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Calculation of Net (Pohar-Perme) Survival in SEER*Stat

“Kaplan-Meier” (Stata-stns) life

Variables table approximation of for interval Actuarial 1 (Stata –strs-)
grouped data
Death indicator, di j = 1, j died in interval i di j = 1, j died in interval i
di j = 0, j did not die at interval i di j = 0 , j did not die at interval i
yi j at risk at yi j = 1, j at risk the start of the yi j = 1, j at risk start of interval i
start of interval interval i yi j = 0, j not at risk start of interval i
yi j = 0, j not at risk the start of the
interval i
ci j is censoring ci j = 0, j was not censored in ci j = 0, j was not censored in inter. i
indicator interval i ci j = 1 , j was censored in interval i
ci j = 1 , j was censored in interval
i
Expected Cond.
prob. of p *i j p *i j
surviving
interval i for
patient j
Expected
Hazard dying λij* = − log( p *i j ) λij* = − log( p *i j )
interval i for
patient j
Cum. prob. of S *i j = p *1 j p *2 j ... p *i −1, j p *i j S *i j = p *1 j p *2 j ... p *i −1, j ( p *i j )
1/2

surviving up to
 i −1 
= exp ∑ − log ( p *k j )  p *i j
interval i
 k =1 
At the mid-point of the interval i

Pohar Perme 1 1
wi j = wi j =
weight S *i j S *i j

http://seer.cancer.gov/seerstat/pohar-perme.html 1
 “Kaplan-Meier” (Stata-stns) life
Variables table approximation of for interval Actuarial 1 (Stata –strs-)
grouped data
1.Alive at start N N
yi = ∑ yi j yi = ∑ yi j
j =1 j =1

2.Lost N N

∑c
j =1
ij ∑c
j =1
ij

3.Interval N n

number of di = ∑ di j di = ∑ di j
j =1 j =1
deaths (Died)
5.Interval W N

Observed ∑d
j =1
i j wi j
Hazard of Λ =N w
i
ci j
Death ∑w j =1
ij ( yi j −
2
)

Interval W ∑𝑁𝑁
𝑗𝑗=1 𝑑𝑑𝑖𝑖𝑖𝑖 𝑤𝑤𝑖𝑖𝑖𝑖
Observed 𝑞𝑞𝑖𝑖𝑤𝑤 = 𝑐𝑐𝑖𝑖𝑖𝑖
∑𝑁𝑁
𝑗𝑗=1 𝑤𝑤𝑖𝑖𝑖𝑖 (𝑦𝑦𝑖𝑖𝑖𝑖 −
probability of 2)
Death
6. Interval W N ci j N ci j di j
Expected ∑λ *
ij wi j ( yi j − ) ∑λ *
ij wi j ( yi j −
2
−
2
)
j =1 2 Λ * wA
=N j =1
Hazard of Λ*i w = N i
ci j di j
Death ∑w ij ( yi j −
ci j
) ∑w
j =1
ij ( yi j −
2
−
2
)
j =1 2
Interval Net
Hazard of dΛ iNet = Λ iw − Λ*i w
Cancer Death
Interval Net NSiw = 1 − d Λ iNet 1 − 𝑞𝑞𝑖𝑖𝑤𝑤
𝑁𝑁𝑁𝑁𝑖𝑖𝑤𝑤𝑤𝑤 =
Survival exp(−𝛬𝛬∗𝑤𝑤𝑤𝑤
𝑖𝑖 )
Interval W OSiw = 1 − Λ iw
Observed Surv 𝑂𝑂𝑂𝑂𝑖𝑖𝑤𝑤 = 1 − 𝑞𝑞𝑖𝑖𝑤𝑤
Interval W ESiw = 1 − Λ*i w =
ES i
w
exp {−Λ*i wA }
Expected Surv
Cumulative W t t

Observed Surv OS w (t ) = ∏ OSiw OS w (t ) = ∏ OSiw

i =1 i =1

http://seer.cancer.gov/seerstat/pohar-perme.html 2
 “Kaplan-Meier” (Stata-stns) life
Variables table approximation of for interval Actuarial 1 (Stata –strs-)
grouped data
Cumulative W t t

Expected Surv ES w (t ) = ∏ ESiw ES w (t ) = ∏ ESiw

i =1 i =1

Cumulative t t

Net Survival NS (t ) = ∏ NSiw NS (t ) = ∏ NSiwA

i =1 i =1
N
Variance
Interval W Obs ∑d
j =1
ij wij 2
prob of Death Var (qiw ) = 2
N cij dij 
∑ wij ( yij − − ) 
 j =1 2 2 
N
Variance
Interval W ∑d
j =1
i j ( wi j ) 2
Observed Var (Λ iw ) = 2
 N ci j 
 ∑ wi j ( yi j − ) 
Hazard of
Death  j =1 2 
Variance Int.
W Observed
Survival
Variance
Cumulative W
Observed
Survival
Variance Int. = 2
Var ( NSiw )  NSiw  Var (Λ iw )
2
Var ( NSiw ) =  NSiw  Var (qiw )
Net Survival
Variance Cum. t t
[ ] ∑Var (Λiw ) Var ( NS (t )) = [ NS (t ) ] ∑Var (q
2 2
Net Survival =
Var ( NS (t )) NS ( t ) i
w
)
i =1 i =1

http://seer.cancer.gov/seerstat/pohar-perme.html 3