CMBEBIH 2017 Proceedings of the

International Conference on Medical

and Biological Engineering 2017 1st
Edition Almir Badnjevic (Eds.)
Visit to download the full and correct content document:
https://textbookfull.com/product/cmbebih-2017-proceedings-of-the-international-confe
rence-on-medical-and-biological-engineering-2017-1st-edition-almir-badnjevic-eds/
More products digital (pdf, epub, mobi) instant
download maybe you interests ...

CMBEBIH 2019: Proceedings of the International

Conference on Medical and Biological Engineering, 16 ■■
18 May 2019, Banja Luka, Bosnia and Herzegovina Almir
Badnjevic
https://textbookfull.com/product/cmbebih-2019-proceedings-of-the-
international-conference-on-medical-and-biological-
engineering-16-%cc%b6%cc%b6-18-may-2019-banja-luka-bosnia-and-
herzegovina-almir-badnjevic/

Proceedings of International Conference on

Computational Intelligence and Data Engineering ICCIDE
2017 1st Edition Nabendu Chaki

https://textbookfull.com/product/proceedings-of-international-
conference-on-computational-intelligence-and-data-engineering-
iccide-2017-1st-edition-nabendu-chaki/

Proceedings of 5th International Conference on Advanced

Manufacturing Engineering and Technologies NEWTECH 2017
1st Edition Vidosav Majstorovic

https://textbookfull.com/product/proceedings-of-5th-
international-conference-on-advanced-manufacturing-engineering-
and-technologies-newtech-2017-1st-edition-vidosav-majstorovic/

Proceedings of the 2nd International Conference on Data

Engineering and Communication Technology ICDECT 2017
Anand J. Kulkarni

https://textbookfull.com/product/proceedings-of-the-2nd-
international-conference-on-data-engineering-and-communication-
technology-icdect-2017-anand-j-kulkarni/
Principles of Security and Trust 6th International
Conference POST 2017 Held as Part of the European Joint
Conferences on Theory and Practice of Software ETAPS
2017 Uppsala Sweden April 22 29 2017 Proceedings 1st
Edition Matteo Maffei
https://textbookfull.com/product/principles-of-security-and-
trust-6th-international-conference-post-2017-held-as-part-of-the-
european-joint-conferences-on-theory-and-practice-of-software-
etaps-2017-uppsala-sweden-april-22-29-2017-pro/

WALCOM Algorithms and Computation 11th International

Conference and Workshops WALCOM 2017 Hsinchu Taiwan
March 29 31 2017 Proceedings 1st Edition Sheung-Hung
Poon
https://textbookfull.com/product/walcom-algorithms-and-
computation-11th-international-conference-and-workshops-
walcom-2017-hsinchu-taiwan-march-29-31-2017-proceedings-1st-
edition-sheung-hung-poon/

Cyber Security Cryptography and Machine Learning First

International Conference CSCML 2017 Beer Sheva Israel
June 29 30 2017 Proceedings 1st Edition Shlomi Dolev

https://textbookfull.com/product/cyber-security-cryptography-and-
machine-learning-first-international-conference-cscml-2017-beer-
sheva-israel-june-29-30-2017-proceedings-1st-edition-shlomi-
dolev/

Smart Objects and Technologies for Social Good Third

International Conference GOODTECHS 2017 Pisa Italy
November 29 30 2017 Proceedings 1st Edition Barbara
Guidi
https://textbookfull.com/product/smart-objects-and-technologies-
for-social-good-third-international-conference-
goodtechs-2017-pisa-italy-november-29-30-2017-proceedings-1st-
edition-barbara-guidi/

Recent Advances in Computational Engineering

Proceedings of the 4th International Conference on
Computational Engineering ICCE 2017 in Darmstadt
Michael Schäfer
https://textbookfull.com/product/recent-advances-in-
computational-engineering-proceedings-of-the-4th-international-
conference-on-computational-engineering-icce-2017-in-darmstadt-
Almir Badnjevic (Ed.)

Volume 62

CMBEBIH 2017
Proceedings of the International Conference
on Medical and Biological Engineering 2017
IFMBE Proceedings

Volume 62

Series editor
James Goh

Deputy Editors
Fatimah Ibrahim
Igor Lacković
Piotr Ładyżyński
Emilio Sacristan Rock
The International Federation for Medical and Biological Engineering, IFMBE, is a federation of national and transnational
organizations representing internationally the interests of medical and biological engineering and sciences. The IFMBE is a
non-profit organization fostering the creation, dissemination and application of medical and biological engineering knowledge
and the management of technology for improved health and quality of life. Its activities include participation in the formulation
of public policy and the dissemination of information through publications and forums. Within the field of medical, clinical,
and biological engineering, IFMBE’s aims are to encourage research and the application of knowledge, and to disseminate
information and promote collaboration. The objectives of the IFMBE are scientific, technological, literary, and educational.

The IFMBE is a WHO accredited NGO covering the full range of biomedical and clinical engineering, healthcare, healthcare
technology and management. It is representing through its 60 member societies some 120.000 professionals involved in the
various issues of improved health and health care delivery.

IFMBE Officers
President: James Goh, Vice-President: Shankhar M. Krishnan
Past President: Ratko Magjarevic
Treasurer: Marc Nyssen, Secretary-General: Kang Ping LIN
http://www.ifmbe.org

More information about this series at http://www.springer.com/series/7403

Almir Badnjevic (Ed.)

CMBEBIH 2017
Proceedings of the International Conference on Medical
and Biological Engineering 2017

123
Editor
Almir Badnjevic
Faculty of Engineering and Information Technologies
International Burch University
Sarajevo
Bosnia and Herzegovina

ISSN 1680-0737 ISSN 1433-9277 (electronic)

IFMBE Proceedings
ISBN 978-981-10-4165-5 ISBN 978-981-10-4166-2 (eBook)
DOI 10.1007/978-981-10-4166-2

Library of Congress Control Number: 2017933675

© Springer Nature Singapore Pte Ltd. 2017

This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of
translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information
storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific
statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of
publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The IFMBE Proceedings is an Official Publication of the International Federation for Medical and Biological Engineering (IFMBE)

Printed on acid-free paper

This Springer imprint is published by Springer Nature

The registered company is Springer Nature Singapore Pte Ltd.
The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
 Preface

International Conference on Medical and Biological Engineering in Bosnia and Herzegovina (CMBEBIH2017) is an exciting,
informative and inspiring conference infusing rigorous scientific and engineering practices. CMBEBiH2017 is the largest
Medical and Biological Engineering gathering in South East Europe. The goal of CMBEBIH 2017 is to serve as a platform for
sharing ideas, experiences, best practices and latest advancements in biomedical engineering and all related fields while staying
true to the conference motto: “Pursuing innovation. Shaping the future.”
The conference is a continuation of the extensive work conducted by the Bosnia and Herzegovina Medical and Biological
Engineering Society to encourage and support development of Medical and Biological Engineering in Bosnia and Herzegovina
and Balkan region. The predecessor conference yielded great results with 7 eminent keynote speakers from all around the
world, 120 oral presentations, 50 poster presentations and 3 international workshops.
Medical and Biological Engineering covers all disciplines of the Biomedical and Clinical Engineering spectrum. Research
and development in these areas are impacting the science and technology by advancing fundamental concepts in medicine.
They are helping us better understand human physiology and function at multiple levels by improving tools and techniques for
the detection, prevention and treatment of diseases. The 2017 program consists of 120 accepted papers on new developments
encompassing the conference theme.
More specifically the parallel scientific sessions cover the topics of biomedical signal processing, biomedical imaging and
image processing, biosensors and bioinstrumentation, bio-micro/nano technologies, biomaterials, biomechanics, robotics and
minimally invasive surgery, cardiovascular, respiratory and endocrine systems engineering, neural and rehabilitation engi-
neering, molecular, cellular and tissue engineering, bioinformatics and computational biology, clinical engineering and health
technology assessment, health informatics, e-health and telemedicine, biomedical engineering education, pharmaceutical
engineering, genetic engineering.
International workshops include topics of new perspectives in health technologies regarding diagnostics and therapy,
management systems in the health sector and discussions on how to build a thriving Medical and Biological Engineering
Industry in Bosnia and Herzegovina and other South East European Countries.
Furthermore, the Conference program is highlighted by the seven keynote lecturer sessions. All sessions discuss different
areas of Medical and Biological (biomedical) engineering and are moderated by prominent experts and professionals in the
area.
The session held by Dr. Ernesto Iadanza (Italy), Chair of IFMBE Clinical Engineering Division discuss the Clinical
Engineering. The title of his lecture is “Biomedical and Clinical Engineers: the key to success is a wide knowledge”.
Keynote lecture in the area of processing of biomedical signals is held by Dr. Ervin Sejdic (USA) and focus on discussing
the usage of big data to understand functional changes in swallowing, gait and handwriting.
This keynote lecture entitled “Neuro-prosthetic technologies to restore movement and communication of people with
paralysis” is held by Dr. Tomislav Milekovic (Croatia). Dr. Milekovic is one of the rising stars of Neuro-prosthetics, a field at
the intersection between Engineering, Mathematics and Neuroscience.
More on neural networks, complex algorithms and new advancements is a focus of prof. Dr. Christopher James
(UK) keynote lecture.
Prof. Dr. Nesrin Hasirci (Turkey) will give lecture entitled “Multifunctional Biomaterials and Tissue Engineering Appli-
cations”, while prof. Dr. Vesna Maras (Montenegro) will focus and discuss advancements in Genetic Engineering.
Nanotechnology, one of the Conference themes will be discussed by prof. Dr. Sefik Suzer (Turkey), leading scientists in
surface science and spectroscopy.
We express our gratitude to the Bosnia and Herzegovina leading academic institutions for supporting this project. Particular
thanks are expressed to the kind support and effort of international organizations such as IFMBE, IEEE and ESEM for
endorsing this project, as well as our publisher Springer Nature. Furthermore, there is a limited number of external sponsors for
which we are sincerely thankful.
VI Preface

Finally, a heartfelt thanks to all of you, the participants, for your outstanding contributions. We wish you all the best with
your ongoing research in advancing medical and biological engineering for humanity. We hope that CMBEBIH 2017 creates
opportunities for professional growth and networking with fellow scientist, engineers and other enthusiasts. It is our vision that
this conference creates a lasting memory of Sarajevo and that the networking enables successful and ongoing collaborations
amongst fellow professionals.
We hope that you will appreciate the CMBEBIH 2017 Proceedings as much as we have and that you take pride in this
outstanding project.
Sincerely,
Almir Badnjevic, Phd.
CMBEBIH 2017 Conference Chair
Sarajevo, 16–18 March, 2017
 Organization

Organised by

Bosnia and Herzegovina Medical and Biological Engineering Society

Endorsed by

International Federation for Medical and Biological Engineering (IFMBE)

European Foundation for Education in Biomedical Engineering (ESEM - Educating Students in Engineering and Medicine)

Technical Co-sponsors

IEEE Bosnia and Herzegovina Section

IEEE Croatia Section

Sponsored by
Platinum Sponsors
Oracle Bosnia and Herzegovina
Računari d.o.o. Banja Luka, Bosnia and Herzegovina
Infostudio doo Sarajevo, Bosnia and Herzegovina

Gold Sponsors
Verlab doo Sarajevo, Bosnia and Herzegovina
Privredna banka dd Sarajevo, Bosnia and Herzegovina

Silver Sponsors
Symphony Sarajevo, Bosnia and Herzegovina
Erkona doo Sarajevo, Bosnia and Herzegovina

Bronze Sponsor
Bosnalijek dd Sarajevo, Bosnia and Herzegovina
Ministarstvo za obrazovanje nauku i mlade Kantona Sarajevo

Sponsors
La Trobe University, Australia
Biosistemi BiH doo Sarajevo, Bosnia and Herzegovina
Phoenix Pharma, Bosnia and Herzegovina
Medic BH, Bosnia and Herzegovina
BBI Centar Sarajevo, Bosnia and Herzegovina
FDS, Bosnia and Herzegovina
Coca Cola, Bosnia and Herzegovina
Klas dd Sarajevo, Bosnia and Herzegovina
BioIRC, Serbia
D-Med Healthcare, Bosnia and Herzegovina
VIII Organization

Conference Organization Board

Conference Chair

Almir Badnjevic, Bosnia and Herzegovina Medical and Biological Engineering Society

Conference Co-chairs

Dusanka Boskovic, University of Sarajevo, Bosnia and Herzegovina and IEEE Region 8 Vice-Chair for Member Activities
Eddie Custovic, La Trobe University Melbourne Australia and Publication Services and Products Board at IEEE
Mario Cifrek, University of Zagreb, Croatia and President of IEEE Croatia EMB Chapter

Program Committee
Abdulhamit Subasi Effat University, Saudi Arabia
Adnan Beganović International Burch University, Bosnia and Herzegovina
Aida Sapcanin University of Sarajevo, Bosnia and Herzegovina
Aljo Mujcic University of Tuzla, Bosnia and Herzegovina
Aleksandar Karač University of Zenica, Bosnia and Herzegovina
Alma Džubur-Kulenović University Clinical Center Sarajevo, Bosnia and Herzegovina
Alma Sofo University Clinical Center Sarajevo, Bosnia and Herzegovina
Amina Kozarić International Burch University Sarajevo, Bosnia and Herzegovina
Anne Humeau-Heurtier University of Angers, France
Antonio Pedotti Politecnico di Milano, Italy
Atif Hodžić University of Bihać, Bosnia and Herzegovina
Božidar Ferek Medtronic, Croatia
Christopher James University of Warwick, United Kingdom
Damir Marjanović International Burch University Sarajevo, Bosnia and Herzegovina
Damijan Miklavčić University of Ljubljana, Slovenia
Davorka Zavrsnik University of Sarajevo, Bosnia and Herzegovina
Dragan Primorac University of Zagreb, Croatia
Dževad Zečić University of Zenica, Bosnia and Herzegovina
Eddie Custovic La Trobe University, Australia
Edin Mujcic University of Bihac, Bosnia and Herzegovina
Edin Pjanić University of Tuzla, Bosnia and Herzegovina
Edina Vranić University of Sarajevo, Bosnia and Herzegovina
Edo Hasanbegović University Clinical Center Sarajevo, Bosnia and Herzegovina
Elma Veljovic University of Sarajevo, Bosnia and Herzegovina
Edhem Hasković University of Sarajevo, Bosnia and Herzegovina
Elmedin Mešić University of Sarajevo, Bosnia and Herzegovina
Enra Suljic-Mehmedika University Clinical Center Sarajevo, Bosnia and Herzegovina
Enisa Omanović Mikličanin University of Sarajevo, Bosnia and Herzegovina
Erna Karalija University of Sarajevo, Bosnia and Herzegovina
Ernesto Iadanza Florence University, Italy
Ervin Sejdić University of Pittsburg, USA
Fahir Bečić University of Sarajevo, Bosnia and Herzegovina
Farid Ljuca University of Tuzla, Bosnia and Herzegovina
Haris Huseinagić University of Tuzla, Bosnia and Herzegovina
Harun Siljak International Burch University, Bosnia and Herzegovina
Hurija Džudžević-Čančar University of Sarajevo, Bosnia and Herzegovina
Herve Liebgot Universitaire de France & Creatis, France
Organization IX

Ibrahim Omerhodzic University Clinical Center Sarajevo, Bosnia and Herzegovina

Igor Lacković University of Zagreb, Croatia
Ismet Tahirovic University of Sarajevo, Bosnia and Herzegovina
Izet Mašić University of Sarajevo, Bosnia and Herzegovina
Jasmin Azemović University “Dzemal Bijedic” Mostar, Bosnia and Herzegovina
Jasmin Kevric International Burch University, Bosnia and Herzegovina
Jasmina Ibrahimpašić University of Bihac, Bosnia and Herzegovina
Leandro Pecchia University of Warwick, United Kingdom
Lejla Mehmedovic University of Tuzla, Bosnia and Herzegovina
Leonardo Bocchi University of Florence, Italy
Mario Medvedec University Hospital Center Zagreb, Croatia
Mario Vasilj University of Mostar, Bosnia and Herzegovina
Matej Zajc University of Ljubljana, Slovenia
Milorad Božić University of Banja Luka, Bosnia and Herzegovina
Mirjana Maksimovic University of East Sarajevo, Bosnia and Herzegovina
Miroslav Končar Oracle Healthcare Zagreb, Croatia
Mirsada Hukić Academy of sciences and arts of Bosnia and Herzegovina
Mirza Dedic University of Sarajevo, Bosnia and Herzegovina
Monia Avdic - Ibrisimovic International Burch University, Bosnia and Herzegovina
Nenad Filipovic University of Kragujevac, Serbia
Nermin Suljanović University of Tuzla, Bosnia and Herzegovina
Paulo de Carvalho University of Coimbra, Portugal
Radovan Stojanović University of Montenegro, Montenegro
Ranko Skrbic University of Banja Luka, Bosnia and Herzegovina
Ratko Magjarević University of Zagreb, Croatia
Safija Islamovic - Herenda University of Sarajevo, Bosnia and Herzegovina
Samija Muratovic University of Sarajevo, Bosnia and Herzegovina
Samim Konjicija University of Sarajevo, Bosnia and Herzegovina
Samir Avdaković University of Sarajevo, Bosnia and Herzegovina
Sandra Vegar-Zubović University Clinical Center Sarajevo, Bosnia and Herzegovina
Sebija Izetbegović University Clinical Center Sarajevo, Bosnia and Herzegovina
Selma Spirtovic-Halilovic University of Sarajevo, Bosnia and Herzegovina
Semir Bešlija University Clinical Center Sarajevo, Bosnia and Herzegovina
Semira Galijasevic Sarajevo School of Science and Technology, Bosnia and Herzegovina
Serkan Dogan International Burch University, Bosnia and Herzegovina
Sinisa Car University of Zagreb, Croatia
Suad Kunosić University of Tuzla, Bosnia and Herzegovina
Sven Lončarić University of Zagreb, Croatia
Tamer Bego University of Sarajevo, Bosnia and Herzegovina
Tarik Uzunovic University of Sarajevo, Bosnia and Herzegovina
Thomas Penzel Charite University Hospital Berlin, Germany
Tomislav Pribanić University of Zagreb, Croatia
Vedran Bilas University of Zagreb, Croatia
Vera Kerleta Tuzovic University of Tuzla, Bosnia and Herzegovina
Vesna Spasić – Jokić University of Novi Sad, Serbia
Yves Lemoigne IFMP Ambilly France & CERN, Switzerland
Zdenka Babić University of Banja Luka, Bosnia and Herzegovina
Zlata Mujagić University of Tuzla, Bosnia and Herzegovina
X Organization

Local Organizing Committee

*Members of Bosnia and Herzegovina Medical and Biological Engineering Society

President of Local Organising Committee

Lejla Gurbeta

Members

Ahmed Osmanović
Alma Jakupović
Amra Mujkanović
Amra Dautbegović
Berina Alić
Branimir Ećimović
Dijana Sejdinović
Fatima Mašić
Fatima Mrkulić
Haris Čampara
Hana Uzunović
Hana Šahinbegović
Iris Kico
Ivana Granzov
Ivana Todorović
Jasna Nuhić
Kristina Rendić
Layla Abd Elilah
Leila Keškić
Lemana Spahić
Nerma Kantić
Sabahudin Ćordić
Sabina Halilović
Zerina Bešić
Zerina Đozić
Snežana Prorok
 Contents

Plenary Lectures I - Session I: BIOMEDICAL SIGNAL PROCESSING 1

Using machine learning tool in classification of breast cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3

Layla Abdel-Ilah and Hana Šahinbegović

MULTISAB project: a web platform based on specialized frameworks for heterogeneous biomedical
time series analysis - an architectural overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Kresimir Friganovic, Alan Jovic, Kresimir Jozic, Davor Kukolja, and Mario Cifrek

Short-term variations of parameters of heart rate variability in subjects with mild hypertension
and normotensive subjects during preoperative period . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
Omerbegovic Meldijana

Cardiac pulse waves modeling and analysis in laser Doppler perfusion signals of the skin microcirculation . . . . . . . 20
Michele Sorelli, Antonia Perrella, and Leonardo Bocchi

Discrimination of Psychotic Symptoms from Controls Through Data Mining Methods Based on Emotional
Principle Components . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
Abdullah MARAŞ and Serap AYDIN

Differences in temporal gait parameters between multiple sclerosis and healthy people . . . . . . . . . . . . . . . . . . . . . 31
Kristina Daunoravičienė, Vigita Apanskienė, Jurgita Žižienė, Agnė Ovčinikova, Rasa Kizlaitienė,
Ieva Sereikė, Gintaras Kaubrys, Donatas Lukšys, and Julius Griškevičius

An Adaptive Scheme for X-ray Medical Image Denoising using Artificial Neural Networks and Additive
White Gaussian Noise Level Estimation in SVD Domain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36
Emir Turajlić and Vedran Karahodzic

Using Neural Networks and Ensemble Techniques based on Decision Trees for Skin Permeability Prediction. . . . . . 41
Emir Bušatlić, Ahmed Osmanović, Alma Jakupović, Jasna Nuhić, and Adnan Hodžić

Plenary Lectures I - Session II: BIOMEDICAL IMAGING AND IMAGE PROCESSING

Fully Automated Brain Tumor Segmentation and Volume Estimation Based on Symmetry Analysis
in MR Images . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
C. Öğretmenoğlu Fiçici, O. Eroğul, and Z. Telatar

Multi-Regional Adaptive Image Compression (AIC) for Hip Fractures in Pelvis Radiography . . . . . . . . . . . . . . . . . 61
Huseyin Nasifoglu, Osman Erogul, Gokce Kaan Atac, and Galip Ozdemir

Endovascular treatment of intracranial arteriovenous malformations using ONYX . . . . . . . . . . . . . . . . . . . . . . . . . 68

Haris Huseinagić, Mirza Morankić, and Irma Huseinagić

Evaluation of spatial distribution of skin blood flow using optical imaging. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74

Lorenzo Frassineti, Francesco Giardini, Antonia Perrella, Michele Sorelli, Leonardo Sacconi,
and Leonardo Bocchi
XII Contents

Computer-assisted diagnosis of osteoartrithis on hip radiographs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81

SEDA SAHİN, EMİN AKATA, OSMAN EROĞUL, CENGİZ TUNCAY, ORCUN SAHİN,
and HATICE TUBA SANAL

DETERMINATION OF SEX BY DISCRIMINANT FUNCTION ANALYSIS OF LINEAR DIAMETERS

IN BOSNIAN HUMAN SKULLS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
Zurifa Ajanović, Aida Sarač-Hadžihalilović, and Refet Gojak

Plenary Lectures I - Session III: BIOSENSORS AND BIOINSTRUMENTATION

Eustachian Tube Dysfunction Assessment Through Tympanic Cavity Air Exchange Sensor . . . . . . . . . . . . . . . . . . 97
Tarik Ozkul and Murat H. Ozkul

Design, Simulation and Implementation of a Selective Recording Systemfrom Peripheral nervous system . . . . . . . . 104
Hamed Taghipour Farshi and Javad Frounchi

Fabrication and testing of a multi-electrode spiral nerve cuff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 110

Polona Pečlin and Janez Rozman

Personal electromyographic biofeedback system „MyMyo“ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114

Una Pale, Mario Cifrek, Igor Krois, and Stanislav Peharec

A NOVEL ACTIVE DEVICE FABRICATION METHOD FOR INTERVENTIONAL MRI PROCEDURES. . . . . . 122
Dursun Korel Yildirim, Merdim Sonmez, Robert J. Lederman, and Ozgur Koca-turk

Experimental verification of EOG signal measurement using the modified digital stochastic measurement method. . . 129
J. Djordjević-Kozarov, P. Sovilj, V. Vujičić, D. Mitić, M. Simić, and D. Radenković

Plenary Lectures I - Session IV: BIO-MICRO/NANO TECHNOLOGIES

Application of Artificial Neural Network in modelling of photo-degradation suspension of manganese

doped zinc oxide nanoparticles under visible-light irradiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
Halida Avdihodzic, Zerina Redzovic, and Sabina Halilovic

Quantification of protein concentration adsorbed on gold nanoparticles using Artificial Neural Network. . . . . . . . . . 142
Adnan Fojnica, Ahmed Osmanović, Dzevida Tarakčija, and Selma Demirović

Design and Fabrication of a PDMS Microfluidic Device for Titration of Biological Solutions. . . . . . . . . . . . . . . . . 147
Medina Dzebic, Olzhas Kurikov, Oleksander Dobroliubov, and Omar C.A. Nava

BEAUTY OF FINE DOTS: Detection and treatment of Alzheimer's disease using quantum dots . . . . . . . . . . . . . . 153
Anida Devedžić

EFFECT OF CHEMICALLY-SYNTHESIZED SILVER NANOPARTICLES(AG-NP) ON GLYCEMIC

AND LIPIDEMIC STATUS IN RAT MODEL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158
Alireza Lotfi, Elham Ghavidel Aghdam, and Mohammad Narimani-Rad

Towards green nanotechnology: maximizing benefits and minimizing harm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164

Mirjana Maksimović and Enisa Omanović-Mikličanin

Development of the method for quantification of amino acid adsorbed on nanoparticle surface . . . . . . . . . . . . . . . . 171
Amra Dorić, Džana Mulaomerović, Adnan Fojnica, Belma Alispahić, Sabina Halilović,
and Enisa Omanović-Mikličanin
Contents XIII

Application of biological surface adsorption index approach (BSAI) in characterization

of interactions between gold nanoparticles and biomolecules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 176
Enisa Omanović-Mikličanin, Tarik Husremović, Alma Jakupović, and Anes Omerbašić

Plenary Lectures I - Session V: BIOMECHANICS, ROBOTICS AND MINIMALLY INVASIVE SURGERY

MECHANICAL TESTING STRATEGIES FOR DENTAL IMPLANTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185

Mehmet Melih TATLISOZ and Cetin CANPOLAT

CONTACT FORCE PROBLEM IN THE REHABILITATION ROBOT CONTROL DESIGN . . . . . . . . . . . . . . . . 193

Zlata Jelačić

Implementation and Validation of Human Kinematics Measured Using IMUs for Musculoskeletal
Simulations by the Evaluation of Joint Reaction Forces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Maximilian Aurbach, Kilian Wagner, Franz Süß, and Sebastian Dendorfer

FEA of the transiliacal internal fixator as an osteosynthesis of pelvic ring fractures . . . . . . . . . . . . . . . . . . . . . . . . 212
Dominik Jungtäubl, Paul Schmitz, Simon Gross, and Sebastian Dendorfer

Overview of the Development of Hydraulic Above Knee Prosthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218

M. Rupar, A. Vučina, R. Dedić, and H. Đindo

Non-invasive estimation of respiratory depression profiles during robot-assisted laparoscopic surgery

using a model-based approach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Lars Pilegaard Thomsen, Asta Aliuskeviciene, Kasper Sørensen, Astrid Clausen Nørgaard,
Peter Lyngø Sørensen, Esben Bolvig Mark, Signe Juul Riddersholm, and Per Thorgaard

Plenary Lectures I - Session VI: CARDIOVASCULAR, RESPIRATORY

AND ENDOCRINE SYSTEMS ENGINEERING

Subclinical inflammation: The link between increased cardiovascular risk and subclinical hypothyroidism
in postmenopausal women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Amina Godinjak, Zelija Velija-Ašimi, Azra Bureković, Mehmed Kulić, Selma Gicić, and Fadila Serdarević

Computational Vascular Surgery Planning and Predicting for Abdominal Aortic Aneurysm . . . . . . . . . . . . . . . . . . 241
Nenad Filipovic, Igor Koncar, Zarko Milosevic, and Lazar Davidovic

Determination of Probabilistic Neural Network’s Accuracy in Context of Cardiac Stress Test . . . . . . . . . . . . . . . . . 246
Sabina Baraković, Jasmina Baraković Husić, and Fahir Baraković

Effects of electrical stimulation as a new method of treating diabetes on animal models: Review . . . . . . . . . . . . . . 253
Hena Divanović, Dženan Mulić, Asima Padalo, Edita Rastoder, Šejla Pedljak, Nermina Žiga, and Tamer Bego

Numerical Simulation of Blood Flow Through the Aortic Arch. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259

Berin Šeta, Muris Torlak, and Alija Vila

Computational modeling of plaque development in the coronary arteries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269

Nenad Filipovic, Velibor Isailovic, Zarko Milosevic, Dalibor Nikolic, Igor Saveljic, Milos Radovic,
Milica Nikolic, Bojana Cirkovic-Andjelkovic, Exarchos Themis, Dimitris Fotiadis, Gualtiero Pelosi,
and Oberdan Parodi
XIV Contents

Plenary Lectures II: Poster session

People identification using Kinect sensor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277

Adnan Ramakić and Amel Toroman

Artificial Neural Network: Gas recognition. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283

Leila Keškić, Jasin Hodžić, and Belma Alispahić

A Fuzzy Model to Predict Risk of Urinary Tract Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289

Monia Avdic Ibrisimovic, Günay Karlı, Hasan Emin Balkaya, Mirza Ibrisimovic,
and Mirsada Hukic

Conceptual image of heart – path to patient benefit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 294

Aida Botonjic, Edin Begic, Denis Zvizdic, and Nedim Begic

A Novel Gait Detection Algorithm Based on Wireless Inertial Sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300

Yueming Gao, Ziqin Jiang, Wenshu Ni, Zeljka Lucev Vasic, Mario Cifrek, Min Du, Mang I Vai,
and Sio Hang Pun

Single-Chip Intrabody Communication Node . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305

Filip Grilec, Antonio Stanešić, Željka Lučev Vasić, Yueming Gao, Min Du, and Mario Cifrek

Microneedle-assisted delivery of NSAIDs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311

E. Vranić, A. Tucak, Dž. Vrabac, O. Rahić, A. Elezović, and J. Hadžiabdić

PREPARATION OF NANOEMULSIONS BY HIGH-ENERGY AND LOW-ENERGY EMULSIFICATION

METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317
Hadžiabdić Jasmina, Orman Džana, Elezović Alisa, Vranić Edina, and Rahić Ognjenka

Characterisation of NiTi orthodontic archwires characteristic functional properties . . . . . . . . . . . . . . . . . . . . . . . . . 323

Rebeka Rudolf, Janko Ferčec, Vojkan Lazić, Valentina Veselinović, and Sergej Tomić

LONG-LATENCY INTRACORTICAL INHIBITION DURING UNILATERAL MUSCLE ACTIVITY . . . . . . . . . 333

Kapka Mancheva, Diana I. Stephanova, Werner Wolf, and Andon Kossev

Simulation of kinematic behaviour of prosthetic devices. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339

Vesna Raspudić

Thyroid pathology and platelet functional activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 344

Ralchenko I.V., Chepis M.V., and Ralchenko E.S.

TRENDS AMONG NEONATOLOGISTS IN DECISION TO VENTILATE PRETERM INFANTS

WITH PERMISSIVE HYPERCAPNIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 350
S. Terzic, S. Heljic, and H. Maksic

A mathematical model of the effect of metabolic control on joint mobility in young type 1 diabetic subjects . . . . . . 355
Piergiorgio Francia, Antonia Perrella, Michele Sorelli, Sonia Toni, Barbara Piccini, Gabriella Sardina,
Massimo Gulisano, and Leonardo Bocchi

Basics of mathematical modeling of pulmonary ventilation mechanics and gas exchange . . . . . . . . . . . . . . . . . . . . 360
Nataša Popović, Milica Naumović, and Sonja Roganović

TESTING OF THE INFLUENCE OF MEDIA’S pH VALUE ON THE SOLUBILITY AND PARTITION

COEFFICIENT OF THE ACETYLSALICYLIC ACID . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 368
Darija Knežević and Irena Kasagić-Vujanović
Contents XV

The use of ELM and MnM servers for the prediction of RANK function in osteoclast formation . . . . . . . . . . . . . . 372
Sarah Alibegović, Adlija Čaušević, Stefan Kulaš, Tilen Kranjc, Janja Marc, and Tamer Bego

QSAR modeling and structure based virtual screening of new PI3K/mTOR inhibitors
as potential anticancer agents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379
Jelena Oluić, Katarina Nikolic, Jelica Vucicevic, Zarko Gagic, Slavica Filipic, and Danica Agbaba

Career development in Green Biotechnology in B&H: roadblocks and prospects . . . . . . . . . . . . . . . . . . . . . . . . . . 384

Erna Karalija

E-health in Bosnia and Herzegovina: exploring the challenges of widespread adoption . . . . . . . . . . . . . . . . . . . . . 388
Borka Popović and Mirjana Maksimović

5-HIAA and HVA in the Coma Cerebri, Hydrocephalus and Tumor Cerebri . . . . . . . . . . . . . . . . . . . . . . . . . . . . 396
Salihović M. and Sofić E.

Estimation of lipophilicity data for derivatives of alkandiamine-N,N’-di-2-(3-cyclohexyl) propanoic

acid with potential antineoplastic activity, by UHPLC-MS method . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 402
Biljana Tubić, Bojan Marković, Sote Vladimirov, Aleksandar Savić, Jelena Poljarević, and Tibor Sabo

Detremination of kinetic effect of Metoprolol and Ranitidine on HRP- modified GC electrode biosensor . . . . . . . . . 410
Zerina Bešić, Safija Herenda, Trivo Stanković, and Jelena Ostojić

Monitoring of bisoprolol fumarate stability under different stress conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415

Irena Kasagić-Vujanović, Biljana Jančić Stojanović, and Darko Ivanović

Measuring the feeling: correlations of sensorial to instrumental analyses of cosmetic products . . . . . . . . . . . . . . . . 425
Elezović Alisa, Hadžiabdić Jasmina, Rahić Ognjenka, and Vranić Edina

Hydrophilic antioxidant scores against hydroxyl and peroxyl radicalsin honey samples from Bosnia
and Herzegovina . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 429
Ismet Tahirović, Dženita Helbet, Adisa Gaštan, Nermin Buza, Muamer Dizdar, Anela Topčagić,
Jasmin Toromanović, Amira Čopra-Janićijević, and Harun Kurtagić

Polymorphisms of 1691G>A and 4070A>G FV in Bosnian women with pregnancy loss . . . . . . . . . . . . . . . . . . . . 435
Mahmutbegovic Emir, Adler Grażyna, Edin Medjedovic, Mahmutbegovic Nevena, Serkan Dogan,
Pawińska-Matecka Anna, Czerska Ewa, and Damir Marjanovic

Lack of association between I/D ACE and -675 ID 4G / 5G PAI-1 polymorphisms and predicting risk
of pregnancy loss (PROPALO) in Bosnian women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 440
Mahmutbegovic Emir, Skonieczna-Żydecka Karolina, Valjevac Amina, Mahmutbegovic Nevena,
Pawińska-Matecka Anna, Czerska Ewa, Marjanovic Damir, and Adler Grażyna

Gene clustering using Gene expression data and Self-Organizing Map (SOM) . . . . . . . . . . . . . . . . . . . . . . . . . . . 445
Leila Keškić, Jasin Hodžić, and Belma Alispahić

Public opinion toward GMOs and biotechnology in Bosnia and Herzegovina . . . . . . . . . . . . . . . . . . . . . . . . . . . . 452
Lejla Bevanda, Monika Žilić, Branimir Ećimović, and Vlatka Matković

Future trends and possibilities of using induced pluripotent stem cells (iPSC) inregenerative medicine . . . . . . . . . . . 459
A. Tucak, Dž. Vrabac, A. Smajić, and A. Sažić
XVI Contents

Plenary Lectures II - Session VII: BIOMEDICAL SIGNAL PROCESSING 2

ECG Signal Classification Using Artificial Neural Networks: Comparison of Different Feature Types . . . . . . . . . . . 467
J. Memić

Surface EMG Signal Classification by Using WPD and Ensemble Tree Classifiers . . . . . . . . . . . . . . . . . . . . . . . . 475
Amnah A. Abdullah, Abdulhamit Subasi, and Saeed Mian Qaisar

Tool for Comparative Case Studies of Heart Rate and Heart Rate Variability . . . . . . . . . . . . . . . . . . . . . . . . . . . . 482
Haris Ackar, Iris Kico, Anel Tahirbegovic, and Dusanka Boskovic

A novel approach for parameter estimation of Fricke-Morse model using Differential Impedance Analysis . . . . . . . . 487
Mitar Simić, Zdenka Babić, Vladimir Risojević, and Goran Stojanović

Wavelet and Teager Energy Operator (TEO) for Heart Sound Processing and Identification . . . . . . . . . . . . . . . . . . 495
Aiša Ramović, Lejla Bandić, Jasmin Kevrić, Emina Germović, and Abdulhamit Subasi

Ovary Cancer Detection using Decision Tree Classifiers based on Historical Data of Ovary Cancer Patients. . . . . . . 503
Ahmed Osmanović, Layla Abdel-Ilah, Adnan Hodžić, Jasmin Kevric, and Adnan Fojnica

Mental workload vs. stress differentiation using single-channel EEG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 511

A. Secerbegovic, S. Ibric, J. Nisic, N. Suljanovic, and A. Mujcic

Human-machine interface via EMG signals derived from EEG measurement device . . . . . . . . . . . . . . . . . . . . . . . 516
Nina Maljković, Sofya Pantović, and Jovan Mitrović

Plenary Lectures II - Session VIII: BIOMEDICAL IMAGING AND IMAGE PROCESSING 2

A Novel Feature Extraction Approach with VBM 3D ROI Masks on MRI. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 523
Muhammet Üsame Öziç, Seral Özşen, and Ahmet Hakan Ekmekci

A modified fuzzy C means algorithm for shading correction in craniofacial CBCT images . . . . . . . . . . . . . . . . . . . 531
Awais Ashfaq and Jonas Adler

Detection and Segmentation of Nodules in Chest Radiographs Based on Lifetime Approach . . . . . . . . . . . . . . . . . 539
Hayati Ture and Temel Kayikcioglu

Automated Colony Counting Based on Histogram Modeling Using Gaussian Mixture Models . . . . . . . . . . . . . . . . 548
Igor S. Maretić and Igor Lacković

Plenary Lectures II - Session IX: CLINICAL ENGINEERING AND HEALTH TECHNOLOGY ASSESSMENT

The electrode setup for vibratory evoked potentials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 557

Magdalena Krbot Skorić, Mario Cifrek, Igor Krois, Ana Branka Jerbić, and Velimir Išgum

Quality control of angular tube current modulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 563

M. Redžić, A. Beganović, L. Čiva, R. Jašić, A. Skopljak-Beganović, and S. Vegar-Zubović

A testbed evaluation of MAC layer protocols for smart home remote monitoring
of the elderly mobility pattern. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 568
Alireza Jafari, Mohsen Shirali, and Mona Ghassemian

Proposal of integrated software system for simulation and GIS visualization of accidents caused
by emission of hazardous gases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 576
Živorad Kovačević and Radovan Stojanović
Contents XVII

LEGAL METROLOGY: MEDICAL DEVICES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 583

Alen Bošnjaković and Zijad Džemić

Diagnosis of Chronic Kidney Disease by Using Random Forest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 589

Abdulhamit Subasi, Emina Alickovic, and Jasmin Kevric

Global Survey on Biomedical Engineering Professionals in Health Technology Assessment . . . . . . . . . . . . . . . . . . 595

Mario Medvedec

Plenary Lectures II - Session X: BIOINFORMATICS AND COMPUTATIONAL BIOLOGY

CLASSIFICATION OF METABOLIC SYNDROME PATIENTS USING IMPLEMENTED EXPERT SYSTEM . . . 601

Berina Alić, Lejla Gurbeta, Almir Badnjević, Alma Badnjević-Čengić, Maja Malenica, Tanja Dujić,
Adlija Čaušević, and Tamer Bego

Pre-classification process symptom questionnaire based on fuzzy logicfor pulmonary function test cost reduction . . . 608
Almir Badnjevic, Lejla Gurbeta, Mario Cifrek, and Leandro Pecchia

Artificial Neural Network and Docking Study in Design and Synthesis of Xanthenes as Antimicrobial Agents . . . . . 617
Elma Veljović, Selma Špirtović-Halilović, Samija Muratović, Amar Osmanović, Almir Badnjević, Lejla Gurbeta,
Berina Tatlić, Zerina Zorlak, Selma Imamović, Đenana Husić, and Davorka Završnik

Mathematical and Computational Models of Cell Cycle in Higher Eukaryotes . . . . . . . . . . . . . . . . . . . . . . . . . . . 627

Alma Krivdic

Plenary Lectures II - Session XI: HEALTH INFORMATICS, E-HEALTH AND TELEMEDICINE

Using Information and Communications Technology as an Enabler for Designing an Efficient National
Level Vaccination Planning and Dispensing System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 637
Alishba Siab Khan and Shoab Ahmed Khan

Stroke Center Heart Rate Data Acquisition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 644

Damir Bilić, Amila Kaharević, Dalibor Đumić, Ermin Šunj, Jasna Nuhić, Naida Hodžić,
and Tarik Ibrahimpašić

Health service quality measurement from patient reviews in Turkish by opinion mining. . . . . . . . . . . . . . . . . . . . . 649
Migena Ceyhan, Zeynep Orhan, and Elton Domnori

e-Medical Test Recommendation System Based on the Analysis of Patients’ Symptoms and Anamneses . . . . . . . . . 654
Migena Ceyhan, Zeynep Orhan, and Elton Domnori

Antihypertensive therapy dosage calculator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 660

Edin Begić, Mensur Mandžuka, Zijo Begić, Amra Dobrača, and Edo Hasanbegovic

Wireless Body Area Network Studies for Telemedicine Applications Using IEEE 802.15.6 Standard. . . . . . . . . . . . 666
Hasan Yavuz Özderya, Hakan Erdöl, Temel Kayıkçıoğlu, Ali Özgür Yılmaz, and İsmail Kaya

Real-Time Monitoring of ST Change for Telemedicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 671

İlknur Kayıkçıoğlu, Fulya Akdeniz, Temel Kayıkçıoğlu, and İsmail Kaya
XVIII Contents

Plenary Lectures II - Session XII: BIOMEDICAL SIGNAL PROCESSING 3

Micro cell culture analog Apparatus (lCCA) output prediction using microcontroller system based
on a Artificial Neural Network . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 681
Halida Avdihodzic, Sabina Halilovic, Mehrija Hasicic, and Damir Bilk

CLASSIFICATION OF PREDIABETES AND TYPE 2 DIABETES USING ARTIFICIAL

NEURAL NETWORK . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 685
Dijana Sejdinović, Lejla Gurbeta, Almir Badnjević, Maja Malenica, Tanja Dujić, Adlija Čaušević,
Tamer Bego, and Lejla Divović Mehmedović

Multi-biophysical event detection using blind source separated audio signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . 690
Jonathan Stanger, Matthew Felicetti, Michael Jenkins, and Edhem Custovic

Diversity performance of microstrip patch antennas placed on human body at ISM and MBAN frequencies. . . . . . . 698
Mehmet Ali Öztürk, Ufuk Tamer, Ali Özgür Yılmaz, Tayfun Özdemir, and İsmail Kaya

Flexible system for HRV analysis using PPG signal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 705

Danilo Janković and Radovan Stojanović

AN APPLICATION OF KINECT DEPTH SENSOR FOR SCOLIOSIS AND KYPHOSIS SCREENING . . . . . . . . 713
Octavian Ciobanu, Gabriela Ciobanu, and Antonella Aiello

Development of a muscle activated switch for the severely debilitated . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 718

Hok Yin Stephen Chiu and Christopher James

A Dynamic Stopping Algorithm for P300 Based Brain Computer Interface Systems . . . . . . . . . . . . . . . . . . . . . . . 723
Eda AKMAN AYDIN, Ömer Faruk BAY, and İnan GÜLER

Plenary Lectures II - Session XIII: PHARMACEUTICAL ENGINEERING

Effects of various metal and drug agents on excretion of enzyme aspartyl proteinase in Candida albicans
and its role in human physiological processes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 731
Mirza Ibrišimović, Nadira Ibrišimović-Mehmedinović, Jasmina Dedić, Aldina Kesić, Snježana Marić,
and Almir Šestan

Practical Transport Optimization Method and Concept in Pharmaceutical Industry. . . . . . . . . . . . . . . . . . . . . . . . . 736

Emir Žunić, Almir Djedović, and Željko Jurić

Antiproliferative Evaluation and Docking Study of Synthesized Biscoumarin Derivatives . . . . . . . . . . . . . . . . . . . . 744

Muratović Samija, Veljović Elma, Osmanović Amar, Đeđibegović Jasmina, Nikšić Haris,
Džudžević-Čančar Hurija, and Završnik Davorka

Passive absorption prediction of transdermal drug application with Artificial Neural Network . . . . . . . . . . . . . . . . . 756
Vedad Terzić, Arnela Tarakčija, Almir Vardo, Alma Hadžajlić, Vildana Šakić, Sabrina Smajlović,
Ana-Marija Milisav, Elma Midžić, Alisa Smajović, and Mirza Dedić

The role of population pharmacokinetic analysis in rational antibiotic therapy in neonates . . . . . . . . . . . . . . . . . . . 762
Duspara Kristina, Smits Anne, Allegaert Karel, Heljic Suada, Turcic Petra, Rakovac Tupkovic Lejla,
Kusturica Jasna, Rakanovic-Todic Maida, Burnazovic-Ristic Lejla, Maleskic Sanita, and Kulo Aida

The ratio of hematological parameters and markers of inflammation in patients with iron deficiency
and pernicious anemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 769
Berina Hasanefendić, Almedina Hajrović, Ermin Begović, and Harun Uzunalić
Contents XIX

BLOOD GROUP, HYPERTENSION, AND OBESITY IN THE STUDENT POPULATION OF NORTHEAST

BOSNIA AND HERZEGOVINA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 774
Amela Hercegovac, Edina Hajdarević, Snježana Hodžić, Emir Halilović, Aldijana Avdić, and Mirela Habibović

Plenary Lectures II - Session XIV: GENETIC ENGINEERING

Free fatty acid profile in Type 2 diabetic subjects with different control of glycemia . . . . . . . . . . . . . . . . . . . . . . . 781
S. Mandal, A. Causevic, H. Dzudzevic-Cancar, and S. Semiz

Clonal selection of autochthonous grape variety Vranac in Montenegro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 787

Vesna MARAŠ, Vesna KODŽULOVIĆ, Milena MUGOŠA, Jovana RAIČEVIĆ, Anita GAZIVODA,
Sanja ŠUĆUR, and Mirko PERIŠIĆ

A Dissimilar Approach to Associating Angiotensin Converting Enzyme Polymorphisms . . . . . . . . . . . . . . . . . . . . 791

Hacer Konaklı, Hasan Emin Balkaya, Indira Özçoban, and Serkan Doğan

Successful collection of stem cells in one day in the process of autologous stem cell transplantation . . . . . . . . . . . . 796
Alma Sofo-Hafizovic, Aida Dizdarevic-Rekic, Lejla Ibricevic-Balic, Lejla Burazerovic, Meliha Vila,
EminaSuljovic-Hadzimesic, Marina Skuric-Tomic, Elma Catovic-Baralija, Gorana Ahmetovic,
Amela Sahovic, Sanela Sicanica, and Amina Omanovic

Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 803

 Plenary Lectures I - Session I:
BIOMEDICAL SIGNAL PROCESSING 1
 Using machine learning tool in classification of breast cancer

Layla Abdel-Ilah, Hana Šahinbegoviü

International Burch University

Sarajevo, Bosnia and Herzegovina
layla.a.ilah@stu.ibu.edu.ba
hana.sahinbegovic@stu.ibu.edu.ba

Abstract. This research implements a feed forward back
propagation network (FFBPN) for classification of breast cancer
cases to malignant or benign. The purpose of the research is to
design an Artificial Neural Network (ANN) with high and
acceptable level of accuracy by selecting the number of hidden
layers, number of neurons in the hidden layer and the type of
activation functions in hidden layers. Samples for training and
validation of ANN are obtained from Wisconsin Breast Cancer
Database (WBCD) which is open access dataset. The dataset
contains 699 samples that were distributed to two groups: 599
samples in training setand 100 samples in testing set. Each
sample has 9 attributes representing 9 characteristics of breast fine-
needle aspirates (FNAs) as inputs of the network. This experiment
includes a comparison among the obtained mean square error
(MSE) when using three transfer functions: LOGSIG, TANSIG,
and PURELINE in neural network architetcures.Impact of
different number of layers (1, 2, and 3 layers were used)in ANN
architectureon output accuracy was also investigated. Also, this
research provides the results of ANN performance for different
number of neurons in hidden layer (20, 21, 22, 23, 24 neurons
were implemented). The results show that the best network design
is that one with three hidden layers, 21 neurons in the hidden layer,
and TANSIG as activation function.
Keywords: Artificial Neural Network, breast cancer,
classification, machine learning, malignant, benign, accuracy, fine-
needle aspirates, Wisconsin Breast Cancer Database (WBCD).
1 Introduction
Cancer, also known as malignant neoplasm, is a class of
over a hundred diseases characterized by abnormal growth
of cells with a potential to spread to surrounding tissues of
the body [1]. It is a vicious disease which is responsible for
numerous deaths in both developing and developed coun-
tries of the world. Breast cancer is the second leading cause
of cancer death among females in more developed coun-
tries, and it is the leading cause of cancer death among fe-
males in less developed countries. [2]. some new statistics
found that about 1 in 8 women in the US develop breast
cancer during their lifetime [3]. Thus, the fight against can-
cer is far from completed.
© Springer Nature Singapore Pte Ltd. 2017
A. Badnjevic (ed.), CMBEBIH 2017,
IFMBE Proceedings 62,
DOI: 10.1007/978-981-10-4166-2_1
Early breast cancer detection, is one very important area
that researchers are working on, and it can increase the rate
of diagnosis, treatment and survival of the affected women
[4]. Considering the high cost of treatment and the high
prevalence of the disease among women worldwide, early
diagnosis is found to be the most effective step in reducing
the health and social complications of this disease. There
are many different methods and procedures to detect this
type of cancer, with different advantages but also disad-
vantages. Cancer is usually detected and diagnosed when
the cancer has progressed to its later stages. This is particu-
larly bad because upon discovery, the chances that cancer
has metastasized are high making the chances of curing it
very low. People rarely perform self-tests which leads to
detecting cancer in its later stages. Most breast cancers are
detected as a lump/mass on the breast, or through self-
examination or mammography [5].
Automated systems that can assist professionals in de-
tecting certain disease can help in early diagnosis and can
facilitate the treatment process. Developing tools for disease
classification can be extensive and challenging, especially
when the association between diagnosis parameters and
disease classification is non-linear and de-pends on various
factors. The usage of artificial intelligence techniques in
disease classification have been in focus of research exten-
sively in the past few years. Artificial Neural Networks
(ANN) can be used for this purpose. The idea behind these
systems lies in parallel information analyzing in structures
that mimic biological nervous system. The main units, neu-
rons, can be connected in feed forward and feedback archi-
tectures [6]. The activation of each neuron is determined by
linear or non-linear transfer function. ANNs have the ability
to perform many functions: classification, fault detection,
speech analysis, and processing of inaccurate inputs [7].
Over the past few years, these methods have been used,
more extensively, in disease classification to improve the
diagnoses procedures and to aid the physician’s efforts [8].
For example, ANNs were used in [9] in neurodegenerative
disease classification, cardiac disorders [10], predictions on
a Nano-scale [11] as well as different respiratory disease
classification [12-14].
3
4 L. Abdel-Ilah, H. Šahinbegoviü

2 Methods 2.2 Design of Artificial Neural Network for Breast

Cancer Classification

2.1 Wisconsin Breast Cancer Database (WBCD)
This breast cancer database, used in this research, is col-
lected from the UCI machine-learning repository, which
was developed by Dr. William H. Wolberg from the Uni-
versity of Wisconsin Hospitals, Madison [15]. The dataset is
comprised of elements that have various scalar observa-
tions. The total number of the samples is 699. The dataset
contains two classes referring to benign and malignant sam-
ples. There are 458 samples in the dataset that are assigned
to benign and the other 241 samples are malignant, the total
number of samples is used in this research. The original
dataset contains 11 attributes including both sample ID
number and class label, which are deleted in the dataset that
are used in this work since it can just cause disruption. The
remaining 9 attributes represent 9 characteristics of breast
fine-needle aspirates (FNAs), as shown in Table 1.
A fine-needle aspirates (FNA) is performed for the diag-
nosis of lesions, which requires the removal of cells from a
breast lesion or cyst with a fine needle. The cytological
characteristics of breast FNAs were valued on a scale of one
to ten, with one being the most benign and ten the closest to
malignant. These attributes measure the physical appearance
and chromosome changes in the cell. There are two values
in the class variable of breast cancer: Benign (non-
cancerous), and Malignant (cancerous).
Artificial Neural Networks (ANNs) are a strong tool for
classificationof cancer [16-18] and are very clear examples
of using ANNs in classification purposes for different types
of cancer: liver, colon, and skin cancers respectively with a
successful results.When designing neural network for solv-
ing specific problem, network architecture, number of lay-
ers, number of neurons in hidden layers, training dataset
distribution and training algorithm have significant impact
on system performance [19]. A feed forward neural network
is most commonly used for classification and prediction
purposes [20].
In this study, not only impact of number of neurons in
hidden layer on system performance is examined, but also
the impact of hidden layer number and type of activation
function in neuron. Based on previously mentioned recom-
mendations from experts, in this study, feed forward archi-
tecture is chosen for breast cancer classification. Number of
input and output neurons is determined with parameters that
are used for disease classification. Trial method with chang-
ing number of neurons and comparing performance between
neural network architecture is used. Number of neurons in
hidden layer is set to be 20, 21, 22, 23 and 24 and perfor-
mance in terms of Mean Square Error (MSE) and Absolute
Error was compared.
ͳ
௡
ଶ
‫ ܧܵܯ‬ൌ ෍൫ܺ௣௥௘ௗ௜௖௧௘ௗ െ ܺ௔௖௧௨௔௟ ൯
݊
௜ୀଵ

Table 1. Attributes representing cytological characteristics of ‫ݎ݋ݎݎܧ‬௔௕௦௢௟௨௧௘ ൌ ܱ‫ݐݑ݌ݐݑ‬௧௔௥௚௘௧ െ ‫ܰܰܣ‬௢௨௧௣௨௧

breast fine-needle aspirates (FNAs). For ANN development, dataset was partitioned into two
sets: training and testing set. The first 599 samples are used
Classification groups Number of samples
for the training set, and the rest 100 examples for the testing
Benign samples – Healthy 458
set.
Malignant samples – Breast Cancer 241
෍ 699
Table 2. Number of samples used for training and testing
Sample characteristics
Training dataset Testing dataset
Cytological characteristics Values assigned
1 Clump thickness Classification Number of Classification Number of
2 Uniformity of cell size group samples group samples
3 Uniformity of cell shape 1-10 Healthy 395 Healthy 63
4 Marginal Adhesion with 1 being the closest to Breast Cancer 204 Breast cancer 37
5 Single Epithelial Cell Size benign and 10 the most malig-
෍ 599 ෍ 100
6 Bare Nuclei nant
7 Bland Chromatin
8 Normal Nucleoli In training data, it is important to use appropriate dataset
9 Mitoses division on training and estimation data. If the number of
points in the whole dataset is larger than any division of the
training dataset, it would consequently satisfy the perfor-

IFMBE Proceedings Vol. 62

Using machine learning tool in classification of breast cancer 5

mance criteria, but when the dataset is limited, division ratio 3.2 Predictive ability of neural network architecture
may play a crucial role. For smaller database most research- with different number of neurons in hidden layer
ers suggest 70-30 distribution [21]. In this study, the
devision is about 85-15. Performance in terms of accuracy in breast cancer classi-
For neural network training, Levenberg- Marquardt fication for neural network architecture with one hidden
algorithm was used which approves a high performance and layer and 20, 21, 22, 23, 24 hidden neurons with all other
minimized error in disease classification [22]. At the start of parameters fixed is presented in Table 3. As it can be seen
training, all connection weights in network are set to from Table 3. The network with 21 neurons achieves the
random values. All input vectors are normalized so that the highest accuracy (98%), whereas the one with 22 neurons
minimum and maximum are 0 and 1 respectively. has the lowest accuracy (95%).
Normalization was done according to:
Table 4. Second group contains five networks with different
ܰ‫݁ݑ݈ܽݒ݀݁ݖ݈݅ܽ݉ݎ݋‬ number of neurons and different accuracies of testing outputs.
ܴ݈݁ܽ‫ ݁ݑ݈ܽݒ‬െ ‫ݐ݁ݏܽݐܽ݀݊݅݁ݑ݈ܽݒ݉ݑ݉݅݊݅ܯ‬
ൌ Index Number of Number of Number of Accuracy
‫ ݐ݁ݏܽݐܽ݀݊݅݁ݑ݈ܽݒ݉ݑ݉݅ݔܽܯ‬െ ‫ݐ݁ݏܽݐܽܦ݊݅݁ݑ݈ܽݒ݉ݑ݉݅݊݅ܯ‬
neurons correct incorrect %
results results
1. 20 97 3 97
3 Results and discussion
2. 21 98 2 98
3. 22 95 5 95
3.1 Predictive ability of neural network architecture 4. 23 96 4 96
with different number of hidden layers 5. 24 96 4 96

Performance in terms of accuracy in breast cancer classi-

fication for neural network architecture with number of 3.3 Predictive ability of neural network architecture
hidden layers changed between 1, 2 and 3 with all other with different activation functions in hidden layer
parameters fixed is shown in Table 4. Network containing
three hidden layers achieves the highest accuracy results To assess the impact of neuron activation functions on
(98%), whereas the one with two layers achieves the lowest overall system accuracy performance of neural network
with TANSIG, LOGSIG, and PURELINE as activation
accuracy (94%).
functions is shown in Table 5.
Table 3. First group contains three networks with different number
Table 5.Relationships between activation function and training of
of hidden layers and different accuracies of testing outputs.
network with respect to MSE. TANSIG provides the least MSE,
Index Number of Number of Number of Accuracy which means the best performance.
hidden correct incorrect %
Activation function MSE (mean square error)
layers results results
LOGSIG 0.0071
1. 1 95 5 95
TANSIG 0.0001
2. 2 94 6 94
PURELINE 0.0089
3. 3 98 2 98

Figure 1 presents the performance chart obtained after

According to previous work, multi-layer network (the
exact number of layers is unknown) has a better accuracy
than a single layer network no matter the size of training
and testing sets [23]. It is shown in the Table 3 that increas-
ing the number of hidden layers from 1 to 2 decreases the
accuracy, while increasing it from 2 to 3 increases the accu-
racy, so we can conclude that increase in the number of
hidden layers does not correlate to a better accuracy.
training the three networks: a) TANSIG, b) LOGSIG, and
c)PURELINE. As it can be noticed, TANSIG function
achieves the best performance.
Combining the data obtained by the three groups above,
it is clear now that the best network design is that one with
three hidden layers, 21 neurons in the hidden layer, and
TANSIG as activation function.

IFMBE Proceedings Vol. 62

6 L. Abddel-Ilah, H. Šahiinbegoviü

Fig. 1. MSE
M results afteer training the networks
n impleementing a) TA
ANSIG, b) LOG
GSIG, c) PUR
RELINE activattion
ffunctions. The MSE values arre: 0.000140366, 0.0071772, and
a 0.0089316 respectively. TANSIG
T functtion achieves thhe best
perfformance.

During the designing proceess of an acccurate artificiaal parameterrs will providde us with moore accurate network,
n
neuural network forf breast canncer classificattion, it is veryy which will help in claassifying breaast cancer casees more
im
mportant to takee care about thee different paraameters. As wee efficiently
y and achievinng medical, soocial, and ecoonomical
cann notice, all neetworks in thiss experiment have
h a feed for- benefits.
waard back propaagation architeecture but impplementing diff-
ferrent number off hidden layerss, neurons in thhe hidden layerr
andd different typpes of activatioon functions leead to differennt 4 Conclusion
perrformance resuults. High perfformance cannnot be achievedd
by focusing on one o parameter only like in [24], where thee Even though
t there iss no generalizeed neural netwoork con-
perrformance of the network was w comparedd among threee figuration
n with zero mistakes, for a particular appliccation, a
nettworks with diifferent architeectures: Multi Layer Percep- neural network with a high
h and accepttable level of accuracy
a
troon (MLP), Genneralized Regreession (GRNN)) and Probabil- can be designed
d by manipulating
m thhe number off hidden
istiic (PNN) archhitectures. Ressults state thatt that the most umber of neuroons in the hiddden layer and the type
layers, nu
suiitable neural network
n modell for classifyinng WBCD aree of activattion functions. This experimeent includes a compari-
c
ML LP and GRNN N, and observinng that PNN peerformance wass son amon ng the obtaineed MSE as a result of trainning net-
loww in case of smmall datasets without
w mentiooning the effect works applying
a threee transfer functions: LOGSIG,
L
of the other paraameters. In [20], it is also a comparison
c de- TANSIG,, and PUREL LINE. Also, inncludes a com mparison
pennding on the type of archittecture only, and a the resultss among teesting set accurracies obtainedd by using 1, 2, 2 and 3
staate that the baack propagatioon achieves thhe best perfor- layer/s neetworks. Last comparison
c is among testingg set ac-
maance without coomparing otherr parameters. Improving thee curacies obtained
o from networks conttain 20, 21, 222, 23, 24
nettwork perform mance by foccusing on moore and moree neurons.

IFMBE Prooceedings Vol. 62

6
Using machine learning tool in classification of breast cancer
Results show that best network design is that one with
three hidden layers and 21 neurons in the hidden layer. In-
creasing hidden layers number or neurons number does not
mean for necessary better accuracy. From the three activa-
tion functions LOGSIG, PURELIN AND TANSIG provid-
ed, the network with TANSIG has produced the least MSE
i.e. 0.0001 which is very low error as compared to other
functions i.e. TANSIG function is most suitable activation
function for WBCD dataset. It has been noticed that as the
number of times we train our network model MSE decreas-
es, but overtraining may also lead to increase in error.
In future there is a possibility to study different parame-
ters and find their effect on the results for WBCD data set.
By studying all the aspects we can design a better algorithm
and tool for neural network. Also developing GUI (graph-
ical User interface) can be a strong step toward creating
proper automated system for breast cancer classification and
validation of this system on real time with acquired data
provided by hospitals in Bosnia and Herzegovina.
Designing a better algorithm will provide us a possibility
of replacing some old and less efficient classification tech-
niques by ANN which will help in time, cost, and life sav-
ing by providing the patients with early diagnosis, and re-
duce the pressure on clinics and hospitals. Moreover, it will
reduce the economic and mental burden on patients as a
result of a very long treatment of breast cancer.
Conflict of interest
The authors declare that they have no conflict of interest.
References
1. Klonisch, T., Wiechec, E., Hombach-Klonisch, S., Ande, S.
R., Wesselborg, S., Schulze-Osthoff, K., & Los, M. (2008).
Cancer stem cell markers in common cancers–therapeutic im-
plications. Trends in molecular medicine, 14(10), 450-460.
2. Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet-
Tieulent, J., & Jemal, A. (2015). Global cancer statistics,
2012. CA: a cancer journal for clinicians, 65(2), 87-108
3. Chandrasekar, R. M., & Palaniammal, V. (2013). Perfor-
mance and Evaluation of Data Mining Techniques in Cancer
Diagnosis. IOSR Journal of Computer Engineering, 15(5), 39-
44. doi:10.9790/0661-1553944.
4. Cohen, M., & Azaiza, F. (2005). Early breast cancer detection
practices, health beliefs, and cancer worries in Jewish and
Arab women. Preventive medicine, 41(5), 852-858.
5. Etingov, P. V., & Voropai, N. I. (2006, December). Applica-
tion of fuzzy logic PSS to enhance transient stability in large
IFMBE Proceedings Vol. 62
7
power systems. In Power Electronics, Drives and Energy Sys-
tems, 2006. PEDES'06. International Conference on (pp. 1-9).
IEEE.
6. Techopedia, Artificial neural network, https://www.
techopedia.com/definition/5967/artificial-neural-network-ann.
Accessed: 4 Feb 2016
7. Singh, S., & Murthy, T. V. (2013). Neural network-based sen-
sor fault accommodation in flight control system. Journal of
Intelligent Systems, 22(3), 317-333.
8. Hiyama, T. (1990). Rule-based stabilizer for multi-machine
power system. IEEE Transactions on Power Systems, 5(2),
403-411.
9. Aljovic, A., Badnjevic, A., Gurbeta, L. (2016, June). Artificial
neural networks in the discrimination of Alzheimer's disease
using biomarkers data. In Embedded Computing (MECO),
2016 5th Mediterranean Conference on (pp. 286-289). IEEE.
10. Gurbeta, L., Sajdinovic, D., Berina, A., & Badnjevic, A.
(2016, June). Classification of stress recognition using Artifi-
cial Neural Network. In Embedded Computing (MECO),
2016 5th Mediterranean Conference on (pp. 297-300). IEEE.
11. Haliloviü, S., Avdihodžiü, H., Gurbeta, L. (2016, June). Micro
cell culture analog apparatus (ýCCA) output prediction using
Artificial Neural Network. In Embedded Computing (MECO),
2016 5th Mediterranean Conference on (pp. 294-296). IEEE.
12. Fojnica, A., Osmanoviü, A., & Badnjeviü, A. (2016, June).
Dynamical Model of Tuberculosis-Multiple Strain Prediction
based on Artificial Neural Network. In Embedded Computing
(MECO), 2016 5th Mediterranean Conference on (pp. 290 -
293). IEEE.
13. Badnjevic, A, Cifrek, M., Koruga, D., Osmankovic, D. (2015)
Neuro-fuzzy classification of asthma and chronic obstructive
pulmonary disease. BMC Medical Informatics and Decision
Making Journal. 15 Suppl 3:S1; doi: 10.1186/1472-6947-15-
S2-S1
14. Badnjevic, A., Cifrek, M., & Koruga, D. (2014). Classifica-
tion of Chronic Obstructive Pulmonary Disease (COPD) using
integrated software suite. In XIII Mediterranean Conference
on Medical and Biological Engineering and Computing
2013 (pp. 911-914). Springer International Publishing.
15. UCI Machine Learning Repository, Breast Cancer Wisconsin
(Original) Data Set,’’https://archive.ics.uci.edu/ml/datasets/
Breast+Cancer+Wisconsin+(Original). Accessed: 4 Feb 2016
16. Hafizah, S., Haszlinna, N., Mustaffa, Sallehuddin, R., &
Ubaidillah, S.A. (2014). Classification of Liver Cancer Using
Artificial Neural Network and Support Vector Machine.
17. Ahmed, F. E. (2005). Artificial neural networks for diagnosis
and survival prediction in colon cancer. Molecular can-
cer, 4(1), 29.
18. B, A.R., Jaleel, J.A., & Salim, S. (2012). Artificial Neural
Network Based Detection of Skin Cancer
19. Devika, C., Amita, S. M., (2014) Case Study on Classification
of Glass using Neural Network Tool in MATLAB.
International Journal of Computer Applications® (IJCA)
(0975 – 8887), International Conference on Advances in
8 L. Abdel-Ilah, H. Šahinbegoviü

Computer Engineering & Applications (ICACEA) at
IMSEC,GZB
20. Swathi, S., Rizwana, S., Babu, G. A., Kumar, P. S., & Sarma,
P. V. G. K. (2012). Classification of Neural Network Struc-
tures For Breast Cancer Diagnosis. International Journal of
Computer Science and Communication, 3(1), 227-231.
21. Shahin, M. A., Maier, H. R., & Jaksa, M. B. (2004). Data di-
vision for developing neural networks applied to geotechnical
engineering. Journal of Computing in Civil Engineer-
ing, 18(2), 105-114.
22. Khan, N., Gaurav, D., & Kandl, T. (2013). Performance eval-
uation of Levenberg-Marquardt technique in error reduction
for diabetes condition classification. Procedia Computer Sci-
ence, 18, 2629-2637.
23. Rani, K. U. (2010). Parallel approach for diagnosis of breast
cancer using neural network technique. International Journal
of Computer Applications, 10(3), 1-5.
24. Elgader, H. A. A., & Hamza, M. H. (2011). Breast Cancer Di-
agnosis Using Artificial Intelligence Neural Networks. J. Sc.
Tech, 12, 159-171.
Corresponding author:
Author: Layla Abdel-Ilah
Institute: International Burch University
Street: Francuske Revolucije BB
City: Sarajevo
Country: Bosnia and Herzegovina
Email: Layla.abdelilah@hotmail.com

IFMBE Proceedings Vol. 62

 MULTISAB project: a web platform based on specialized frameworks for
heterogeneous biomedical time series analysis - an architectural overview

Kresimir Friganovic*, Alan Jovic*c, Kresimir Jozic**, Davor Kukolja* and Mario Cifrek*

*University of Zagreb Faculty of Electrical Engineering and Computing, Unska 3, 10000 Zagreb, Croatia
**INA – industrija nafte, d.d., Avenija Veceslava Holjevca 10, p.p. 555, HR – 10002 Zagreb, Croatia
kresimir.friganovic@fer.hr, (corr. author): alan.jovic@fer.hr, kjozic@gmail.com, davor.kukolja@fer.hr, mario.cifrek@fer.hr
c

Abstract. The aim of this work is to present an architectural over-
view of a novel web platform used for heterogeneous biomedical
time series analysis. Its architecture is based on three subprojects:
frontend, backend, and processing. Frontend uses several contem-
porary web technologies to present a fast, responsive and pleasing
user interface. Backend, written in Java, communicates with a
database and with other servers, on which the processing subpro-
ject is deployed. The processing subproject contains several
frameworks intended for: record input handling, signal prepro-
cessing, data visualization, general time series features extraction,
specific time series features extraction (e.g. heart rate variability
and electroencephalogram), data mining, and reporting. The plat-
form is in an early phase of implementation, but we demonstrate
its features and capabilities, of which feature extraction frame-
works and signal visualization currently stand out.
Keywords: framework, web platform, biomedical time series,
frontend development, signal visualization
1 Introduction
The need for biomedical software is showing growth in
healthcare community and in general population users. De-
spite a great number of web and mobile applications target-
ing general users, such as sports and fitness enthusiasts,
specialized software developed for medical professionals is
limited to continuous monitoring of biomedical time series
(BTS). To overcome this problem, we pursue the develop-
ment of an efficient and upgradeable BTS analysis system
in a form of an integrative web platform for automatic clas-
sification of human body disorders. We call it "MULTISAB
project" (short for: Multiple Time Series Analysis in Bio-
medicine). The system will serve as a help for medical spe-
cialists in diagnostics and early detection of various diseases
[1].
In our previous work, we described the early efforts in
designing such a system, which included an overview of
© Springer Nature Singapore Pte Ltd. 2017
A. Badnjevic (ed.), CMBEBIH 2017,
IFMBE Proceedings 62,
DOI: 10.1007/978-981-10-4166-2_2
used technologies and use case based scenarios specifica-
tion [1,2]. The platform predicts a total of 8 fundamental
use case scenarios: analysis type selection, scenario selec-
tion, input data selection, records inspection, records pre-
processing, feature extraction, model construction, and re-
porting [2]. Additional scenarios for handling the user ac-
count and platform administration were also provided. The
approach that we followed allows adaptive control of user
needs, and can be specialized for different kinds of analysis
goal (e.g. classification, visualization, prediction). As the
system is under development as a web platform, the users
will be able to access it from afar and transmit biomedical
data to the server, where efficient analysis can be per-
formed. Also, a web platform enables easier maintenance
and larger user base. This distinguishes our platform from
local or hospital-specific software solutions [2].
The aim of the current paper is to provide an architectural
overview and detailed description of the MULTISAB pro-
ject's frameworks, and to show the currently implemented
visualization aspects of the platform.
The architectural overview of the platform is shown in
Fig. 1. MULTISAB project is divided into three subpro-
jects: frontend, backend and processing. The frontend and
backend subprojects support communication between end
users and servers. Basic functions are currently supported:
web browser login into the system, uploading and visualiza-
tion of the heterogeneous BTS, specification of the steps
included in the analysis and defining the outcomes of the
analysis. The processing subproject contains several
frameworks for heterogeneous BTS data analysis and will
be discussed in more details in Section 2. In ideal condi-
tions, every subproject runs on different computer host(s),
therefore, they do not share physical computer resources.
TypeScript, which is used on frontend, is a strict superset of
JavaScript that compiles to the selected version of JavaS-
cript. Through his web browser, a user (client) can send
requests to the server implemented on backend.
9
10
Fig. 1. Architectural overview of the MULTISAB project web platform
The backend subproject is written in Java 8 and serves
for processing requests from users and for communication
with a database and data analysis hosts. Java 8 is used, be-
cause it enables efficient parallel processing with data
streams. A JPA framework (EclipseLink) is used to estab-
lish communication between the Java-written backend and a
relational database by using object-relational mapping. It
also implements a persistent control of data. In order to run
all the necessary resources on the backend host, Spring Boot
framework is used, which facilitates web application im-
plementation. In the future, 3D visualization of body disor-
ders using WebGL on the client-hand side will be support-
ed. In order to communicate with the graphical processing
units in Java, OpenGL/OpenCL are used with jocl Java
framework.
Communication between backend and frontend uses
HTTPS protocol to insure secure transfer and communica-
tion. For communication between Java 8 on backend and
JavaScript on frontend, RESTful protocol is used.
2 Processing frameworks
The processing subproject is written entirely in Java 8
and implements everything regarding data processing and
analysis. The subproject is divided into several frameworks
in order to improve maintainability and scalability of the
integrated system. The frameworks consist of one or more
IFMBE Proceedings Vol. 62
K. Friganovic et al.
packages specialized for different tasks in signal analysis,
which correspond to the mentioned use case scenarios.
Detailed description of some of the implemented frame-
works is given in the following subsections. Frameworks
for ECG analysis and data mining algorithms currently un-
der construction are discussed in Section 5.
2.1 Common signal features framework
The framework for common signal features extraction
includes a great number of features for time series analysis
in time (both linear and nonlinear), frequency and time-
frequency domain. The EEGframe and HRVframe [3,4]
frameworks have been refactored to extrude general BTS
features for MULTISAB processing into a common signal
features framework. The idea behind such a great number of
common features is a more accurate and more all-
encompassing analysis than it is usually pursued for BTS
(comparable to the work of Fulcher et al. [5]). The common
features can be used alone or together with specialized fea-
tures to train data mining classifiers in order to efficiently
classify diseases.
Power spectral density (PSD) of a signal, which is used
for frequency domain analysis, is implemented using three
different algorithms: fast Fourier transform (FFT), Burg
method and Lomb-Scargle method. Three window types are
supported for FFT-based PSD estimate: rectangular, Hann,
and Hamming window. Other included transformations are
Another random document with
no related content on Scribd:
hablauan, ni en el puesto ni
meneo mostrauan algun
descuydo deshonesto, y
solamente se reyan de aquellos
que hasta entonçes por solo el
hábito, estado y opinion
venerauan honrrauan y obedeçian
pensando que en si fuessen de
algun valor y preçio: y agora se
acusan por verdaderos ydiotas
engañados, pues ven por
experiençia desto sus desmanes,
su poco recogimiento y poca
vergüença. Quando los ven tan
desordenados, descomedidos en
su comer y beber, tan infames y
disolutos en sus injurias, con
tantas vozes y grita por tan façiles
y ligeras ocasiones venir á las
manos y cabello; y sobre todo me
admiraua ver aquel monstruo de
naturaleza Alcidamas cura de San
Nicholas tan desbaratado en su
vibir y costumbres, obras,
conuersaçion, que nos dexó
confusos y admirados a quantos
estauamos alli. Sin empacho
ninguno de las dueñas hazia
cosas de su cuerpo y partes
vergonçosas, y dezia de su
lengua que avn avria empacho de
lo dezir y hazer vn muy profano
joglar.
Miçilo.—Por çierto que me has
admirado, gallo, con tu tan
horrenda historia, o por mejor
dezir, atroz tragedia. ¡Quán
comun cosa es faltar los hombres
de su mayor obligaçion!
Supliquemos a nuesto Señor los
haga tan buenos que no
herremos en los imitar, y
merezçan con su ofiçio inpetrar
graçia de nuestro Señor para sí, y
para nos, y auisemos de oy más a
todos los perlados que pues en la
iglesia son pastores deste ganado
no permitan que en los tales
auctos y çelebridades de misas
nueuas aya estos ayuntamientos,
porque vengan a tanto desman.
Gallo.—Ya, Miçilo, quiero dexar
guerras y contiendas y heridas y
muertes de honbres con las
cuales te he escandalizado hasta
aqui, y quiero que agora oyas la
más alta y más feliçissima
nauegaçion que nunca a honbres
aconteçio. En fin oyras vna
admirable ventura que te quiero
contar, la qual juntamente con el
prospero suçeso te dara tanto
deleyte que holgarás
grandemente de le [980] oyr; y
pues es ya venido el dia abre la
tienda, que en el canto que se
sigue lo oyras.

Fin del deçimo septimo canto del

gallo.
 NOTAS:
[845] G., segun tengo entendido por tu esperimentada narraçion
es la mejor y más segura.
[846] me ha pareçido.
[847] G., que comunmente en semejantes lugares suelen passar
[848] G., monstruosas y prodigiosas.
[849] G., puedan entretener el tiempo.
[850] R., Jambulo.
[851] R., de oçeano.
[852] G., escriuan.
[853] G., y.
[854] G., del dezir.
[855] G., poeta.
[856] G., con tu.
[857] G., prometiste.
[858] G., en ello hago ser publico el desorden y poca templança
con que esta gente consagrada toma semejantes ayuntamientos;
los quales les auian de ser vedados por sus perlados y juezes, y
a estos querria yo ser destos relactor, porque lo podrian remediar,
antes que no a tí; porque en contartelo solo doy ocasion con mi
lengua a que auiendo tú plazer, te rias y mofes de aquella
consagrada caterua qne está en la tierra en lugar de la diuina
magestad.
[859] G., que jures de no lo.
[860] G., será.
[861] G., el fundamento.
[862] G., fiesta.
[863] G., tenía.
[864] G., llamaua.
[865] G., que no se si le conoçiste. Este mançebo.
[866] G., y el.
[867] G., de su parte.
[868] G., eran muchos.
[869] G., de la historia.
[870] G., del año.
[871] G., solenidad.
[872] G., boluimonos.
[873] G., alli.
[874] G., auia otra.
[875] G., el missa cantano.
[876] G., otra mano.
[877] G., de San Julian.
[878] G., su.
[879] G., gran.
[880] G., se sento.
[881] G., fueron.
[882] G., por ser más viejo.
[883] G., que la sçiençia son canas en el hombre.
[884] G., asentó.
[885] G., asento.
[886] Y luego dixo.
[887] G., de la Gramatica.
[888] R. (Nota marginal) Gramatica. Figura antiptosis est casus
pro casu posi.
[889] G., notandolos de ambiçiosos, glotones y de poco sosiego:
fingiendose todos tener cuenta con el plato, pero más la tenian
con lo que entre los clerigos pasaua.
[890] G., tras.
[891] G., que rodauan.
[892] G., pastel.
[893] G., de la sala.
[894] G., agora, como sali.
[895] G., apresuré por acabar presto lo misa, que avu no me
sufria.
[896] G., ser.
[897] G., entre.
[898] R. (Tachado) has de saber que.
[899] G., la arroxo.
[900] G., quebro.
[901] G., y no.
[902] G., rodeaua.
[903] G., por todas.
[904] G., a las.
[905] G., grande.
[906] G., prestando y cambiando auia adquerido.
[907] G, y vituperaua.
[908] G., mugeres; y ansi, pensandolo remediar Aristeneto
dandole muy bien a beber y que con esto le haria su amigo, ansi
mando.
[909] G., y en alta voz, que todos con silençio le oyeron,
hablando con la muger de Aristeneto, madre de misa cantano:
señora Magençia (que ansi se llamaua) yo bebo a tí; y mira que
has de beber otro tanto del vaso como yo bebiere, so pena que
no lo beuiendo se arroxe lo que quedare sobre ty; y alçando la
copa bebio della casi vn azumbre y luego la mando tornar a
enchir, y estendiendo el braço la dio a Magençia, diziendola que
sino beuia incurreria en la pena puesta y que la abrá de executar;
y Magençia encogiendose con gran verguença, diziendo que no
acostumbraua beuer, reusó el vaso con miedo que Alçidamas no
la afrontasse; y teniendo lo mesmo los combidados trabajaron
por le apartar fuera, pero él juró por sus ordenes que sino daua
vn fiador que beuiesse por ella que se lo auia de derramar
acuestas; y el cura de San Miguel, que alcançaua buena parte
deste menester se leuantó y dando a entender que lo hazia por
defender a la señora huespeda y empedir que no la afrontasse
Alçidamas, pues este se leuantó de su lugar y saliendo en el
medio de la sala dixo a Alçidamas: dame acá la copa, que yo
quiero cumplir por la señora Magençia; y ansi tomando el vaso en
sus manos beuio vn terrible golpe, que a juizio de todos igualó.
[910] G., amago determinado de arrojar sobre Magençia lo que
en el vaso quedó, pero el cura.
[911] G., tomó.
[912] G., y hizole.
[913] G., y Eustochio, cura de San Martin, porque a todos auia
injuriado con sus donayres; y por el contrario, en fabor de
Alçidamas, por ser sus vezinos y amigos viejos se leuantaron el
sacristan de San Miguel y el cura de San Juan y el cura de San
Pedro y el cura de Santa Marina.
Miçilo.—Que, alli vino el cura de San Pedro? no faltarian
gargajos y importunidad en su vejez.
Gallo.—Alli vino con asco y desgraçia de todos; que en vna silla
le truxieron porque estaua muy enfermo.
[914] G., arroxadas.
[915] G., como graniço.
[916] G., en.
[917] G., a que las damas çerrassen las orejas y avn los ojos.
[918] G., y ansi a este tono si.
[919] G., este tiempo.
[920] G., con vna cuerda.
[921] G., de la sala, començaron.
[922] G., de sautoriçada.
[923] G., y proçedio el.
[924] G., por mi amor.
[925] G., hazian.
[926] G., dexauan.
[927] G., limpiarse el.
[928] G., suçias maneras de festejar, porque avn viles joglares se
desdeñarian tratarlas, por no perder credito con el auditorio.
Estando en esto que todos callauan.
[929] Falta este epígrafe en el ms.
[930] G., ayas.
[931] G., mio.
[932] G., fue infamado con peligro y jatura de mi honrra.
[933] G., que tenía.
[934] G., injurias.
[935] G., los.
[936] diziendo tú a todos que.
[937] G., los.
[938] G., en.
[939] G., ay estan en tu.
[940] G., bueluas.
[941] G., lo.
[942] G., dixe.
[943] G., la oyste.
[944] G., començaron todos a murmurar.
[945] G., vnos dezian que era aguda, a lo menos los amigos de
Etemocles, y dezian que era muy sabiamiente escripta, que bien
pareçia ser de letrado. Los contrarios dezian que no era muy
cuerda y acusauan a Etemocles de hombre gloton y dezian que
la auia escripto como afrontado por no le aver combidado a la
fiesta y comida. Estando...
[946] G., graciosa.
[947] G., representó ingeniosamente la proçesion que hacen los
portugueses el dia de Corpus Cristi y predicó el sermon que ellos
suelen predicar el dia que celebran la batalla del Aljubarrota.
[948] G., despues tañendo con su laud començó en copla de
repente a motejar a todos quantos estauan en la mesa, sin
perjudicar ni afrontar a ninguno, y reyendo donayres.
[949] G., con el.
[950] G., dexando el.
[951] G., procuró por le.
[952] G., tomo.
[953] G., osasse.
[954] G., y cruel como de la Farsalia.
[955] G., acudio.
[956] G., y que el xoglar auia dado a Alçidamas con el palo vn
gran golpe que le descalabró mal. De manera que todos aquellos
curas fueron por el semejante heridos, qual en la cabeça, qual en
el rostro; por lo qual fue neçesario que todos los lleuassen a sus
posadas a los curar. Pues echada toda aquella gente arriscada
fuera de la sala, se alçaron las mesas y se tornaron los que
quedaron a sosegar. Pero como el diablo nunca sosiega de meter
mal y dar ocasion a que suçeda siempre peor, suçedio que
Cleodemo, padrino, boluiendo a la carta de Etemocles, porque
sintio afrontado a Aristeneto y avn a aquellos religiosos que junto
a si tenía, dixo: ¿qué os parecede las elegantes razones de
Etemocles?
[957] G., torta.
[958] G., el.
[959] G., la.
[960] G., que la carta venia elegante muy cuerdamente escripto y
como de letrado.
[961] G., por lo qual.
[962] G., principalmente porque en lo que yo he dicho ninguna
injuria le hize, pues de todos es conoçido Etimoclides bien de
quantos aqui estan, y no me marauillo que responda por él, pues
ambos tienen hecho liga y monipodio en el trato de sus
feligreses, y ansi an jurado ambos a dos de no enterrar a ninguno
en su feligresia.
[963] G., le dio con la copa de vino en el rostro, que le enuistio
todo del, y luego Zenotemides tomó a Cleodemo por la
sobrepelliz y le truxo al suelo y hizole dar con el rostro y cabeça
en vn vanco, de que mal le descalabró. En fin los frayles y misa
cantano y los demas los apartaron, y fue neçesario que
Cleodemo se fuesse luego a su casa a curar, y tambien
Zenothemides se fue. Pues purgada la casa de todos aquellos
arriscados y belicosos capitanes, porque todos fueron de tres
recuentros heridos y sacados del campo, como te he contado...
[964] G., enbobeçidos.
[965] G., ver en gente de tanto exemplo tanto desman.
[966] G., pensaron que hazer.
[967] G., como fue echada.
[968] G., llegosse.
[969] G., Dionico al misa cantano.
[970] G., entiznole.
[971] G., y llenaronle fuera de.
[972] G., del.
[973] G., homo. Misçilo. Propriamente lo pudo dezir.
[974] G., todo el lugar.
[975] G., Dime, gallo, en el entretanto que estas cosas pasauan,
¿que pensauas tú?
[976] G., cosas se çelebrauan pensaua yo otras muchas.
[977] G., alta.
[978] G., letras.
[979] G., ellas.
 ARGUMENTO
DEL DEÇIMO
OCTAUO CANTO
DEL GALLO

En el deçimo octauo canto o

sueño que se sigue el auctor
muestra los grandes daños
que en el mundo se siguen por
faltar la verdad[981] de entre
los hombres.

Miçilo.—Pues por tu buena

ventura, gallo, o Pithagoras, o
como más te quisieres llamar, de
todas las cosas tienes esperiençia
que en el çielo y en la tierra
pueden aconteçer agora: yo
deseo mucho de ti saber me
declares vna admirable dubda
que grauemente atormenta mi
spiritu sin poder hallar quién me
satisfaga con bastante respuesta.
¿De dónde prouiene en algunos
vna insaçiable cobdiçia de mentir
en quanto hablan, en tanta
manera que a sí mesmos con
sumo deleyte se saborean, como
sepan que todo es vanidad
quanto dizen, y con suma
efficaçia tienen en atençion los
animos de los oyentes?
Gallo.—Muchas cosas son ¡o
Micilo! las que fuerçan algunas
vezes los hombres a mentir.
Como es en los belicosos y
hombres de guerra se tiene por
ardid saber con mentira engañar
al enemigo, como en esta arte fue
muy sagaz y industrioso Ulises; y
tanbien lo vsan los cobdiçiosos de
riquezas y honrras mundanas por
vender sus mercaderias y
auentajarse en sus
contrataçiones. Pero avnque todo
esto sea ansi te ruego me digas la
ocasion que a saberlo te mueue?
Miçilo.—Todo eso se sufre que
me has dicho por ofreçerse en
esos casos intereses que a mentir
os[982] mueue. Pero donde no se
les ofreçe interes de más que
satisfazer[983] su apetito, ¿de
dónde les viene la inclinaçion a
tan nefando y odioso viçio? Que
ay hombres que en ninguna cosa
ponen más arte, cuydado y
industria que en mentir sin algun
interes como al presente te quiero
contar. Bien conoçes a
Demophon nuestro vezino.
Gallo.—¿Es este rico que está
en nuestra vezindad?
Miçilo.—Ese mesmo. Ya sabes
que abrá ocho dias que se le
murio su muger. Pues a esta
causa por ser mi vezino y amigo
que sienpre me combidó a sus
çenas y çelebridades, quisele yr
la noche passada a visitar y
consolar en su viudez.
Gallo.—Antes auias de dezir[984]
a le dar la buena pro haga.
Miçilo.—Pues auianme dicho
que con el gran pessar que tenía
de la muerte de su muger estaua
enfermo, y ansi le hallé en la
cama muy afligido y llorando, y
como yo entré y le saludé me
reçibio con alguna liberalidad
mandandome sentar en vna silla
que tenía muy cerca de sí, y
despues que le vbe dicho
aquellas palabras que se suelen
dezir en el comun: señor,
pessame de la muerte de vuestra
muger y de vuestro mal;
començele a inportunar me
dixesse qué era la causa que de
nueuo le hazia verter lagrimas
auiendo ya algunos dias que se le
auia muerto la muger. A lo qual
me respondio, que no se le
ofreçia cosa que más nueua le
fuesse que auersele muerto la
muger, su compañera la que él
tanto amó[985] en esta vida y de
que tanto se deuia perpetuamente
acordar[986], y dixome que
estando alli en su cama solo la
noche passada en consideraçion
de la[987] soledad y miseria que le
quedaua sin su[988] amada
Feliçia, que ansi se llamaua su
muger, pessandole mucho por
auerla desgraçiado[989] poco
antes de su muerte[990], porque
rogandole ella que le renouasse
çiertas joyas de oro y faldrillas
que ella tenía de[991] otro tiempo,
no lo auia hecho, y que estando
muy apesarado pensando en
esto, por no le auer complazido le
apareçio Feliçia increpandoles
porque auiendole sido en todo
muy cunplido y liberal, auia sido
muy corto en lo que más
hazia[992] a su honrra, porque en
su entierro y obsequias no la
auian acompañado el cabildo
mayor y cantores con musica, y
porque no la auian tañido las
campanas con solenidad, que
llaman enpino, y que la lleuaron al
tenplo en vnas comunes andas
auiendola de lleuar en ataud; y
otras cosas dixo del paño que
ençima de si lleuaua[993], si era
de brocado, luto o seda. Lo qual
todo pareçiendome muy grandes
disparates y liuiandades me reí
diziendo que se consolasse
mucho, que buen remedio tenía
tornando de nueuo a hazer las
obsequias; y por pareçerle que yo
no lo creya lo trabajó apoyar con
grandes juramentos, y por que via
que mientra él más juraua yo
menos le creya, se leuantó en
camisa de la cama y se abajó
inclinado de rodillas en el suelo
señalándome con el dedo las
señales de sus pies que alli auia
dexado y imprimido, y estaua todo
el suelo tan llano y tan igual que
no se hallara vn cabello de
differençia aunque tuuierades
ojos de linçe; y ansi por me
persuadir su sueño se tornó a la
cama donde sentado y
mandándose encorporar de[994]
almohadas que le tuuiessen
proçedio en cosas tan
monstruosas y tan sin orden
acerca de su sueño y vision, y en
loor de su mujer que no
huviera[995] en el mundo tan vano
juizio que las creyera[996], hasta
que quebrada la cabeça de le
oyr[997] me despedi dél y me
vine[998] acostar.
Gallo.—Verdad es ¡o, Miçilo! que
esas cosas que Demophon ay te
conto no son de creer de
razonable juizio, porque ya te he
dicho lo que en la buelta de las
almas de los defuntos ay[999].
Pero mira bien no incurras tú en
vn genero de incredulidad que
tienen algunos hombres, que
ninguna cosa les dizen por façil y
comun que sea que la quieran
creer; pero marauillandose de
todo, se espantan y santiguan y
todo dizen que es mentira y
monstruosidad. Lo qual todo es
argumento de poca esperiençia y
saber. Porque como no han visto
nada, ni han leydo nada,
qualquiera cosa que de nueuo
vean les pareçe ser hecho[1000]
por arte de encantamiento o
embaymiento, y por el semejante,
qualquiera cosa que de nueuo
oyan y[1001] les digan se
encogen, espantan y admiran, y
tienen por aueriguado que la
fingen siendo mentira por vurlar
dellos y los engañar. Pero los
sabios, los que todo lo han visto,
los que todo lo han leydo, todo lo
menospreçian, todo lo tienen en
poco, y ansi passando adelante lo
rien y mofan y tachan y
reprehenden, mostrando auer
ellos visto mucho más sin
comparaçion. Ansi agora tú
considera que no es peor
estremo, no creer nada, que
creerlo todo, y piensa que
ninguna cosa puede imaginar el
entendimiento humano que no
pueda ser, y que marauilla es que
todo lo que puede ser, sea de
hecho ya y acontezca. Pues ansi
agora yo, Miçilo, me temo si no
quieres creer cosa de quantas
hasta agora te he dicho, y pienses
y sospeches que todo ha sido
mentira y fingido por te dar
passamiento, y ansi creo que
menos creras vn admirable
aconteçimiento que agora te
queria contar, porque junto con lo
que hasta aqui te he contado
exçede en admiraçion sin
comparaçion alguna a lo que
Demophon tu vezino te persuadio
auer visto.
Miçilo.—Mira, gallo, que
entendido tengo que todas las
cosas verdaderas que se dizen si
bien se quieren mirar muestran en
sí vna verisimilitud que fuerçan al
entendimiento humano a las
creer; porque luego representan y
reluze en ellas aquella deidad de
la verdad que tienen en sí, y
después desto tiene gran fuerça
la auctoridad del que las dize, en
tanta manera que avn la mesma
mentira es tenida por verdad. Ansi
que por todas estas razones soy
forçado a que lo que tú dixeres te
aya yo de creer; por lo qual, di, yo
te ruego, con seguridad y
confiança, que ninguna cosa que
tú dixeres dubdaré,
prinçipalmente que no ay
marauilla alguna que me
marauille despues que vi a tí
siendo gallo hablar nuestra
lengua; por lo qual me persuades
a creer que tengas alguna deydad
de beatitud, y que por esta no
podras mentir.
Gallo.—Por cierto yo queria
çesar ¡o Miçilo! de mi narraçion
por auerla interrumpido con
alguna señal de dubda. Dexaras
en verdad de gozar de la más alta
y más feliçissima historia que
nunca hasta agora ingenio de
historiador ha[1002] escripto, y
prinçipalmente por narrartela yo
que soy el que la passé. Pero por
la seguridad que al credito y fe
me tienes dada quiero proçeder,
porque no quiero pribarte del
gusto y deleyte admirable que en
oyrla gozarás, y verás despues
que la ayas oydo de quanto sabor
te pribarás si por ignorar antes lo
que era menos preçiaras de lo
oyr, y conoçerás quanto amigo te
soy y buen apaniguado y familiar,
pues no estimando la injuria que
me hazias con tu dubdar te
comunico tan gran beatitud. Por
tanto prestame atençion, que oy
verás quan elegante rectorico soy.
Tú sabras, que en vn tiempo
siendo mançebo y cobdiçioso de
ver, vino nueua en Castilla que se
auian ganado en las partes
oçidentales aquellas grandes
tierras de la Nueua España[1003]
que nueuamente ganó aquel
animoso marques del Valle,
Cortés, y por satisfazer en alguna
manera el insaçiable animo de mi
deseo que tenía de ver tierras y
cosas nueuas determinéme de
enbarcar, y auenturarme a esta
nauegaçion, y ansi en este
mesmo deseo me fue para la
çiudad y ysla de Caliz donde se
hazia el flete mas conueniente y
natural para semejante xornada; y
llegado alli[1004] hallé diez
conpañeros que con el mesmo
affecto y voluntad eran venidos
alli, y como en aquella çiudad
venian muchos de aquella nueua
tierra y nos dezian cosas de
admiraçion, creçianos mas el
apetito de caminar. Deziannos el
natural de las gentes, las
costumbres, atauio y dispusiçion;
la diuersidad de los animales,
aues, frutas y mantenimientos y
tierra. Era tan admirable lo que
nos dezian juntamente con lo que
nos mostrauan los que de allá
venian que no nos podiamos
contener[1005], y ansi juntandonos
veynte compañeros todos
mançebos y de vna edad, hecho
pacto entre nosotros inuiolable de
nunca nos faltar, y çelebradas las
çerimonias de la[1006] amistad con
juramento solene fletamos vn
nauio vezcayno velero y ligero,
todos de bolsa comun, y con
prospero tiempo partimos vn dia
del puerto, encomendados a Dios,
y ansi nos continuó siete dias
siguientes hasta que se nos
descubrieron las yslas fortunadas
que llaman de Canaria. Donde
tomado refresco[1007] despues de
vista la tierra, con prospero
tiempo[1008] tornamos a salir de
alli y caminando por el mar al
terçero dia de nuestro camino dos
horas salido el sol haziendo claro
y sereno el çielo dixeron los
pilotos ver vna ysla de la qual no
tenian notiçia ni la podian
conoçer, de que estauan
admirados y confusos por no se
saber determinar, poniendonos en
gran temor ansi a deshora,
admirauanse más turbados de ver
que la ysla caminaua más
veniendo ella azia[1009] nosotros
que caminauamos nosotros para
ella. En fin en breue tiempo nos
venimos tanto juntando que
venimos a conoçer que aquella
que antes nos pareçia ysla era vn
fiero y terrible animal. Conoçimos
ser vna vallena de grandeza
increyble, que en sola la frente
con un pedaço del çerro que se
nos descubria sobre las aguas del
mar juzgauamos auer quatro
millas. Venia contra nosotros
abierta la boca soplando muy
fiera y espantosamente que a
diez millas haçia retener el nauio
con la furia de la ola que ella
arroxaua de sí; de manera que
viniendo ella de la parte del
poniente, y caminando nosotros
con prospero leuante nos forçaua
calmar, y avn boluer atras el
camino. Venia desde lexos
espumando y turbando el mar con
gran alteraçion; ya que estuuimos
más çerca que
alcançauamos[1010] a verla más
en particular pareçiansele los
dientes tan terribles cada vno
como vna montaña[1011] de
hechura de grandes palas;
blancos como el fino marfil.
Venimos adelante a juzgar por la
grandeza que se nos mostró
sobre las aguas, ser de longura
de dos mil leguas. Pues como nos
vimos ya en sus manos y que no
le podiamos huyr[1012]
començamonos a abraçar entre
los compañeros, y a darnos las
manos con grandes lagrimas y
alarido, porque viamos el fin de
nuestra vida y compañia estar en
aquel punto sin remedio alguno, y
ansi dando ella un terrible
empujon por el agua adelante y
abriendo la boca nos tragó tan sin
embaraço ni estorbo de dientes ni
paladar que sin tocar en parte
alguna con gauia, velas, xarçia y
muniçion y obras muertas fuemos