You are on page 1of 11

See discussions, stats, and author profiles for this publication at: https://www.researchgate.

net/publication/3132273

Active Microwave Imaging II: 3-D System Prototype and Image


Reconstruction From Experimental Data

Article in IEEE Transactions on Microwave Theory and Techniques · May 2008


DOI: 10.1109/TMTT.2008.919661 · Source: IEEE Xplore

CITATIONS READS
119 1,705

8 authors, including:

John Stang William T. Joines


Indiana University-Purdue University Indianapolis Duke University
52 PUBLICATIONS 1,256 CITATIONS 185 PUBLICATIONS 5,164 CITATIONS

SEE PROFILE SEE PROFILE

Qing Huo Liu


Duke University
1,430 PUBLICATIONS 26,681 CITATIONS

SEE PROFILE

All content following this page was uploaded by William T. Joines on 06 December 2013.

The user has requested enhancement of the downloaded file.


IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, VOL. 56, NO. 4, APRIL 2008 991

Active Microwave Imaging II: 3-D System Prototype


and Image Reconstruction From Experimental Data
Chun Yu, Senior Member, IEEE, Mengqing Yuan, John Stang, Elan Bresslour,
Rhett T. George, Gary A. Ybarra, Senior Member, IEEE,
William T. Joines, Fellow, IEEE, and Qing Huo Liu, Fellow, IEEE

Abstract—A 3-D microwave imaging system prototype and an between normal and malignant human breast tissues [3]. This
inverse scattering algorithm are developed to demonstrate the fea- high contrast is due to significantly different sodium concentra-
sibility of 3-D microwave imaging for medical applications such as tions, fluid contents, and electrochemical properties. A recent
breast cancer detection with measured data. In this experimental
prototype, the transmitting and receiving antennas are placed in a research on the variability of normal breast tissue properties
rectangular tub containing a fluid. The microwave scattering data [21] reveals that the breast can, in fact, be quite heterogeneous,
are acquired by mechanically scanning a single transmit antenna and this may pose a significant challenge for microwave breast
and a single receive antenna, thus avoiding the mutual coupling imaging, although actual clinical tests in [22] and [23] have
that occurs when an array is used. Careful design and construc- demonstrated the significant potential and new advances of
tion of the system has yielded accurate measurements of scattered
fields so that even the weak scattered signals at 21 =
90 dB (or microwave breast imaging from previous simulations and
phantom studies.
30 dB below the background fields) can be measured accurately.
Measurements are performed in the frequency domain at several Previously, microwave imaging has been reported primarily
discrete frequencies. The collected 3-D experimental data in fluid based on numerical simulation data and on 2-D reconstruction.
are processed by a 3-D nonlinear inverse scattering algorithm to Only recently has imaging from 3-D experimental data been re-
unravel the complicated multiple scattering effects and produce
high-resolution 3-D digital images of the dielectric constant and ported based on space–time beamforming [20] and tomographic
conductivity of the imaging domain. Dielectric objects as small as reconstruction [15]. For a more thorough review, the reader is
5 mm in size have been imaged effectively at 1.74 GHz. referred to [12], [18], and [19]. Our previous work, presented in
Index Terms—Born iterative method, breast cancer detection, [11], [16], [17], and [19], focused on theoretical modeling and
diagonal tensor approximation, distorted Born iterative method, numerical investigation of active microwave imaging to demon-
inverse scattering, microwave imaging, nonlinear inverse scat- strate the feasibility of 3-D microwave imaging for breast cancer
tering algorithm, stabilized biconjugate-gradient fast Fourier detection using fast volume integral-equation solvers and non-
transform (FFT) algorithm.
linear inverse scattering algorithms. In this study, we further
demonstrate the feasibility of a high-resolution 3-D microwave
I. INTRODUCTION imaging system with accurate experimental data. We will dis-
cuss the design of a 3-D experimental prototype and utilize some
T IS of practical significance to detect, locate, characterize, recently improved simulation and reconstruction algorithms for
I and image tumors in healthy tissue of the breast. Over
the last two decades, intensive investigations have been con-
3-D microwave imaging simulation and image reconstruction.
The 3-D microwave imaging system prototype consists of one
ducted for early breast cancer detection using microwaves (e.g., transmitting and one receiving dipole antenna that are placed in
[1]–[23]). These studies include confocal microwave imaging a rectangular tub containing fluid. To avoid mutual coupling, we
[6], [7], [12]–[14], 2-D microwave topographic imaging [8], do not use an array of antennas in this study; instead, we scan
[9], [11], and 3-D active microwave tomographic imaging the receiving antenna using a positioner (stepper motor). Mea-
[15]–[17]. Microwave imaging has been proposed for breast surements are performed in continuous wave (CW) mode for
detection [8], [9], [6], [7] because of its potentially high speci- both background (without objects) and with anomalous objects
in the fluid, with the corresponding fields called the “incident”
ficity for breast cancer diagnosis due to the high contrast in
electrical properties between normal and malignant human and “total” fields, respectively. The “scattered” field is obtained
breast tissues. The electrical properties of normal and malig- by subtracting the incident field from the total field. The col-
nant human breast tissues have been a subject of great interest lected 3-D scattered field is then processed by a newly devel-
oped 3-D hybrid nonlinear inverse scattering method based on
over the last two decades. It has been reported that a significant
contrast in electrical properties at microwave frequencies exists the combination of several algorithms, which are: (1) the diag-
onal tensor approximation [27]–[29] combined with the Born
iterative method to produce an approximate image rapidly and
Manuscript received June 9, 2007; revised November 1, 2007. This work
was supported by the National Institutes of Health (NIH) under Grant
(2) the stabilized biconjugate-gradient fast Fourier transform
5R01CA102768-02. (FFT) method [25], [26], [30]–[32] combined with the distorted
The authors are with the Department of Electrical and Computer Engineering, Born iterative method to solve the full 3-D nonlinear inverse
Duke University, Durham, NC 27708-0291 USA (e-mail: qhliu@ee.duke.edu). problem. To test the capability of the microwave imaging system
Color versions of one or more of the figures in this paper are available online
at http://ieeexplore.ieee.org. with the proposed 3-D nonlinear inverse scattering algorithm,
Digital Object Identifier 10.1109/TMTT.2008.919661 reconstructions from experimentally measured data have been
0018-9480/$25.00 © 2008 IEEE
992 IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, VOL. 56, NO. 4, APRIL 2008

Fig. 1. Experimental setup of microwave imaging system prototype. Two


dipole antennas are placed in a rectangular tub containing a lossy fluid. The
2 2
dimension of the tub is 54 40 38 cm . The distance of the antennas from
the tub walls is at least 15 cm during scanning so that the reflection from the
tub walls is negligible.

performed. High-resolution reconstructed results are presented


for multiple objects in fluid. Here we note that the proposed
algorithm and system has been tested against accurate experi-
mental data, while the experimental model is based on a simpli-
fied scenario, rather than a real breast. We are currently studying
microwave imaging for more realistic breast phantoms.
This paper is organized as follows. Section II presents a
description of the experimental 3-D microwave tomographic Fig. 2. (a) Geometry of the dipole antenna with a balun to reduce the radiation
imaging system, including the system prototype, the design and from the outer conductor of the semirigid coaxial cable. (b) Measured return
loss S of two dipole antennas in water.
performance of the transmitting and receiving dipole antennas,
and the measurement procedure for 3-D data acquisition.
Section III summarizes the inverse scattering algorithm used in
will be defined later). The positioner, its scanning speed and
this study. Reconstructed results from experimental data and
location, and the collection of data by the network analyzer are
discussions are presented in Section IV. Finally, conclusions
controlled by a desktop computer. The collection time needed
are given in Section V.
for each receiver position is 3 s.
II. 3-D MICROWAVE IMAGING SYSTEM There are several advantages of this microwave imaging
system prototype, which are: (1) the coupling between mul-
A. System Overview tiple transmitting antennas and receiving antennas in a typical
As shown in Fig. 1, the experimental 3-D microwave high-resolution 3-D microwave imaging system is minimized
imaging system consists of two dipole antennas (one acting due to the use of scanning antennas, thus simplifying the
as a transmitter and the other as a receiver), a rectangular tub design; (2) the antenna positions are known to a high precision
as an imaging chamber, one automatic positioner (two-axis (3 m); and (3) the system does not require switching devices
stage controller: SHOT-602), and an HP 8753E vector network as in systems containing multiple antenna array elements, thus
analyzer. The tub is filled with either a fluid with electrical reducing the additional noise and loss from these switching
properties matching those of normal breast tissue or water. devices. The main disadvantage of this system is its relatively
The automatic positioner, serving as a mechanical scanning long acquisition time, but this is not a critical issue during
system, moves the transmitting and/or receiving antennas in prototyping and will be improved in the clinical version.
the fluid through a series of locations with high precision. As
a result, the 3-D data acquisition is implemented with flexible B. Design and Performance of Antennas
multiview transmitters/receivers on given measuring surfaces The data acquisition of the 3-D microwave imaging system
around the object to be imaged. This setup avoids the issue of requires accurate and sensitive measurements of the scattered
mutual coupling in an actual array. The HP network analyzer electromagnetic waves. To achieve this aim, a linearly polarized
is used to collect both the incident field (i.e., the field when dipole antenna has been designed to function as both the trans-
no anomalous objects are in the chamber) and the total field mitting antenna and the receiving antenna. Fig. 2(a) shows the
(i.e., the field in the presence of anomalous objects in the geometry of the dipole antenna. The two arms of the linearly
chamber) in the form of scattering parameters ( -parameters). polarized dipole antenna were made from the inner and outer
In particular, measurements with and without objects in the conductors of a semirigid coaxial cable. The total length of the
imaging domain inside the chamber (corresponding to the total two arms is . A matching balun of length is formed at the
field and incident field ) are recorded (these parameters front-end of the antenna to reduce the radiation from the outer
YU et al.: ACTIVE MICROWAVE IMAGING II: 3-D SYSTEM PROTOTYPE AND IMAGE RECONSTRUCTION FROM EXPERIMENTAL DATA 993

respectively. If the transmitting and receiving dipole antennas


are oriented in the and directions, the signal measured at
the receiver is

(1)

for the incident field when only the background medium exists
(i.e., no objects are in the imaging domain), and

(2)
0
Fig. 3. Example of transmitting dipole locations (on a plane at x = 4:1 cm)
and receiver locations (on a plane at x = 4:1 cm) along five dotted lines sepa- for the total field when there are objects in the imaging domain.
rated by 1 cm in the z -direction, each with 21 points (increments of 0.4 cm in
2
the y -direction). The total number of receiver points is 5 21 = 105 for each In the above, the incident field and the total field
transmitter location. at the receiver depend on the orientation of
the transmitting dipole antenna and the dyadic Green’s func-
tion. is a network analyzer calibration constant such that the
conductor of the coaxial cable. Antennas of various dimensions -parameter is equal to one when ports 1 and 2 are directly
have been designed and fabricated for matching fluid ( , connected.
S m) and water in the chamber. In particular, for the From the incident and total field measurements, we can obtain
dipole in water, we chose mm. the scattered signal
Fig. 2(b) shows the measured for two fabricated dipole
antennas in water. The return loss of these two antennas is below
11 dB at 1.74 GHz, and they are well matched to work at a (3)
common optimal frequency with a bandwidth of approximately
200 MHz. The difference between the values of the two where is the scattered field at the receiver location due
antennas is due to a small difference between the antennas in to the presence of anomalous objects in the imaging domain.
size. These fabricated dipole antennas were also characterized In the general case, there are transmitter locations, each
experimentally for radiation into a matching fluid with a rela- with receiver locations. The scattering parameter is
tive permittivity of 20 and a conductivity of 0.16 S/m. For this measured for each transmitter–receiver combination. Therefore,
matching fluid, the measured return loss is below 15 dB at there are complex data points for , corresponding
the optimal frequency of 2.7 GHz for both transmitting and re- to the th receiver signal due to the th transmitter excitation.
ceiving antennas. From this set of data, the complex permittivity distribution
in the imaging domain can be found using an image reconstruc-
C. 3-D Data Acquisition tion algorithm.
In microwave breast cancer detection, tomographic imaging
is achieved by transmitting a sequence of electromagnetic waves III. IMAGE RECONSTRUCTION ALGORITHM
through the breast and measuring the scattered fields around the The objective of the image reconstruction algorithm is to infer
breast. For the experimental prototype shown in Fig. 1, the trans- the complex permittivity distribution in the
mitting antenna sends out electromagnetic waves to illuminate imaging domain , where and are the unknown di-
a breast phantom placed in a fluid background that matches the electric constant and electrical conductivity, respectively. Con-
breast in terms of electrical parameters; for each transmitting sider a general 3-D inhomogeneous object with in a back-
antenna position, the receiving antenna collects the fields at dif- ground medium with . The integral equation governing the
ferent locations controlled by the positioner with a locating ac- inverse problem [33] is
curacy of approximately 3 m. The transmitting antenna is not
scanned automatically in this experimental setup. An example
of the transmitting dipole location distribution (on a plane at
cm) and the receiver-scanning pattern (on a plane (4)
at cm) is shown in Fig. 3. The multiple views of the
receiving antenna are obtained by scanning on five lines (incre- where the magnetic permeability in the target is assumed to be
ments of 1 cm in the -direction) with 21 points along each line the same as in the background medium, is the transmitter
(increments of 0.4 cm in the -direction), resulting in a total location, is an electric dyadic Green’s function due to
number of receiver points of . an electric current source, and is the contrast function de-
The microwave signals at the receiving antenna are measured fined as
in the form of scattering parameters (or -parameters) through
the HP vector network analyzer with its two ports connected to (5)
the transmitter and receiver. Consider just two antennas in the
system, one for transmitting and the other for receiving. The Methods for solving the above inverse problem include the Born
complex scattering parameters are , , and , iterative method, the distorted Born iterative method, and the
where subscripts 1 and 2 refer to the transmitter and receiver, contrast source inversion (see [34]–[39] for more details). In
994 IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, VOL. 56, NO. 4, APRIL 2008

this study, we utilize a hybrid inversion method, as summarized Since the total field within the objects (and in the dis-
below. torted Born iterative method) is an unknown function of the ma-
terial contrast function , (8) is a nonlinear equation in . More-
A. Forward Solver over, the limited amount of information makes the problem ill
A forward solver is necessary in an inversion method such as posed. The Born iterative method [34] or the distorted Born iter-
the Born iterative method or the distorted Born iterative method ative method [35]–[37] can be used to solve the above nonlinear
to calculate the predicted measured data and the gradient infor- inverse scattering equation. In this study, we use an algorithm
mation. The first task of the forward solver is to calculate the combining the diagonal tensor approximation and the Born it-
electric field inside the imaging domain (i.e., ) in (4). The erative method to obtain an initial reconstruction for a fast es-
scattered field at any receiver location on a surface can then timate of the image, and then use an algorithm combining the
be calculated as stabilized biconjugate-gradient FFT and the distorted Born iter-
ative method to provide an accurate and fast inversion.
In iterative inversion algorithm, since the actual location of
(6) the objects to be imaged is not given, we can only rely on the
Equation (6) is called the data equation, as it defines the scat- data misfit information to determine whether the inversion has
tered field at the observation point. In contrast, the integral equa- converged. Thus, we define the relative data residual error RES
tion (4) for is called the object equation, and can be as
solved by using the full-wave stabilized biconjugate-gradient
FFT method, or by using approximation methods such as the
(10)
diagonal tensor approximation. In this paper, we use a hybrid
technique [40] by combining the diagonal tensor approxima-
tion and the stabilized biconjugate-gradient FFT method where where and are the th measured and simulated scat-
the diagonal tensor approximation acts as a preconditioner for tered field, respectively. When this data residual reduces to a
the stabilized biconjugate-gradient FFT method. Such a hybrid predetermined criterion (e.g., 0.1%), or when the residual error
method has the advantage that, for low-to-moderate contrasts, changes very little between subsequent iterations (e.g., 0.1%),
the diagonal tensor approximation alone will give accurate re- or when a maximum iteration number is reached, the inversion
sults without going through the stabilized biconjugate-gradient iteration is terminated.
FFT iterations; for high contrasts, the diagonal tensor approx- In the first-step inversion from experimental data, the stop-
imation gives a good preconditioner so that the stabilized bi- ping criteria is related to the above relative data residual error
conjugate-gradient FFT iterations will converge rapidly. Thus, and a maximum iteration number. When the data error is less
both low- and high-contrast problems can be solved efficiently than the small number (e.g., 0.1%), or when the iteration ex-
and accurately by this hybrid method. ceeds the maximum iteration number (10), the first-step inver-
B. Nonlinear Inverse Scattering Method sion is terminated and the inversion is switched into the second-
step inversion using the stabilized biconjugate-gradient FFT and
In the inverse scattering problem, the total number of data the distorted Born iterative method. The CPU time on an AMD
points collected is . Suppose the imaging do- Opteron Processor 250 is approximately 2 min/iteration for this
main is discretized into small voxels. By using the trape- first-step inversion. Finally the iteration in the second-step in-
zoidal rule, the data equation with the unknown contrast func- version stops with a given number of iteration (e.g., 20). The
tion can be discretized as follows: flowchart of the computer program for the algorithm combining
the diagonal tensor approximation and the Born iterative method
(7) for the microwave imaging system is shown in Fig. 4. The flow-
chart of the algorithm combining the stabilized biconjugate-gra-
dient FFT and the distorted Born iterative method is the same
where is an -dimensional data column vector whose ele-
as shown in Fig. 4, except that “Updating Diagonal Tensor and
ments are the measured scattered electric field collected by the
Solving Expected Scattered Field by DTA” in the box should
receiver, is the volume of each voxel, and
be replaced with “Updating Green’s Function and Solving Ex-
and denote the indices for the receiver and
pected Scattered Field by BCGS-FFT.” The CPU time on an
transmitter, respectively. For measurements and dis-
AMD Opteron Processor 250 is approximately 10 min/iteration
cretized voxels, (7) can be written compactly as
for this second-step inversion. Note that the above performance
(8) of the codes has not been optimized; furthermore, the codes have
been developed for the more general case of objects embedded
where represents the simulated scattering fields, is an in a layered medium, thus there is an overhead for the compu-
-dimensional column vector of the contrast function , and tation of Green’s functions.
is an matrix whose elements are given by
IV. MICROWAVE IMAGING FROM MEASURED DATA
(9)
In order to avoid the environmental effects from the reflec-
where and . tions caused by an outer boundary of the fluid container, we
YU et al.: ACTIVE MICROWAVE IMAGING II: 3-D SYSTEM PROTOTYPE AND IMAGE RECONSTRUCTION FROM EXPERIMENTAL DATA 995

Fig. 5. Measured jS j versus frequency for a pair of dipole antennas sepa-


rated by 8.2 cm in water. Solid line: S without object; heavy dotted line: S
with an clay ball of 5-mm diameter located at the center of the two antennas;
lighter dotted line: S with two metal balls of 5-mm diameter (the locations of
two metal balls are the same as the example in Section IV-C). Dashed line: the
scattered field S for a clay ball. Dashed–dotted line: the scattered field S
for two metal balls.

67 dB, or 25 dB lower than the background field for the clay


ball placed at the center of the two antennas, and approximately
59 dB, or 17 dB lower than the background field for the two
metallic spheres. The use of a lower frequency would yield
a weaker scattered field, as well as lower resolution in image
reconstruction. The following examples will use 1.74-GHz mi-
crowaves to image small objects in water. Although the objects
and water in our initial experiments are not exactly equivalent
Fig. 4. Flowchart of the algorithm combining the diagonal tensor approxima- to tumors and normal breast tissue, it serves as a good test
tion (DTA) and the Born iterative method (BIM) for microwave imaging. for our 3-D inverse scattering algorithm and 3-D microwave
imaging experimental setup. Current research is investigating
more realistic phantoms and imaging by array antennas.
use a large container and fill it with water (measured , Since experimental data sets are measured by linearly polar-
S m). The following examples use the microwave ized resonant dipole antennas, a calibration procedure is used
imaging system shown in Fig. 1 to collect the scattered data. in the image reconstruction algorithm with an infinitesimal
In our experiments, dielectric spheres made of clay of various electric dipole having the same polarization as the finite-length
diameters have been used. The clay material has been measured dipole. In fact, the radiation field patterns from a short dipole
to have a dielectric constant of approximately 5 and lossless; and a resonant dipole are very similar within the viewing
however, when immersed in water, it is likely that the dielec- angles of the given antenna array. The difference between
tric constant and conductivity increase because the material is the measured data and simulated data can be calibrated out
slightly porous. Measurements have been made to determine the with a scale factor or a simple normalization procedure. In the
dielectric constant and conductivity changes during immersion following imaging examples, we use a normalization procedure
in water, and the results have shown that there is a small change in which the normalization factor is the measured background
less than 15% for both dielectric constant and conductivity be- field and the simulated background field, respectively, at the
fore and after immersion. Such objects have large contrasts with same receiver location.
the background medium, and thus large multiple scattering ef-
fects are expected. A. Microwave Imaging With One Dielectric Ball
The transmission coefficient ( ) between the transmitter The first example utilizes a small dielectric sphere of 0.5-cm
and receiver, both polarized in the -direction and separated diameter placed at the center of the chamber (also the center
by 8.2 cm in water, is measured as a function of frequency, of the imaging domain and the origin), as shown in Fig. 6. To
as shown in Fig. 5. The five curves in Fig. 5 represent the produce multiple source excitations, the dipole transmitting
background without object (solid line), the total with antenna is placed at nine locations on the plane cm
a clay ball of 0.5-cm diameter placed at the center of the two with , , where cm, and
antennas (heavy dotted curve), the total with two metallic cm. As shown in Fig. 3, the receiving antenna collects
spheres of 0.5-cm diameter (lighter dotted curve), the scattered multiview microwave field information by scanning automat-
obtained from (3) for a clay ball (dashed curve), and for two ically at 105 locations on the opposite side with cm
metallic spheres (dashed–dotted curve), respectively. It is noted and , , where , cm, and
that at 1.74 GHz, corresponding to the common frequency for , cm. Only the -polarized field is collected
the -parameters shown in Fig. 2, the background is ap- since the two antennas are oriented in the same vertical direc-
proximately 42 dB, while the scattered is approximately tion. Measurements are performed in the frequency domain
996 IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, VOL. 56, NO. 4, APRIL 2008

Fig. 6. Imaging of a dielectric sphere in water using nine transmitter and 105 re-
0
ceiver locations. The transmitting antenna is placed on the plane x = 4:1 cm.
The receiving antenna scans on the plane x = 4:1 cm.

Fig. 8. Convergence curve of the data error as a function of the iteration number
of the stabilized biconjugate gradient FFT-distorted Born iterative method for
one dielectric sphere in water.

Fig. 9. Imaging of two clay balls in water. The two spheres are placed along
y -axis and separated center to center by 2.4 cm. The transmitting antenna is
0
placed on the plane x = 4:1 cm. The receiving antenna scans on the plane
x = 4:1 cm.

terminated at the twentieth iteration step. It is observed that,


Fig. 7. Reconstructed permittivity profile for a 0.5-cm clay ball from measured
due to a good inverse result of the diagonal tensor approxima-
data in 3-D plots using: (a) the diagonal tensor approximation–Born iterative tion–Born iterative method being used as an initial solution (data
method and (b) the stabilized biconjugate gradient FFT-distorted Born iterative error 20%) for inversion, the data error of the inversion using
method; the reconstructed permittivity profile on the x = 0 plane using: (c) the
diagonal tensor approximation–Born iterative method and (d) the stabilized bi-
the stabilized biconjugate gradient FFT-distorted Born iterative
conjugate gradient FFT-distorted Born iterative method. method converges quickly to 6% after 20 iterations for the real
measurement data.

at several discrete frequencies. Here, only single-frequency B. Microwave Imaging for Two Dielectric Balls
reconstructed results are presented. For the first example, the Fig. 9 shows the geometry of the imaging system for two
imaging domain of dimension of 8 8 8 cm is divided into dielectric spheres (0.5-cm diameter) in water. The dipole
32 32 32 voxels so the total number of complex unknowns transmitting antenna is placed at three locations on the plane
to be reconstructed is , while the number of cm with , , where
measured data is . Both the diagonal tensor approx- and cm, to test the capability to image in a different
imation–Born iterative method and the stabilized biconjugate experimental setup. The receiving antenna collects multiview
gradient FFT-distorted Born iterative method are used for in- microwave field information by scanning automatically at
version. In the second step inversion process, the inverse result 105 locations on the opposite side with cm and the
produced by the diagonal tensor approximation–Born iterative receiving points are exactly the same as in the last example.
method is used as an initial solution to speed up convergence. The transmitting and receiving dipoles are all -polarized. The
Fig. 7 shows reconstructed results of the permittivity at measured data at 1.74 GHz is used for image reconstruction
1.74 GHz using the diagonal tensor approximation–Born iter- of an imaging domain of size 8 8 8 cm divided into
ative method and the stabilized biconjugate gradient-distorted 32 32 32 voxels. The total number of complex unknowns
Born iterative method, respectively. The reconstructed images to be reconstructed is .
indicate highly accurate location of the object. The value of Fig. 10 presents the measured for all combinations of
the relative permittivity is substantially higher than 5, perhaps transmitters for the total and incident fields. The scattered field
because of the small size of the object. can be obtained by subtracting the incident field from
Fig. 8 shows the convergence curve of the data error as a the total field . It is observed that: 1) the difference is very
function of the iteration number of the stabilized biconjugate small between the total field with the objects and incident field
gradient FFT-distorted Born iterative method. The inversion is without the objects; 2) the magnitude of the scattered field is
YU et al.: ACTIVE MICROWAVE IMAGING II: 3-D SYSTEM PROTOTYPE AND IMAGE RECONSTRUCTION FROM EXPERIMENTAL DATA 997

Fig. 11. Reconstructed permittivity profile for two clay balls in 3-D plots using:
(a) the diagonal tensor approximation–Born iterative method and (b) the stabi-
lized biconjugate gradient FFT-distorted Born iterative method. The 2-D cross
section at x = 0 for the: (c) diagonal tensor approximation–Born iterative
Fig. 10. Measured jS j from three transmitters and 105 receivers for two di- method and (d) the stabilized biconjugate gradient FFT-distorted Born itera-
electric spheres in water. (a) Magnitude jS j for the incident and total fields. tive method.
(b) Magnitude jS j for the incident and scattered fields.

approximately from 70 to 80 dB, or approximately from 20


to 30 dB lower than the incident field ( 50 dB). This means
that the signal-to-noise ratio (where the signal refers to the total
field) should be better than an average of the ratio of the total
field to the scattered field (say, 25 dB) to image such small
objects. The system has been carefully designed to meet this
requirement.
Fig. 11 shows the 3-D tomographic results in a 3-D view and a
2-D cross section with the diagonal tensor approximation–Born
iterative method and the stabilized biconjugate gradient FFT-
distorted Born iterative method. The positions and sizes of the
spheres are clearly determined. As expected, Fig. 11(a) and (b)
shows that the resolution in the -direction is slightly lower than
in the other two directions because the scattered field informa-
tion is collected only on the – -plane. The reconstructed con-
ductivity profiles for the two clay balls are presented in Fig. 12
in 3-D view and in a 2-D cross section with the diagonal tensor
approximation–Born iterative method and the stabilized bicon-
Fig. 12. Reconstructed conductivity profile for two clay balls in 3-D plots
jugate gradient FFT-distorted Born iterative method. It is noted using: (a) the diagonal tensor approximation–Born iterative method and (b) the
that the positions and sizes of the objects can also be determined stabilized biconjugate gradient FFT-distorted Born iterative method. The 2-D
by the reconstructed conductivity profiles. cross section at x = 0 for: (c) the diagonal tensor approximation–Born iterative
method and (d) the stabilized biconjugate gradient FFT-distorted Born iterative
Comparison between the experimental scattered field method.
and reconstructed scattered field in Fig. 13 shows excellent
agreement. This example demonstrates the capability of our
3-D imaging system and reconstruction method in the recon- the background, here we show an imaging example for two
struction of multiple small objects from measured data. metallic spheres. The setup is exactly the same as in the pre-
vious experiment in Fig. 9, except that the two metallic spheres
C. Microwave Imaging for Two Metallic Balls are separated center to center by 3.2 cm.
In the above experiments, dielectric spheres with permit- Fig. 14 shows the measured for this imaging example.
tivity value smaller than the background have been imaged. The scattered field is obtained by subtracting the incident
To demonstrate the performance of the system and algorithms field from the total field . It is observed that the dif-
for objects having a higher complex permittivity value than ference between the total field and incident field is substantially
998 IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, VOL. 56, NO. 4, APRIL 2008

Fig. 13. Comparison of measured and reconstructed scattered field j S j for


two dielectric spheres.

Fig. 15. Conductivity profiles reconstructed from the experimental data for two
metallic spheres in 3-D plot using: (a) the diagonal tensor approximation–Born
iterative method and (b) the stabilized biconjugate gradient FFT-distorted Born
iterative method. The 2-D cross section at x = 0 for the: (c) diagonal tensor ap-
proximation–Born iterative method and (d) the stabilized biconjugate gradient
FFT-distorted Born iterative method.

simple dipole antennas in isolation and in a large water


chamber. No background heterogeneities have been added. We
are currently investigating more realistic imaging environments
with array antennas.

V. CONCLUSION
We have demonstrated a 3-D microwave tomographic
imaging system. An inversion technique that combines the
diagonal tensor approximation, stabilized biconjugate gradient
FFT algorithm, Born iterative method, and distorted Born
iterative method has been applied to nonlinear image recon-
struction in microwave imaging for breast cancer detection. In
this system, two dipole antennas are designed to transmit and
receive electromagnetic waves, reducing the mutual coupling
of antennas and resulting in accurate measurements of scattered
near-field waves. The collected 3-D electromagnetic wave data
Fig. 14. Measured jS j from three transmitters and 105 receivers for two di-
electric spheres in water. (a) Magnitude jS j for the incident and total fields. in water are processed by a 3-D nonlinear inverse scattering
(b) Magnitude jS j for the incident and scattered fields. algorithm to unravel the multiple scattering effects. With the
developed 3-D microwave imaging system prototype, dielectric
objects of 5-mm diameter have been detected and localized
larger than in the previous example of two dielectric spheres; the effectively with high resolution, even when the scattered field
magnitude of the scattered field is approximately 20 dB lower intensity is approximately 90 dB, or approximately 30 dB
than the incident field. below the incident field. One remaining challenge is the imaging
The reconstructed results for the conductivity are shown in of tumors in the presence of skin and highly heterogeneous
Fig. 15. The reconstructed images clearly demonstrate that the structures. Future work includes developing a 3-D microwave
two metallic objects can be localized very effectively. tomographic imaging system designed for a more realistic
heterogeneous environment and for clinical applications.
D. Discussion
The above results have shown that the prototype and hy- REFERENCES
brid algorithms can successfully image small objects using [1] S. S. Chaudhary, R. K. Mishra, A. Swarup, and J. M. Thomas, “Di-
electric properties of normal and malignant human breast tissues at ra-
microwave imaging. For simplicity and for the sake of demon- diowave and microwave frequencies,” Indian J. Biochem. Biophys., vol.
strating 3-D microwave tomographic imaging, we have used 21, pp. 76–79, 1984.
YU et al.: ACTIVE MICROWAVE IMAGING II: 3-D SYSTEM PROTOTYPE AND IMAGE RECONSTRUCTION FROM EXPERIMENTAL DATA 999

[2] A. J. Surowiec, S. S. Stuchly, J. R. Barr, and A. Swarup, “Dielec- [23] P. M. Meaney, M. W. Fanning, T. Raynolds, C. J. Fox, Q. Fang, S. P.
tric properties of breast carcinoma and the surrounding tissues,” IEEE Poplack, and K. D. Paulsen, “Initial clinical experience with microwave
Trans. Biomed. Eng., vol. 35, no. 4, pp. 257–263, Apr. 1988. breast imaging in women with normal mammography,” Acad. Radiol.,
[3] W. T. Joines, Y. Zhang, C. Li, and R. L. Jirtle, “The measured elec- vol. 14, pp. 207–218, 2007.
trical properties of normal and malignant human tissues from 50 to 900 [24] C. F. Smith, A. F. Peterson, and R. Mittra, “The biconjugate gra-
MHz,” Med. Phys. J., vol. 21, no. 4, pp. 547–550, 1994. dient method for electromagnetic scattering,” IEEE Trans. Antennas
[4] L. Jofre, M. S. Hawley, A. Broquetas, E. de los Reyes, M. Ferrando, and Propag., vol. 38, no. 6, pp. 938–940, Jun. 1990.
A. R. Elias-Fuste, “Medical imaging with a microwave tomographic [25] Q. H. Liu, X. M. Xu, B. Tian, and Z. Q. Zhang, “Applications of nonuni-
scanner,” IEEE Trans. Biomed. Eng., vol. 37, no. 3, pp. 303–312, Mar. form fast transform algorithms in numerical solutions of differential
1990. and integral equations,” IEEE Trans. Geosci. Remote Sens., vol. 38,
[5] S. Caorsi, G. L. Gragnani, and M. Pastorino, “An electromagnetic no. 4, pp. 1551–1560, Jul. 2000.
imaging approach using a multi-illumination technique,” IEEE Trans. [26] X. Xu, Q. H. Liu, and Z. Q. Zhang, “The stabilized biconjugate gradient
Biomed. Eng., vol. 41, no. 4, pp. 406–409, Apr. 1994. fast Fourier transform method for electromagnetic scattering,” J. Appl.
[6] S. C. Hagness, A. Taflove, and J. E. Bridges, “Two-dimensional FDTD Comput. Electromagn. Soc., vol. 17, no. 1, pp. 97–103, Mar. 2003.
analysis of a pulsed microwave confocal system for breast cancer de- [27] L. P. Song and Q. H. Liu, “Fast three-dimensional electromagnetic non-
tection: Fixed-focus and antenna-array sensors,” IEEE Trans. Biomed. linear inversion in layered media with a novel scattering approxima-
Eng., vol. 45, no. 12, pp. 1470–1479, Dec. 1998. tion,” Inv. Problems, vol. 20, no. 6, pp. S171–S194, 2004.
[7] S. C. Hagness, A. Taflove, and J. E. Bridges, “Three-dimensional [28] L. P. Song and Q. H. Liu, “A new approximation to three dimensional
FDTD analysis of a pulsed microwave confocal system for breast electromagnetic scattering,” IEEE Geosci. Remote Sensing Lett., vol.
cancer detection: Design of an antenna-array element,” IEEE Trans. 2, no. 2, pp. 238–242, Apr. 2005.
Antennas Propag., vol. 47, no. 5, pp. 783–791, May 1999. [29] C. Yu, L. P. Song, and Q. H. Liu, “Inversion of multi-frequency experi-
[8] P. M. Meaney, K. D. Paulsen, A. Hartov, and R. K. Crane, “An ac- mental data for imaging complex objects by a DTA–CSI method,” Inv.
tive microwave imaging system for reconstruction of 2-D electrical Problems, vol. 21, pp. S165–S178, 2005.
property distributions,” IEEE Trans. Biomed. Eng., vol. 42, no. 10, pp. [30] M. Xu and Q. H. Liu, “The BCGS-FFT method for electromagnetic
1017–1025, Oct. 1995. scattering from inhomogeneous objects in a planarly layered-medium,”
[9] P. M. Meaney, M. W. Fanning, D. Li, P. Poplack, and K. D. Paulsen, “A IEEE Antennas Wireless Propag. Lett., vol. 1, pp. 77–80, 2002.
clinical prototype for active microwave imaging of the breast,” IEEE [31] X. Millard and Q. H. Liu, “Fast volume integral equation solver for
Trans. Microw. Theory Tech., vol. 48, no. 11, pp. 1841–1853, Nov. electromagnetic scattering from large inhomogeneous objects in pla-
2000. narly layered-media,” IEEE Trans. Antennas Propag., vol. 51, no. 9,
[10] E. C. Fear and M. A. Stuchly, “Microwave detection of breast cancer,” pp. 2393–2401, Sep. 2003.
IEEE Trans. Microw. Theory Tech., vol. 48, no. 11, pp. 1854–1863, [32] B. Wei, E. Simsek, C. Yu, and Q. H. Liu, “Three-dimensional electro-
Nov. 2000. magnetic nonlinear inversion in layered media by a hybrid diagonal
[11] Q. H. Liu, Z. Q. Zhang, T. Wang, G. Ybarra, L. W. Nolte, J. A. Bryan, tensor approximation—Stabilized biconjugate gradient fast Fourier
and W. T. Joines, “Active microwave imaging I: 2-D forward and in- transform method,” Waves in Random Complex Media, vol. 17, no. 2,
verse scattering methods,” IEEE Trans. Microw. Theory Tech., vol. 50, pp. 129–147, May 2007.
no. 1, pp. 123–133, Jan. 2002. [33] W. C. Chew, Waves and Fields in Inhomogeneous Media. Piscat-
[12] E. C. Fear, S. C. Hagness, P. M. Meaney, M. Okoniewski, and M. A. away, NJ: IEEE Press, 1995.
Stuchly, “Enhancing breast tumor detection with near-field imaging,” [34] Y. M. Wang and W. C. Chew, “An iterative solution of the two-dimen-
IEEE Micro, vol. 3, no. 1, pp. 48–56, Mar. 2002. sional electromagnetic inverse scattering problem,” Int. J. Imag. Syst.
[13] S. K. Davis, H. Tandradinata, S. C. Hagness, and B. D. Van Veen, Technol., vol. 1, pp. 100–108, 1989.
“Ultrawideband microwave breast cancer detection: A detection theo- [35] W. C. Chew and Y. M. Wang, “Reconstruction of two-dimensional per-
retic approach using the generalized likelihood ratio test,” IEEE Trans. mittivity distribution using the distorted born iteration method,” IEEE
Biomed Eng., vol. 52, no. 7, pp. 1237–1250, Jul. 2005. Trans. Med. Imag., vol. 9, no. 2, pp. 218–225, Jun. 1990.
[14] P. Kosmas and C. M. Rappaport, “A matched-filter FDTD-based time [36] A. Roger, “A Newton–Kantorovich algorithm applied to an elec-
reversal approach for microwave breast cancer detection,” IEEE Trans. tromagnetic inverse problem,” IEEE Trans. Antennas Propag., vol.
Antennas Propag., vol. 54, no. 4, pp. 1257–1264, Apr. 2006. AP-29, no. 2, pp. 232–238, Mar. 1981.
[15] S. Y. Semenov, R. H. Svenson, A. E. Bulyshev, A. E. Souvorov, A. G. [37] R. F. Remis and P. M. van den Berg, “On the equivalence of the
Nazarov, Y. E. Siziv, A. V. Pavlovsky, V. Y. Borisov, B. A. Voinov, G. Newton–Kantorovich and distorted born method,” Inv. Problems, vol.
I. Simonova, A. N. Starostin, V. G. Posukh, G. P. Tatsis, and V. Y. 16, pp. L1–L4, 2000.
Baranov, “Three-dimensional microwave tomography: Experimental [38] F. Li, Q. H. Liu, and L. P. Song, “Three-dimensional reconstruction
prototype of the system and vector born reconstruction method,” IEEE of objects buried in layered media using born and distorted born iter-
Trans. Biomed. Eng., vol. 46, no. 8, pp. 937–946, Aug. 1999. ative methods,” IEEE Geosci. Remote Sensing Lett., vol. 1, no. 2, pp.
[16] Z. Q. Zhang, Q. H. Liu, C. Xiao, E. Ward, G. Ybarra, and W. T. Joines, 107–111, Apr. 2004.
“Microwave breast imaging: 3-D forward scattering simulation,” IEEE [39] P. M. van den Berg and R. E. Kleinman, “A contrast source inversion
Trans. Biomed. Eng., vol. 50, no. 10, pp. 1180–1189, Oct. 2003. method,” Inv. Problems, vol. 13, pp. 1607–1620, 1997.
[17] Z. Q. Zhang and Q. H. Liu, “3-D nonlinear image reconstruction for [40] B. Wei, E. Simsek, and Q. H. Liu, “Improved diagonal tensor approx-
microwave biomedical imaging,” IEEE Trans. Biomed. Eng., vol. 51, imation (DTA) and hybrid DTA/BCGS-FFT method for accurate sim-
no. 3, pp. 544–548, Mar. 2004. ulation of 3-D inhomogeneous objects in layered media,” Waves in
[18] K. D. Paulsen, P. M. Meaney, and L. C. Gilman, Alternative Random Complex Media, vol. 17, no. 1, pp. 55–66, Feb. 2007.
Breast Imaging: Four Model-Based Approaches. Berlin, Germany:
Springer-Verlag, 2005.
[19] W. T. Joines, Q. H. Liu, and G. Ybarra, “Electromagnetic imaging of Chun Yu (SM’07) received the Ph.D. degree in
biological systems,” in CRC Handbook on Biological Effects of Elec- electrical engineering from Shanghai University,
tromagnetic Fields, B. Greenebaum and F. Barnes, Eds. Boca Raton, Shanghai, China, in 1998.
FL: CRC, 2006. From 1982 to 1992, he was an RF Design and
[20] X. Li, E. J. Bond, B. D. Van Veen, and S. C. Hagness, “An overview Research Engineer with the China Research Institute
of ultra-wideband microwave imaging via space–time beamforming of Radiowave Propagation, Xingxiang, China.
for early-stage breast-cancer detection,” IEEE Antennas Propag. Mag.,
From 1997 to 2001, he was a faculty member and
vol. 47, no. 1, pp. 19–34, Feb. 2005.
an Associate Professor with the Department of
[21] M. Lazebnik, L. McCartney, D. Popovic, C. B. Watkins, M. J.
Lindstrom, J. Harter, S. Sewall, A. Magliocco, J. H. Booske, M. Communication Engineering, Shanghai University,
Okoniewski, and S. C. Hagness, “A large-scale study of the ultrawide- Shanghai, China. In March 2001, he joined the Elec-
band microwave dielectric properties of normal breast tissue obtained tromagnetics Laboratory, Department of Electrical
from reduction surgeries,” Phys. Med. Biol., vol. 52, pp. 2637–2656, and Computer Engineering, University of Kentucky, initially as a Post-Doctoral
2007. Research Fellow and then as a Research Scientist. Since December 2004, he
[22] S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. has been a Research Associate with the Department of Electrical and Computer
Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Engineering, Duke University, Durham, NC. His research interests include
Paulsen, “Electromagnetic breast imaging: Results of a pilot study in computational electromagnetics, electromagnetic scattering and wave propa-
women with abnormal mammograms,” Radiology, vol. 243, no. 2, pp. gation, inverse scattering, microwave and biomedical imaging, and antenna
350–359, 2007. analysis and design.
1000 IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, VOL. 56, NO. 4, APRIL 2008

Mengqing Yuan, photograph and biography not available at time of publication. Qing Huo Liu (S’88–M’89–SM’94–F’05) received
the Ph.D. degree in electrical engineering from the
University of Illinois at Urbana-Champaign, in 1989.
From September 1986 to December 1988, he
John Stang, photograph and biography not available at time of publication. was a Research Assistant with the Electromagnetics
Laboratory, University of Illinois at Urbana-Cham-
paign, and from January 1989 to February 1990,
he was a Post-Doctoral Research Associate. From
1990 to 1995, he was a Research Scientist and
Elan Bresslour, photograph and biography not available at time of publication. Program Leader with Schlumberger-Doll Research,
Ridgefield, CT. From 1996 to May 1999, he was an
Associate Professor with New Mexico State University. Since June 1999 he
has been with Duke University, Durham, NC, where he is currently a Professor
Rhett T. George, photograph and biography not available at time of publication. with the Department of Electrical and Computer Engineering. He has authored
or coauthored over 350 papers in refereed journals and conference proceedings.
He is an Associate Editor for Radio Science. His research interests include
computational electromagnetics and acoustics, inverse problems, geophysical
Gary A. Ybarra (S’86–M’86–SM’06) was born subsurface sensing, biomedical imaging, electronic packaging, and the simula-
in Hampton, VA, on May 13, 1960. He received tion of photonic devices and nanodevices.
the B.S., M.S., and Ph.D. degrees from North Dr. Liu is a Fellow of the Acoustical Society of America. He is a member of
Carolina State University, Raleigh, in 1983, 1986, Phi Kappa Phi, Tau Beta Pi. He is a full member of the U.S. National Com-
and 1992, respectively, all in electrical and computer mittee, URSI Commissions B and F. He is currently an associate editor for
engineering. the IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING. He was the
He is currently a Professor of the Practice and Di- recipient of the 1996 Presidential Early Career Award for Scientists and En-
rector of Undergraduate Studies with the Department gineers (PECASE) presented by the White House, the 1996 Early Career Re-
of Electrical and Computer Engineering, Duke Uni- search Award presented by the Environmental Protection Agency, and the 1997
versity, Durham, NC. His research interests include CAREER Award presented by the National Science Foundation (NSF).
radar signal processing and microwave imaging.

William T. Joines (M’61–SM’94–LSM’97–F’08) was born in Granite Falls,


NC. He received the B.S.E.E. degree (with high honors) from North Carolina
State University, Raleigh, in 1959, and the M.S. and Ph.D. degrees in electrical
engineering from Duke University, Durham, NC, in 1961 and 1964, respectively.
From 1959 to 1966, he was a Member of Technical Staff with Bell Telephone
Laboratories, Winston-Salem, NC, where he was engaged in research and de-
velopment of microwave components and systems for military applications. In
1966, he joined the faculty of Duke University, where he is currently a Professor
of electrical and computer engineering. His research and teaching interests are
in the area of electromagnetic-wave interactions with structures and materials,
mainly at microwave and optical frequencies. He has authored or coauthored
over 100 technical papers on electromagnetic-wave theory and applications. He
holds seven U.S. patents.
Dr. Joines was the recipient of the Scientific and Technical Achievement
Award presented by the Environmental Protection Agency in 1982, 1985, and
1990.

View publication stats

You might also like