3/21/24, 4:59 PM Molecular Basis of Inheritance - Test

Molecular Basis of Inheritance - Test

Questions

1. Escherichia coli with completely radioactive DNA was allowed to replicate in non-radioactive medium for
two generations. Percentage of bacteria with radioactive DNA in second generation is
(a) 100%
(b) 50%
(c) 25%
(d) 12.5%

2. A short length of DNA molecule has 80 thymine and 80 guanine bases. The total number of nucleotides in the
DNA fragment is
(a) 40
(b) 80
(c) 160
(d) 320

3. Choose the correct statement.

(a) Haploid content of human DNA is 4.6 × 106
(b) A nitrogenous base is linked to pentose sugar through phosphodiester linkage
X-ray diffraction data of Maurice Wilkins and Rosalind Franklin was the basis of Watson and Crick’s
(c)
DNA model
(d) DNA as an acidic substance was first identified by Watson and Crick

4. Hershey and Chase proved experimentally that

(a) Bacteriophages live as parasites in bacteria
(b) Protein coats of viruses enter the host along with the DNA
(c) DNA is the genetic material
(d) RNA is the genetic material in case of viruses

5. Scientists have discovered how to put together a bacteriophage with the protein coat of phage T2 and the
DNA of phage T4. If this composite phage were allowed to infect a bacterium, the phages produced in the
host cell would have:
(a) the coat protein of T2 and the DNA of T4
(b) the coat protein of T4 and the DNA of T2
(c) the coat protein and DNA of T2
(d) the coat protein and DNA of T4

6. Due to discovery of which of the following in 1980, the evolution was termed as RNA world:
(a) m-RNA, t-RNA, r-RNA synthesise proteins
(b) In some virus RNA is genetic material
(c) RNA has enzymatic property
(d) RNA is not found in all cells

7. The promoter site and the terminator site for transcription are located at
(a) 3' (downstream) end and 5' (upstream) end, respectively of the transcription unit
(b) 5' (upstream) end and 3' (downstream) end, respectively of the transcription unit
(c) The 5' (upstream) end
(d) The 3' (downstream) end

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3/21/24, 4:59 PM Molecular Basis of Inheritance - Test

8. Which was the last human chromosome to be completely sequenced?

(a) Chromosome 1
(b) Chromosome 11
(c) Chromosome 21
(d) Chromosome X

9. Through which experiments, the first proof that DNA is the genetic material was provided?
(a) Transfection
(b) Phage infection
(c) Bacterial translocation
(d) Bacterial transformation

10. In a 3.2 kbp long piece of DNA, 820 adenine bases were found. What would be the number of cytosine
bases?
(a) 780
(b) 1560
(c) 2380
(d) 1480

11. Which of the following is NOT true about Watson and Crick’s DNA double helix model?
(a) The two strands are anti-parallel to each other
(b) The anti-parallel nature of the strands makes them form a right-handed helix
(c) A large-sized purine always binds to a small-sized pyrimidine
(d) The DNA backbone is formed of sugar-phosphate groups, with the nitrogenous bases pointing outwards

12. Which of the following represents the mRNA language?

(a) Transcription unit
(b) Amino-acyl tRNA
(c) Triplet codons in the genetic code
(d) Degeneracy of the genetic code

13. Correct sequence of code transfer during polypeptide formation is

(a) DNA, mRNA, tRNA and amino acids
(b) DNA, tRNA, rRNA and mRNA
(c) mRNA, tRNA, DNA and amino acids
(d) rRNA, DNA, mRNA and tRNA

14. How many base pairs does the haploid human genome consist of?
(a) 4 x 109 bp
(b) 3 x 109 bp
(c) 5 x 109 bp
(d) 2 x 109 bp

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3/21/24, 4:59 PM Molecular Basis of Inheritance - Test

15. Given diagram represents the components of a transcription unit. Select the correct answer regarding it.

(a) (A) – Terminator; (B) – Promoter; (C) – Template strand; (D) – Coding strand
(b) (A) – Promoter; (B) – Terminator; (C) – Coding strand (D) – Template strand
(c) (A) – Promoter; (B) – Terminator;(C) – Template strand; (D) – Coding strand
(d) (A) – Terminator; (B) – Promoter; (C) – Coding strand; (D) – Template strand

16. Capping of RNA is necessary as_______

(a) It helps us distinguish 5’ from 3’ end
(b) It has a rolling action and condenses the transcript as it is produced
(c) To protect the transcript from exonuclease
(d) To prevent the transcript from sticking to DNA

17. Identify the correct statement w.r.t. lac operon.

(a) Regulation of lac operon by repressor is referred to as positive control
(b) Operator gene has the site for binding of RNA polymerase
(c) lac Z gene codes for beta-galactosidase
(d) Regulator gene binds with repressor protein molecule, prevents the transcription of structural genes

18. Who first theorised the semiconservative mode of replication for DNA?
(a) Watson and Crick
(b) Meselson and Stahl
(c) Hershey and Chase
(d) Beadle and Tatum

19. Any mistakes during DNA replication by the enzyme would result into:
(a) Cancer
(b) Apoptosis
(c) Cell fragmentation
(d) Mutation

20. Mode of DNA replication in Escherichia coli is

(a) Conservative and unidirectional
(b) Semiconservative and unidirectional
(c) Conservative and bidirectional
(d) Semiconservative and bidirectional

21. Histone proteins are rich in

(a) Histidine and arginine
(b) Histidine and lysine
(c) Histidine and arginine and lysine
(d) Arginine and lysine

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3/21/24, 4:59 PM Molecular Basis of Inheritance - Test

22. Which of the following heavy/radioisotopes is not suitable for DNA labeling based studies?
(a) 3H
(b) 32P
(c) 15N
(d) 35S

23. A DNA nucleotide chain has AGCTTCGA sequence. The nucleotide sequence of other chain would be
(a) TCGAAGCT
(b) GCTAAGCT
(c) TAGCATAT
(d) GATCCTAG

24. DNA replication is

(a) Conservative and discontinuous
(b) Semiconservative and semidiscontinuous
(c) Semiconservative and discontinuous
(d) Conservative

25. DNA or RNA fragment tagged with a radioactive molecule is called :

(a) Clone
(b) Plasmid
(c) Vector
(d) Probe

26. When lactose is present

(a) The repressor is able to bind to the operator
(b) The repressor is unable to bind to the operator
(c) Transcription of lac Y, lacZ and lacA genes occurs
(d) Both (b) and (c) are correct

27. Select the correct option in case of replication and transcription.

(a) In both → Direction of synthesis-5’-3’; Direction of reading of the template DNA strand-3’-5’.
(b) In replication → Direction of synthesis-5’-3’; Direction of reading of the template DNA strand-5’-3’.
(c) In both → Direction of synthesis-3’-5’; Direction of reading of the template DNA strand-5’-3’.
(d) In replication → Direction of synthesis-3’-5’; Direction of reading of the template DNA strand-3’-5’.

28. Which of the following is true for both transcription and DNA replication?
(a) Principle of complementarity governs the process
(b) Only one of the two strands acts as a template

(c) DNA-dependent DNA polymerase is present

(d) Adenine base pairs with thymine

29. Which of the following statements is true with respect to AUG ?

(a) It plays dual role
(b) It is an initiator codon
(c) It codes for methionine
(d) All of the above

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3/21/24, 4:59 PM Molecular Basis of Inheritance - Test

30. In case of prokaryotes, synthesis of an mRNA molecule from DNA is terminated with the help of
(a) Alpha factor
(b) Sigma factor
(c) Delta factor
(d) Rho factor

31. If one strand of DNA has the nucleotide sequence 5'GATCAA3' , its complementary strand will have the
sequence.
(a) 5' CTAGTT 3'
(b) 5' TTCATC 3'
(c) 5' TTGATC 3'
(d) 5' TTGTTC 3'

32. If the length of E.coli DNA is 1.36 mm, then how many base pairs are present in E.coli ?
(a) 3.6 × 104
(b) 3.6 × 106
(c) 4.0 × 106
(d) 4.6 × 106

33. The phosphodiester bonds that link adjacent nucleotides in both RNA and DNA:
(a) always link A with T and G with C
(b) join the 5' C sugar residue of one nucleotide to the 3'C sugar residue of the next nucleotide
(c) form between the planar rings of adjacent bases
(d) are uncharged at neutral pH

34. In Meselson and Stahl’s experiment, when N14 DNA molecules were grown in a medium with heavy
nitrogen N15
Half the daughter DNA molecules in Generation I had both light strands and the remaining half were
(a)
hybrids
Half the daughter DNA molecules in Generation I had both heavy strands and the remaining half were
(b)
hybrids

(c) All the daughter DNA molecules in Generation II had both heavy strands

(d) All the daughter DNA molecules in Generation I were hybrids

35. Which of the following is NOT a feature of the genetic code?

(a) Code is degenerate

(b) Codons have punctuations

(c) Codons are read in a Contiguous fashion

(d) The code is universal

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3/21/24, 4:59 PM Molecular Basis of Inheritance - Test

36. A gene which synthesises a repressor protein is

(a) Operator gene
(b) Structural gene
(c) Promoter gene
(d) Regulator gene

37. Wild type Escherichia coli growing on medium having glucose is transferred to lactose containing medium.
Which change occurs?
(a) Lac operon is induced
(b) Lac operon is suppressed
(c) All operons are induced
(d) The bacterium stops dividing

38. Which one of the following is not a part of a transcription unit in DNA?
(a) The inducer
(b) A terminator
(c) A promoter
(d) The structural gene

39. Regulatory proteins turn transcription off through binding to a site rapidly at the front of the promoter and
many times even overlaps the promoter, this site is the
(a) Regulatory site
(b) Operator site
(c) Suppressor site
(d) Transcriptional control site

40. What is added to the 3’ end of many eukaryotic mRNA’s after transcription?
(a) Intron
(b) Poly A tail
(c) Trinucleotide –CCA
(d) a cap

41. In Hershey and Chase experiment, what findings led to the conclusion that DNA is the genetic material?
(a) The presence of radioactivity in the bacteria when 35S was used.
(b) The presence of radioactivity in the supernatant when 35S was used.
(c) The presence of radioactivity in the bacteria when 32P was used.
(d) The presence of radioactivity in the supernatant when 32P was used.

42. RNAse can digest

(a) Protein
(b) RNA
(c) DNA
(d) both (b) and (c)

43. Which of the following statements about DNA packaging is true?

(a) The linker DNA is a histone protein
(b) H1 proteins are part of the histone octamer
(c) Negatively charged amino acids help in packaging of DNA since it is positively charged
(d) The formation of euchromatin and heterochromatin depends on the pattern of DNA packaging

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3/21/24, 4:59 PM Molecular Basis of Inheritance - Test

44. The net electric charge on DNA and histones is:

(a) both positive
(b) both negative
(c) negative and positive, respectively
(d) zero

45. Which one of the following makes use of RNA as a template to synthesize DNA?
(a) Reverse transcriptase
(b) DNA dependent RNA polymerase
(c) DNA polymerase
(d) RNA polymerase

46. The goal of HGP was to identify all the approximately ______ genes in human DNA
(a) 15000-20,000
(b) 20,000-25,000
(c) 25000-30000
(d) 35000-40000

47. Which of the following is used as cloning vectors for storing HGP data:
(a) BAC (bacterial artificial chromosomes)
(b) YAC (yeast artificial chromosomes)
(c) Both A and B
(d) None of the above

48. The sequence of structural gene of the lac operon is

(a) y, z, a
(b) z, y, a
(c) a, y, z
(d) a, z, y

49. Select the correct statement from the following regarding transcription.
A. In transcription only a segment of DNA and only one of the strands is copied into RNA.
B. Terminator is located upstream of the structural gene.
C. Intervening sequences do appear in processed RNA.
D. In bacteria translation can begin much before the mRNA is fully transcribed
(a) A & D
(b) B & C
(c) A & C
(d) B & D

50. How many amino acids can be translated from the given sequence of nucleotides in mRNA if 6th nucleotide
undergoes deletion?
AUG UGC ACU AUA GCG UAA
(a) Two
(b) One
(c) Four
(d) Three

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3/22/24, 6:38 PM p-block (group 13 and 14) - Test

p-block (group 13 and 14) - Test

Questions

1. The structural unit present in pyro sillicates is:

(a) S i O 3
6−

(b) S iO 4−

(c) S i O 2
6−

(d) (S i O ) 2
2−

5 n

2. Which of the following statement is correct?

(a) C-F bond is stronger than Si-F bond because C-F bond length is shorter than that of Si-F
(b) C-F bond is weaker than Si-F bond because of less difference in electronegativity
(c) Si-F bond is stronger than C-F bond because of double bond character due to back bonding from F to Si
(d) Si-F bond is stronger than C-F bond due to more difference in electronegativities

3. H3BO3 is
(a) monobasic acid and weak Lewis acid
(b) monobasic and weak Bronsted acid
(c) monobasic and strong Lewis acid
(d) tribasic and weak Bronsted acid

4. Which of the following tetrahlides does not act as Lewis acid?

(a) SnCl4
(b) GeCl4
(c) SiF4
(d) CCl4

5. Buckminsterfullerene is an allotropic form of

(a) phosphorus
(b) sulphur
(c) carbon
(d) tin

6. Carborundum on heating with caustic soda in presence of air produces

(a) N a S iO + H 2 3 2

(b) N a S iO + N a C O
2 3 2 3

(c) N a S iO + H 2 2 2

(d) N a S iO + H 2 4 2

7. Boric acid is polymeric due to:

(a) Its monobasic nature
(b) Its acidic nature
(c) The presence of hydrogen bonds
(d) Its geometry

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3/22/24, 6:38 PM p-block (group 13 and 14) - Test

8. Which set shows inert pair effect?

(a) Fe, Co, Ni
(b) Br, I, At
(c) Ge, Sn, Pb
(d) He, Ne, Ar

9. When aluminium is heated in atmosphere of nitrogen, it forms:

(a) AIN
(b) AI2N
(c) Al3N
(d) Al2N3

10. Borax is used as a cleansing agent because on dissolving in water, it gives

(a) Alkaline solution
(b) Acidic solution
(c) Neutral solution
(d) None of these

11. The species present in solution when CO2 is dissolved in water are:
(a) H2CO3, CO32–
(b) HCO3Ɵ, CO32–
(c) CO2, H2CO3
(d) CO2, H2CO3, HCO3Ɵ, CO32–

12. Silica is reacted with sodium carbonate. What is the gas liberated?
(a) CO
(b) O2
(c) CO2
(d) O3

13. A liquid which is permanently supercooled is frequently called

(a) Gasoline
(b) Mercury
(c) Glass
(d) Bromine

14. The anhydride of carbonic acid is:

(a) CO
(b) CO2
(c) C3O2
(d) none of these

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3/22/24, 6:38 PM p-block (group 13 and 14) - Test

15. In graphite and diamond, the percentage of p-characters of the hybrid orbitals in hybridisation are
respectively :
(a) 33 and 25
(b) 33 and 75
(c) 50 and 75
(d) 67 and 75

16. Which of the period 4th elements given below exhibit its identical valency in its hydride and higher oxide?
(a) Bromine
(b) Germanium
(c) Arsenic
(d) Selenium

17. Which element has lowest electronegativity in group 13?

(a) Al
(b) B
(c) Ga
(d) In

18. Which of the following statements is not correct regarding diamond and graphite?
(a) In diamond, each carbon atom is covalently bonded to four other carbon atoms.
(b) In graphite, each carbon atom is covalently bonded to three other carbon atoms in the same plane.
(c) The C – C bond length in graphite is intermediate between single and double bond distance.
(d) Diamond is a layered structure, the two layers joined by van der Waals' forces.

19. The amorphous form of silica is:

(a) Tridymite
(b) Kieselguhr
(c) Cristobalite
(d) Quartz

20. The relative stability of +2 oxidation state of group 14 elements follows the order:
(a) Si < Ge > Sn > Pb
(b) Si < Ge < Sn < Pb
(c) Ge < Si < Pb < Sn
(d) Si > Ge > Sn > Pb

21. Read the statements and choose the correct option

1) Carbon only exist in free state
2) Diamond, graphite, fullerene are the allotropes of carbon
3) Diamond has 2 free electrons
4) Graphite has 1 free electrons
(a) 1 and 3
(b) 2 and 3
(c) 2 and 4
(d) 1, 3 and 4

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3/22/24, 6:38 PM p-block (group 13 and 14) - Test

22. High melting point of boron is due to its existence as

(a) Small covalent molecule
(b) Giant covalent molecule
(c) Giant covalent solid
(d) Giant ionic molecule

23. Elements of group 13 mainly form covalent compounds because

(a) Size of ions is small
(b) Sum of three ionization energies is very high
(c) Electronegativity values are high
(d) All of these

24. The stability of +1 oxidation state increases in the sequence

(a) Ga < In < Al < Tl
(b) Al < Ga < In < Tl
(c) Tl < In < Ga < Al
(d) In < Tl < Ga < Al

25. Direct oxidation of C in limited supply of air yields

(a) carbon dioxide
(b) carbon monoxide
(c) Both (a) and (b)
(d) None of these

26. On small scale pure CO is prepared by dehydration …X… with conc. H2SO4 at 373 K. Here, X refers to
(a) steric acid
(b) benzoic acid
(c) acetic acid

(d) formic acid

27. Which of the following ion(s) balance(s) negative charge of aluminosilicate?

(a) Na+
(b) K+
(c) Ca2+
(d) All of these

28. Which of the following represents the laboratory preparation of carbon dioxide?
Δ
(a) C aC O −→ C aO + C O
3 2

(b) C aC O + 2H C l → C aC l + H O + C O
3 2 2 2

(c) C H O + 6O → 6C O + 6H O
6 12 6 2 2 2

(d) C H + 2O → C O + 2H O
4 2 2 2

29. Reaction of Nitrogen with Alumina and carbon yields

(a) Aluminium carbide
(b) Aluminium oxide
(c) Aluminium Nitride
(d) None of the above

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3/22/24, 6:38 PM p-block (group 13 and 14) - Test

30. The electronegativity of aluminium is similar to:

(a) Carbon
(b) Beryllium
(c) Boron
(d) Lithium

31. The number of 2-centre-2-electron and 3-centre-2-electron bonds in B2H6, respectively, are:
(a) 2 and 1
(b) 4 and 2
(c) 2 and 2
(d) 2 and 4

32. Borax is salt of

(a) weak acid and weak base
(b) weak acid and strong base

(c) strong acid and strong base

(d) strong acid and weak base

33. Which one of the following has highest Lewis acid strength?
(a) BI3
(b) BBr3
(c) BF3
(d) BCl3

34. An allotrope of carbon which exhibits only two types of C–C bond distance of 143.5 pm and 138.3 pm, is
(a) charcoal
(b) graphite
(c) diamond
(d) fullerene

35. On strong heating boric acid yields

(a) B
(b) B2
(c) B2O3
(d) B2H6

36. Which of the following statement is correct with respect to the property of elements with an increase in
atomic number in the carbon family (group 14)?
(a) Atomic size decreases
(b) Ionization energy increases
(c) Metallic character decreases
(d) Stability of +2 oxidation state increases

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3/22/24, 6:38 PM p-block (group 13 and 14) - Test

37. The increasing order of atomic radii of the following Group 13 elements is
(a) Al < Ga < ln < TI
(b) Ga < Al < In < TI
(c) Al < In < Ga < TI
(d) Al < Ga < TI < In

38. Which of the following statements is correct?

(a) Pb2+ is a reducing agent and Sn2+ is not a reducing agent
(b) Both Pb2+ and Sn2+ are reducing agents
(c) Pb2+ is not a reducing agent while Sn2+ is a reducing agent.
(d) Both Pb2+ and Sn2+ are not reducing agents.

39. What is the effect of density on moving down the 13th group?
(a) Increases
(b) Decreases
(c) First decreases then increases
(d) Remains same

40. The first ionization enthalpy of group-14 members is …A… than the corresponding members of group-13.
Here, A refers to
(a) higher
(b) lower
(c) smaller
(d) Both (b) and (c)

41. Hydrogen bridge bond is present in

(a) methanol
(b) diborane
(c) inorganic benzene
(d) water

42. The order of catenation of C, Si, Ge, Sn is

(a) C < Si < Ge < Sn
(b) C > Si > Ge > Sn
(c) C >> Si > Ge ≈ Sn
(d) C ≈ Si >> Ge ≈ Sn

43. Carbon dioxide is used for extinguishing fire because

(a) It has a relatively high critical temperature
(b) In solid state, it is called dry ice
(c) It is neither combustible nor a supporter of combustion
(d) It is a colorless gas

44. Which of the following is not a kind of silicate?

(a) Chain
(b) Ring
(c) Sheet
(d) 2-dimensional silicate

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3/22/24, 6:38 PM p-block (group 13 and 14) - Test

45. Which of the following ion does not exist?

(a) B3+
(b) Al3+
(c) Ga3+
(d) In3+

46. The correct statements among I to III regarding group 13 element oxides are,
(I) Boron trioxide is acidic
(II) Oxides of aluminium and gallium are amphoteric
(III) Oxides of indium and thallium are basic.
(a) (I) and (II) only
(b) (I), (II) and (III)
(c) (I) and (III) only
(d) (II) and (III) only

47. Which one of the statements is incorrect for aluminium metals?

(a) It is a good conductor of heat and electricity
(b) It is malleable and ductile
(c) It can be welded and cast but difficult to solder
(d) Its alloys are heavy

48. Diborane (B2H6) reacts independently with O2 and H2O to produce, respectively;
(a) B2O3 and H3BO3
(b) B2O3 and [BH4]–
(c) H3BO3 and B2O3
(d) HBO2 and H3BO3

49. The power of halides of boron to act as Lewis acids decreases in the order:
(a) BF3 > BCl3 > BBr3
(b) BBr3 > BCl3 > BF3
(c) BCl3 > BF3 > BBr3
(d) BCl3 > BBr3 > BF3

50. Which among the following statements are correct regarding Boron family ?
(I) Boron has high melting and Boiling point.
(II) All oxide of Boron-family are acidic.
(III) Thallium trichloride (TlCl3) may act as oxidizing agent unlike other trihalides of Boron-family.
(IV) Lewis acidity order: BF3 > BCl3 > BBr3.
(a) (I), (II), (III)
(b) Only (I)
(c) (I) and (III) only
(d) (I) (II) (III), (IV)

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