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A 21 years-old medical student went to a Friday night party.

She had a history of asthma


and was on inhaled corticosteroid and intermittent bronchodilator for 2 years; however, the
medication was discontinued for 2 weeks. During non-stop dancing in the party a few hours
after dinner, she felt shortness of breath and lightheadedness. She was brought to emergency
room for investigation and treatment. Physical examination revealed BT36.7 C,
PR100/minutes, RR 24/minutes, BP 100/70 mmHg, generalized erethrematous rashes,
stridors and wheezing heard both lungs and increased bowel sound. Similar'Ñw anaphylaxis law
VAO Iaiwili asthma exacerbation ilainniliitxasanaphyiaoi
Question:
1. What is your diagnosis?
2. What is your investigation plan?
3. What are the possible causes of her symptoms?
4. What is the possible mechanism of the disease?
5. What is your treatment plan? Prevention?
-
VID asthma ñivinoi niiwihlmwoiuiitoonivii

1) DX Signs

on Ñioln

Jail ñvonointu urticaria in ,

ovnnnriiwinw.mn/i.BPiooh-oinornal/riininwoii
too 13PM

HW of anaphylaxis

Iailinullisysteno:/ iilñ
onset Shuai ow
"

Ñow Nri
online

chili urticaria in

101mi 01 ÑwuÑn ,
no Rs symptoms ,

1in.Ñw multi -

systems
protein / WmiÉow

w .anphyie.gu/nIiHRhaiqnvouiatnNwalvga-
e.g.iuhniiwmtid.ir Vain histamine

one ,

e. ñwuwiiaino.info/Uonrioi
g.
anaphy onset rio

balooiluniinnuiiooiiiiuoiuvunooiiuiin.nnwnumhinn.in reactions
delay anaphylaxis In
'

vin d- cross -

llainioirolulnu ) iñnoimiwiiñuoiuiictshrln
.

1 exceptional ,
-
Naini ninimwi :overDx anaphylaxis
hey noiñoimimishinrdwo :
anaphylaxis systemic / generalized mast cell degranulation syndrome
niwiiodpñishin nilwiiw urticaria ilainointu anaphylaxis
Iairininñifluidhileahonvsiln Shiu urticaria / ñ
'

shooter:ñniw Bpriiwn
Exception i.

Ñnniioi antihistamine willoch histamine release ilainhwiinroiouisñishinln


.

i. ñwovniiniwviow

generalized urticaria ,
- ni include nwliñiai urticaria
'

iii. n-iriniw.nhiiw.nluo-iiinuwlilaioonoiiln.nu/iIin8iuwinoi e.
g. psychi ivirnw WHO moi DX ratio severity roo : wodwnoi

or angioedema ñi airway resp compromise

¥: Iwiiñnowiliiainluo !

urticaria
ñniin mast cell degranulation IgE mediated
-

atypical ,

Non IgE mediated


-

lnoiñuoiuiiñi minnow exercise Irion


lniirioiiw ; Ivi ihr minim
-

food in ÑwNi e.
g. ruwfv.hn uh , pitta

wheat related exercise-induced


-

anaphylaxis
www.n Nidia
histamine + leukotriene

wheezing / stridor ,

: inn peristalsis
food

Anaphylaxis iñnainñnnn
adult ainiñnnn drug drug-induced anaphylaxis www.nrio NSAIDs not AIB

.nu/iainIninirioiiiiiwiwi-ihruriiriwoivin urticaria / angioedema Iou Dxainoiiini ATB


( DX Ñn so go
-

%)

oinituwiinnirtillioonw.in

ñnvaiocon strict iii. owñv uovñ"n riri onset i. innit iuiniuoi.tl hrs + kiln response rio antihistamine ooiiioniioiuaiouwon-1.GE mediated Irion
-
i i
- iunoir.no ,
nalnuñniñnnn leukotriene not histamine
, ,

:
-

iñnnn NSAIDs Uni: n.in .


wii leukotriene nmiwnrilunulivnnwiain.int/nriroicoX pathways

minnow noi mechanism É espnwñii ni


.

NSAIDs wing
para
-

i. vinnouñwi tats iitabniiniwoioiilaiwdonv ,


nisi shock linin In niihoihnoir.li Ivooiñ"w dilute rioiliiri ,
lain tissue perfusion
'

IM -

:
poor

Pitfall insulin i. absorb Siri


in Ir Inoki dilute ruin arrhythmia / ischemia :Ñw vasoconstrictor
Adrenaline auto injection
hiivniiirnu ooiioviilililihnnivhro
( symptomatic -1×1

Dx anaphylaxis noilii adrenaline no hiii Nio BP drop aioli


-

: adrenaline Euro vasoconstrictor prevent nail


+ cell degranulation
initio path physio ,
o
lithium n.nwiwn.vn in
,
g)

Ii tube Kirin : on
early intubate / hi adrenaline mining
inoihiñieñilñnrinoiti adrenaline Wion rinwiiñu kimono comin; tracheostomy / cricolhyroidotonyi

marker of mail cell degranulation


niiw.tw ai lab in: rival rainbow ñinioilñ
'

• .
Case discussion

Infective endocarditis penicillin gentamicin

penicillin
penicillin

penicillin
normal saline

penicillin

penicillin dose
PR 100/min, BP 80/60 mmHg, generalized
erythematous rash, and wheezing both lungs, anaphylaxis oil

infective endocarditis
or desensitization

nwriidiiuoiunioidiwlunikirioouw.vn iñniin ADR mon -
immune )

owlwiiwniunwliinlicox.ch
-

Fltx of drug allergy

rfoulunilaicrossirinñnaonvii li uñiuñiui structure ñioii cross - react nwliiroulunir.nw.com inhibitor ñinoiwidiuuoiiiiniuriñorñoo )

out structure noioñuruinioiuoioñolñ e.


g.
sulfa B- lactam
.
uitwdiwwoi , e.
g. Ini NSAIDs uÑ structure niiirriwoiwir leukotriene ruÑouÑw

owcross-reac-ln.ir/rinio;hCMHaireagen-lniorIririiirio

diiuhnwlininw-oiinumorioniniin.ir/noIainw-oviu i.nowninoir.itniiwwiuahpnn.info latex


oroirwñinoililatexioo :( www.nmnimin.nwnii.n.ntitoleyiooe.g.su COVID vaccine 1011 MRNA Ñ PEG

ñnñiihr nrio anaphylaxis non -


immediate Iaiwili anaphylaxis , sinovacnoPEG.polysorba-le.la/exIomdvinaMergywoiwn
At
Ñpolysorbateiwulwvaccinenilñuaiorñn ,

von IgE vs non -

IgE ( anaphylaxis us pseudo allergy ,

points anaphylaxis law


IgE vs non -

IgE e.g.SE/ drug overdose ñwcpmiioiios immune-mediated

IgE oiinishintestln
.

ñiniiriunñoñiñ reagent
'

linishintes-llrie.g.r.niID-leslnointwoiinn.is/erile oiñwoiinishinpriihteitlñ

g.nu/i uCPMnioushintes-lnegni vJwnoiI oi ignoi o' facility woluwt-xanaphyors-VTENIn.hn


e.

now .Ñ
txlailññooiluioo
oiilailñrivon mediated ñnioolailñi
161'
plain pseudo allergy
'

E NSAIDs
.

Ig -
i voi

pride -

ve n'ooni ID

minutia a mini PPD on


anaphy no !

IgE mediated nail cell degranulation Ibibio days


'

u so mins ,
-

:
-
i. inn ñuñ i -3 our PPD ,

control NawabiIn
g.nu/iiwCPM
.

e.
+ ve o:
neg
iñiiriimñiñ allergist / dermatologist / Ents nitwit histamine ili morphine nnwlñ i nail cell degranulation Inonu
'

: no :p

iliniimñ"o , iovintnoiuwn.mn urticaria uwn !


lin.vn/iriiJudermalographisnuovriuv.nivin urticaria nail
noiin initial wheal linin in diameter uoniwuvi

wing/ uaiñiis -30min luoniuuvi )

ni delta :3 mm nÑ
irwin: pseudopod

concriivw.no/aiioo:viw
test Inion urticaria 11g E- mediated ,
:
-
rhino MP rash nor shin test Bibi mechanism
intro :

immediate reaction I Dxainilainio ,


iihioiirowluniiiwiivu MP rash : non severe non
-
-

niÑw immediate nrioanaphy no

.
: noon; shin test Iiniivitwnoihioi + refer in specialist hiii
liii graded challenge ooilioi
.
nilaiivitu i avoid no :

Edp refer rñio verify oiinioiiluw Igor.


lainwith
MP linin causes Hiroo win
:
nwliuonlailñuionoi ihr law winaintwnuuonoiinoiitwnowiñn
e.
g. iuunouoiuui

Trivino UNNI

return vasodilatation
'

- -

.
esp
niwinlu form in Enn immediate reaction
.

poioiñoluwitwdvun
,
+ Ñ vi.written

hioinioii
'

graded challenge
n.i.v.im
oiñilñnoiiñnoimiiiolri

oniirioirion.uw.fi
IIGE mediated ,
-

IAGEP )

- 1Wh
niñwovioiñnmpiou Iailniñnnnoiñoñi nidiionw.in/iNv-noiriiIniaiioiwhriinoi
- 1-1 Wh
onset it www.wnii
( DRESS ) - 3Wh
MP +
fever
IÑWUWOI )
lrnirli ,

Iiuonoi SE iiiñnnnoniiluw i dose dependent ,

ilailñdni www.iopn.nw/ immune reaction ,


i :/ inion.nu ninirili
iuwonoiiii
e.g.lninuoivinonwiwiiiootilidvun.vn SJVTEN

AIDEN 4 ñii:Ñw cause hi


unniiiivitwñoiliioiñiini e. bacterial meningitis ñiiini let -3 noir's risk benefit
g.
-

ÉE→

÷¥¥ Kili absolute vi. ronlioiii


Iuaiñirioloiuo onolwawiuoo
: iñv / Ininhuman I

nilwitumnimivunoiloitorilrinoiuonoilv.in/
in us union

iiitulriñi IgE a DRESS )



nimmi + timeline + rhino wifi iuii :Ñu DRESS

rñnñiniluiñn DRESS ius-snaion.ir

NSAIDs inn drug induced


- AIN conn - DRESS
twin aromatic )
-

: sens Iaiñwn
Patch test Mini non - immediate reactions OP Iainoini
iniivfwnoilu.in/unoriiIwii
'

danger signs ,

I unionin :/ ii.www.mail
.lu adult hi ig www.oiouhiigqiihrililu graded challenges

1 therapeutic dose
Amoxicillin llavufanic
Oral form e.
g. Augment in 1 61s
my
+
37s
mgl
oiñwlaiownnoinioinn dose riinhi In observe
'

wino until -1 lot lanai


01.5mg ) is so mins
-


: .
on + .

lion .
: practical hint is iii. si )
.

1- lab iinniilrivi initiative Eoninoiiiimiln.ve


du-ñwÑu it dose ,
observe is so
-
mins

do 15-30 mins hi 11¢

hi lnowhiiln nail
.

do is -30 mins V1 87.5 !

Iaiuiiiwiioi linin therapeutic dose niki


optimism

ninin.nouiiiniii exclude titi


diwlunini shin test Bibi
:Ñu non - immediate

uiwliuiñiiwiou !
unicef -3 Whip lactam Éulri across react ñwlñ ,
e.
g.
- -

Severe immediate nwo graded challenge Iñiooinilw severe non - immediate ,


-

: Tx anaphy ironists no:


A 20-year-old forth year medical student has walery running nose sneeze, itching of
nose and eye almost daily in the morning. Her symptoms increase when she visits her boy friend
who has cats at home.
Past medical history: asthma
Past surgical history: none
Allergy: No known drug allergy
Medication: antihistamine as needed
Physical examination: Well developed, well nourish female
Vital sign:T 37 C, p 64/min, R 16/min, BP 100/60
HEENT:moderately congested and pale nasal mucosa with moderate amount of clear rhinorrhea.
Chest: clear to auscultation
Cardiovascular:unremarkable.
Further information and laboratory date will be available upon request.
Questions:
1. What is your diagnosis?
2. What is your investigation plan?
3. What are the possible causes of his symptoms?
4. What the possible mechanism of the disease?
5. What is your treatment plan? Prevention?

Suggested reading:
1. Clinical practice guideline: Internal Medicine Department, Chulalongkorn University.
2. Cecil text book of Medicine
3. Harrison text of Internal medicine

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