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COVID-19 patients presenting

with seizures
Heather Mason
20 May 2022

View more articles on:

COVID-19 General Medicine HIV/Infectious Diseases

Neurology Seizures

The results of a registry-based study published

in the Journal of Clinical Neuroscience revealed
that, although rare, epileptic seizures can occur
during SARS-CoV-2 infection. Seizures can
occur both in patients with predisposing risk
factors and patients without known risk factors,
highlighting the need for clinicians to be aware
of the possibility of seizures in their COVID-19
patients.

The analysis included 232 cases of patients with

confirmed COVID-19 who experienced seizures
during the disease course. The researchers
described the clinical presentation of COVID-
19, seizures, results of complementary tests,
and the suspected aetiology of the seizures.

Of the included cases, 26 (11.2%) presented

with seizures; seven had a prior history of
epilepsy, while the remaining 19 had no history
of seizures. In most cases, seizures presented
during the first week post-infection. Eight
patients (30.7%) presented with generalised
tonic-clonic seizures, seven (26.9%) with status
epilepticus, eight (30.7%) with focal impaired-
awareness seizures, and four (11.7%) with
secondary generalised seizures. Six patients
(23.1%) also presented with other neurological
symptoms, including altered mental status and
decreased level of consciousness.

These findings suggest COVID-19 may be

associated with epileptic seizures, either in
isolation or in the context of encephalopathy,
the authors said.

References Disclaimer
Fernández SF, Pérez Sánchez JR, Pérez GH, Pérez MR, Castro CG,
García-Azorín D, et al. Seizures and COVID-19: Results from the
Spanish Society of Neurology’s COVID-19 registry. J Clin Neurosci.
2022;101:112–7. https://doi.org/10.1016/j.jocn.2022.05.013.

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