Amorolfine | SpringerLink https://link.springer.com/chapter/10.

1007/978-3-642-75458-6_24

Amorolfine

Abstract

Amorolfine (3-[p-(1,1-dimethylpropyl)-phenyl]2-methyl-propyl-2,6-cis
dimethylmorpholine hydrochloride; Ro 14-4767/002) shows activity against
fungi pathogenic to plants, animals and humans (P and D 1987).
Given here is a resume of preclinical findings with this drug as well as a
summary of published clinical data. In vitro the spectrum against
representative species pathogenic for humans was defined measuring
fungistatic as well as fungicidal effects. In vivo studies were conducted using
models of dermatophytosis, vaginal candidosis and various organ mycoses.

Preview

1 of 4 27-01-2018, 17:43
Amorolfine | SpringerLink https://link.springer.com/chapter/10.1007/978-3-642-75458-6_24

References
Galimberti R, Garcia A, Milicich R, Cuomo G, Bonino MV, Flores V,
Traballi CA (1988) Amorolfine (Ro 14-4767) a new trend for the
treatment of tinea pedis. In: Torres-Rodríguez JM (ed) Proceedings of
X congress of international society for human and animal mycology,
Barcelona. JR Prous, Barcelona, pp 223–226
Google Scholar
Gip L (1989) In vitro studies of the antifungal activity of amorolfine, a
phenylpropyl morpholine. Adv Ther 6: 26–38
Google Scholar
Haller I (1979) Zum Wirkungstyp von Imidazol-Antimykotika:
Konsequenz für die Empfindlichkeitsbestimmung. Mykosen 22:
423–430
PubMed
Google Scholar
Mensing H, Splanemann V (1988) Evaluation of the antimycotic
activity of the pathological substance under the nail after treatment
with Ro 14-4767 nail lacquer. Revista Ibérica de Micológia 5 (Suppl 1):
20
Google Scholar
Nolting S (1988) Double-blind, randomized study comparing 3
concentrations (0.125, 0.25, 0.5%) of Ro 14-4767 and bifonazole 1%
creams in patients with dermatomycosis. Revista Ibérica de Micológia 5
(Suppl 1): 19
Google Scholar
Odds FC, Abbott AB (1984) Relative inhibition factors - a novel
approach to the assessment of antifungal antibiotics in vitro. J
Antimicrob Chemother 13: 31–43
PubMed
CrossRef
Google Scholar
Odds FC, Webster CE, Abbott AB (1984) Antifungal relative inhibition
factors: BAY 1-9139, bifonazole, butoconazole, isoconazole, itraconazole
(R 51211), oxiconazole, Ro 14-4767/002, sulconazole, terconazole, and
vibunazole (Bay n-7133) compared in vitro with nine established
antifungal agents. J Antimicrob Chemother 14: 105–114
PubMed
CrossRef
Google Scholar
Parissis N, Noutsis C, Rigopoulos D (1987) A single dose treatment of
vaginal mycosis with the morpholine derivative Ro 14-4767. In:
Berkarda B, Kuemmerle H-P (eds) Progress in antimicrobial and
anticancer chemotherapy, vol. II. Ecomed, Munich, pp 1576–1578
Google Scholar
Polak A (1982a) Oxiconazole, a new imidazole derivative. Evaluation of

2 of 4 27-01-2018, 17:43
Amorolfine | SpringerLink https://link.springer.com/chapter/10.1007/978-3-642-75458-6_24

antifungal activity in vitro and in vivo. Arzneimittelforsch 32: 17–24

PubMed
Google Scholar
Polak A (1982b) Experimental activity of a new antimycotic. Curr Chem
Immunother. Proceedings of the 12th international congress of
chemotherapy, Florence, 19–24 July 1981, pp 1023–1025
Google Scholar
Polak A (1983) Antifungal activity in vitro of Ro 14-4767/002, a
phenylpropylmorpholine. Sabouraudia 21:205–213
Google Scholar
Polak A (1984) Antifungal activity of four antifungal drugs in the
cutaneous retention time test. Sabouraudia 22: 501–503
PubMed
CrossRef
Google Scholar
Polak A, Dixon DM (1987) Antifungal activity of amorolfine (Ro
14-4767/002) in vitro and in vivo. In: Fromtling RA (ed) Recent trends
in the discovery, development and evaluation of antifungal agents. JR
Prous, Barcelona, pp 554–573
Google Scholar
Reinel D (1988) Double-blind, randomized, multicentre trial of 2% vs.
5% Ro 14-4767 nail lacquer in patients suffering from onychomycosis.
Revista Ibérica de Micológia 5 (Suppl 1): 93
Google Scholar
Rohde E, Zaug M, Hartmann D (1987) Preliminary clinical experience
with Ro 14-4767 (Amorolfine) in superficial mycoses. In: Fromtling RA
(ed) Recent trends in the discovery, development and evaluation of
antifungal agents. JR Prous, Barcelona, pp 575–582
Google Scholar
Scharlau L, Goldberg M, Lutziger H, Probst H, Schaal HJ (1987)
Double-blind, randomized multicentre, dose-finding trial comparing
three single doses (10, 25 and 50 mg) of amorolfine in patients
suffering from vaginal mycosis. In: Berkarda B, Kuemmerle H-P (eds)
Progress in antimicrobial and anticancer chemotherapy, vol. II.
Ecomed, Munich, pp 1573–1575
Google Scholar

Copyright information

© Springer-Verlag Berlin
Heidelberg 1990

3 of 4 27-01-2018, 17:43
Amorolfine | SpringerLink https://link.springer.com/chapter/10.1007/978-3-642-75458-6_24

About this chapter

4 of 4 27-01-2018, 17:43