ĐỘC CHẤT TRÊN DA

ĐẠI CƯƠNG VỀ DA: CẤU TRÚC & CHỨC NĂNG

I .
Can tric da :

Bien bi :

lop dangracing gin ,

5 lop tibo lop day lop gai lop hat lopbonga lipsing
:
, , ,

Trung hi (hahi) bove co the khei ah ca cac nhan to benngrai nui

ding lop ngodining ->
thay the lop bien hi gia chei di
-
:

Clap dai en

Lop medici da :

gi :
I me , se collagen das bit mach man ,

two nang hig ciacothe

E
ra

whi 1 tain dem va cach whiet choco the

# .

Chenang da :

- Baove co the ching lai cac tac nhan bin ngoi :

C , nhie chan thing
, ,
tac nhan chai his , va x tia UV ...

Dien ho +'co the

-cam thankich thich-taedap, tong hip vitD khitx as mas Frien

#
. Cac qua trinh chuyen ha rai da

-D to co the rich tu trong da do hap the khi king hit tim See ch tu des th ah bei
rgian a tan su pheinhiem
[phan b
,
.

Lop sing hang rac vai ly quan trong

E hang
:

ro sinh hea'thu: 2 Thing qua Id ca enzym va cac protein van chuyen

↳ Cac
enzym gia de tai da Khanang giai dec nor tinh ti 2 % -61 Kha nang giai de
co .
wia gan

-
Chuyn hid gi 1 ) : a xenchierics phan lon la lipophilic xam nhap vo tang lip sing)

Hydroxyl hoa carbon ,

wito hoac nguyen th him huinh so oxyphant->Tinh phan ac via phan th ,
xt be he thing enzym
cytochrome P450 toi da

-
Chuyin hid got 2 lien hip chat pi get 1 - sportan /H 0-didacthai
:
,
hen be
enzym
:
Phend Uridine-S-di-

phosphat (UDP) glucuronosyltransferase glutathione S transferase

-

-
Qua trink daothai spchugin had tai da de he tre bei cac protein van chigen chigen Diet
I .
Cac you to ah den d Finh tren da
-dai tinh than
-Ban chan dec chan
-MW thap
,

daicas)- That san vic can trucda-thay dei dec Mich

- Vitri phei nhiem

(Nong
can
-
[chatphinhiem] DT be mat phi nhiem
↑
-> D tinh cao

-
Cac d tai da khiphei nhiem
-
Cac qua irh chugen hoa rai da :
1 s
enzym cytochrom ding tile CHnhe

CÁC LOẠI ĐỘC TÍNH TRÊN DA

Viem da xuc
1 .
tiep
Viem da tie xic kich thich (Chien 80% ).
Viem da tip xc di ng
-

Ting tac tric tiep gina hoa chai va can Tric bi mai da -
La tinh trang dap ng min quatrung gian tibo +
xay rangay khi vii hoa chai

trong---stan,cacttbethedurcclacra divac tanhan

-
Binh tx
I

-Xayraoving daho bantay canh tay :

,
mi enter

dich va gan voo protein mang

-Bin hien :
d da- bong & a lot -
KN hear chinh au xily bith Langerhans & hie thitren be mat
phac hip hea hip to chi chinh so I
 I
-
Can i Langerhans trink dien KN da qua xilij cho T-helper
↳ nhien lai interferen chemokine
gp ye to tang tring his hod
a -
↑
,

th Inhay cam
F

ca dong

2 .
Si nhay cam as :

-
La si nhay cam bat thing av tia acti (UV) - as kha kien a cothe do cas ye toni sinh angrai sinh -
L

-Tong tac theo & each :

Hip chi thay doi trang that nang hig I

(i it cban-tkich Mich (kein ben King) -
gp ranghing
tro vett coban= HCnhan rang hig tro thank HC oxh Ig Oxi ride) thng) -
be mat da ton

Hip chat thay doi CTHH (dang doing phan) thay doi TCVL-dang HC hap the san hon-lkphan th many
-

-> sau
ging vie da

I I
Phototoxic Photoaflegic
o PUxay ra lan phei nhiem dan Tien Co
Khang
CO
c Can thii giani-hthanh dap "ng MD
Khang
③ thay di CTHH Khong thay doi trang thou NL
, -
CO

Lien kei ai dien vs phan i Khong (chi ton tai tren be mat da Co (tham saul
④ mang protein mang
Vi tri bin hien trenching Phoi nhie trenching ngay de Cach tri phi nhiem
i

⑤ it nic ,
ut xa
/ S

⑥ Hong de i triphei nhiem Cao Thap

3 .
Nei me
day :

-
Xhien Trong vai philt-In sau khi tie xc =
Viem da x di
I
Ung
-PO qua loai It's thi qua trung gian bot cac th mast hoat hea
man .

"I mast d? hot hea tric tiep bei heacht (nonimmunel hos chai gay di ng /quatrung gian min dich)-l IgE /tb mast Is chan
L

co hot tinh tao ra cac putrin da histamine prostaglandins leukotrienes va cac kinins
:

, , ,
.

.
4 Ri loan sc t da
- tbo bin hi too hacte (Melanocytel -

boove da Khoitac hai cna as tia aic

/
tim= x melanin
Sx melanin la ki qua ca 1 lot cac pi exh lien quan den amin acid Tyrosine voi si hien dien ea enzym Tyrosinase
-Coch :

Tac nhan bi CH bi
.
Tyrosinase -> ROS :

gay des choth hacte'

Iding -
him taoth Melanocyte /imatinib mesylat) ->↓
tin s truyn tin si bist how the Melanocyte
We che hot tinh enzym Tyrokinase (U che canh tranh tric tiep"L
-

S .

Ung thi da :

-
Tia UVB (290-320 nm) x cas tac than gay ung thu-thay doi
·

DNA trong th him bi-T sinh mat kie scat->Ung the

Tia UVB tapyrimidine dimers 8-exoguanine -> det bien DNA

S
,
-

!
ve chemien dich L
- co the lam t s giam sat a loai be th ung this he thing MD :

cytochrom
-Polycyclic aromatic hydrocarbons di Cttaida--dan
P450
chai epoxid"chanang Ik voi
I
DNA- ten
thing DNA
↳ totren da
Ging tia UV h singngan

6 Hoai i.

thing bi nhiem d : - Ban cha :

Ad ng MD khong kie scat

- Benhingrai da nguy hiem den tinh mang

- L

- ty leth vong : 25-30%, co the len 75 % can ti ->

VD :
S5S/TEN

·
Dac -
tring
:

si khoi phat det ngt cna Hing da de tren dien rong- tien thin hoai th a bongtroc tai cas khn
/
I
/ -
:

mic hi h
:
↳
Lop hien hi hi ma anh hung nghiem trong den CN ca da dien heat' -

can bang nei mi dien giai

ching lai hor chat xam nhap eia VSV ye to ben ngoai
E -
a

-gan 200 loai thus' dic baocdo gay heiching nay thuss ching cogiai NSAID sulfonamid altopurinol :

, , ,

Dinh tinh test-phac

d
,

7 Muntrngca/viem lott
.
:

-Mun trieu Chung ngo de rat :

khe cha , nhing han nhn gay ra toi thing lan da cho da
-
I

-
Nei fam vie , ng nhan
.
pho bin nht
tring ca dan me nhna than da cac sp dan Khong ca mun
/
:
,

-
Ha ch halogen ha-naphthalene polyhalogenated hiphenyls dibenzoturans cas chai lan trong , ,
a can thui diei co :

polychloropheno dichloroanitie gay him dang bien dang tring a chlorache

tinh trang
a
nang via
-
1 +x dinhe slo
-

/
a

-Chlorache thing dr das tring bei si hien dien nhien mun hit u
nang man Vang : tai
, quank mat ,
vai
,

coquan sinh dic

/
/

hing a
/

-
1
hea chi gay loc da Co che su bong trac cha lop hien bi a tin thing den lop
so .
:

-
ha bi ti xc
raboi cac acid viibong a chan
Lait thing , ef the xayra tren mang whay a da
-
-

M
gay ,

I
X imang crom