TON DUC THANG UNIVERSITY

FACULTY OF APPLIED SCIENCES

Department of Biotechnology

Chapter 2:
Production of bioactive secondary
metabolites
Course number: 601093

Lecturer: Dieu-Hien Truong

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  Secondary metabolites

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601093 – Chapter 2. Production of bioactive secondary metabolites
  Why secondary metabolites?

- Chemical warfare to protect plants

from the attacks.
- Attract pollinators or seed dispersal
agents.
- Important for abiotic/biotic stresses.
- Medicine.
- Industrial additives.

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  Why secondary metabolites?

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601093 – Chapter 2. Production of bioactive secondary metabolites
  Bioactive compound sources

- Vaccine
- Antibodies
- Antigen

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 2.1. Isolation of bioactive secondary metabolites

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601093 – Chapter 2. Production of bioactive secondary metabolites
 Chapter 2. Production of bioactive secondary
metabolites
2.1. Isolation of bioactive secondary metabolites
2.2. Purification of bioactive secondary metabolites
2.3. Detection of bioactive secondary metabolites

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 Chapter 2. Production of bioactive secondary
metabolites

2.4. Production of bioactive compounds using bioreactor technology

2.5. Production of bioactive compounds using in vitro cultures
2.6. Application of bioactive secondary metabolites

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 2.1. Isolation of bioactive secondary metabolites

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601093 – Chapter 2. Production of bioactive secondary metabolites
 2.1. Isolation of bioactive secondary metabolites

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601093 – Chapter 2. Production of bioactive secondary metabolites
 2.2. Purification of bioactive secondary metabolites

Sigamani et al., 2016

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  Chromatography

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 Chapter 2. Production of bioactive secondary
metabolites
Your tasks are to listen Video (V4) and to answer the
following questions:
1. What are materials and devices to carry out paper
chromatography in video?.
2. Draw the protocol to identify compounds of material in
video.

601093 – Chapter 2. Production of bioactive secondary metabolites

 2.3. Detection of bioactive secondary metabolites

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601093 – Chapter 2. Production of bioactive secondary metabolites
  Detection process of hydrotcarbon/VOCs

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601093 – Chapter 2. Production of bioactive secondary metabolites
  Detection process of bioactive compounds

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601093 – Chapter 2. Production of bioactive secondary metabolites
 2.4. Production of bioactive compound using
bioreactor technology

Shim et al., 2015

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 2.5. Production of bioactive compounds using
in vitro cultures

Mohammed et al., 2015

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  In vitro production of bioactive compounds

Xia et al., 2013

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601093 – Chapter 2. Production of bioactive secondary metabolites
 2.6. Application of bioactive secondary metabolites

Weissman et al., 2010

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601093 – Chapter 2. Production of bioactive secondary metabolites
 2.6. Application of bioactive secondary metabolites

Zhang lab.
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 Chapter 2. Production of secondary metabolites

Your tasks in Chapter 2 are to:

1. Understand and Apply new words in

production of bioactive SD and its application.

2. Writing essays in SD production techniques in

English

3. Finish the home works on eLearning and

library
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