Rajiv Gandhi University of Health Sciences, Karmataka

Fourth Semester B. Pharm Degree Examination- JUNE-2019

Time: Three Hours Max. Marks: 75 Marks
Physical Pharmaceutics - II
Q.P. CODE: 5015
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2x 10 = 20 Marks

w Define colloids. Discuss the electrical properties and kinetic properties of colloids.
Define and explain in detail Non-Newtonian flow of liquids.
3. Define emulsions. Explain in detail different identification tests for emulsions.
SHORT ESSAYS (Answer any Seven) 7x3=35 Marks
4 With the help of neat diagram explain Andreason's pipette method tôdetermine the particde
size.
5. Discuss the general properties of collolds.
6. Define order of reaction. Explain the differential method for determination of order of
reaction.
"7. Explain the principle of cup and bob viscometer.
"8. Discuss settling of suspensions.
9.
with the help of graphical representation explain the weight distribution of powder.
-10. Explain the effect of electrolytes on collolds.
11. Discuss the chemical factors affecting chemical degfadation of pharmaceutical product.
12. Define angle of repose. Explain the method to determine the same.

SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks

j3: What is gold number?
14. What are Bulges and Spurs?
15 Define phase inversion.
t6. Classify colloids.
17: Signiflcance of shape factor
J8. Define pseudo zero order reaction with example.
19. Differentiate between bulk and true density
20. Define the term microemulsion.
21. Define the term viscosity.
22. Photolytic degradation

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 Rajiv Fourth
Gandhi University of Health Sciences, Karnataka
Semester B. Pharm Degree Examination - 09-Jan-2020
Time: Three Hours Max. Marks: 75 Marks
Physical Pharmaceutics - II
Q.P. CODE: 5015
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2x 10 = 20 Marks

1. Describe the kinetic properties of colloids.

2. What is thixotropy? Explain the thixotropic properties of the plastic and pseudoplastic
materials.
3. Define emulsions. Classify with examples. Write a note on instab1lities of emulsions.

SHORT ESSAYS (Answer any Seven) 7x5=35 Marks

4. How do you prepare lyophobic colloids? Give examples.
5. Give the equation and graphical representation of zero order, first order and second order
rcaction.
6. How do you determine bulk density?
7. Differentiate creaming and cracking of an emulsion
8.. What are d1latant systems? Explain with examples.
9. Explain the concept of Donnan membrane equilibriumn.
10. Discuss the, physical and, chemical factors influencing the chemital degradation of
pharmacceutical product.
Give the importance of porosity and anglc of repose.
12. . 40w.do you represent the particle slze distribution graphically?

..SHORT ANSWERS (Answer AlI) 10 x2= 20 Marks

13. Why deflocculating agent is added in the determination of particle size'
by sedimentation
method.
14. What is hysteresis effect?
15. Define hysteresis loop.
16. Differentiate Micro and Multiple enulsions
17. What do you mean by polydisperse system?
18. What is hydrolysis? Write any two preventive methods of the same.
19. What s +dc/dt?
20. Name two instruments used to measure turbidity.
21. What is 'Rheogram'?
22. .Define an emulsion. Write two advantages of emulsion.

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 Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination - 08-Dec-2020
Time: Three Hours Max. Marks: 75 Marks
Physical Pharmaceutics - II
Q.P. CODE: 5015
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2x 10 = 20 Marks
1. Describe in detail optical and kinetic properties of colloids.
2 Explain in detail different systems of Non-Newtonian flow of licquids with respective equations.
3 Derlve the equation for the determination of rate constant, half life and shelf fife for first order
reaction kinetics.
7x5= 35 Marks
SHORT ESSAYS (Answer any Seven)
4. Write a short note on stability of emulsions.
5. Write the principle and working of coutter counter method to determine particle size with neat
diagram.
6. Briefly explainthe preventive measures for chemical degradation by oxidation.
v.7, Discuss.briefly thecorncept of DLVO theory with energ9y curves.
8 Explain the principle and. working of Ostwald's viscometer.v. aive"
9. Write short note onsettling properties of suspensions.
10:: Write in brief on derived properties of powders.
1lr: What arethe different-methods for detecmining order of reaction'and explain any two
i 12... Briefly.describe electrical double layer with diagram.
SHORT ANSWERS (AnswerAll): r a S : 10 x 2 20 Marks
J3. Define first order reaction and zero order with example.
14. Define pseudo first order-reactian and molecularity ofreaction withrexample.
15. Rheogramn and rheopexya.
16. State Edmundson's equation.
17. Ferret diameter and Projected diameter.
18. What are assoclation collolds?
19. Gold number and Tyndall effect.
20. Heckte equation.
21. Stress and Strain.
22. Relative viscosity and specific viscosity.

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 Sciences, Karnataka
Health
Gandhi University of Examination - 22-Mar-2021
Rajiv Pharm Degree
Fourth Semester B. Max, Marks: 75 Marks
Time: Three Hours
PHARMACEUTICS - II
PHYSICAL
Q.P. CODE: 5015 asked.
questions
be specific to the necessary.
Your answers shoulddiagrams wherever
neat labeled
Draw compulsory.
All the Questions are Marks
2 x 10 = 20
specific
the method to determine
LONG ESSAYS
properties of powder and explain
1 List out various derived displacement method.
surface area of powder by gas relationship
OR
order reaction rate constant. Show the inter
Deduce an equation for first reaction.
the half period in first order
between the initial concentration and Thixotrophy.
different methods of measurement of
2. Define Thlxotrophy. Explain the 7x5 = 35 Marks
SHORT ESSAYS
colloids.
3. Write ay two methods of purification of
OR
application.
Describe association colloids. Mention their and plate
overcome. Mention the advantages of a cone
Define plug flow and how it can be
viscometer.
OR
Explain dilatant systems with suitable cxample.
and plastíc deformation of solids.,
5 Dfine deformation. Explainrelastic
E. Discúss the factors affecting settlement of
particle in suspensions,
Explain-any two physical instability parameters-in an emulsion.
Doefiie'ahgle of repose and discuss"the method
todetermine it. Give ts significance.
8.
oxidative breakdown?: 1

How do you protect drugs against

SHORT ANSWERS
29.2 = 20 Marks
10. Define Hardy-Schulze rule.
11. Why colloidal solutions are coloured?.
reaction
" 12. Define photolysis and zero order
13. Give the importance of bulges and spurs.
14. Define poise.
15. Define degree of flocculation.
give its equation.
16. Write the applications af bulk density and
17. Define porosity. Give Its applications in pharmacy.
18. Define half-life and shelf life of a reaction.
19. Define energy of activation and give its importance

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 Gandhi of Health
University Degree Sciences, Karnataka
Rajiv Fourth Semester B. Pharm Examination - 18-Nov-2021
Max. Marks: 75 Marks
Tlme: Three Hours
Physlcal Pharmaceutics - II
Q.P. CODE: 5015
questlons asked
Your answers should be speclfic to the necessary
Draw neat labeled dlagrams wherever
Allthe Questions are compulsory.
2x 10 = 20 Marks
LONG ESSAYS
of colloids.
1. Explain different methods of preparation and purification
OR
WIth the help of neat dlagram explaln the worklng principle of Cup and bob and Cone and plate
viscometer with Its advantages and disadvantages.
means by which controlled flocculation
2. What Is meant by controlled flocculation? Discus varlous
can be achleved with example.
7x5= 35 Marks
SHORT ESSAYS
3. Explaln kinetic properties of colloids.
OR
Explain protectlon of collolds.
4. Explaln the mechanism of thixotropy with example.
OR
Wrlte the varlous ldentiflcation tests for different types of emulsions.
to determine the particie
5. With the help of neat diagram explain Andreason's plpette method
s0ze.
of coulter counter method to
6. WIth the help of a neat dlagram explain principle and working
determlne the particle size.
7. Explain porosity. Glve its applicatlons In pharmacy.
of order of reaction.
8. Define order of reaction, Explain the substitution methÍd for determination
and oxidation.
9 Explaln the preventive measures for chemlcal degradation due to hydrolysis
10x 2= 20 Marks
SHORT ANSWERS

10. What is Tyndall effect?

11. Define zeta potential with example.
12. Define Viscosity along with its units of expressions.
13.
Define Newton's law of flow with equatlon.

14. Define creaming and cracking.

15. Define HLB value and Griffins HLB Scale.
16. What Is compresslbility Index?
17. What Is void voiume and porosity?
18. Define zero order reactlon with sultable
example.

19. Define shelf life of a medicinal product.

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 Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination - 02-Jul-2022
b w n e d i p

Time: Three Hours Max. Marks: 75 Marks

PhysicalPharmaceutics - II
Q.P. CODE: 5015
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever
Sory. necessary
All the Questions are
LONG ESSAYS 2 x 10 = 20 Marks

1. What are colloids? Give example. Explain any four methods of preparation of different types of
colloids.
OR
Define Newtonian flow of liquids. Explain shear thinning system of liquids with
Ww.
graphical
representation.
2. Discuss various theories of emulsification.

n e d i p d

SHORT ESSAYS 7x5 = 35 Marks

3. Explain the concept of DLVO theory with energy curves. How this theory is applied in stabilizing
the colloidal dispersion.
OR
Explain any two methods of purification of colloids.
4. Explain any two physical instability parameters in an emulsion.
OR
Explain the formulation of formulation of flocculated suspension.
5 How do you represent particle size distribution?
6. With the help of neat diagram explain principle and working of coulter counter method to
determine the particle size.
7. Define angle of repose. Explain the method to determine the same.
8. Write short notes on accelerated stability studies and application in pharmacy.
m e d i p d i n

Explain factors affecting rate of a chemical reaction.

SHORT ANSWERS 10 x 2 = 20 Marks

10. State and explain Hardy schulze rule.
w w n e d i o d

11. What is gold number?

12. Define Rheology. Give any two applications. n e d o d i n

13. What is Negative thixotropy?

14. Define sedimentation volume and degree of floCculation.
15. Define HLB value and Griffins HLB Scale.
16. Define poly disperse system.
17. What is bulk density and true density?
18. Define molecularity of a reaction with example.
19. Define first order reaction with suitable example.
e d i p c

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Rajiv Gandhi University of Health Sciences, Karnataka

W

Fourth Semester B. Pharm Degree Examination - 22-Nov-2022

m e d i p

Time: Three Hours Max. Marks: 7S Marks

Physical Pharmaceutics - II
Q.P. CODE: 5015
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
All the Questions are sory.
LONG ESSAYS 2x 10= 20 Marks
1. Discuss the electrical properties and kinetic properties of colloids.
OR
in
Define Thixotropy. Explain different methods for its determination and give its application
pharmacy.
2. How do you prepare flocculated suspension? Define sedimentation volume and degree of
Flocculation.
e d i p d h
SHORT ESSAYS 7x5 = 35 Marks
3. What are colloids? Classify the colloids. Differentiate between different types of colloids.
OR
Explain methods of purification of colloids with the help of neat labeled diagram.
4. Discuss plastic and pseudoplastic system of flow.
OR
Differentiate flocculated and de-flocculated suspension.
5. Enumerate methods to determine the particle size. Explain any two methods to determine the e d i p d
particle size.
6. What are derived properties of powders? Explain any two.
7. What is specific surface area? How is it measured by air permeability method?
Explain the factors influencing the rate of reaction.
9. Define order of reaction. Explain the substitution method for determination of order of reaction.
m è d i o c t i n

SHORT ANSWERS 10 x 2 = 20 Marks

W w

10. What is Kraft point?

w w n e d i o d

11. What is Hardy Schulze Rule?

12. Define Viscosity along with its units of expressions.
13. Define Newton's law of flow with equation. i p d t i n

14. Define molecularity of reaction.

15. Define micro emulsion and multiple emulsions.
16. State stokes law.
17. What is particle size distribution and particle number?
18. Differentiate between half life and shelf life for a first order reaction,

19. Define pseudo zero order reaction with example.

e d i p d h

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 Rajiv GandhiUniversity of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination - 03-Jun-2023
D P I N
Time: Three Hours
W W w .
Max. Marks: 75 Marks
W w

Physical Pharmaceutics - II
Q.P. CODE: 5015
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
All the Questions are compulsory.
WW

LONG ESSAYS 2x 10 = 20 Marks

1, Derive the equation for the determination of rate constant, half life and shelf life for zero order
o I P D
reaction kinetics.
OR
Discuss electrical properties of colloids and add a note on purification of colloids.
W.MEDY

2 Explain methods to determine particle size

W W w . M

SHORT ESSAYS 7x5 = 35 Marks

3. Note on measurement of thixotropy.
OR
Briefly explain the preventive measures for chemical degradation by hydrolysis.
4. Write the principle and working of cup and bob viscometer with a neat diagram.
OR
What are the factors affecting chemical degradation of pharmaceutical
WWw product? w w

5 Write a note on effect of electrolytes on colloids.

6. Explain plastic and elastic deformation.
7. Write a note on stability of emulsion.
8. Explain Newtonian system of flow of fluids with examples.
9 Define surface area. Discuss the air permeability method for determination of surface area.
W w w . M E D I P

SHORT ANSWERS 10 x2= 20 Marks

10. Write Arrhenius equation with its significance.
W w W . M

11. Define half life and shelf life. w w . w E D I P D

12. Bulges and spurs.

13. Shear thinning and shear thickening system.
14. Void volume and porosity.
15. Angle of repose.
16. What is plug flow?
17. Electro-osmosis and Electrophoresis.
18. Coacervation.
19. Flocculated and deflocculated suspension.
W W . M E D I

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