‫ م‬4:33 2023/‫‏‬7/‫‏‬11 SOP for Operation and Cleaning of COD Digester

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USP 2023 (USP 46 –N

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SOP for Operation and Cleaning of COD Digester Dexamethasone Engineering

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 Anonymous  May 22, 2022 Tablets USP 500mg
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 January 04, 2022
OBJECTIVE Marketing Microbiology Pack
To provide a procedure for the operation of the COD Digester. SOP forPharmacopei
Entry, Exit
Pharma Education
procedure for Pow
SCOPE Product Development
Area Productio
This procedure applies to COD Digester at XYZ Ltd.  May 25, 2023 Contro
Quality Assurance Quality

RESPONSIBILITY Trading Validation Video

Quality Control Chemist and above  ACCOUNTS
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ACCOUNTABILITY  AHU
Quality Control Head May 2022 (25)
 AUDIT

 BUSINESS

 CALIBRATION

 CLEANING

 COSTING

 EXPORT

 FACEMASK

PROCEDURE  GPAT

Precaution  HUMAN RESOURCES

• Ensure that the instrument is clean and free from dust.  INTERVIEW
• Keep the instrument 1 foot away from the wall.
 STERILE
• Keep the instrument away from the washbasin or any water source.
•Ensure that any solvent/chemical does not fall on the aluminum block when it is  VALIDATION
hot.
• Use asbestos gloves while handling the hot tubes. USP 2021 (United St
• Do not try to remove the tubes from the COD block and keep it in the tube stand. 44 - NF 39)
 January 09, 2022
• Do not try to remove the condenser tube when it is hot.
• Switch OFF the instrument when not in use. USP 2023 (USP 46 –N
•Calibrate the digital timer controller and heating sensor of the COD Digester  May 23, 2023

once a year by the approved outside agency.

Types of Tooling in
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Cleaning
SOP for Preparatio
• Disconnect the instrument from the electrical connection.
Formula Record (M
• Clean the instrument with a soft cloth.  January 13, 2022
 St
USP 2021 (United
• Clean the tubes as per SOP of Cleaning of Laboratory Glassware. 44 - NF 39)
SOP for Analytical
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‫ م‬4:33 2023/‫‏‬7/‫‏‬11 SOP for Operation and Cleaning of COD Digester
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 January 09, 2022
 May 19, 2023
Operation
USP 2023 (USP 46 –N
• Connect the instrument to the main supply. Switch on the main supply.
 May 23,
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Scoring
• The red-colored bulb will glow indicating the power supply is connected. Tablets USP 500mg
• The orange-colored bulb will glow indicating the heater is on. Study)
Types of 04,
 January Tooling
2022 in
•The orange-colored bulb remains on till the temperature is attained and will get Machine
switched off when the desired temperature is attained.  May 28, 2020
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• Adjust the required temperature and time with the help of keys given on the
digital control panel. Books SOP for Preparatio
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Formula Record (M
• Press the SET key. Cosmetics Costing COVID-19
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• The display will show SP for temperature. Dexamethasone Engineering

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• Set 150°C temperature with the help of the up and down keys. Facemask GPAT HPLC Hu
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• Again press the SET key. Insurance Study)
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• The display will show soak time. Marketing

 January 04, 2022
Microbiology Pack

• Set 2.0 Hours with the help of up and down keys. SOP forPharmacopei
Pharma Education Entry, Exit
•In the soak time parameter, the digits before the decimal are hours & after the procedure for Pow
Product Development
Area Productio
decimal it is minutes. i.e, (hh: mm)
 May 25,
Quality Assurance 2023 Contro
Quality
• Fill 30 ml of the content of the sample in each tube and tightly close it with the
Trading Validation Video
condenser tube.
 ACCOUNTS
•Place 30 ml filled tubes in the aluminum COD block of the COD Digester for 2 ZyCoV-D

hours.  AHU
•After completing the cycle, a digital alarm for 10 seconds will produce and the
 AUDIT
heating will get automatically stopped.
• Allow cooling at room temperature.  BUSINESS

• Perform further analysis as per the Specification of Chemical Oxygen Demand.  CALIBRATION

 CLEANING
ABBREVIATIONS
COD: Chemical oxygen demand
 COSTING
SP: Set point
°C: Degree Celsius  EXPORT
hh: mm
Hours: Minutes  FACEMASK
%: Percentage
ml: Milliliter  GPAT

ANNEXURES  HUMAN RESOURCES

Nil
 INTERVIEW
REVISION HISTORY
 STERILE
Nil
 VALIDATION
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USP 2021 (United St
44 - NF 39)
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‫ م‬4:33 2023/‫‏‬7/‫‏‬11 SOP for Operation and Cleaning of COD Digester
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