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PDF 4Th International Conference On Nanotechnologies and Biomedical Engineering Proceedings of Icnbme 2019 September 18 21 2019 Chisinau Moldova Ion Tiginyanu Ebook Full Chapter
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Volume 77
Volume 77
Series Editor
Ratko Magjarevic, Faculty of Electrical Engineering and Computing, ZESOI, University of
Zagreb, Zagreb, Croatia
Associate Editors
Piotr Ładyżyński, Warsaw, Poland
Fatimah Ibrahim, Department of Biomedical Engineering, Faculty of Engineering, University
of Malaya, Kuala Lumpur, Malaysia
Igor Lackovic, Faculty of Electrical Engineering and Computing, University of Zagreb,
Zagreb, Croatia
Emilio Sacristan Rock, Mexico DF, Mexico
The IFMBE Proceedings Book Series is an official publication of the International Federation
for Medical and Biological Engineering (IFMBE). The series gathers the proceedings of
various international conferences, which are either organized or endorsed by the Federation.
Books published in this series report on cutting-edge findings and provide an informative
survey on the most challenging topics and advances in the fields of medicine, biology, clinical
engineering, and biophysics.
The series aims at disseminating high quality scientific information, encouraging both basic
and applied research, and promoting world-wide collaboration between researchers and
practitioners in the field of Medical and Biological Engineering.
Topics include, but are not limited to:
IFMBE proceedings are indexed by SCOPUS and EI Compendex. They are also submitted
for ISI proceedings indexing.
Proposals can be submitted by contacting the Springer responsible editor shown on the
series webpage (see “Contacts”), or by getting in touch with the series editor Ratko
Magjarevic.
123
Editors
Ion Tiginyanu Victor Sontea
Academy of Sciences of Moldova Department of Microelectronics
Chisinau, Moldova and Biomedical Engineering
Technical University of Moldova
Serghei Railean Chisinau, Moldova
Department of Microelectronics
and Biomedical Engineering
Technical University of Moldova
Chisinau, Moldova
This Springer imprint is published by the registered company Springer Nature Switzerland AG
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
This volume presents the Proceedings of the 4th International Conference on Nanotech-
nologies and Biomedical Engineering (ICNBME), which was held on September 18–21, 2019
in Chisinau, Republic of Moldova. ICNBME-2019 continued the series of international
conferences in the field of nanotechnologies and biomedical engineering with the main goal
focused at bringing together scientists and engineers dealing with fundamental and applied
research for reporting on the latest theoretical developments and applications in the fields
involved.
The conference covered a wide range of subjects of primary importance for research and
development such as nanotechnologies and nanomaterials; plasmonics and metamaterials;
bio-micro/nanotechnologies and devices; biomaterials for medical applications; biomimetics
and sensors; biomedical instrumentation; biomedical signal processing; biomedical imaging
and image processing; bioinformatics; medical physics and biophysics; molecular; cellular and
tissue engineering; clinical engineering; health technology management and assessment;
health informatics, e-health and telemedicine; biomedical engineering education; innovation,
development and interdisciplinary research; nuclear and radiation safety and security.
The papers included in the Proceedings reflect the results of multidisciplinary research
undertaken by about one hundred of groups worldwide. Special attention is paid to the devel-
opment of novel nanotechnologies and nanomaterials, in particular of bio-nanotechnologies and
bio-nanomaterials. New biocompatible materials are proposed for use in regenerative medicine,
cellular and tissue engineering. Interesting data on novel chemical and biosensors are reported
which are based on nanostructured metal oxides and hybrid nanocomposite materials.
Considerable progress has been achieved at the intersection of nanotechnologies, infor-
mation technologies, and biomedicine as, for example, in health informatics, biomedical
signal, and image processing. New theoretical and experimental results are highlighted in such
fields as superconductivity, novel magnetic materials, metamaterials, aeromaterials, opto-
electronic and photonic materials, photovoltaic structures, quantum dots, one- and
two-dimensional nanomaterials, multifunctional hybrid materials like core–shell structures,
etc. The Proceedings reflect the state of the art in controlling the properties of several classes
of nanocomposite materials for important future applications in various fields. It is worth to
note that the Proceedings include also a number of review papers reflecting the fascinating
history and recent achievements in the development of novel solid-state structures as well as
nanoelectronic and optoelectronic devices on their basis.
We hope that the papers included in the ICNBME-2019 Proceedings will be of interest for
established researchers working in multidisciplinary fields of science and technology, young
scientists, students and broad community wishing to get up-to-date information on progress in
the fast-developing areas of nanotechnology and biomedical engineering.
v
4th International Conference on Nanotechnologies
and Biomedical Engineering
ICNBME-2019, September 18–21, 2019, Chisinau,
Republic of Moldova
Organizers
In Collaboration with
Sponsored by
vii
Committees
Conference Chairs
ix
x Committees
Organizing Committee
Sergey Railean Technical University of Moldova, Head
Nicolai Ababii Technical University of Moldova
Tudor Braniste Technical University of Moldova
Vasilii Cretu Technical University of Moldova
Elena Darii Technical University of Moldova
Eugenia Groza State Medical and Pharmaceutical University “Nicolae
Testemiţanu”
Nicolae Magariu Technical University of Moldova
Ion Pocaznoi Technical University of Moldova
Vasile Postica Technical University of Moldova
Alexandr Sereacov Technical University of Moldova
Reviewers List
Ion Tiginyanu
tiginyanu@asm.md
Gallium nitride, a wide-bandgap semiconductor compound (Eg = 3.4 eV at 300 K), has in the
past two decades registered a fascinating increase in the crystalline quality of epitaxial layers
determining its leading role in the development of the modern solid-state lighting industry.
Exhibiting an impressive number of unique properties such as high breakdown voltage, high
switching frequencies, enhanced power efficiency, high electrical conductivity, excellent
thermal stability, and radiation hardness, over the past decade GaN has been remarkably
successful in the area of high-power/high-frequency electronic applications and is now con-
sidered the second most important semiconductor material after Si. In this paper, we report on
new fields of research and applications of gallium nitride.
First, we describe the possibility to fabricate ultrathin GaN-suspended membranes for
multifunctional applications. In particular, these suspended membranes were used to fabricate
networks of memristor devices exhibiting basic learning mechanisms such as habituation and
dishabituation to a certain electrical stimulus [1].
Second, we report on GaN biocompatibility and on the possibility to mark living cells with
hollow GaN nanoparticles exhibiting piezoelectric and magnetic properties. We show that the
living cells marked by GaN:Fe nanoparticles can be guided in a controlled fashion using
applied magnetic fields which is important for use in cell therapy [2].
Third, we report on three-dimensional nanoarchitectures of GaN for nano/microfluidic,
microrobotic, and biomedical applications. The three-dimensional nanoarchitectures are based
on GaN microtubular structures with nanoscopic thin walls which exhibit dual hydrophobic–
hydrophilic behavior [3]. The microtubular structures are shown to self-organize when
interacting with water, forming self-healing waterproof rafts with impressive cargo capabilities
(cargo up to 500 times heavier than the floating raft). Along with this, we demonstrate
self-propelled liquid marbles with exceptional mechanical robustness which may find appli-
cations as bioreactors for scalable in vitro cell growth. The physical properties of the new
material based on three-dimensional GaN architectures will be presented in the context of its
prospects for various biomimetic applications. Along with this, the novel material is shown to
exhibit shielding capabilities against electromagnetic radiation in X-band [4].
We will discuss the feasibility to use the nano/microtubular structures on GaN for the
fabrication of light-driven nano/microengines with performances higher than those inherent to
microengines based on arrays of TiO2 nanotubes [5].
References
1. Dragoman, M., Tiginyanu, I., et al.: Learning mechanisms in memristor networks based on GaN
nanomembranes. J. Appl. Phys. 124, 152110 (2018)
2. Braniste, T., Tiginyanu, I., et al.: Targeting endothelial cells with multifunctional GaN/Fe nanoparticles.
Nanoscale Res. Lett. 12, 486 (2017)
xv
xvi New Areas of Research and Applications for GaN
3. Tiginyanu, I., Braniste, T., et al.: Self-organized and self-propelled aero-GaN with dual
hydrophilic-hydrophobic properties. Nano Energy 56, 759 (2019)
4. Dragoman, M., Braniste, T., et al.: Electromagnetic interference shielding in X-band with aero-GaN.
Nanotechnology 30, 34LT01 (2019)
5. Enachi, M., Guix, M., et al.: Light-induced motion of microengines based on microarrays of TiO2 nan-
otubes. Small 12, 5497 (2016)
Recent Progress of Cold Cathodes:
Volcano-Structured Field Emitters and GOS
Tunneling Cathodes
H. Mimura
mimura.hidenori@shizuoka.ac.jp
T. Masuzawa
Y. Neo
K. Murakami
M. Nagao
Vacuum devices are dominant in high power and high frequency. Though thermal cathodes
are widely used in vacuum devices, if the thermal cathodes are replaced with cold cathodes,
more superior devices are expected. The conventional cold cathodes with an electron
extraction gate are field emitters (FEs). The FEs, however, have two big problems such as
current fluctuation and beam divergence. The current fluctuation is suppressed when the FE is
operated in ultrahigh vacuum or connected in series to a constant current source such as a
field-effect transistor [1, 2]. For the beam divergence, though the double-gated FE with both an
electron extraction gate and a focus gate was proposed, the electron emission current was
significantly reduced when the electron beam was focused. Recently, we have developed the
volcano-structured double-gated field emitter (VDG-FE) [3, 4]. The VDG-FE can focus
electron beam without a decrease of the emission current. By using the VDG-FE, we are
developing the compact image pickup tube which is applicable to a radiation-tolerant image
sensor [5].
As the second topic, I will talk about fabrication of graphene and its application to planar
Graphene–Oxide–Si (GOS) tunneling cathodes with an extremely high electron emission
efficiency. The MetalOxide–Si (MOS) tunneling cathode is a fine cold cathode, because it has
fluctuation free emission current, produces uniform emission from the whole emitter area, and
has a highly directional electron beam. Furthermore, the electron emission is almost inde-
pendent of the ambient gas pressure. However, MOS cathodes have very low electron
emission efficiency less than 1% [6]. We synthesized graphene by low-pressure chemical
vapor deposition. We have developed GOS tunneling cathodes with an extremely high
electron emission efficiency larger than 20% by replacing the poly-Si gate electrode of MOS
cathodes with a graphene electrode [7].
References
1. Hashiguchi, G., Mimura, H., Fujita, H.: Jpn. J. Appl. Phys. 35 (1996) L84
2. Shimawaki, H., Tajima, K., Mimura, H., Yokoo, K.: IEEE Trans. Electron Devices 49 (2002) 1665
3. Neo, Y., Soda, T., Takeda, M., Nagao, M., Yoshida, T., Yasumuro, C., Kanemaru, S., Sakai, T., Hagiwara,
K., Saito, N., Aoki, T., Mimura, H.: App. Phys. Express. 1 (2008) 053001
xvii
xviii Recent Progress of Cold Cathodes: Volcano-Structured …
4. Neo, Y., Takeda, M., Soda, T., Nagao, M., Yoshida, T., Kenamaru, S., Sakai, T., Hagiwara, K., Saito, N.,
Aoki, T., Mimura, H.: J. Vac. Sci. Technol. B 27 (2009) 701
5. Honda, Y., Nanba, M., Miyakawa, K., Kubota, M., Nagao, M., Neo, Y., Mimura, H., Egami, N.: J. Vac.
Sci. Technol. B 34 (2016) 052201
6. Mimura, H., Neo, Y., Shimawaki, H., Abe, Y., Tahara, K., Yokoo, K.: Appl. Phys. Lett. 88 (2006) 123514
7. Murakami, K., Miyaji, J., Furuya, R., Adachi, M., Nagao, M., Neo, Y., Takao, Y., Yamada, Y., Sasaki, M.,
Mimura, H.: Appl. Phys. Lett. 114 (2019) 213501
Macromolecular Nanovectors for Gene Delivery
Bogdan C. Simionesci
“Petru Poni” Institute of Macromolecular Chemistry of the Romanian Academy, Iasi, Romania
“Gheorghe Asachi” Technical University of Iasi, Iasi, Romania
xix
Nanosensors: Current Status and Perspectives
Oleg I. Lupan
oleg.lupan@mib.utm.md; ollu@tf.uni-kiel.de
L. Chow
R. Adelung
Nanosensors play a great role in the world of nanotechnology and are demanded nowadays
due to miniaturization of electronic devices in many countries for the development of faster
portable diagnostics techniques or sensing systems, as well as interconnected setups for
extensive customer applications. Size effect and introducing additives in semiconducting
oxides make them suitable for sensing by tuning their selectivity, response, and reliability. The
present overview is aimed to summarize our results in this field and reported ones too [1, 2]. It
is known that companies developing nanosensors, especially in medical applications should
consider a series of characteristics (molecular, toxically, secondary reactions creating side
products, etc.). I will demonstrate how networked or single nanowire/nanosensors are built by
a new bottom-up approach with electronic [1], chemical [3], physical [2], magnetic properties
of emerging semiconducting oxide materials leading to their tuning toward new applications in
nanotechnology, nanoelectronics, and biomedical fields. Improvements in the past years were
made following new requirements of selectivity, response, reliability, and lower power con-
sumption of the nanosensors [4]. One of the major factors driving the market for nanosensors
is increasing demand for nanosensors in homeland security (e.g., detection of biotoxines,
radiations, etc). In this work, we report on a single nanowire/nanorod/nanotetrapod nanode-
vices fabricated by using platinum complex maskless nanodeposition in the dual-beam
focused electron/ion beams (FIB/SEM) scientific instrument Dualbeam Helios Nanolab (FEI).
The bottom-up method is based on the assembly of nanoscale building blocks to design and
growth the desired nanostructure-based sensor. The main advantages of such an approach are
the nanomaterial growth control with near-atomic precision and synthesize it with
desired/tuned chemical compositions which are not accessible or very expensive with con-
ventional top-down technologies. These nanodevices open absolutely new perspectives for
nanoelectronics and biomedical applications. I gratefully acknowledge the support of the Kiel
xxi
xxii Nanosensors: Current Status and Perspectives
University, Germany for an invited professor and visiting scientist positions in 2019. This
research was partly supported by the Technical University of Moldova. This research was
partly supported by the STCU within the Grant 6229.
References
1. Lupan, O., Postica, V., Wolff, N., Polonskyi, O., Duppel, V., Kaidas, V., Lazari, E., Ababii, N., Faupel, F.,
Kienle, L., Adelung, R.: Localized synthesis of iron oxide nanowires and fabrication of high performance
nanosensor based on a single Fe2O3 nanowire. Small (Weinheim an der Bergstrasse, Germany), 13 (2017),
1602868
2. Lupan, O., Braniste, T., Deng, M., Ghimpu, L., Paulowicz, I., Mishra, Y.K., Kienle, L., Adelung, R.,
Tiginyanu, I.: Rapid switching and ultra-responsive nanosensors based on individual shell-core Ga2O3/
GaN:Ox@SnO2 nanobelt with nanocrystalline shell in mixed phases. Sensors and Actuators, B: Chemical
221, 544–555 (2015)
3. Siebert, L., Lupan, O., Mirabelli, M., Ababii, N., Terasa, M.-I., Kaps, S., Cretu, V., Vahl, A., Faupel, F.,
Adelung, R.: 3D-printed chemiresistive sensor array on nanowire CuO/Cu2O/Cu heterojunction nets. ACS
Appl. Mater. Interfaces 11, 25508−25515 (2019)
4. Lupan, O., Postica, V., Pauporté, T., Faupel, F., Adelung, R.: UV nanophotodetectors: A case study of
individual Au-modified ZnO nanowires. Sensors and Actuators, A, 296, 400–408. (2019). https://doi.org/
10.1016/j.sna.2019.07.040
Complex Nanostructured Materials
Lorenz Kienle
lk@tf.uni-kiel.de
Today’s advanced materials are coined by structural, chemical, and functional properties that
require combined approaches of cutting-edge methods for their characterization. In order to
determine the structures on multiscale, several techniques have to be combined synergistically,
e.g.. atomic resolution transmission electron microscopy (TEM), X-ray- and
Synchrotron-based analyses. In this contribution, several complex nanostructured materials
will be discussed with respect to their real structure–property relationships. In case of mul-
tilayer materials, the design of sensor devices is enabled via tuning of their layered compo-
nents. For instance, ultrathin films of FeCo have been magnetically decoupled by layers of TiN
to ensure high thermal stability, soft magnetic behavior and a coercive field strength scaling
with the individual FeCo layer thickness. In the field of thermoelectrics, chalcogenide-based
multilayers are known as the materials of choice for achieving ultralow thermal conductivity.
Moreover, these materials are of great interest for fundamental research as demonstrated by the
discovery of novel transition metal based heterostructures. In case of telluride-based phase
change materials, the interfaces between the nanolayered components themselves are estab-
lishing the device function. Via in situ TEM, the atomic processes and defect dynamics
interrelated to switching can be examined, enabling the characterization of switching mech-
anisms. More complex nanoarchitectures can be produced by dedicated syntheses as
demonstrated for spark plasma sintered chalcogenides and the laser ablation synthesis of
bimetallic core–shell nanoparticles. In the latter case the bimetallic particles, e.g., for the
system Au–Fe, can be used as templates for etching experiments thus enabling the preparation
of highly porous Au nanoparticles with well-defined porosity distribution.
xxiii
Topology- and Geometry-Induced Properties
of Advanced Nanoarchitectures
Vladimir M. Fomin
v.fomin@ifw-dresdxen.de
Study of topological matter is one of the fascinating main roads of modern physics. The
present overview is aimed at topology- and geometry-driven effects, owing to special
geometries of novel micro- and nanoarchitectures fabricated of both conventional and topo-
logically nontrivial materials implemented by the high-tech techniques, in particular,
self-organization [1, 2]. I will demonstrate how topology of the quantum fields determines
electronic [3], excitonic [4], optical, superconducting [5], magnetic, thermal [6] properties of
emerging nanostructured materials leading to their functionalization towards novel applica-
tions in advanced nanotechnologies, including biomedical ones [7]. Self-assembled quantum
volcanos, which are singly connected, surprisingly exhibit the Aharonov–Bohm behavior in
experiment. This is explained by the fact that in a quantum volcano the electron wave
functions are identical to the electron wave functions in a quantum ring from a topological
point of view. Combination of a geometric potential and an inhomogeneous twist renders an
observation of the topology-driven effects in the electron ground-state energy in Möbius rings
at the microscale into the area of experimental verification. Advances in the high-tech roll-up
fabrication methods have provided qualitatively novel curved superconductor micro- and
nanoarchitectures, e.g., nanostructured microtubes and microhelices. Rolling up supercon-
ductor Nb nanomembranes into open tubes allows for a new, highly correlated vortex
dynamics regime that shows a threefold increase of a critical magnetic field for the beginning
of vortex motion and a transition magnetic field between single- and many-vortex dynamic
patterns. These results demonstrate pathways of tailoring nonequilibrium properties of vortices
and phase slips in curved superconductor nanoarchitectures leading to their application as
tunable superconducting flux generators for fluxon-based information technologies. For var-
ious micro- and nanoarchitectures, we have found a possibility of efficiently engineering the
Seebeck coefficient and electric conductivity in one-dimensional stacks of quantum dots,
acoustic phonon energy dispersion in one-dimensional quantum-dot superlattices,
cross-section-modulated nanowires, Si wires ranging from nanoscale to microscale, and, more
recently, multishell tubular structures, which are promising candidates for an advancement in
thermoelectric materials [6]. Soft and reconfigurable swimming microrobots [7], which are
fabricated within the high-tech roll-up approach, open new avenues for biomedical applica-
tions. I gratefully acknowledge the support of the COST Action “Nanoscale Coherent Hybrid
Devices for Superconducting Quantum Technologies” CA16218 and the German Research
Foundation (DFG) under grants #FO 956/4-1 and FO 956/5-1.
xxv
xxvi Topology-and Geometry-Induced Properties of Advanced Nanoarchitectures
References
1. Fomin, V. M.: Topology-driven effects in advanced nanoarchitectures. In: Sidorenko, A. (ed.) Functional
Nanostructures and Metamaterials, pp. 195–220. Springer International Publishing, Cham (2018)
2. Fomin, V. M.: Topology and geometry controlled properties of nanoarchitectures. Phys. Stat. Sol.—Rapid
Research Letters 13, 1800595 (2019)
3. Fomin, V. M.: Physics of Quantum Rings, 2nd Edition, p. 586. Springer International Publishing, Cham,
(2018)
4. Corfdir, P., Marquardt, O., Lewis, R. B., Sinito, C., Ramsteiner, M., Trampert, A., Jahn, U., Geelhaar, L.,
Brandt, O., Fomin, V. M.: Excitonic Aharonov–Bohm oscillations in core–shell nanowires. Adv. Mater. 31,
1805645 (2019)
5. Rezaev, R. O., Posenitskiy, E. A., Smirnova, E. I., Levchenko, E. A., Schmidt, O. G., Fomin, V. M.:
Voltage induced by superconducting vortices in open nanostructured microtubes. Phys. Stat. Sol.—Rapid
Research Letters 13, 1800251 (2019)
6. Fomin, V. M.: Tailoring electron and phonon energy dispersion and thermal transport in nano- and
microarchitectures. Moldavian J. Phys. Sci. 17, 121–131 (2018)
7. Medina-Sánchez, M., Magdanz, V., Guix, M., Fomin, V. M., Schmidt, O. G.: Swimming microrobots: Soft,
reconfigurable and smart, feature article. Advanced Functional Materials 28, 1707228 (2018)
From Transplantation to Organ and Tissue
Biofabrication
Axel Haverich
haverich@thg.mh-hannover.de
Department of Cardiothoracic, Transplantation and Vascular Surgery
Hannover Medical School
Hannover, Germany
End-stage diseases lead to permanent organ failure and can occur in all ages. Organ trans-
plantation often appears as a single option to save the patient’s life and represents the current
standard of care for chronic end-stage disease of many organs. Transplantation of a new organ
improves not only the life expectancy but also the quality of life of the patient. However, the
main problem in transplantation remains donor organ shortage. Often patients are dying on a
waiting list, because not enough organs are available through donation to meet the increasing
demand.
To overcome this situation, since years alternative approaches have been intensively
investigated by the researchers. The usage of animal organs for human transplantation may
solve the problem of organ shortage. However, organ rejection still remains the main problem
for xenogenic transplantation. Animal breeding using gene therapy represents ongoing efforts
to knock-out from xenogenic tissue the epitopes responsible for hyper-acute rejection.
The past decade’s rapid advancement in cell biology and bioengineering opened new
perspectives for treatment of end-stage diseases. On the one hand, the efforts are made toward
stimulation of endogenous repair mechanisms and tissue regeneration. On the other hand, the
idea of biofabrication of new organs is currently pursued by scientists, engineers, and
physicians. Active research in the field of biocompatibility and tissue engineering will give the
possibility to restore damaged or diseased tissues in vivo and create living tissue and organ
replacements.
xxvii
Engineered Microbots for Biomedical Applications
Micro- and nanotechnologies together with the creation of new materials have facilitated the
development of a variety of medical microbots, with low power consumption and certain
degree of complexity. Such medical microbots are classified into three main categories,
according to their propulsion mechanism: chemical, physical, and biohybrid [1]. The first
group are the ones that employ catalytic materials which react with the microbot surroundings,
forming subproducts which lead to their forward motion if the asymmetry in any of its forms is
present. In this work, catalytic micromotors made by using two-photon lithography, with
highly reproducible geometry, are presented as model structures to understand the different
propulsion regimes which are present when varying parameters such as medium viscosity,
microbot surface tension, or fuel concentration. Physical microbots, on the other hand, need
external physical sources to be actuated, for example, magnetic fields, light, or acoustic waves.
An application using magnetically driven helical micromotors is shown to capture, transport,
and release immotile but living sperm cells, to encounter one of the most common men
infertility problems, asthenozoospermia or reduced sperm motility [2]. Therefore, the proposed
artificial flagellum is conceived as a sperm prosthesis to help sperm reach the oocyte. Finally,
the third category, biohybrid microbots, is constituted by a biological and an engineered
component to combine the advantages of both, such as the ability of cells to move through
different taxis mechanisms (e.g., chemotaxis, rheotaxis, thigmotaxis), their compliance which
allows them to move in intricate and complex cavities and channels in living organisms, and
their ability to sense their environment and interact with the surrounding biological tissues. On
the other side, the engineered component is used to improve cargo-capacity, as contrast agent
for imaging, to perform alternative operations such as micro-drilling, micro-grasping, or
synthetic sensing, among others [3]. In this presentation, one of the most known biohybrid
systems is presented, the so-called spermbots or sperm-hybrid microbots [4–6]. In this
assembly, the sperm is motile and provides the whole system with a natural propulsion
mechanism. The synthetic part is used for sperm guidance, release, and cargo-delivery of
drugs. All of the above-mentioned microbots have in common the engineered microparts
which can also be functionalized with imaging reporters for further in vivo bioimaging, which
is a key prerequisite to transfer this technology to in vivo settings. Thus, the use of different
materials and structures is shown to improve their contrast and selectivity when visualized
below biological tissues [7]. Other current challenges which still remain like microbots bio-
compatibility, multifunction, and adaptability will also be discussed.
xxix
Exploiting the Versatility of Nanostructured
Transistors for Biosensing Applications
Bergoi Ibarlucea
bergoi.ibarlucea@tu-dresden.de
Institute for Materials Science and Max Bergmann Center for Biomaterials, Center for
Advancing Electronics Dresden (Cfaed)
Technical University of Dresden
Dresden, Germany
xxxi
xxxii Exploiting the Versatility of Nanostructured Transistors for Biosensing Applications
References
1. Ibarlucea, B., et al.: Nanowire sensors monitor bacterial growth kinetics and response to antibiotics. Lab.
Chip. 17, 4283–4293 (2017)
2. Karnaushenko, D., Ibarlucea, B., et al.: Light weight and flexible high‐performance diagnostic platform.
Adv. Health. Mater. 4, 1517–1525 (2015)
3. Ibarlucea, B., et al.: Lethal disease discrimination using silicon nanowire-based field-effect transistors. In:
Proceedings of 17th IMCS, pp. 182–183, (2018)
4. Ibarlucea, B., et al.: Ultrasensitive detection of Ebola matrix protein in a memristor mode. Nano Res. 11,
1057–1068 (2018)
5. Ibarlucea, B., et al.: Gating hysteresis as an indicator for silicon nanowire FET biosensors. Appl. Sci. 8, 950
(2018)
6. Schütt, J., Ibarlucea, B., et al.: Compact nanowire sensors probe microdroplets. Nano Lett. 16, 4991–5000
(2016)
7. Zhang, P., Yang, S., Pineda‐Gómez, R., Ibarlucea, B., et al.: Electrochemically exfoliated high‐quality 2H‐
MoS2 for multiflake thin film flexible biosensors. Small 15, 1901265 (2019)
Polysaccharide (Nano) Composites
V. Harabagiu
hvaleria@icmpp.ro
R. Rotaru
A. C. Humelnicu
“Petru Poni” Institute of Macromolecular Chemistry
Iasi, Romania
In the last decades, polysaccharides are more and more investigated either as biodegradable
and biocompatible matrices for drug delivery and for tissue engineering systems [1, 2] or as
renewable substitutes of synthetic polymers (tributary of exhaustible fossil resources), usually
combined with different inorganic compounds able to tailor specific properties and high-tech
uses [3, 4].
The presentation deals with clean chemical and physical methods for the preparation of
chitosan hydrogels for cutaneous repairing, of magnetic or high k cellulose-based composites
and of polysaccharide-based polyelectrolyte composite membranes for fuel cell applications.
Their specific properties in correlation with their structures are also discussed.
Acknowledgement This work was supported by a grant of the Romanian Ministry of
Research and Innovation, PCCDI-UEFISCDI, project number PN-III-P1-1.2-PCCDI-2017-
0194/PCCDI/2018, contract no. 25PCCDI, within PNCDI III.
References
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