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Correct answer: b
Correct answer: c
Correct answer: a
Correct answer: a
53. For antibody detection in transfusion medicine by heat elution method, temp of water
bath is kept at:
(a) 37oC
(b) 40oC
(c) 20oC
(d) 56oC
(e) 38oC
Correct answer: d
55. The final step in aPTT procedure to form the clot is addition of
(a) Calcium chloride
(b) Calcium phosphate
(c) Calcium oxalate
(d) Calcium gluconate
(e) Calcium Citrate
Correct answer: b
Correct answer: a
Correct answer: c
62. A defect in which of these coagulation factors would result in abnormal PT and aPTT:
a. Factor II
b. Factor VII
c. Factor XI
d. Factor IX
e. Factor VIII
63. Which of the following translocation is seen in acute promyelocytic leukemia (AML-M3)?
a) t(9;22)
b) t(11;14)
c) t(15;17)
d) t(8;14)
e) t (8:21)
Answer : C
64. A 5 years old boy presented with progressive pallor and easy fatigability. His CBC
shows, TLC: 5x 10 9 /L, platelets 234 x 10 9/ L and Hb of 7 g/dl with MCV of 61fl and
MCH of 21pg. His DLC include 30% neutrophils, 52% lymphocytes, 2% monocytes and
16% eosinophils. What is the most likely cause of his anaemia?
a) Worm infestation
b) Blood loss
c) Strict vegetarian diet
d) Bone marrow failure
e) Acute leukemia
Key: A
65. A 10 year old male, known patient of thalassemia major with history of recurrent Red
cell transfusions. Monitoring of iron overload should be assessed with which of the
following test:
a) Serum iron
b) Serum ferritin
c) TIBC
d) Serum transferrin saturation
e) Perls stain of bone marrow fragment
Key: B
66. A 55 year old male has developed progressive weakness of both limbs, easy
fatigability and pallor. His Hb was 9.5 g/dl with MCV 112 fl, MCH 34 pg. He had
history of partial gastrectomy and oesophagectomy 10 years back. The most
likely diagnosis is:
a) Hemolytic anaemia
b) Megaloblastic anaemia
c) MDS
d) Anaemia of chronic disease
e) Iron deficiency anaemia
Key: B
67. A woman of 32 years age developed shortness of breath and easy fatigability.
Her Hb was 10.5 g/dl. What will be the first sign on peripheral film if she has iron
deficiency anaemia?
a) Hypochromia
b) Anisocytosis
c) Poikilocytosis
d) Microcytosis
e) Target cells
Key: B
68. A patient has been diagnosed as a case of megaloblastic anemia. Which of the
following form is used in the treatment of megaloblastic anaemia:
a) Methycobalamin
b) Ado cobalamin
c) Hydroxy cobalamin
d) Methyl tetrahydrofolate
e) Methotrexate
Key: A
69. A 27 year female, gravida 3 and para 2, presented with iron deficiency anaemia.
Her daily requirement of iron is:
a) 0.5 mg/day
b) 1 mg/days
c) 2 mg/day
d) 0.6 mg/day
e) 1.5- 3 mg/day
Key: E
70. VwF is synthesised in:
a. Endothelial cells
b. Megakaryocytes
c. Platelets
Key: d
71. A 58 year old lady, known case of Hypothyroidism and diabetes mellitus type II for last
two years presented with Hb of 9.1 g/dl with MCV of 112fl. O/E she has vitiligo, no
visceromegaly. Peripheral blood shows macro-ovalocytes. What will be the most likely
diagnosis:
a) Iron deficiency anaemia
b) Pernicious anaemia
c) Hemolytic anaemia
d) Aplastic anemia
e) Anaemia of chronic disorder
Key: B
72. A 17 year old boy presented with complaints of easy fatigability, pallor and
breathlessness on exertion. O/E he has lemon tinged skin and no visceromegaly. His
CBC reveal TLC 2.3 x 10 9/L, Platelet 35 x 10 9 /L, Hb 6.7 g/dl with retics of 0.3 %. All
of the following can cause megaloblastic anaemia except:
a) Colectomy
b) Ileal resection
c) Pernicious anaemia
d) Fish tapeworm infestation
e) Methotrexate
Key: A
73. A 42 years old female, a known patient of rheumatoid arthritis, presented with pallor for
the last 6 months. Her Hb was 9.0 g/dl with MCV of 73fl and ESR 98 mm at end of 1 st
hour. Further workup shows serum ferritin 85 ug/L (14 – 150 ug/L), total iron binding
capacity is 30 umol /L (40- 75 umol/L) and serum iron is 8 umol/L (10- 30 umol/L). Her
most likely diagnosis is :
a) Iron deficiency anaemia
b) Anaemia of chronic disease
c) Thalassemia major
d) Thalassemia minor
e) Sideroblastic anaemia
Key: B
74. A 25 year old man presented with complaints of generalized weakness. He has
undergone laparotomy and illeal resection was done 6 months back. His peripheral
smear revealed anisocytosis, poikilocytosis and macro-ovalocytes. What is the most
likely cause of these morphological findings:
a) Iron deficiency
b) Vit K deficiency
c) Vitamin B12 deficiency
d) Intrinsic factor deficiency
e) Hepcidin excess
Key: C
75. A 14 year old female presented with complaints of High grade fever, drowsiness and
vomiting for last 7 days. On examination: A sick looking young female with multiple
bruises on body. CBC showed WBC of 13.0 x 10 9/L, Hb 5.6 g/dl. On peripheral
smear examination there was marked fragmentation and leucoerythroblastic blood
picture with decrease platelet count. Coagulation profile is normal. LDH is 999 IU/.
Direct coombs test is negative. What is your most likely diagnosis?
91. A 1 year old child presented with severe macrocytic anemia with sub-nephrotic range
protienuria. His Vit B12 levels are low. The diagnosis is
a. Imerslund-grasbeck disease
b. Thiamine deficiency
c. Roger syndrome
d. Pearson syndrome
e. DIDMOD Syndrome
Key: a
95. A 60 year old patient presented with anemia requiring blood transfusion, there is also
associated mild thrombocytosis. The most likely diagnosis is
a. GI bleed
b. MDS 5q
c. Both of above
d. Acute Leukaemia
e. Aplastic Anaemia
Key: c
100. For coagulation studies, blood sample of a patient is taken in anti- coagulant as:
a. Heparin
b. Tri sodium citrate
c. EDTA
d. CPD
e. Coumarin
Key: b