⓑ ✪ Phagocytosis of foreign Ag ➜ Form a phagocte ➜ Fusion with
Ⓐ TGA ☛ Aorta leaves RV and pulmonary trunk
lysosome ➜ Phagolysosome ➜ Destruction
leaves LV ➜ separation of systemic and pulmonary circulations. ✦ Harsh Mohan, Pg. 37
✦ Not compatible with life unless a shunt is present to allow mixing
102. A doctor in his clinical or hospital can practice an
of blood (eg, VSD, PDA, or patent foramen ovale)
✦ First Aid, Pg. 298
effective management by: - ID : 33923

95. A lady came at term with labour pains on examination Ⓐ Evidence based management
crowning, her pelvis has narrow pubic arch and prominent Ⓑ Good and effective communication skills
ischial spines but sacral promontory cannot be reached: - Ⓒ Providing guided information
ID : 25754 Ⓓ Showing empathy and sympathy towards patient

Ⓐ Gynecoid pelvis Ⓑ Contracted pelvis


Ⓑ Better communication ☛ leads to being more patient-centred
Ⓒ Anthropoid pelvis Ⓓ Android Pelvis
➜ physician can gather specific information about patient's
Ⓓ Android pelvis ➤ symptoms.
✪ Pelvic inlet Heart shaped due to prominant sacrum 103. Leucovorin is an antidote for: - ID : 33980
✪ Convergent sidewalls
Ⓐ Sulfasalazine Ⓑ Potassium
✪ Prominant ischial spines
Ⓒ Methotrexate Ⓓ Vitamin K
✪ Narrow subpubic arch

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Ⓒ Antidotes for MTX toxicity ☛ leucovorin, thymidine and 111. A 6-year-old girl is having difficulty seeing at night,
glucarpidase. and her skin is dry and scaly. She has a mildly vascular
conjunctival lesion near the cornea on the medial side of
104. A patient exhibiting hyperprolactinemia with both eyes and decreased corneal sensations. What is the
decreased vision loss has problem in: - ID : 33983 suspected disease? - ID : 34474

Ⓐ Hypothalamus Ⓑ Thalamic nuclei Ⓐ Vit. A deficiency Ⓑ Vit-D deficiency


Ⓒ Pituitary Ⓓ Occulomotor nerve
Ⓐ ✪ Earliest Sign of Vitamin A defeciency ☛ Conjunctival Xerosis
Ⓒ Prolactinomas ☛ most prevalent pituitary tumors ➜ result in ( Dryness )
ocular complications such as vision loss and visual field defects. ✪ Earliest Symptom of Vitamin A Defeciency ☛ Night Blindness
✦ Pubmed USA, Pg. ✦ CMDT, Pg. 1285

105. Systemic lupus erythematosus leads to lupus 112. In hemolysis hemoglobin (Hb) binds with: - ID : 34497
nephritis, type of hypersensitivity reaction: - ID : 34022
Ⓐ Haptoglobin Ⓑ Hemopexin
Ⓐ Type 1 Ⓑ Type 2 Ⓒ Albumin Ⓓ Ferretin
Ⓒ Type 3 Ⓓ Type 4
Ⓐ Haptoglobin ☛ Binds free Hb
Ⓒ ✪ Examples of Type 3 hypersensitivity reactions ☛ ● SLE ● Hemopexin ☛ Binds heme
GPS ● RA ● HSP ● Drug induced vasculitis ✦ Ganong, Pg. 563
✦ Harsh Mohan, Pg. 77
113. Person Feeling Elevated After Appreciation in Stage
106. Na inactivation gate closing represent which phase of Presentation.Which Centre Involved in This Emotion - ID :
action potential ? - ID : 34333 34537

Ⓐ Refractory period Ⓑ Depolarization phase Ⓐ Ventromedial Prefrontal Cortex


Ⓒ Repolarization phase Ⓑ Amygdala Ⓒ Orbitofrontal cortex

Ⓐ Closure of the inactivation gate causes Na+ flow through the Ⓐ vmPFC ☛ plays role in regulating and inhibiting our response to
channel to stop, which in turn causes the membrane potential to emotions ➜ uses our emotional reactions to model our behavior
stop rising. The closing of the inactivation gate creates a refractory and control emotional reactions in certain social situations.
period within each individual Na+ channel
114. A person from Karachi who recently took membership
107. On auscultation , posteroinferior border of lungs from in swimming pool classes presented with signs of
back. where is the stethoscope kept? - ID : 34343 meningitis, microbiologist said ameboid on wet agar.
Ⓐ T6 Ⓑ T8 Cause? - ID : 34580
Ⓒ T10 Ⓓ T12 Ⓐ Naegleria fowleri Ⓑ Listeria monocytogenes
Ⓒ Entamoeba histolytica Ⓓ Neisseria meningitidi
Ⓒ Three borders of lungs ➤
✦ Anterior ➜ Corresponds to pleural reflection and it creates a Ⓐ Naegleria fowleri ☛ Swimming in warm freshwater; enters
cardiac notch in left lung via cribriform plate ➜ Rapidly fatal meningoencephalitis
✦ Posterior ➜ Thick and extends from C7 to the T10 vertebra, ✦ Robbins, Pg. 868

which is also from apex of the lung to inferior border 115. In a patient with obstructive jaundice, there is
✦ Inferior ➜ Thin and separates base of the lung from costal increased clotting time due to? - ID : 34712
surface.
✦ N.I.H USA, Pg. Ⓐ Fibrinogen deficiency
Ⓑ Increase levels of bilirubin in blood
108. After 3 week gestation, blood vessels and cells
Ⓒ Protein C Ⓓ Protein S
formed, Which type of villous - ID : 34348
Ⓔ Prothrombin def and Inc PT time
Ⓐ Primary villi Ⓑ Secondary villi
Ⓒ Tertiary villi Ⓓ Primary chronic villi Ⓔ vitamin K-dependent coagulation factors
Factors II, VII, IX, X, proteins C and S
Ⓒ ✪ 13-15 DAY.PRIMARY VILLOUS(TROPHOBLAST) ✪ 16-21 Gallstone ➜ Obstructive jaundice ➜ ↓ Absorption Of fat soluble
DAY.SECONDRY VILLOUS(TROPHOBLAST+MESODERM) ✪ 21ST Vitamins ( A, D, E and K ) ➜ Inc PT time and Bleeding due to
DAY.TERTIARY VILLOUS(TROPHOBLAST+MESODERM+BLOOD the liver is not making the right amount of blood clotting proteins,
VESSELS) so the clotting process takes longer.
✦ Harsh Mohan, Pg. 246
109. Capsule of kidney supplied by? - ID : 34372
116. V-max always occurs in? - ID : 34740
Ⓐ Interlobular artery Ⓑ Interlobar artery
Ⓒ Arcuate artery Ⓓ Pyramidal artery Ⓐ Simple diffusion Ⓑ Osmosis
Ⓒ Primary active transport Ⓓ Facilitated diffusion
Ⓐ Interlobar artery ➜ Arcute artery ➜ Interlobular artery ➜
Capsule Ⓓ Unlike simple diffusion, facilitated diffusion involves a limited
✦ SNELL, Pg. 209 number of carrier proteins. ↑ solute concentration further will not
change the rate of diffusion. In other words, there is some
110. Patient presents with neuralgia, Analgesic effect of
maximum rate of diffusion (Vmax) when all the carrier pro teins
TCA occurs in - ID : 34378
are saturated.
Ⓐ 1-2 weeks Ⓑ 1 day
117. Mean in large sample: - ID : 34747
Ⓒ 1 month Ⓓ 10 weeks
Ⓐ Get large sample size Ⓑ Always equal to mode
Ⓐ ✪ Analgesic effect ☛ 1-2 weeks. Ⓒ More than median
✪ Antidepressent effect ☛ 3-4 week. Ⓓ Numerically greater than sample distribution

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Ⓓ in Large sample size ☛ mean (average) of a data set is 124. A woman with dysphagia, on/off diarrhea,
generally numerically greater than individual values in sample hoarseness of voice and metastasis to cervical lymph
distribution, particularly if distribution is skewed (i.e., if it has a nodes. Diagnosed as Medullary thyroid carcinoma. The
tumor marker involved is? - ID : 35223
long tail on the right side).
Ⓐ CEA Ⓑ Calcitonin
118. Calculate the embryonic age, if the LMP is
15/11/2020 and today is 15/02/2021? - ID : 34749 Ⓒ HCG Ⓓ Thyroglobulin
Ⓔ AFP
Ⓐ 12 weeks Ⓑ 10 weeks
Ⓒ 9 weeks Ⓓ 11 weeks Ⓑ MEN 2A ☛ ◉ Parathyroid hyperplasia ◉ Medullary thyroid
Ⓔ 13 weeks carcinoma neoplasm of parafollicular C cells ➜ Dysphagia ➜
secretes calcitonin ➜ prophylactic thyroidectomy required ◉
Ⓓ ✪ Gestational age is measured from the first day of your last
Pheochromocytoma (secretes catecholamines)➜ On/Off diarrhea
menstrual period, ✦ First Aid, Pg. 351
✪ Fetal age is calculated from the date of conception. This is
125. Post-operative intra-abdominal bleeding following
during ovulation, which means that fetal age is about two weeks
lower segment C- Section. Most likely source of bleeding: -
behind gestational age. ID : 35286
✦ LMP ➜ 15/11/2020
✦ Day of conception ➜ Ideally 29/11/2020 (14th day) Ⓐ Uterine vein
Ⓑ Branches of uterine artery
✦ Fetal age ➜ 29/11/2020 - 15/02/2021 ➜ 10 weeks and 4
Ⓒ Ovarian artery Ⓓ Internal iliac artery
days
✦ Reference, Pg.
Ⓑ Uterus ☛ Mainly supplied by uterine artery ,Gives smaller
119. Portal of entry of Meningococcal meningitis: - ID : branches to lower part of uterus cervix and vagina
34864 ✦ SNELL, Pg. 287

Ⓐ Feco oral Ⓑ Respiratory droplets 126. Sperms are stored in? - ID : 35784
Ⓒ Airborn Ⓓ Blood
Ⓐ Epididymis Ⓑ Vas deferens
Ⓑ Meningococci ☛ Transmitted via respiratory and oral Ⓒ Seminal vesicle Ⓓ Ductus deferens
secretions
✦ First Aid, Pg. 142 Ⓐ Sperm ➤
✦ Spermatogenesis occure in ➜ Seminiferous tubules
120. A ppd tuberculin test done to a patient After 40
hours, 15mm erythema is noticed. Cells responsible for ✦ Stored in ➜ Epididymis (Small quantity in vas deferens)
erythema are - ID : 34960 ✦ Maturation in (Motility) ➜ Epididymis
✦ Hormones responsible ➜ Testosteron ,LH,FSH and GH
Ⓐ Helper CD4+ T cell Ⓑ Cd8 cells
✦ Time taken by spermatogenesis ➜ 74 days
Ⓒ NK cells Ⓓ Cytotoxic T cell
✦ In female genital tract ➜ 1-2 days
Ⓐ PPD test ☛ CD4+ T-cell mediated reaction
✦ Robbins, Pg. 143 ✦ Guyton, Pg. 1024

121. Vasculitis that involves same vessel or different 127. A 3-year old, while playing outside got scared is not
vessels with lesion of different ages: - ID : 35016 speaking. Mother notices the child has become cold and
has goosebumps all over and takes him to the hospital.
Ⓐ Kawsaki disease Ⓑ PAN The cause of Goosebumps is? - ID : 35890
Ⓒ Giant cell arteritis Ⓓ Temporal Cell arteritis
Ⓐ Contraction of errector pili
Ⓑ PAN ☛ Segmental transmural necrotizing inflammation of small- Ⓑ Relaxation of arrector pili
to medium-sized arteries ➜ Impaired perfusion may lead to Ⓒ Inc blood supply to the skin
ulcerations, infarcts, ischemic atrophy, or hemorrhages Ⓓ Dec blood supply to the skin
✦ Robbins, Pg. 386
Ⓐ Gooseflesh ☛ as a result of overactivity of sympathetic system,
122. Tuberculin test Is performed. Which type of
which causes vasoconstriction of dermal arterioles and contraction
hypersensitivity reaction is - ID : 35167
of arrector pili muscles
Ⓐ Type I Ⓑ Type II ✦ SNELL, Pg. 6

Ⓒ Type III Ⓓ Type IV 128. A soft, low pitched third heart sound auscultated in
many normal individuals due to vibrations set up by - ID :
Ⓓ ✪ Mantoux test ( PPD or Tuberculin skin test ) ☛ Cutaneous T 36028
cell mediated memory recall immune response ( delayed-type 4
Ⓐ Closure of Aortic Valve Ⓑ Closure of AV valve
hypersensitivity ) ➜ done for screening of TB
Ⓒ Flow of blood into aorta
☢ No antibodies involved in Type 4 delayed responses.
Ⓓ Opening of semilunar valves
✦ Robbins, Pg. 143
Ⓔ Rapid inflow of blood into ventricles
123. Lymphatic drainage of breast upper outer lateral
quadrant is: - ID : 35193 Ⓔ Third heart sound ( ventricular gallop ) ☛ usually abnormal
Ⓐ Anterior axillary Ⓑ Posterior axillary sound ➜ due to Rapid passive ventricular filling ➜ occurs in dilated
Ⓒ Inferior phrenic Ⓓ Deltopectoral CHF, severe hypertension, M.I, or mitral incompetence ➜ occurs
Ⓔ Central lymph nodes just after S2 when mitral valve opens, allowing passive filling
of left ventricle.
Ⓐ The lateral quadrants of the breast drain into the anterior ➤ S3 can be a normal finding in children, pregnants and athletes
axillary or pectoral group of nodes ✦ Davidson, Pg. 459 ✦ Davidson, Pg. 459
✦ SNELL, Pg. 337

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129. Pregnant patient with high grade fever and watery ✦ Robbins, Pg. 116

vaginal discharge. Which finding is most specific indicator


135. Biopsy of stomach non specialised mucosa with
of chorioamnionitis - ID : 36122
scattered goblet cells - ID : 36496
Ⓐ IL-1 Ⓑ IL-6
Ⓐ Dysplasia Ⓑ Metaplasia
Ⓒ Transversalis Fascia Ⓓ Internal Oblique muscle
Ⓒ Atrophy Ⓓ Hyperplasia

Ⓑ Amniotic fluid IL-6 ☛ index of severity of chorioamnionitis Ⓑ EXPLANATION


during pregnancy.
136. If the cerebral aqueduct is blocked what structure
130. Patient with Lower orbital wall fracture having will dilate first? - ID : 36515
proptosis, numbness of lower eyelid and cheek. Which
nerve is most probably injured - ID : 36300 Ⓐ Lateral Ventricles Ⓑ 3rd ventricle
Ⓒ 2nd ventricle
Ⓐ Supraorbital nerve Ⓑ Infraorbital nerve
Ⓒ Long buccal nerve Ⓓ Maxillary nerve Ⓑ exp

Ⓑ ✪ Infraorbital nerve ☛ supply skin of lower eyelid and cheek, 137. Sequence of leukocytes event - ID : 36519
side of nose, and upper lip.
Ⓐ Margination, Rolling, Adhesion, Transmigration
✪ Injury to IO nerve ☛ caused by trauma, including facial Ⓑ Rolling, Margination, Adhesion, Transmigration
fractures ➜ presents with numbness and pain in entire cheek, ala Ⓒ Margination, Rolling, Adhesion, Migration
of nose and upper lip. Ⓓ Margination, Rolling, Transmigration, Adhesion
131. Blood Sample stored sometime after withdrawal and
Ⓐ Sequence of leukocytes extravasation
then sent to lab. it shows lactate dehydrogenase raised
with raised K(6.3), raised P04 and LDH (600), Sodium and ➊ Margination ☛ movement towards wall of channel.
Calcium normal. what can be the cause - ID : 36369 ➋ Rolling ☛ low affinity adhesive interaction between leukocytes
and vascular endothelium
Ⓐ Hemolyzed blood Ⓑ CRF
➌ Adhesion ☛ hallmark of inflammatory process
Ⓒ Drug Intoxication Ⓓ Hemolysis of Tissue
➍ Transmigration ☛ diapedesis ➜ passage of cells through intact
Ⓐ Hemolyzed Blood shows : vessel wall.
Raised : LDH , Phsphorus , K+ along Normal : Ca+ and ➎ Migration ☛ chemotaxis towards chemotactic factor.
✦ Pathoma, Pg. 13
NaCalcium should be Low in CRF
138. A Primigravida female of southern area delivered a
132. Gun shot at C7 right-sided hemiplegia Lesion of - ID :
baby boy with hydrops fetalis, Investigation shows Hb 8,
36400
raised Retic count, blast cells, anisocytosis, and
Ⓐ UMN lesion at same level poikilocytosis on smear. The most likely diagnosis is - ID :
Ⓑ LMN lesion below the level 36661
Ⓒ Contralateral loss of pain and temperature below level Ⓐ Alpha Thalassemia Ⓑ Pernicious anemia
Ⓓ Ipsilateral loss of touch at the same level Ⓒ Sickle cell anemia Ⓓ G6Pd
Ⓔ Hereditary elliptocytosis
Ⓒ Brown Sequard Syndrome:
(Hemisection of spinal cord ) Ⓐ Alpha thalassemia ☛ Most severe form anemia lead
Spinothalamic tract damage ➜ Contralateral Loss of ➜ Pain and intrauterine death ( Hydrops fetalis )
temperature, crude touch sensation ( Below the Lesion ). ✦ Harsh Mohan, Pg. 297
✦ Guyton, Pg. 629 ✦ First Aid, Pg. 531
139. Pain at TMJ due to which unable to elevate mandible.
133. Right atrium infarction involve? - ID : 36459 The muscle involved that causes elevation of jaw? - ID :
36667
Ⓐ Pectinate muscle Ⓑ Septomarginal band
Ⓒ Moderator band Ⓓ Papillary muscle Ⓐ Masseter Ⓑ Lateral pterygoid
Ⓒ Posterior fibers of temporalis muscle
Ⓐ Pectinate muscles ☛ "teeth of a comb" shaped parallel Ⓓ Digastric
muscular columns that are present on inner wall of the right and
left atria. The right atrium has thick and coarse pectinate muscles Ⓐ Masseter muscle with its perimysium has direct contact with
while these are few smooth and thinner in left atrium the articular disc on the front edge.
✦ Radiopedia.org, Pg. Action ☛ is to elevate the jaw.
134. 55 years old female undergone hysterectomy for 140. Nerve Supply of the vulva - ID : 36922
ovarian cyst. Readmitted due to pneumonia and after
complete screening, it showed gram-negative (-ve) Ⓐ Pudendal nerve Ⓑ Iliac nerve
organism and develop Shock after 6 days. Mechanism Ⓒ Popliteal nerve Ⓓ Tibial nerve
involved? - ID : 36466 Ⓔ Femoral nerve
Ⓐ Increase vascular / Capillary permeability
Ⓐ Pudendal nerve ☛ supplies perineum, vulva, labia and clitoris
Ⓑ Albumin loss Ⓒ Na and water loss
in women ( scrotum and penis in men ).
Ⓓ Decrease heat contractility
Ⓔ Acute Tubular necrosis 141. A person came with a complaint of a heat stove
injury. It was a minor first-degree burn. Regular warmth
Ⓐ ✪ Septic shock ☛ Triggered by ➜ Gram positive > Gram- receptors? - ID : 37006
negative> fungi
Ⓐ Evenly distress in hands and feet
✪ Pseudomonas ☛ Encapsulated, Gram-negative Rod ➜
Ⓑ Completely adapted to 5 to 10 degree change in temperature
Endotoxin ➜ induce a cascade of cytokines (TNF, IL-1, IL-6, and Ⓒ Decrease body temperature
IL-8) ➜ activate complement and kinin system ➜ Vasodilation Ⓓ Regulates circadian rhythm
+ increase capillary permeability ➜ Septic Shock

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Ⓑ Warmth receptor ☛ The threshold for activation of warmth Ⓒ Increased hydrostatic pressure
receptors is 30°C, and they increase their firing rate as the skin Ⓓ Decreased oxygen carrying capacity of RBCs
temperature increases to 46°C.
✦ Ganong, Pg. 162 Ⓒ CHF ☛ ↑ Backward pressure ➜ ↑ Hydrostatic pressure ➜ Fluid
leakage ➜ Edema
142. Cholecystitis, pain at right hypochondrium
✦ Harsh Mohan, Pg. 81
dermatome - ID : 37416
149. A13-year-old girl consulted her doctor for a few
Ⓐ T7- T9 Ⓑ T3-T9
changes in her body that she had been noticing for the last
Ⓒ T10-T12 Ⓓ T7-L1 few months. The doctor explained to her that the changes
were normal and related to hormonal secretions. The most
Ⓐ EXPLANATION potent C -19 steroid responsible for her changes is ) - ID:
54896
143. Nerve placed in Sodium Free water medium. A
threshold stimulus was given. What will happen next? - ID Ⓐ Estriol Ⓑ Estradiol
: 38008 Ⓒ Estrone Ⓓ Progesterone
Ⓐ No Action Potential Ⓑ Graded Action Potential
Ⓒ Depolarization Ⓓ Repolarization
Ⓑ ↑ ↑ estradiol production is largely responsible for breast
Ⓔ Decremental development, genital growth, and changes in the distribution of
body fat in pubescent girls.
Ⓐ EXPLANATION
150. A 59-year-old previously healthy woman present to
144. Lumber vertebra attachment? - ID : 38716 cardiac emergency with complaints of left-sided chest pain
a few hours ago. She passed away within a few minutes of
Ⓐ Anterior longitudinal ligament arrival. A section of left ventricle showed a deeply
Ⓑ External abdominal oblique eosinophilic myocardium with loss of striations and nuclei
Ⓒ Extensors of hip Ⓓ Transversus abdominis and Collagen fibroblast necrotic tissue Which of the
following pathological change is most likely to be noted? -
Ⓐ EXPLANATION ID : 55091

145. In a population of 1 million, there were 100,000 Ⓐ Apoptosis Ⓑ Coagulative necrosis


females in child bearing age and 100,000 children's born Ⓒ Fatty change Ⓓ Hypertrophy
alive and 50 women's died. The MMR will be ? - ID : 54477
Ⓑ Coagulative necrosis ☛ Cell death (typically caused by
Ⓐ 5 / 10,000 population Ⓑ 50 / 10,000 live births
ischemia or infarction) but No Proteolysis ➜ Cells become dry,
Ⓒ 50 / 100,000 live births
hard, and white ➜ Architecture preserved for at least couple of
Ⓓ 50 / 1 Million population
days (occur in All solid Organs except Brain)
✦ Robbins, Pg. 36
Ⓒ Maternal mortality ratio (MMR) :
Number of maternal deaths during a given time period per 151. A 65-year-old male known case of congestive cardiac
100,000 live births during the same time period. failure presented to the cardiac ER with severe
✦ W.H.O, Pg. breathlessness, examination revealed basal crepitation
bilaterally and decreased cardiac sound. X-ray chest
146. A 30 year old woman, G-2P 1+0 presented at 28 revealed cardiac temponade, resident on duty planned for
weeks of gestational amenorrhea with labor pain. On pericardiocentesis to relive the condition. What is the
examination, she was found in active labor. She has H/o most appropriate site for the insertion of wide bore
vaginal discharge foul-smelling, milky while in color. What needle? - ID : 55415
is the most likely cause of preterm labor? - ID : 54732
Ⓐ Right 4th intercostal space near sternum
Ⓐ Bacterial Vaginosis Ⓑ Candidiasis
Ⓑ Right 5th intercostal space near mid clavicular line
Ⓒ Chlamydia Trachoma Ⓓ Gonorrhea
Ⓒ Left 5th intercostal space near sternum
Ⓓ Left 6th intercostal space in midaxillary line
Ⓐ Bacteial vaginosis ➜ higher risk of Preterm labour.
✦ Levinson, Pg. ✦ Oxford Microbiology, Pg. 696
Ⓒ Pericardiocentesis ➜ Needle should be inserted through left 5th
147. A patient with chronic renal failure has low serum or 6th intercostal space near the sternum To remove the excess
calcium and high phosphate. The following will explain fluid
these biochemical changes - ID : 54769

Ⓐ Decreased absorption in gut


Ⓑ Decreased level of 1,25, dihydroxycholecalciferol
Ⓒ Decreased level of parathormone ✦ KLM, Pg. 134
Ⓓ Increased loss of calcium in urine
152. Patient presented with shock. A physician palpated
artery between trachea and infrahyoid muscle. Which
Ⓑ ✪ CRF ➜ Dec Activation of 1,25- dihydroxycholecalciferol ➜
artery is present at this site? - ID : 57886
Ca++ and PO4 can't reabsorb from kidney ➜ Hypocalcemia and
Hypophophatemia Ⓐ Common carotid artery Ⓑ Internal juglar
✪ CRF ➜ Retention of PO4 ➜ Free Ca++ bind to PO4 ➜ Ⓒ Internal carotid Ⓓ Anterior juglar
Hypocalcemia ➜ Secondary hyperparathyroidism
✦ Ganong, Pg. 660 Ⓐ Common carotid artery ☛ on either side of neck in
groove between infrahyoid muscles and trachea.
148. A 87-year-old lady developed severe difficulty in
breathing due to pulmonary edema. She is known to have 153. A group of mice was taken and injection of plastic
congestive cardiac failure. The most likely cause of edema hydrocarbon was given this will work as initiator in
in her is - ID : 54892 process the initiator work as: - ID : 57896

Ⓐ Cardiac muscle hyperactivity Ⓐ Slow process will take time


Ⓑ Increased alveolar pressure Ⓑ It is last step in ccarcinogensis

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Ⓒ Memory produce Ⓐ Klinefelter's syndrome ( 47XXY)


Ⓓ Cause Clonal proliferation ◉ Taller phenotypically Male
◉ Hypogonadism and Infertility
Ⓒ Initiation of chemical carcinogenesis ☛ normal cell ◉ Less muscle and body hairs
undergoes irreversible change ➜ characterized by intrinsic capacity ◉ Enlarged breast (gynecomastia)
for autonomous growth ➜ capacity remains latent for weeks, ◉ Barr Body present ◉ Cognitive deficits
months, or years ➜ initiated cell may be phenotypically ✦ Robbins, Pg. 267

indistinguishable from other parenchymal cells in that tissue. 160. In a 32-year-old female with fatigue, malaise, fever,
✦ Harsh Mohan, Pg. 211
weight loss, malar rash sparing the nasolabial fold, joint
154. Horseshoe kidney complication - ID : 58092 discomfort, and fingers that turn pale in the cold, which
specific antibody is most likely to be positive? ) - ID: 66947
Ⓐ Renal failure
Ⓑ Ureterovesical Obstruction Ⓐ Anti-dsDNA Ⓑ Anti-histone
Ⓒ Ureteropelvic obstruction Ⓒ Anti-centromere Ⓓ Anti-Jo-1
Ⓓ Bladder exstrophy Ⓔ Anti-Scl-70

Ⓒ Horseshoe kidney ● Inferior poles of both kidneys fuse Ⓐ Dx: Based on the NICE guidelines and other international
abnormally ● hooks under origin of inferior mesenteric artery standard management guidelines, the given symptoms are
which prevents its ascend ● Kidneys function normally associated suggestive of Systemic Lupus Erythematosus (SLE). The malar
with hydronephrosis ➜ Due to Ureteropelvic obstruction rash, joint symptoms, and sensitivity to cold (Raynaud's
✦ Kaplan Anatomy, Pg. 152 ✦ First Aid, Pg. 579 phenomenon) are typical clinical features of SLE. Among the
antibodies mentioned, Anti-dsDNA is the most specific for
155. During surgery in OT, patient needs bladder
SLE. Systemic Lupus Erythematosus (SLE) is a multi-system
emptying, surgeon passed needle to upper surface of
autoimmune disease. The malar rash, joint symptoms, and
bladder vessel at risk of damage is: - ID : 58099
Raynaud's phenomenon are hallmark features. Anti-dsDNA
Ⓐ Inferior epigastric Ⓑ Deep Circumflex artery antibodies are highly specific for SLE. Anti-histone: Mainly
Ⓒ Superficial Circumflex artery associated with drug-induced lupus, not classic SLE.
Ⓓ Superior epigastric Anti-centromere: Seen in Limited Cutaneous Systemic Sclerosis
and associated with CREST syndrome.
Ⓐ Inferior epigastric artery ☛ a branch of external iliac artery. Anti-Jo-1: Associated with polymyositis and dermatomyositis.
It is found on the anterior abdominal wall, passing superomedially Anti-Scl-70: Seen in diffuse cutaneous systemic sclerosis.
from the inguinal canal towards midline.Can gets damage
✦ Reference, Pg. 854, 856
161. Boy with a sudden increase in height, secondary
sexual characteristics, and gonadotrophins are normal.
156. BUN / Cr ratio greater than 20 causes will be: - ID : What sex cell tumor causes precocious puberty,
58129 masculinization, a gynecomastia in adults, and crystalloids
Ⓐ Pre renal azotemia Ⓑ Tubular necrosis of Reinke? - ID : 70419
Ⓒ Kidney injury Ⓐ Leydig cell tumor Ⓑ Pituitary
Ⓒ Increase gonadotrophins Ⓓ Hypothalamus
Ⓐ Prerenal azotemia ☛ refers to elevations in BUN ( blood urea
nitrogen ) and creatinine levels ➜ due to problems in systemic Ⓐ Leydig cell tumors ☛ testicular tumors that originate from the
circulation that decrease flow to kidneys. Leydig cells ( responsible for producing testosterone in the testes)
➜ excessive production of testosterone ➜ sudden increase in
157. A pregnant lady presents with jaundice, deranged
AST, and ALT. In a community endemic of hepatitis virus height, secondary sexual characteristics, and precocious puberty ,
which is typically lethal for pregnant lady? - ID : 58141 masculinization and gynecomastia in boys

Ⓐ Hep A Ⓑ Hep C 162. In a healthy adult what is the volume of ICF or how
Ⓒ Hep E Ⓓ Hep B many liters of water are there in ICF - ID : 71079

Ⓐ 28 L Ⓑ 32 L
Ⓒ Hepatitis E in pregnancy ☛ ↑ risk of acute liver failure, fetal Ⓒ 24 L Ⓓ 46 L
loss and mortality.

158. A 30-year-old P2+0 complaints of excessive clear


Ⓐ ✪ Total Fluid volume ☛ 60 % ➜ 42 liters
odorless discharge. Cervical examination reveals cervical ✪ Intracellular ☛ 28 liters ( 2/3rd of total body fluids and
ectropion. What is predisposing factor for cervical 40% of total body weight )
ectropion? - ID : 58651 ✪ Extracellular ☛ 1/3rd ➜ 14 liters
✦ Guyton, Pg. 306
Ⓐ It is presence of squamous metaplastic change
Ⓑ It is normal and develops due to pregnancy 163. During second degree heart block what happens? - ID
Ⓒ It needs regular follow-up : 71168

Ⓓ It can transform iuto malignant change Ⓐ Increased risk of ventricular Tachycardia


Ⓔ Treatment with antibiotics is recommended Ⓑ Atrial rate greater than ventricular rate
Ⓒ Stroke volume decrease Atrioventricular dissociation
Ⓑ Pregnancy ☛ increased estrogen ➜ Eversion of columnar Ⓓ Atrial contraction less than ventricle
epithelium onto ectocervix ➜ Visible cervical ectropion.
Ⓑ 2nd degree heart block ☛ problem in heart's electrical
159. An 18-year-old boy presents with delayed speech
development, taller than average height, immaturity, conduction system ➜ some signals from atria do not reach
gynecomastia, and small testes, with karyotyping showing ventricles ➜ irregular heart rhythm ➜ atrial rate becomes greater
47XXY. What is the diagnosis? - ID : 60677 than ventricular rate due to missed beats.

Ⓐ Klinefelter syndrome Ⓑ Down syndrome 164. Which bacteria has no cell wall? - ID : 72145
Ⓒ Turner syndrome Ⓓ Ptau syndrome

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Ⓐ Chlamydia Ⓑ Mycoplasma Ⓓ Respiratory changes in pregnancy ➤


Ⓒ Klebsiella Ⓓ Ecoli ✪ Respiratory rate ➜ ↑ Due to progestrone effect ➜ Wash CO2 ➜ ↓
Ⓔ Shigella PCO2
✪ Vital capacity ➜ Unchanged
Ⓑ Mycoplasma ➜ No cell wall ➜ Resistant to β-lactam drugs
✪ Tidal volume ➜ ↑ ↑
(Penicillin and cephalosporins).
✦ Levinson, Pg. 198, 198
✪ Inspiratory capacity ➜ ↑ ↑
✪ TLC ➜ ↓
165. A patient after transplant develop visual problem and ✦ Reference, Pg. 45
diarrhea on examination cells with basophilic inclusion
seem this is due to which of following - ID : 72165 170. Edema can occur due to decrease oncotic pressure
and due to raised hydrostatic pressure . Apart from these
Ⓐ HSV Ⓑ HPV 2 being causes for edema what combination can cause
Ⓒ EBV Ⓓ CMV edema due to local lymphatic obstruction? - ID : 72550
Ⓔ Adenovirus
Ⓐ Infection and neoplasia Ⓑ Trauma and albuneminuria
Ⓓ CMV ☛ Trasnmission ➜ Congenital, transfusion, sexual contact, Ⓒ Renal failure and hypoproteinemia
Ⓓ Cardiac failure and IHD
saliva, urine, transplant, owl eye intranuclear
inclusions
Ⓐ Chronic inflammation ( Filariasis, due to Wuchereria bancrofti )
S/S ➜ Infection in immunocompromised, especially pneumonia in
➜ Fibrosis ➜ Lymphatic obstruction ➜ Lymphedema.
transplant patients; esophagitis; AIDS ✦ Robbins, Pg. 100
retinitis (“sightomegalovirus”): hemorrhage, cotton-wool exudates,
vision loss 171. Which is a measure of dispersion? - ID : 77590

Ⓐ Measure of central tendency of collected data


✦ First Aid, Pg. 165
Ⓑ Measure of standard deviation
166. Patient presented with crushing chest pain for 3 Ⓒ Value repeating frequently
hours O/E bp and pulse was normal but RR= 33/min Ⓓ Measure of variance around the mean
Investigation of choice? - ID : 72266
Ⓑ Measure of dispersion describes the spread of a dataset.
Ⓐ CK.MB Ⓑ Trop T
standard deviation is a measure of dispersion that indicates
Ⓒ Myoglobin Ⓓ LDH
average deviation of data points from mean.
Ⓔ CPK
172. What is the process of studying the shape, size, and
Ⓑ ◉ Within 1 hour ☛ Myoglobin fine structures of chromosomes? ) - ID: 77614
◉ After 2-4 hours ☛ Trop I > Trop T > CKMB
Ⓐ Chromosome mapping Ⓑ Karyotyping
Trop-I is the most sensitive and Specific of all !
Ⓒ Genotype Ⓓ RFLP

Ⓑ Karyotyping is a laboratory technique used to visualize an


✦ Davidson, Pg. 497 ✦ Robbins, Pg. 417 ✦ Pathoma, Pg. 74 ✦ Harsh Mohan, Pg. 414 individual's chromosomes to check for any genetic disorders. It
167. Commonest virus causing CA in AIDS - ID : 72297
provides an organized profile of a person's
chromosomes.Chromosome mapping: Refers to the
Ⓐ HSV Ⓑ HPV determination of the sequence of genes on a chromosome.
Ⓒ EBV Ⓓ CMV Genotype: genetic constitution of an individual organism.
RFLP (Restriction Fragment Length Polymorphism): A technique
Ⓒ HIV infects helper T cells ( CD4-positive cells ) ➜ Suppression of used in molecular biology to determine variations in the length of
cell-mediated immunity ➜ EBV associated polyclonal B-cell DNA fragments produced by restriction enzymes.
lymphomas
173. Femoral nerve leaves lumber plexus at which level ? -
ID : 79191

✦ Oxford Microbiology, Pg. 404 Ⓐ L2-L3 Ⓑ L2-L4


Ⓒ L3-L4 Ⓓ L4-L5
168. Patient has excruciating right leg pain Anterolateral
right leg chordotomy was performed, It will relieve pain Ⓑ LUMBOSACRAL PLEXUS major nerves
by cutting which of following tract ? - ID : 72405
●Femoral nerve ➜ posterior divisions of L2 through L4
Ⓐ Right lateral spinothalamic tract ●Obturator nerve ➜ anterior divisions of L2 through L4
Ⓑ Left anterior spinothalamic tract ●Tibial nerve ➜ anterior divisions of L4 through S3
Ⓒ Dorsal column ●Common fibular nerve ➜ posterior divisions of L4 through S2
Ⓓ Left lateral spinothalamic tract ●Superior gluteal nerve ➜ posterior divisions of L4 through S1
Ⓔ Left Rubrospinal tract
●Inferior gluteal nerve ➜ posterior divisions of L5 through S2
✦ Kaplan Anatomy, Pg. 218 ✦ Kaplan Anatomy, Pg. 218
Ⓓ ➤ Pain in right leg ☛ Left spinothalamic tract
➤ Substantia geletinosa ➜ Lateral spinothalamic tract ➜ 174. Chi square use to measure - ID : 79273
Decussates obliquely 2-3 segments above ➜ Ascend Lateral white Ⓐ Statistical analysis Ⓑ Specificity
column of opposite side. Ⓒ Standard deviation Ⓓ Sensitivity
✦ Snell Neuro, Pg. 164

169. In the last trimester of pregnancy what change in Ⓐ Chi-square (χ2) ☛ Statistic is a measure of difference between
respiratory parameters occurs? - ID : 72532 the observed and expected frequencies of outcomes of a set of
events or variables. Chi-square is useful for analyzing such
Ⓐ Decreased FEV/FVC Ⓑ Decreased vital capacity
differences in categorical variables, especially those nominal in
Ⓒ Increased lung compliance nature.
Ⓓ Decrease PCO2 Ⓔ Decrease tidal volume
175. Abundant Cilia present in - ID : 79431

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Ⓐ Medial wall of ischiorectal fossa is formed by anal sphincter and


Ⓐ PCT Ⓑ Maxillary sinus
cystic dilation of anal gland also extend to these sphincter so
Ⓒ DCT Ⓓ Fallopian tube
infection can easily spread
✦ GRAY'S, Pg. 1157
Ⓑ Cilia ☛ structures of the paranasal sinus mucosa ➜ critical to
respiratory defense. 181. High nuclear-cytoplasmic n/c ratio, Pleomorphism,
increased mitosis, disordered cell maturation - ID : 83050
176. Which one of the following is the least important
regulator of aldosterone? ) - ID: 81884 Ⓐ Anaplasia Ⓑ Dysplasia
Ⓒ Neoplasia Ⓓ Neoplasia
Ⓐ Na concentration Ⓑ K concentration
Ⓒ CI concentration Ⓓ ADH Ⓑ ◉ Pleomorphism ☛ variability in the size, shape, and staining
of nuclei ➜ characteristic of malignancy and dysplasia.
Ⓐ Na concentration: Aldosterone is primarily regulated by the ✦ Robbins, Pg. 193
renin-angiotensin system, with potassium (K) levels being a direct
stimulator of its release. While sodium (Na) plays a role in the 182. Furunculosis on the tip of nose, infection spread to
cavernous sinuses via: - ID : 83074
renin-angiotensin system, its direct effect on aldosterone secretion
is less prominent compared to potassium. Ⓐ Ophthalmic vein Ⓑ Emissary vein
K concentration: Direct stimulator of aldosterone release. Ⓒ Mandibular vein Ⓓ Maxillary vein
Cl concentration: Has a lesser role in aldosterone regulation.
ADH (antidiuretic hormone): more directly involved in water Ⓐ Infection pathway can spread from Boil in Danger Triangle ➜
reabsorption rather than aldosterone regulation. Ophthalmic Vein➜ Cavernous sinus and can cause Thrombosis and
177. Which factor leads to a decrease in GH secretion? ) - eventually Death.
✦ Snell Review, Pg. 581
ID: 81943
183. Upper 2/3rd cervix, Pap smear is done which shows
Ⓐ Hypoglycaemia Ⓑ Stress
dysplasia, pleomorphism, loss of polarity, and active
Ⓒ Testosterone
mitotic figures but the basement membrane is intact what
Ⓓ Increase free fatty acids
is associated with this? - ID : 83094
Ⓔ Deep sleep
Ⓐ Carcinoma in situ
Ⓑ Stress: Growth Hormone (GH) secretion is influenced by Ⓑ Invasion of adjacent tissue
various factors. Stress, especially chronic stress, can inhibit the Ⓒ Invasion of basement membrane
secretion of GH. During stress, the body increases the production Ⓓ Carcinoma
of cortisol, a stress hormone, which acts antagonistically to GH,
leading to its decreased secretion. Ⓐ Carcinoma in situ ☛ characteristic Dysplasia in
Hypoglycaemia: usually stimulates GH secretion. cervix epithelial layer with an intact basement membrane ➜ No
Testosterone: generally stimulates GH secretion. invasion to deeper tissues ➜ precancerous condition
Increase free fatty acids: can decrease GH secretion, but stress
is a more dominant factor. 184. Congenital adrenal hyperplasia, enzyme deficiency -
ID : 83164
Deep sleep: GH secretion is actually increased during deep sleep.
Ⓐ 21 Hydroxylase Ⓑ Beta hydroxylase
178. Female with multiple sexual partners developed
Ⓒ 11 hydroxylase
vaginal irritation and pus, organism found with jerky
movements cause is: - ID : 82882
Ⓐ CAH ☛ 21 hydroxylase > 17 hydroxylase > 11 hydroxylase
Ⓐ Trichomonas vaginalis Ⓑ Vibrio cholera deficiency e female genotype ( XX) and ambigous external
Ⓒ Chlamydia Ⓓ Toxoplasma genitalia
✦ Robbins, Pg. 789
Ⓐ Trichomonas vaginalis ☛ Phase-contrast, dark-ground
185. Phase of cardiac cycles, with 60% ventricle fill - ID :
microscopy of a drop of vaginal discharge ➜ shows TV swimming 83344
with a characteristic motion in 40–80% of female patients.
Ⓐ Rapid inflow Ⓑ Isovolumetric relaxation
✪ Culture techniques are good and confirm diagnosis.
✦ Kumar and Clark, Pg. 182
Ⓒ Atrial contraction

179. Pt has multiple opacities in lung found on general Ⓐ 70-80% of ventricular filling happens passively during rapid
health checkup. 15 cm mass fixed compact granuloma inflow phase when AV valves are open and ventricles are relaxed.
without necrosis, neutrophils surrounded by epithelioid
giant cells: - ID : 82966 186. Structure not in spermatic cord but in inguinal canal -
ID : 83477
Ⓐ Tb Ⓑ Sarcoidosis
Ⓒ Mesothelioma Ⓓ Aspergillosis Ⓐ Ilioinguinal nerve Ⓑ Epididymis
Ⓒ Pampiniform plexus
Ⓑ Sarcoidosis ☛ Non caseating Granuloma ➜ Epithelioid cells
Ⓐ Ilioinguinal nerve is not a part of the spermatic cord but is
rimmed by an outer zone rich in CD4+ T cells
✔ Microscopic features of Granuloma ☛ ➊ Schaumann bodies ➋ found in the inguinal canal ➜ sensory innervation to upper medial
Ateroid Bodies part of thigh, base of penis and anterior scrotum in males, mons
✦ Robbins, Pg. 513 pubis and labia majora in females.

180. Perianal abscess in female infection in lower part of 187. Dapsone was given to lady for erythema nodosum.
the anal canal spreads laterally to - ID : 82973 Now she has decreased Hb, MCV, and retic count 16%. On
Smear, irregular contracted cells with keratocytes - ID :
Ⓐ Ischiorectal fossa Ⓑ Superficial pouch 83946
Ⓒ Deep perineal pouch Ⓓ Birth canal
Ⓐ Megaloblastic anemia
Ⓑ Drug-induced destruction of RBC
Ⓒ Malaria Ⓓ Sickle cell anemia

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Ⓑ Dapsone ☛ can cause drug-induced hemolytic anemia ➜ lead Ⓐ Closure of Mitral valve Ⓑ Close of Tricuspid Valve
to decreased hemoglobin, microcytic anemia (low MCV), and inc. Ⓒ Closure of Aortic + Pulmonary Valve
reticulocyte count. Ⓓ None

188. Early diagnosis of preeclampsia done by: - ID : 83980 Ⓒ ✪ Isovolumetric relaxation ➜ Closure of pulmonic and aortic
Ⓐ Cortisol monitoring Ⓑ HbA1c valve ➜ S2
Ⓒ Early BP monitoring Ⓓ Regular LFT ✪ Isovolemtric contraction ➜ Closure of A-V valves ➜ S1
✦ Guyton, Pg. 115, 114

Ⓒ Early BP monitoring is essential in the early diagnosis of 195. In Vitamin A deficiency complication can occur is
preeclampsia. kidney stones - ID : 84318
189. Person with difficulty in swallowing, on endoscopy, Ⓐ Atrophy of renal epithelium
there was some white growth inside the esophagus with Ⓑ Hypertrophy of renal epithelium
pseudohyphae and dimorphic organisms seen, likely Ⓒ Metaplasia of renal epithelium
reason is: - ID : 83995
Ⓓ Dysplasia of renal epithelium
Ⓐ Candidiasis Ⓑ Aspergillosis Ⓔ Hyperplasia of renal epithelium
Ⓒ Histoplasmosis Ⓓ Mucor
Ⓔ Rhizopus Ⓐ vitamin A deficiency ➜ lack of retinoids can cause reduction
in cell growth and function ➜ atrophy of renal epithelium, which is
Ⓐ Candidiasis ☛ Pseudohyphea causes oral and esophageal a component of urinary system ➜ eventually lead to renal
thursh(Whitesh lesion) in immunocompromised pt dysfunction and increased risk of kidney stones.
✦ First Aid, Pg. 153 ✦ First Aid, Pg. 153
196. Testes are removed. what happened - ID : 84373
190. A 50-year-old patient has right atrial infarct, which of
the following structure is damage and necrosed? - ID : Ⓐ Loss of libido and depression
84019 Ⓑ Voice becomes high pitched
Ⓒ Irritability , Hot flushes
Ⓐ Crista terminalis Ⓑ Septomarginal trabeculae
Ⓓ Dec FSH and LH
Ⓒ Pectinate muscles Ⓓ Chordae tendineae
Ⓔ Annulus fibrosis
Ⓐ Removal of testes (orchidectomy) ☛ leads to decrease in
Ⓐ Crista terminalis ☛ located within right atrium, and an infarct testosterone ➜ testosterone is key to libido and mood ➜ lead to
in this area would directly affect it. loss of libido and depression.
Chordae tendineae ☛ located within the ventricles of the heart, Voice changes Once voice deepens during puberty due to
testosterone, removal of testes typically does not result in a high-
not the atria that connect the papillary muscles to the tricuspid
pitched voice.
valve in the right ventricle and the mitral valve in the left
ventricle. 197. A patient with diabetes has developed hypertension
✦ Sceincedirect Elsevier, Pg. ,
and is experiencing intermittent leg pain when walking.
191. In malnourished child cause of generalized edema is: Which medication should be considered for this patient? ) -
- ID : 84046 ID: 85270

Ⓐ Hypoproteinemia Ⓐ ACE inhibitors Ⓑ Calcium channel blockers


Ⓑ Increase hydrostatic pressure Ⓒ Beta Blockers Ⓓ Diuretics
Ⓒ Increase Oncotic pressure
Ⓐ ACE inhibitors (Angiotensin-converting enzyme
Ⓓ Increase Calcium
inhibitors): are the first-line choice for hypertensive diabetic
Ⓐ Malnourished child ➜ Hypoproteinemia ➜ ↓ osmotic pressure patients, especially those showing signs of nephropathy or
gradient ➜ draws fluid back into the blood vessels from tissues ➜ peripheral vascular disease, as indicated by intermittent
claudication. They also provide protection against diabetic
generalized edema
nephropathy and can improve blood flow in patients with
Increase hydrostatic pressure ☛ can cause localized edema, as
peripheral arterial disease.
seen in CCF, but not the cause in malnutrition.
192. Test that rule out false negative have good: - ID : Calcium channel blockers: effective for hypertension but do not
84067
have the renal protective effects seen with ACE inhibitors.
Ⓐ Specificity Ⓑ Sensitivity Beta Blockers: May exacerbate peripheral arterial disease and
Ⓒ Accuracy Ⓓ Positive predictively mask hypoglycemic symptoms.
Ⓔ Negative predictively Diuretics: May worsen glucose control and aren't primarily
indicated for diabetic patients with intermittent claudication.
Ⓑ Test rules out false negatives ➜ high sensitivity ➜ true
198. A 35-year-old HIV-positive man presents with
positives are correctly identified
diarrhea of 4 weeks' duration accompanied by tenesmus.
193. In alcoholic patient, steatohepatitis develops. Most Blood and mucus are present in the stool. He is not on
dangerous metabolite of alcohol which causes disease: - ID antiretroviral therapy. Which of the following is the most
: 84079 likely diagnosis? - ID : 86495

Ⓐ Acetate Ⓑ Acetoacetate Ⓐ Cryptosporidiosis


Ⓒ H2O1 Ⓓ Acetaldehyde Ⓑ Cytomegalovirus (CMV) colitis
Ⓒ Giardiasis Ⓓ Microsporidiosis
Ⓓ Alcohol consumption ➜ metabolism in liver ➜ produces
acetaldehyde ➜ toxic substance ➜ inflammation and fat Ⓑ Cytomegalovirus (CMV) colitis: The clinical presentation of
deposition ➜ steatohepatitis. chronic diarrhea with blood and mucus in the stool in an HIV-
positive patient is suggestive of CMV colitis. Cytomegalovirus
194. Second heart sound produced by: - ID : 84096 (CMV) is an opportunistic virus that can cause gastrointestinal
infections in individuals with weakened immune systems, including

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