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Term Definition
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An excess of fluid within and around brain cells. It has many causes,
including infections such as meningitis, a prolonged epileptic fit or
starvation of the brain’s oxygen supply. It can result from
Hyponatraemia. Because the brain is within a rigid skull, any
increase in its volume in consequence of oedema causes
increased pressure on the brain which in turn, restricts the amount
Cerebral oedema
of venous blood draining from the brain and further increases the
oedema. The eventual result is that parts of the brain are forced by
the pressure down through the foramen magnum, the hole in the
base of the skull, impairing blood supply to the brainstem and
leading to loss of control over the heart, blood pressure and
breathing. Sudden death may result.
An umbrella term encompassing a group of non-progressive, non-
Cerebral palsy contagious motor conditions which cause physical disability in
human development.
Cerebral perfusion The net pressure gradient causing blood flow to the brain (brain
pressure (CPP) perfusion).
A rare form of stroke that results from thrombosis (a blood clot) of
Cerebral venous the dural venous sinuses, which drain blood from the brain.
sinus thrombosis Symptoms may include headache, abnormal vision, any of the
(CVST) symptoms of stroke and seizures. Intracranial pressure may rise
causing papilloedema (swelling of the optic disc).
A clear, colourless, body fluid, that occupies the subarachnoid
Cerebrospinal fluid
space and the ventricular system around and inside the brain and
(CSF)
spinal cord. In essence, the brain “floats” in it.
Cerebrovascular
A group of conditions affecting the circulation of blood to the brain.
disease
Cervical cord That part of the spinal cord situate in the neck.
A sensory receptor that converts chemical signals into electrical
Chemoreceptor potential. In more general terms, chemoreceptors detect certain
chemical stimuli in the environment.
An abnormal pattern of breathing characterized by progressively
deeper and sometimes faster breathing, followed by a gradual
Cheyne-Stokes
decline and then a temporary stop called an apnea. The pattern is
respiration
repeated with each cycle taking between 30 seconds and 2
minutes.
A malformation of the brain consisting of a downward displacement
Chiari malformation of the cerebellar tonsils through the foramen magnum (the opening
at the base of the skull).
A part of the brain situate in the medial aspect of the cerebral cortex
Cingulate gyrus
and considered part of the limbic lobe.
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The cerebrum is the part of the brain controlling all voluntary activity.
If the cerebrum is not functioning adequately as a result of disease,
Decerebrate
toxin, seizures etc. characteristic muscle spasms can result in
movement
movement of an individual, intermittently or continuously into
abnormal posture.
Inability of the heart to maintain adequate circulation, manifested by
Decompensation
difficulty in breathing, venous engorgement and oedema.
Brain tissue composed of myelin-coated nerve cell fibres. White
matter carries information between the nerve cells in the brain and
Deep white matter
the spinal cord. The inner portion of the cerebrum is composed of
white matter.
A deficiency of fluid in the body caused by insufficient intake,
excessive output or both. Minor degrees of dehydration are
common in illness and may be of no consequence. However an
Dehydration
increase in dehydration, especially in combination with abnormality
of blood chemistry (eg high or low sodium) may result in a
deterioration of various body functions.
The largest single structure linking the cerebellum to the rest of the
Dentate nucleus brain. It is located within the deep white matter of each cerebellar
hemisphere.
Desmopressin
A drug used to regulate urine production.
acetate/DDAVP
Dextrose An alternative term for ‘glucose’.
Dextrostix A blood test used to measure levels of sugar in the bloodstream.
Dialysate A fluid used for peritoneal dialysis (see Cycles).
The period of time when the heart fills with blood after systole
Diastole
(contraction).
A benzodiazepine (psychoactive) drug commonly used in the
Diazepam treatment of anxiety, insomnia and seizures. Diazepam can be
(Diazemuls) administered as a slow intravenous injection or as a continuous
intravenous (‘IV’) infusion.
Any tissue abnormality in that part of the brain which includes the
Diencephalon lesion
thalamus.
Oedema is an abnormal accumulation of fluid within the body. It can
Diffuse oedema
be localised or involve the whole body.
Dilutional
See hyponatraemia
hyponatraemia
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Femoral artery A general term for the large arteries in the thigh.
A potent, synthetic narcotic analgesic with a rapid onset and short
Fentanyl
duration of action.
A soluble plasma glycoprotein, synthesised by the liver, which is
Fibrinogen
converted into fibrin during blood coagulation.
The pupils of the eyes contract and dilate in response to light and
Fixed, dilated pupils the distance of focus. Severe damage to the brain stem results in a
failure in these responses and the pupils remain large.
The process by which the brain is treated in a solution of formalin
Fixing of the brain for up to two weeks in order to assist neoropathological
examination.
A medicine used to reverse the effects of benzodiazepines after
Flumazenil
sedation, general anesthesia or overdose.
An imaging technique commonly used to obtain real-time moving x-
Fluoroscopy
ray images of internal body structures.
Foley catheter A flexible tube passed through the urethra and into the bladder.
A large hole in the base of the skull. It where the brainstem merges
Foramen magnum
into the upper part of the spinal cord.
A rate calculated as the proportion of sodium passing through the
Fractional excretion
kidney and filtered into the urine. It is useful in evaluating acute
rate
kidney failure.
Where radicals are atoms, molecules, or ions with unpaired
electrons or an open shell configuration, free radicals may have
Free radicals
positive, negative, or zero charge. With some exceptions, the
unpaired electrons cause radicals to be highly chemically reactive.
The theoretical proportion of water in blood or urine which can be
Free water
recognised or calculated as containing no dissolved solutes.
Frontal white matter The nerve fibres within the frontal lobe of the brain.
A laboratory blood test to determine the proportions of all the
Full blood picture
components of blood.
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Human plasma A mixture of albumin, other proteins and saline used in the
protein fraction emergency treatment of bleeding until replacement donor blood
(HPPF) becomes available.
Hydrolysis A chemical reaction during which molecules of water are split.
Hyperammonaemia An abnormally high level of ammonia in the blood.
Also known as hypercarbia, a condition where there is excess
Hypercapnia
carbon dioxide (CO2) dissolved in the blood.
Hypercarbia See Hypercapnia above.
An abnormality of blood coagulation that increases the risk of
Hypercoagulability
thrombosis (blood clots in blood vessels).
The condition in which the concentration of the electrolyte
Hyperkalemia
potassium (K+) in the blood is elevated.
A concentration of sodium in the blood which is higher than normal.
Hypernatraemia It is caused either by excessive salt intake or by water loss in excess
of that of salt.
Hypertension A state of raised blood pressure.
The delivery of an intravenous fluid which has a higher osmotic
pressure than blood. Osmotic pressure develops when there are
more molecules on one side of a semi-permeable membrane, such
Hypertonic infusion
as a cell wall, than the other. The result is that water tends to flow
through the membrane into the more concentrated solution until the
concentrations are equal on both sides of the membrane.
The state of being hypertonic or having extreme muscular or arterial
Hypertonicity
tension.
Hypervolemia (fluid
The condition of an excess of fluid in the blood.
overload)
Hypocapnia The presence of abnormally low levels of carbon dioxide in blood.
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Laminar Flat.
Laparotomy The surgical opening of the abdomen.
A rare neurometabolic disorder affecting the central nervous system
Leigh’s disease
and characterized by movement disorders.
Leucocytes White blood cells
Leukoaraiosis Nonspecific changes in the cerebral white matter.
Leukoencephalopathy Any of a group of diseases affecting the white matter of the brain.
The creation of a ligature or suture typically tied around a vessel to
Ligation
seal it off.
Any one of several tests used to evaluate various functions of the
Liver function test
liver, including metabolism, storage, filtration and excretion.
Lumbar The region of the back lying lateral to the lumbar vertebrae.
The placement of a cannula into the epidural space (near but
outside the spinal cord) through which drugs can be delivered to
Lumbar epidural
produce anaesthesia of the lower part of the body without
necessarily having to render the patient unconscious.
Lumen line A line inserted into a tubular structure, such as an artery or intestine.
The swellings which occur at various points in the lymphatic system
Lymph nodes through which lymph (a watery fluid derived from blood and
absorbed food material) drains.
Those cells whose role it is to engulf and digest cellular debris and
Macrophages
pathogens.
Macroscopic Observable by the naked eye.
A skin eruption where the lesions are flat and less than 1cm in
Macular rash
diameter.
The IV fluid rate which provides for ongoing and insensible losses
in a patient who is not dehydrated and not suffering other abnormal
Maintenance rate
body fluid loss. It is calculated by reference to weight or body
surface area.
(a) A surgical operation within the abdominal, pelvic, cranial, or
thoracic cavities.
(b) A procedure which constitutes a hazard to life or the function of
Major surgery
an organ or of tissue.
(c) Any surgical procedure that involves general anaesthesia or
respiratory assistance.
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Medullary Of or relating to the medulla (inner core) if any body part or organ.
Medullary Cystic An inherited kidney disorder characterized by cysts in both kidneys
(kidney disease) and tubulointerstitial sclerosis, leading to end-stage renal disease.
Membrane pump A diaphragm pump.
Meninges The three membranes that envelop the brain and spinal cord.
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Organic aciduria Excessive excretion of one or more organic acids in the urine.
A rare metabolic urea-cycle disorder. The urea cycle is a series of
Ornithine
five liver enzymes that rid the body of ammonia. When one of these
transcarbamylase
enzymes is missing or deficient, ammonia accumulates in the blood
(OTC) deficiency
and travels to the brain, causing coma, brain damage and death.
A measure of the osmoles (the number of moles of a chemical
Osmolality compound that contribute to a solution's osmotic pressure) of solute
per kilogram of solvent (osmol/kg or Osm/kg).
Osmolarity is an estimation of the osmolar concentration of plasma
Osmolarity and is proportional to the number of particles per litre of solution; it
is expressed as mmol/L.
The passage of water molecules through a semi-permeable
Osmosis membrane such as a cell wall. This occurs when one fluid contains
fewer molecules of dissolved solids than the other.
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Osmotic
Where the osmotic equilibrium normally present between two fluid
disequilibrium
compartments is no longer present.
syndrome
The movement of water across a semi permeable membrane which
Osmotic fluid shift has the result of tending to equalise the osmotic pressure across
the membrane.
Osmotic A neurological disease caused by severe damage to the myelin
myelinolysis sheath of nerve cells in the brainstem.
Osmotic oedema Oedema caused through osmosis.
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The rate at which air passes into and out of the lungs. This occurs
Respiratory rate
18 times a minute in a healthy adult at rest.
Resuscitation Methods of revival for a patient in cardiac or respiratory failure.
That part of the brain concerned with the waking/sleeping cycle and
Reticular formation
the filtering of incoming stimuli.
A vein formed by the union of the superficial temporal and maxillary
Retromandibular
veins which descends in the substance of the parotid gland beneath
vein
the facial nerve.
A metabolic disorder principally affecting the liver and brain, marked
Reye's syndrome by the rapid development of life-threatening neurological
symptoms.
A fundus (pleural fundi) usually refers the interior surface of the eye
Right & left fundi opposite the lens and includes the retina and optic disc. It can be
viewed through an ophthalmoscope.
A genus of viruses of the family Reoviridae having a wheel-like
Rotavirus appearance and causing acute infantile gastroenteritis and
diarrhoea.
The method by which medication is administered to a patient eg
Routes of Topical where a substance is applied to a localized area of the
Medication body, Oral being through the mouth or Per Rectum, through the
rectum.
Salaam attacks (or A rare type of epilepsy usually starting in the first eight months of
infantile spasms) life.
A method of calculating glomerular filtration rate (see above) in a
Schwartz formula
child with reference to blood levels of creatinine and height.
Sclerosis A hardening of tissue or other anatomical features.
Scoliosis A condition in which there is curvature of the spine.
An operating theatre nurse who has access to the instruments and
the exposed parts of the body (‘the operative field’). Accordingly and
Scrub nurse in order to be sterile, they ‘scrub’ their hands and arms prior to
surgery, wear a sterile gown and gloves and are masked. They may
not touch any unsterile area during the procedure.
Any unanticipated event in a healthcare setting resulting in death or
Sentinel Event serious physical or psychological injury to a patient which is
unrelated to the natural course of illness.
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The scientific study of blood serum and other bodily fluids. Used in
Serology practice to refer to the diagnostic identification of antibodies in the
serum.
A group of inherited blood disorders characterized by chronic
Sickle cell disease anaemia, acute episodes of limb or joint pain and occurring with
complications due to associated organ and tissue damage.
Sodium chloride A solution for IV use containing 30 mmol/litre of sodium and chloride
0.18% / dextrose or one-fifth of the concentration in ‘natural body fluids’ such as
4% blood.
The concentration of sodium in solution is expressed as the number
of milliosmoles in each litre (mOsmol/L). An osmole is a unit used
Sodium
to define chemicals which can contribute to osmosis and represents
measurement
the number of osmotically active particles which, when dissolved in
(mmol/litre)
22.4 L of solvent at 0 degrees Centigrade, exert an osmotic
pressure of 1 atmosphere. A milliosmole is 1/1000 of an osmole.
Sodium thiopentone
A rapid-onset short-acting drug used to induce general anaesthesia.
(STP)
Sodium valproate An anti-convulsive drug.
Sphenopalatine
An artery of the head.
artery
Repeated epileptic fits without return to consciousness in between.
Status epilepticus Breathing stops between each fit and the body is deprived of
oxygen causing damage to the brain.
An abnormal narrowing in a blood vessel or other tubular organ or
Stenosis
structure.
An optical microscope, often referred to as the "light microscope" to
Stereomicroscope
magnify small samples.
A paired muscle in the superficial layers of the anterior portion of
Sternomastoid
the neck. It acts to flex and rotate the head.
Abbreviation of sodium thiopentone, a drug used to induce
STP anaesthesia intravenously.
Also an acronym for Standard Temperature & Pressure.
Striatum A subcortical part of the forebrain.
The sudden and localised death of brain cells due to inadequate
Stroke
blood flow.
A description applied to a disease, the duration of which persists
Subacute
between the acute and chronic.
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The space within the brain between the arachnoid membrane and
Subarachnoid
the pia mater (the delicate innermost layer of the meninges).
Subclavian The area beneath the clavicle (collar bone).
Subclinical Without clinical presentation
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Venous sinus A large vein or channel for the circulation of venous blood.
A procedure, usually carried out in an intensive care unit, by which
Ventilation
a device called a ‘ventilator’ takes over a patient’s breathing.
Breathing assistance to enable sufficient air entry into their lungs,
Ventilatory support commonly achieved by the use of a mechanical ventilator delivering
oxygen and air through an endotracheal tube.
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