Pharma 426 team

NOTES
1) Pregnant women with UTI & the microorganisms were pseudomonas which drugs can be use:
A) Gentamycin: it is contraindicated in preg. as it's crosses placental barrier& affect fetus.
B) Cefaclone: second generation ,safe with preg.but not effective
C) Ticarcillin: Extended penicillin, safe with preg.,it`s the best one.**
D) Ceftriaxon:3rd generation, not contraindicated in preg., can be used.

2) Erythromycin
 In low concentration ---- bacteriostatic
 In high concentration ---- bactericidal

3) Which one has high therapeutic index

A. Streptomycin
B. Cephalosporin {cifazoline} (1st generation and safe)
C. Vancomycine
D. Doxycycline
E. Tetracycline

4) Super infection common with:

A. Narrow spectrum
B. broad spectrum as it eradicate normal floraAntibiotic which effect on gram +ve & -ve
organism

5) Select the antibiotic which it's dose must be decreased in patient with renal insufficiency :
A. Penicillin
B. Tobromycin: must be reduced.
C. Erythromycin: not as it has other rout {bile 50-60%}

6) Bacteriostatic is not advice to use to cure bacterial infection:

A. Diabetic patient.
B. Allergic disorder.** {hypersensitvity}
C. Patient on corticosteroid therapy.
D. U.T.I

7) Choose the condition in which the drug combination are broad spectrum:
A. Pneumonia
B. Typhoid fever
C. Syphilis
D. Peritonitis - diverticulitis - stap wound ** as it is mixed organisms

8) Select the sulfonamide suitable in eye infection topically:

sulfacetamide ONLY.
 Pharma 426 team

9)Trimethobrim inhibit bacterial without effect mammalian cells:

A. As it does not penetrate cells.
B. Inhibit bacterial foliates syntheses and foliates reductase.
C. Inhibit bacterial foliates reductase .** this enzyme is not found in mammalian cells.
D. High affinity to bacterial enzyme and low affinity to mammalian cells
E. All of the above.

10) Pharmacokinetics of Penicillin G :

A. excreted rapidly through PCT {√}
B. High oral bioavailablity. {√}
C. Does not crosses BBB even when meninges is inflamed { X } true if the meninges not inflamed.
D. Metabolized mainly by acetylating reaction.{X} not metabolized

11) Phenoxy meththicillin is:

A. Acid stable & oral active
B. Penicillinase sensitive
C. Less effective than penicillin G but all are narrow spectrum.
D. Used in minor infection.
All are true.

12) Choose the correct sentence about tetracycline:

A. Broad spectrum.
B. Used in treatment of life threatening infection {X} as it bacteriostatic not bactericidal.
C. Used with young child. {X} teeth discoloration

13) Most suitable tetracycline in renal impairment is:

doxycycline. The ONLY one

14)Premature neonate suffer from respiratory infection and given antibiotic, After two days he have
worse destintion of abdomen, and blue to grayish appearance , which antibiotic was he given?
cloramphenichol.

DONE BY :
PHARMA-426-TEAM

‫إيمان حجر‬
‫الهنوف القباني‬
‫دانه البسام‬
‫عروبة المفلح‬
‫منيرة المهيدب‬