drug brand name onset of action peak of action duration of action half life

benazepril Lotensine 1-2 h 2-4-h 24h 10-11h

captopril capoten 0.25 h 1-1.5 h 6h 2h

enalipril vasotec 1h 4-6 h 12-24 h 11 h

fosinopril monopril 1h 3h 24 h 12 h

lisnopril zestril 1h 6h 24 h 12 h

moexipril univasc 1-2 h 1.5 h 24 h 1h

perindopril coversyle 1-2 h 1h 24 h 1.5-3 h

quinapril accupril 1h 2_4h 24h 25h

ramipril altace 1-2 h 1.1-4.5 h 24 h 13-17 h

trandolapril Mavik 1h 4-10 h 24 h 22.5 hr

food drug interaction protein bond metabolism excreated unchange prodrug
potassium rich food, 96.70% liver urine 80% yes

decrease absorption 25-30 % 50% urine 40-50% no

50 %

none - liver urine 60-80% yes

none 95% liver urine 40-50% yes

none 25% - urine 100 % no

decrease absorption 90% Liver Urine 52% Yes

decrease absorption 60% liver urine 75 % yes

decrease absorption 97% liver urine96% yes

none 56% liver urine 60 % yes

slows absorption 80% liver urine 33% yes

dosage adjucement for CrCl< 30ml\min. contraindication indication
yes aliskerin/ hypertension/nondiabetic
sacubitril&valsartan/ nephropathy(offlable)
idipathic
angioedema/bilateral renal
artery stenosis /pregnancy

yes bilaterial renal artery hypertention ,Urgent

stenosis , pregnancy hypertention ,LV systolic heart
failure , post MI ,nephropathy
(type 1 DM )
yes bilaterial renal artery hypertention ,LV systolic heart
stenosis , pregnancy failure , post MI
yes pregnancy hypertension,heart failure

yes bilaterial renal artery hypertention ,LV systolic heart

stenosis , pregnancy
Yes Pregnancy , bilateral renal
artery stenosis
yes bilaterial renal artery
stenosis , pregnancy
yes bilaterial renal artery
stenosis , pregnancy
yes bilaterial renal artery
stenosis , pregnancy
yes bilaterial renal artery
stenosis , pregnancy , high
potassium levels,
decreased bone marrow
function
failure , post MI
Hypotension
hypertention
hypertention ,LV systolic heart
failure
hypertention ,post MI
hypertention , congestive heart
failure, left ventricular
dysfunction post MI
pregnancy lactation
fetal harm not
recommended

C and D in 2nd not

and 3rd trimester recommended

may cause fetal not use

harm
C un 1st and D in not
2nd and 3rd recommended
may cause fetal no data
harm available
C in 1st and D in with caution
2nd and 3rd
D with caution

C and D in 2nd with caution

and 3rd
trimester
D not
recommended
D no data
available