C146-E236

Liquid Chromatograph Mass Spectrometer

LCMS-8050

Speed and Sensitivity Beyond Comparison

from Shimadzu: Now an Unparalleled Combination of High Speed and High Sensitivity

UF-MRM
■ High-Sensitivity Analysis & High-Speed
Positive/Negative Ionization Switching in 5 msec
Even when performing polarity switching analysis, the LCMS-8050 acquires
sufficient data points for even the sharpest UHPLC peaks, recording accurate
peak data and allowing excellent reproducibility. UFsensitivity
■ High-Sensitivity Analysis & High-Speed UFswitching
UFscanning
Scanning at 30,000 u/sec
Acquisition occurs so rapidly that MS/MS scans and MRM measurements can
be performed concurrently while maintaining quantitative accuracy.

■ High-Sensitivity Analysis & High-Speed

MRM at 555 ch/sec
Improved ionization efficiency and ion transmission deliver new levels of
sensitivity at the industry-leading MRM analysis speed of 555 MRM/sec.
 UF Te chno logies Com bine S e n s i t i v i t y a n d Hi g h S p e e d
The LCMS-8050 combines the following technologies to ensure highly sensitive, high-speed performance:

[UFsensitivity™] achieves high-sensitivity performance utilizing a new heated ESI probe and new UFsweeper™ III collision cell.
[UFswitching™] high-speed positive/negative ionization switching and high-speed MRM [UF-MRM] maintain data quality and sensitivity.
[UFscanning™] high-speed scan rate obtains high-quality mass spectra, even during high-speed analysis.

■ Heated ESI Probe ■ Just One Minute per Analysis CYP

In order to improve desolvation Inhibition Assay Using High-Speed
Heating gas flow Nebulizer gas flow
efficiency, the newly developed Positive/Negative Ionization Switching
heated ESI probe combines a
※ ※ 100 ● Easily
obtains over 20 points per
high-temperature gas with the
nebulizer spray, assisting in the
peak with UHPLC.
● Achieves excellent reproducibility
desolvation of large droplets %
and facilitating ionization. This
even at the lowest calibration level.
● Features a wider dynamic range
development allows for
0 than other available triple quads.
high-sensitivity analysis of a
wide range of target 0.00 0.25 0.50 0.75 1 min

compounds. Dynamic Range Points/ %RSD

Compounds Polarity
（nmol/L） peak 0.6 nmol/L（n=4）
※The transmission of heat
to the LC line has been Resorufin ＋ 0.6 -1000 21 4.30
minimized by mounting
the heaters in the 1 -Hydroxy Bufuralol ＋ 0.6 -1000 24 1.82
bottom-most position.
（＋/−）-4 -Hydroxy Mephenytoin ＋ 0.6 -1000 23 2.18

Oxidized Nifedipine ＋ 0.6 -1000 23 5.07

Hydroxy Tolbutamide − 0.6 -1000 23 2.96

■ UFsweeperⅢ Collision Cell ■ High Speed Simultaneous Analysis

Achieving fast sweeping on successive scans, it offers twice the CID
of 12 toxicological drugs
efficiency of UFsweeper II, maintains signal intensity, and suppresses (1 ng/mL of each drug).
crosstalk, even for high-speed or simultaneous multi-component
268 ● Maintains a high-quality
analysis.
30,000 u/sec spectrum even at the
100 world s fastest scanning
455.4 > 165.0 239
100 speed of 30,000 u/sec.
500 ag In plasma 211
119 183 314 ● The 30,000 u/sec
scanning speed provides
50 100 150 200 250 m/z
% for more sampling points.
Flunitrazepam
1ng/mL
13points
%
%RSD (n=3)
0 2.45%
11.00 12.00 min

0.8 0.9 1.0 1.1 1.2 min

Excellent reproducibility with a % RSD of 2.77 % was obtained when

analyzing just 500 ag of Verapamil. The LCMS-8050 demonstrates optimal
performance for quantitative analysis, even for trace components in a
complex matrix.

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For Research Use Only. Not for use in diagnostic procedures.

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