MCQ: Answer

1. The most important benefit of using nanoparticles (which was impossible

before) is ...

a) Increasing drug efficacy

b) Decreasing drug side effects and toxicity
c) Sustained release
d) Targeting specific tissues

2. Liposomes can carry ………….. drugs.

a) Lipophilic only
b) Hydrophilic only
c) Both lipophilic and hydrophilic
d) None of the above

3. Micelles can carry …………… drugs.

a) Lipophilic only
b) Hydrophilic only
c) Both lipophilic and hydrophilic
d) None of the above

4. PLGA and PLA are characterized by …………………

a) Antibacterial activity
b) Sustained drug release
c) Initial burst release of the drug
d) All of the above

5. Silver nanoparticles is characterized by their …………………….

a) Antibacterial activity
b) Sustained drug release
c) Initial burst release of the drug
d) All of the above
6. When designing nanoparticles, the most important concern is …………….

a) Release kinetics
b) Size and shape
c) Functionalization
d) Biodegradability & Biocompatibility

7. Silver nanoparticles (AgNPs) shows ………………..

a) Cytotoxic activity
b) Antibacterial activity
c) Anticancer activity
d) All of the above
e) None of the above

8. The risks associated with AgNPs delivery system includes ………………..

a) Hepatotoxicity
b) Renal impairment
c) DNA damage
d) Epithelial cell damage
e) All of the above
f) None of the above
Complete: [Answer]
1. Liposomes is one type of nanoparticles which is a bilayer of [Phospholipids]

2. Micelles is one type of nanoparticles which is a monolayer of [Surfactant]

3. Micelles is formed by increasing surfactant concentration above [Critical

Micelle Concentration (CMC)]

4. We can increase the short half-life of liposomes by [PEG coating or Increasing

liposomal layers]

5. [Chitosan] is a natural occurring polymer which is biocompatible,

biodegradable, and immuno-naïve.

6. PEG coating has many advantages mention two of them

a. [Improving the short half-life of liposomes]

b. [Decreasing the cytotoxicity of ZnO2 in sunscreens]

c. [Decreasing the cytotoxicity of AgNPs]

7. Mention one proposed mechanism of action for AgNPs

a. [Induce Reactive Oxygen Spices (ROS)]

b. [Induce mitochondrial apoptosis]