DANVEER SINGH YADAV

Assistant Professor
Livestock Production Management
Collage of Veterinary Science A.H. (NDVSU), MHOW
 Laboratory animals
 “Laboratory Animals” are defined as animals which
are used for experimental and diagnosis purpose which
may resemble in result with human beings.

 They can be very well used for carrying out various

biological experiments and research in biomedical as
well as veterinary and animal sciences.
Mice
 Mice: are used for toxicological purpose,
microbiological and vaccine assay, insulin testing, ID,
LD-50, studies on cancer tissues various drug studies,
especially toxicology of various drugs.

 80 % of experiments are done on rodents.

 About 70% of experiments are done on mice.

Mice
Rat
 Rat: are used for pharmacological studies of various
drugs.

Insulin research

Diabetes and for

Various toxicological test.

Guinea pig
 Guinea Pigs: these laboratory animals are used for
microbiological studies, allergic, anaphylactic shock
and preparation of anti sera.

 Guinea pigs are used in lab. Diagnosis of T.B. Because

lesions of T. B. are prominent in Guinea pigs.
Hamster
 Hamster: these animals are used for cancer tissue
testing parasitological and viriological research.
Rabbit
Rabbit: these animals are used for

 Pyrogen testing

 Insulin potency testing

 Immunological research

 Reproductive studies

 Virological research.
Hare
 Importance (Utility/Role) of Laboratory Animals
Laboratory animals are used in basic biological research, diseases
diagnosis, immunology, virology, applied medicine and
demonstration.
1. Pharmacology
2. Toxicology
3. Physiology
4. Experimental surgery
5. Diagnosis-Virology, Bacteriology, Pathology
6. Pregnancy testing
7. Bio-assay-vaccines, drugs and infusion fluids
8. Preparation of immune sera.
 Bio-assay
 To confirm safety potency and utility of vaccines,
drugs, infusion fluids, immune sera, bio-assay is of
great help.

 These all aspects are standardized in laboratory

animals, prior to their distribution in the field.

 The level of toxins and toxins also need to be

confirmed for their potency.
 19th century a major movement began against
animal experimentation.

 The Victoria Street Society (1875) in England.

 England that the first low on the protection of

experimental animals (Cruelty to Animals Act,1876)
Institutional Animal Ethics Committee (IAEC)
 “Laboratory Animal Bureau” was set up in India in
1947.

 CPCSEA Committee for the purpose of control &

supervision of experiments on animals under rule.
 CCMB Centre for Cellular and Molecular Biology

 24th April World laboratory day

 Biological data of Laboratory animals
s.n Physiological Mice Rat Hamste Guinea Rabbit
o. Norms r pig

1 Gestation 21 days 21 16 68-72 30-32

period
2 Estrous cycle 4 days 5 4 16 continuou
s
3 Ovulation Spontaneo Spontan Spontan Spontan Induced
mechanism us eous eous eous
4 Duration of 13 hrs 14 hrs 12 hrs 09 hrs 10 hrs
heat period
5 Breeding age 6 weeks 10-12 06-08 5 6 months
months
6 Breeding life 1-1.5 year 1-1.5 1-1.5 2-3 year 3 year
7 Method of Harem 1:4 1:2 1: 6 1:1
breeding breeding
1male 4
s.n Physiologica Mice Rat Hamster Guinea Rabbit
o. l Norms pig
8. Birth weight ½-1 gm 5-6 gm 2 gm 75-100 100gm
gm
9 Litter size 07-09 do 05-07 03-05 05-10
10 Weaning age 21 days 21 21 10 45
11 Weaning 25-30 35-40 40 180-200 800-1kg
weight gm gm
12 Opening of 11 days 10-12 10 At birth 10-12
eyes after
birth
13 Daily food 5 gm 15 15 30-50 100
consumption
14 Daily water 6 ml 24 ml 30 30 120-150
requirement
15 Opening of 11 days 10-12 10 At birth 10-12
eyes after
birth
16 Pulse 120 120 150 120 130
rate/mint
17 Respiration 110 110 110-150 110 120-130
18 Scientific Mus Rattus Mesocrice Cavia Orectolagus
name musculus novergicu tus porcellus cuniculus
s auratis
19 Chromosome 40 42 22 64 44
number
20 No. of pairs of 05 05 6-7 01 3-4
mammary
21 Common Salmonell Salmonell Wet tail Salmonella, pasturella,
diseases a, Typhoid a, CRD pasturella, Mange,
pseudotube Coccidiosis
rculosis
22 Remarks Teats are ‘’ Cheek Vitamin C
absent in pouches is must in
male +, gall the diet
Thank you